Patents by Inventor Shi-Fang Yan

Shi-Fang Yan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for suppressing early growth response—1protein (Egr-1) to reduce vascular injury in a subject
    Patent number: 6969704
    Abstract: The invention provides a method for reducing damage to an ischemic tissue which comprises contacting cells of the tissue with an inhibitor of Early Growth Response Factor-1 Protein (Egr-1). In addition, the invention provides a method for reducing vascular injury during reperfusion of an ischemic tissue in a subject which comprises contacting the tissue with a compound which inhibits expression of Early Growth Response Factor-1 (Egr-1) protein in the tissue so as to reduce vascular injury in the tissue during reperfusion. wherein the inhibitor is a nucleic acid consisting essentially of the polynucleotide sequence 5?-CTTGGCCGCTGCCAT-3? (SEQ ID NO:1). In one embodiment of the invention, the subject has suffered a stroke, or a myocardial infarction. In another embodiment of the invention, the subject is undergoing or has undergone angioplasty, cardiac surgery, vascular surgery, or organ transplantation.
    Type: Grant
    Filed: August 25, 2000
    Date of Patent: November 29, 2005
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: David Pinsky, David M. Stern, Shi-Fang Yan