Patents by Inventor Shey-Shing Sheu

Shey-Shing Sheu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Low intensity magnetic field devices for treatment of cardiac and neurological disorders
    Patent number: 9873000
    Abstract: There is provided a medical device comprising a low intensity electromagnetic field source to increase the respiratory control index values (RCI) of mitochondria. The medical device may be implantable, such as a cardiac rhythm management device, a stent, or a vascular graft. The device may also be worn externally, such as a treatment device having a matrix of magnetic coils that is worn on the head for the treatment of various neurological conditions.
    Type: Grant
    Filed: August 1, 2012
    Date of Patent: January 23, 2018
    Assignee: UNIVERSITY OF ROCHESTER
    Inventors: Arthur Jay Moss, Ilan Goldenberg, Shey-Shing Sheu, Gisela Beutner, Mark F. Bocko, Ido Goldenberg
  • Low Intensity Magnetic Field Devices For Treatment of Cardiac And Neurological Disorders
    Publication number: 20140228619
    Abstract: There is provided a medical device comprising a low to intensity electromagnetic field source to increase the respiratory control values (RCI) of mitochondria. The medical device may be implantable, such as a cardiac rhythm management device, a stent, or a vascular graft. The device may also be worn externally, such as a treatment device haying matrix of magnetic coils that is worn on the head for the treatment of various neurological conditions.
    Type: Application
    Filed: August 1, 2012
    Publication date: August 14, 2014
    Applicant: University of Rochester
    Inventors: Arthur Jay Moss, Ilan Goldenberg, Shey-Shing Sheu, Gisela Beutner, Mark F. Bocko, Ido Goldenberg
  • Mitochondria-targeted antioxidant prodrugs and methods of use
    Patent number: 8470861
    Abstract: The present invention is a mitochondria-targeted antioxidant prodrug useful for the prevention or treatment of diseases or conditions associated with mitochondrial dysfunction resulting from changes in the mitochondrial redox environment. Antioxidant prodrugs of the invention are produced by modifying an antioxidant to a fatty acid so that the resulting prodrug is targeted to and activated by an enzyme of mitochondrial fatty acid beta-oxidation.
    Type: Grant
    Filed: January 27, 2010
    Date of Patent: June 25, 2013
    Assignee: University of Rochester
    Inventors: Marion W. Anders, James L. Robotham, Shey-Shing Sheu, Paul Spencer Brookes, Jalil Shojaie, Leif Olson, Richard L. Parton
  • Compounds for Delivering Amino Acids or Peptides with Antioxidant Activity into Mitochondria
    Publication number: 20110257107
    Abstract: Disclosed are compounds containing single amino acids, peptides, or derivatives thereof which are selectively delivered to the mitochondria of a cell. Compounds of the invention exhibit antioxidant activity thereby reducing reactive oxygen species in cells. These compounds are useful for inhibiting oxidative stress-induced cell injury or death both in vivo and ex vivo. In addition, methods for the synthesis of these compounds are disclosed.
    Type: Application
    Filed: June 27, 2011
    Publication date: October 20, 2011
    Applicant: University of Rochester
    Inventors: Shey-Shing Sheu, Marion W. Anders, Lin Xu, Virendra K. Sharma, Dhanajaya Nauduri
  • Mitochondria-targeted antioxidant prodrugs and methods of use
    Publication number: 20100168198
    Abstract: The present invention is a mitochondria-targeted antioxidant prodrug useful for the prevention or treatment of diseases or conditions associated with mitochondrial dysfunction resulting from changes in the mitochondrial redox environment. Antioxidant prodrugs of the invention are produced by modifying an antioxidant to a fatty acid so that the resulting prodrug is targeted to and activated by an enzyme of mitochondrial fatty acid beta-oxidation.
    Type: Application
    Filed: January 27, 2010
    Publication date: July 1, 2010
    Inventors: Marion W. Anders, James L. Robotham, Shey-Shing Sheu, Paul Spencer Brookes, Jalil Shojaie, Leif Olson, Richard L. Parton
  • Mitochondria-Targeted Antioxidant Prodrugs and Methods of Use
    Publication number: 20090306125
    Abstract: The present invention is a mitochondria-targeted antioxidant prodrug useful for the prevention or treatment of diseases or conditions associated with mitochondrial dysfunction resulting from changes in the mitochondrial redox environment. Antioxidant prodrugs of the invention are produced by modifying an antioxidant to a fatty acid so that the resulting prodrug is targeted to and activated by an enzyme of mitochondrial fatty acid beta-oxidation.
    Type: Application
    Filed: November 20, 2006
    Publication date: December 10, 2009
    Inventors: Marion W. Anders, James L. Robotham, Shey-Shing Sheu
  • Compounds for Delivering Amino Acids or Peptides with Antioxidant Activity into Mitochondria and Use Thereof
    Publication number: 20090298782
    Abstract: Disclosed are compounds containing single amino acids, peptides, or derivatives thereof which are selectively delivered to the mitochondria of a cell. Compounds of the invention exhibit antioxidant activity thereby reducing reactive oxygen species in cells. These compounds are useful for inhibiting oxidative stress-induced cell injury or death both in vivo and ex vivo. In addition, methods for the synthesis of these compounds are disclosed.
    Type: Application
    Filed: December 18, 2006
    Publication date: December 3, 2009
    Applicant: UNIVERSITY OF ROCHESTER
    Inventors: Shey-Shing Sheu, Marion W. Anders, Lin Xu, Virendra K. Sharma, Dhananjaya Nauduri
  • Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof
    Patent number: 7585846
    Abstract: Disclosed are hydrophilic choline/N-heterocycle ester compounds containing single amino acids, peptides, or derivatives thereof which have the potential to express anti-oxidant activity capable of reducing reactive oxygen species in cells. These compounds may be used to inhibit oxidative stress-induced cell injury or death both in vivo and ex vivo. In addition, methods for the synthesis of these compounds are disclosed.
    Type: Grant
    Filed: November 26, 2004
    Date of Patent: September 8, 2009
    Assignee: University of Rochester
    Inventors: Shey-Shing Sheu, Marion W. Anders, Lin Xu, Virendra K. Sharma
  • Compositions and Methods for Attenuating Mitochondria-Mediated Cell Injury
    Publication number: 20090149540
    Abstract: The present invention relates to a S-nitrosated mitochondria-targeted thiol-based antioxidant prodrug and uses therefore for the prevention or treatment of diseases or conditions associated with mitochondrial dysfunction resulting from changes in the mitochondrial redox environment. When activated, prodrug of the present invention can specifically provide a NO* donor and a thiol-based antioxidant to mitochondria thereby decreasing the degree of mitochondrial dysfunction.
    Type: Application
    Filed: December 18, 2006
    Publication date: June 11, 2009
    Inventors: Paul S. Brookes, Shey-Shing Sheu, Marion W. Anders
  • FLUORESCENT PROTEINS FOR MONITORING INTRACELLULAR SUPEROXIDE PRODUCTION
    Publication number: 20080299599
    Abstract: Protein probes and methods for measuring real-time changes in intracellular superoxide formation are provided. The probes include superoxide sensitive variants of yellow fluorescent and green fluorescent proteins. The probes, or nucleic acids encoding the probes, may be delivered to cells or organisms. Changes in the fluorescence of the probes may then be detected using standard real-time fluoroscopy techniques.
    Type: Application
    Filed: September 6, 2007
    Publication date: December 4, 2008
    Inventors: Robert Dirksen, Heping Cheng, Shey-Shing Sheu, Wang Wang, Linda Groom
  • Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof
    Publication number: 20070099845
    Abstract: Disclosed are compounds containing single amino adds, peptides, or derivatives thereof which have the potential to express anti-oxidant activity capable of reducing reactive oxygen species in cells. These compounds may be used to inhibit oxidative stress-induced cell injury or death both in vivo and ex vivo. In addition, methods for the synthesis of these compounds are disclosed.
    Type: Application
    Filed: November 26, 2004
    Publication date: May 3, 2007
    Inventors: Shey-Shing Sheu, Marlott Anders, Lin Xu, Virendra Sharma
  • Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof
    Publication number: 20060160748
    Abstract: Disclosed are compounds containing single amino acids, peptides, or derivatives thereof which are selectively delivered to the mitochondria of a cell. Compounds of the invention exhibit antioxidant activity thereby reducing reactive oxygen species in cells. These compounds are useful for inhibiting oxidative stress-induced cell injury or death both in vivo and ex vivo. In addition, methods for the synthesis of these compounds are disclosed.
    Type: Application
    Filed: December 20, 2005
    Publication date: July 20, 2006
    Inventors: Shey-Shing Sheu, Marion Anders, Lin Xu, Virendra Sharma, Dhananjaya Nauduri
  • Compositions and methods for attenuating mitochondria-mediated cell injury
    Publication number: 20060122267
    Abstract: The present invention relates to a S-nitrosated mitochondria-targeted thiol-based antioxidant prodrug and uses therefore for the prevention or treatment of diseases or conditions associated with mitochondrial dysfunction resulting from changes in the mitochondrial redox environment. When activated, prodrug of the present invention can specifically provide a NO• donor and a thiol-based antioxidant to mitochondria thereby decreasing the degree of mitochondrial dysfunction.
    Type: Application
    Filed: December 20, 2005
    Publication date: June 8, 2006
    Inventors: Paul Brookes, Shey-Shing Sheu, Marion Anders