Patents by Inventor Shi-Da Yu Lu

Shi-Da Yu Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gag gene primers for the detection of HIV-1
    Patent number: 5908743
    Abstract: The present invention provides improved primers for the polymerase chain reaction (PCR) amplification of a nucleic acid sequence from the gag gene of the human immunodeficiency virus type 1 (HIV-1). The primers and amplification methods of the invention enable the detection of all HIV-1 group M isolates with nearly uniform efficiency.
    Type: Grant
    Filed: January 9, 1998
    Date of Patent: June 1, 1999
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Cindy Dawn Christopherson, Shirley Yee Kwok, Shi-Da Yu Lu
  • Cysteine-depleted muteins of biologically active proteins
    Patent number: 4959314
    Abstract: Muteins of biologically active proteins such as IFN-.beta. and IL-2 in which cysteine residues that are not essential to biological activity have been deleted or replaced with other amino acids to eliminate sites for intermolecular crosslinking or incorrect intramolecular disulfide bridge formation. These muteins are made via bacterial expression of mutant genes that encode the muteins that have been synthesized from the genes for the parent proteins by oligonucleotide-directed mutagenesis.
    Type: Grant
    Filed: February 7, 1985
    Date of Patent: September 25, 1990
    Assignee: Cetus Corporation
    Inventors: David F. Mark, Leo S. Lin, Shi-da Yu Lu, Alice M. Wang
  • Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of biologically active proteins
    Patent number: 4853332
    Abstract: Muteins of biologically active proteins such as IFN-.beta. and IL-2 in which cysteine residues that are not essential to biological activity have been deleted or replaced with other amino acids to eliminate sites for intermolecular crosslinking or incorrect intramolecular disulfide bridge formation. These muteins are made via bacterial expression of mutant genes that encode the muteins that have been synthesized from the genes for the parent proteins by oligonucleotide-directed mutagenesis.
    Type: Grant
    Filed: December 21, 1984
    Date of Patent: August 1, 1989
    Assignee: Cetus Corporation
    Inventors: David F. Mark, Leo S. Lin, Shi-Da Yu Lu
  • Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-.beta.
    Patent number: 4737462
    Abstract: A modified IFN-.beta. is provided wherein the cysteine residue at position 17 is deleted and serine is substituted therefor. DNA sequences coding for the modified protein, nucleotide primers used for the mutagenesis, appropriate cloning vectors, host organisms transformed with the vectors, methods for the production and use of the modified IFN-.beta. (IFN-.beta..sub.ser17) are also provided. The specific activity of IFN-.beta..sub.ser17 is found to be substantially the same as that of native IFN-.beta..
    Type: Grant
    Filed: July 10, 1985
    Date of Patent: April 12, 1988
    Assignee: Cetus Corporation
    Inventors: David F. Mark, Leo S. Lin, Shi-Da Yu Lu
  • Human recombinant cysteine depleted interferon-.beta. muteins
    Patent number: 4588585
    Abstract: Muteins of biologically active proteins such as IFN-.beta. and IL-2 in which cysteine residues that are not essential to biological activity have been deleted or replaced with other amino acids to eliminate sites for intermolecular crosslinking or incorrect intramolecular disulfide bridge formation. These muteins are made via bacterial expression of mutant genes that encode the muteins that have been synthesized from the genes for the parent proteins by oligonucleotide-directed mutagenesis.
    Type: Grant
    Filed: September 28, 1984
    Date of Patent: May 13, 1986
    Assignee: Cetus Corporation
    Inventors: David F. Mark, Leo S. Lin, Shi-Da Yu Lu