Abstract: Stably consolidated compounds assembled from a statin and a metformin analog, and metabolically labile dual prodrugs assembled from the same, methods of making both, and methods of using them to treat metabolic diseases such as cancers are described.

Abstract: Exosomes that express peptides in CD9 proteins, and smart exosomes that co-express two peptides incorporated into CD9 proteins to home delivery of the exosomes to a desired target and evade phagocytosis by macrophages, are described. Provided are exosomes useful for delivering drugs to desired targets. The exosomes comprise drugs, such as chemotherapeutic drugs, encapsulated in their core. The targets include pancreatic cancer cells.

Abstract: Described herein are compositions, formulations, and methods useful for sensitizing cancer cells to chemotherapeutic agents, for inhibiting expression or translation of oncogenic proteins, for inhibiting eIF4A, for inhibiting c-MYC, for reducing sternness of breast cancer cells, for treating breast cancer, for overcoming drug resistance of drug-resistant cancer cells, and for reducing tumor cell viability, involving one or more inhibitors of eIF4A, LASP1, CXCR4, CXCL8, CXCL12, ROCK1, BIRC5, MDM2, CCND1, and c-MYC.

Abstract: Disclosed is an energy-saving bidirectional ship lift by gravity balancing, including: a ship lift body. A first support is provided in a middle of the ship lift body. A second support is provided at a side of the first support. A third support is provided at the other side of the first support. A space between the second support and the first support forms a first shaft. A space between the first support and the third support forms a second shaft. A first ship-carrying chamber and a second ship-carrying chamber are respectively provided in the first shaft and the second shaft to allow two ships to be transported at the same time. An entry water tank and an exit water tank are provided at two sides of each ship-carrying chamber to adjust the weight of the two ship-carrying chambers.

Abstract: The present invention provides nucleic acid constructs, expression vectors, transgenic cell and methods of making and using the same, wherein the nucleic acid construct includes a synthetic promoter designed from the endogenous promoter of BIRC5 and LAMC2. In illustrative working embodiments of the invention, an exogenous nucleic acid fragment encoding thymidine kinase is operably linked to the synthetic promoter which is then shown to regulate the expression of this polypeptide.

Abstract: Disclosed is an energy-saving bidirectional ship lift by gravity balancing, including: a ship lift body. A first support is provided in a middle of the ship lift body. A second support is provided at a side of the first support. A third support is provided at the other side of the first support. A space between the second support and the first support forms a first shaft. A space between the first support and the third support forms a second shaft. A first ship-carrying chamber and a second ship-carrying chamber are respectively provided in the first shaft and the second shaft to allow two ships to be transported at the same time. An entry water tank and an exit water tank are provided at two sides of each ship-carrying chamber to adjust the weight of the two ship-carrying chambers.

Abstract: Exemplary embodiments relate to methods, mediums, and systems for messaging bots configured to converse with page administrators and advertisers to assist them in managing their presence on a platform, such as a social networking service. A user may have a problem or be able to optimize their presence on the platform in some way, but may not know to search for the issue (or may not even know that they have a problem). Exemplary embodiments provide a helper bot that can be triggered by real-time or asynchronous events, and guide the user through problem-solving. Triggered messages to the users can be delayed or sent under certain conditions to prevent spamming the user. The messages have a custom format that allows the conversation to be represented as a chain encapsulating the entire conversation context.

Abstract: The present invention provides nucleic acid constructs, expression vectors, transgenic cell and methods of making and using the same, wherein the nucleic acid construct includes a synthetic promoter designed from the endogenous promoter of BIRC5 and LAMC2. In illustrative working embodiments of the invention, an exogenous nucleic acid fragment encoding thymidine kinase is operably linked to the synthetic promoter which is then shown to regulate the expression of this polypeptide.

Abstract: The present invention provides nucleic acid constructs, expression vectors, transgenic cell and methods of making and using the same, wherein the nucleic acid construct includes a synthetic promoter designed using selected PDX-1 activation sites such as those observed in the human insulin promoter (HIP). In illustrative working embodiments of the invention, an exogenous nucleic acid fragment encoding thymidine kinase is operably linked to the synthetic promoter which is then shown to regulate the expression of this polypeptide.

Abstract: The present invention provides nucleic acid constructs, expression vectors, transgenic cell and methods of making and using the same, wherein the nucleic acid construct includes a synthetic promoter designed using selected PDX-1 activation sites such as those observed in the human insulin promoter (HIP). In illustrative working embodiments of the invention, an exogenous nucleic acid fragment encoding thymidine kinase is operably linked to the synthetic promoter which is then shown to regulate the expression of this polypeptide.

Abstract: A covering apparatus includes a seat assembly and a cover. The seat assembly includes at least a seat with a plurality of flights on an internal side. Each of the flights includes a plurality of steps. The cover includes, on a lower side along an edge, a plurality of flights corresponding to the flights of the seat. Each of the flights of the cover includes a plurality of steps corresponding to the steps of each of the flights of the seat. Various combinations of the steps of each of the flights of the cover can be positioned on related combinations of the steps of each of the flights of the seat so that the cover can be positioned on various levels on the seat.

Abstract: There is disclosed a covering apparatus for a personnel opening of a sewer, a tap water pipeline, or an underground pipeline or box for telecommunication or electric power devices. More particularly, the covering apparatus includes an adjustable height corresponding to the rising of paving. The covering apparatus includes seat assembly and a cover installed on the seat assembly. The seat assembly includes a primary seat and at least one secondary seat. The primary seat defines a cavity for receiving the cover or, if necessary, a lip of the secondary seat. The secondary seat defines a cavity for receiving the cover. Thus, the height of the covering apparatus can be increased. Level difference between new paving and the cover can be eliminated, and the safety of pedestrians, riders and drivers using the new paved road is improved. Moreover, the covering apparatus can be assembled effectively regarding time and labor.

Abstract: This material is kind of wear-resistant Nickel-base alloy for hard surfacing which can be substituted for Cobalt-base alloy. The new alloy is mainly comprised of C, Si, Cr, W and Cu and is of a low carbon, high chromium, high silicon, high tungsten and copper type Ni-base alloy. The said Ni-base alloy has excellent high temperature adhesive wear resistance and intercrystalline corrosion resistance properties, which are superior to that of the stellite No. 6 alloy Co-base alloy. In addition, the hardness, abrasive wear resistance, scratch resistance, corrosion resistance, elevated temperature oxidation resistance, heat resistance fatigue, crack resistance, operational applicability and other properties are equal to that of Stellite No. 6 Co-base alloy. The alloy of this invention can be used as a substitute for Co-base alloy in hard surfacing of high temperature, high pressure valves and valves for nuclear industry as well as other easily worn spare parts.