Patents by Inventor Shi-Jiang Lu

Shi-Jiang Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11241460
    Abstract: Methods are provided for the production of photoreceptor cells and photoreceptor progenitor cells from pluripotent stem cells. Additionally provided are compositions of photoreceptor cells and photoreceptor cells, as well as methods for the therapeutic use thereof. Exemplary methods may produce substantially pure cultures of photoreceptor cells and/or photoreceptor cells.
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: February 8, 2022
    Assignee: Astellas Institute for Regenerative Medicine
    Inventors: Robert P. Lanza, Shi-Jiang Lu, Wei Wang
  • Publication number: 20210395684
    Abstract: Provided herein, in one aspect, is hematopoietic lineage cells such as natural killer cells generated in vitro from human pluripotent stem cells (hPSCs) that can be used as a cell source for therapeutics. Methods and compositions for making and using the same are also provided.
    Type: Application
    Filed: October 24, 2019
    Publication date: December 23, 2021
    Inventors: Qiang Feng, Miao-yun Zhang, Shi-jiang Lu
  • Publication number: 20210315938
    Abstract: Provided herein, in one aspect, is a population of retinal neurons including photoreceptors precursor cells (PRPCs) generated in vitro from human pluripotent stem cells (hPSCs) that can be used as a cell source for regenerative therapies, drug discovery and disease modeling. Methods and compositions for making and using the same are also provided.
    Type: Application
    Filed: September 6, 2019
    Publication date: October 14, 2021
    Inventors: Feng Qiang, Gina Elsen, Shi-Jiang Lu
  • Publication number: 20210299218
    Abstract: The present disclosure relates generally to biocompatible nanoparticles, and in particular, neuroprotective nanoparticles comprising ciliary neurotrophic factor and/or oncostatin M. Methods for making and using the same are also provided.
    Type: Application
    Filed: August 1, 2019
    Publication date: September 30, 2021
    Inventors: Qiang Feng, Gina Elsen, Po-Hsuen Chen, Shi-Jiang Lu
  • Publication number: 20210161964
    Abstract: Methods for production of platelets from pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) are provided. These methods may be performed without forming embryoid bodies or clusters of pluripotent stem cells, and may be performed without the use of stromal inducer cells. Additionally, the yield and/or purity can be greater than has been reported for prior methods of producing platelets from pluripotent stem cells. Also provided are compositions and pharmaceutical preparations comprising platelets, preferably produced from pluripotent stem cells.
    Type: Application
    Filed: December 8, 2020
    Publication date: June 3, 2021
    Applicant: Astellas Institute for Regenerative Medicine
    Inventors: Qiang Feng, Shi-Jiang Lu, Robert P. Lanza
  • Patent number: 10894065
    Abstract: Methods for production of platelets from pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) are provided. These methods may be performed without forming embryoid bodies or clusters of pluripotent stem cells, and may be performed without the use of stromal inducer cells. Additionally, the yield and/or purity can be greater than has been reported for prior methods of producing platelets from pluripotent stem cells. Also provided are compositions and pharmaceutical preparations comprising platelets, preferably produced from pluripotent stem cells.
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: January 19, 2021
    Assignee: Astellas Institute for Regenerative Medicine
    Inventors: Qiang Feng, Shi-Jiang Lu, Robert P. Lanza
  • Publication number: 20200263132
    Abstract: Methods for generating enucleated erythroid cells using pluripotent stem cells are provided. The methods permit the production of large numbers of cells. The cells obtained by the methods disclosed may be used for a variety of research, clinical, and therapeutic applications. Methods for generating megakaryocyte and platelets are also provided.
    Type: Application
    Filed: February 25, 2020
    Publication date: August 20, 2020
    Inventors: Robert Lanza, Shi-Jiang Lu
  • Publication number: 20200157503
    Abstract: Methods of generating and expanding human hemangio-colony forming cells and non-engrafting hemangio cells in vitro and methods of expanding and using such cells are disclosed. The methods permit the production of large numbers of hemangio-colony forming cells, non-engrafting hemangio cells as well as derivative cells, such as hematopoietic and endothelial cells. The cells obtained by the methods disclosed may be used for a variety of research, clinical, and therapeutic applications. Human non-engrafting hemangio cells are a novel progenitor cell population that is related to but distinct from the hemangioblast and human hemangio-colony forming cells. The invention also provides compositions, preparations, and solutions comprising hemangio-colony forming cells, non-engrafting hemangio cells or cells differentiated therefrom.
    Type: Application
    Filed: November 21, 2019
    Publication date: May 21, 2020
    Inventors: Robert Lanza, Shi-Jiang Lu
  • Publication number: 20200131475
    Abstract: This invention provides methods of generating natural killer (NK) cells and dendritic cells (DCs). The methods utilize human hemangioblasts as intermediate cells to generate the NK cells and DCs. In various embodiments, the methods do not require the use of stromal feeder layers.
    Type: Application
    Filed: October 31, 2019
    Publication date: April 30, 2020
    Applicant: ASTELLAS INSTITUTE FOR REGENERATIVE MEDICINE
    Inventors: Erin Kimbrel, Shi-Jiang Lu
  • Publication number: 20200023011
    Abstract: Methods for production of platelets from pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) are provided. These methods may be performed without forming embryoid bodies or clusters of pluripotent stem cells, and may be performed without the use of stromal inducer cells. Additionally, the yield and/or purity can be greater than has been reported for prior methods of producing platelets from pluripotent stem cells. Also provided are compositions and pharmaceutical preparations comprising platelets, preferably produced from pluripotent stem cells.
    Type: Application
    Filed: August 1, 2019
    Publication date: January 23, 2020
    Applicant: Astellas Institute for Regenerative Medicine
    Inventors: Qiang Feng, Shi-Jiang Lu, Robert P. Lanza
  • Publication number: 20190321414
    Abstract: Methods are provided for the production of photoreceptor cells and photoreceptor progenitor cells from pluripotent stem cells. Additionally provided are compositions of photoreceptor cells and photoreceptor cells, as well as methods for the therapeutic use thereof. Exemplary methods may produce substantially pure cultures of photoreceptor cells and/or photoreceptor cells.
    Type: Application
    Filed: March 27, 2019
    Publication date: October 24, 2019
    Applicant: Astellas Institute for Regenerative Medicine
    Inventors: Robert P. Lanza, Shi-Jiang Lu, Wei Wang
  • Patent number: 10426799
    Abstract: Methods for production of platelets from pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) are provided. These methods may be performed without forming embryoid bodies or clusters of pluripotent stem cells, and may be performed without the use of stromal inducer cells. Additionally, the yield and/or purity can be greater than has been reported for prior methods of producing platelets from pluripotent stem cells. Also provided are compositions and pharmaceutical preparations comprising platelets, preferably produced from pluripotent stem cells.
    Type: Grant
    Filed: December 21, 2013
    Date of Patent: October 1, 2019
    Assignee: Astellas Institute for Regenerative Medicine
    Inventors: Qiang Feng, Shi-Jiang Lu, Robert P. Lanza
  • Publication number: 20190290701
    Abstract: Methods are provided for the production of photoreceptor cells and photoreceptor progenitor cells from pluripotent stem cells. Additionally provided are compositions of photoreceptor cells and photoreceptor cells, as well as methods for the therapeutic use thereof. Exemplary methods may produce substantially pure cultures of photoreceptor cells and/or photoreceptor cells.
    Type: Application
    Filed: February 25, 2019
    Publication date: September 26, 2019
    Applicant: Astellas Institute for Regenerative Medicine
    Inventors: Robert P. Lanza, Shi-Jiang Lu, Wei Wang
  • Patent number: 10307444
    Abstract: Methods are provided for the production of photoreceptor cells and photoreceptor progenitor cells from pluripotent stem cells. Additionally provided are compositions of photoreceptor cells and photoreceptor cells, as well as methods for the therapeutic use thereof. Exemplary methods may produce substantially pure cultures of photoreceptor cells and/or photoreceptor cells.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: June 4, 2019
    Assignee: Astellas Institute for Regenerative Medicine
    Inventors: Robert P. Lanza, Shi-Jiang Lu, Wei Wang
  • Publication number: 20190060370
    Abstract: Methods are provided for the production of photoreceptor cells and photoreceptor progenitor cells from pluripotent stem cells. Additionally provided are compositions of photoreceptor cells and photoreceptor cells, as well as methods for the therapeutic use thereof. Exemplary methods may produce substantially pure cultures of photoreceptor cells and/or photoreceptor cells.
    Type: Application
    Filed: July 2, 2018
    Publication date: February 28, 2019
    Applicant: Astellas Institute for Regenerative Medicine
    Inventors: Robert P. Lanza, Shi-Jiang Lu, Wei Wang
  • Publication number: 20190017027
    Abstract: Methods of generating and expanding human hemangio-colony forming cells in vitro and methods of expanding and using such cells are disclosed. The methods permit the production of large numbers of hemangio-colony forming cells as well as derivative cells, such as hematopoietic and endothelial cells. The cells obtained by the methods disclosed may be used for a variety of research, clinical, and therapeutic applications.
    Type: Application
    Filed: February 22, 2018
    Publication date: January 17, 2019
    Applicant: Astellas Institute for Regenerative Medicine
    Inventors: Robert Lanza, Shi-Jiang Lu
  • Publication number: 20190002828
    Abstract: Methods for generating enucleated erythroid cells using pluripotent stem cells are provided. The methods permit the production of large numbers of cells. The cells obtained by the methods disclosed may be used for a variety of research, clinical, and therapeutic applications. Methods for generating megakaryocyte and platelets are also provided.
    Type: Application
    Filed: April 25, 2018
    Publication date: January 3, 2019
    Applicant: Astellas Institute for Regenerative Medicine
    Inventors: Robert Lanza, Shi-Jiang Lu
  • Publication number: 20190002829
    Abstract: The present invention provides a method of generating megakaryocytes and platelets. In various embodiments, method involves the use of human embryonic stem cell derived hemangioblasts for differentiation into megakaryocytes and platelets under serum and stromal-free condition. In this system, hESCs are directed towards megakaryocytes through embryoid body formation and hemangioblast differentiation. Further provided is a method of treating a subject in need of platelet transfusion.
    Type: Application
    Filed: May 1, 2018
    Publication date: January 3, 2019
    Applicant: Stem Cell & Regenerative Medicine International
    Inventors: Feng Li, Shi-Jiang Lu
  • Publication number: 20180318353
    Abstract: Methods for production of platelets from pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) are provided. These methods may be performed without forming embryoid bodies or clusters of pluripotent stem cells, and may be performed without the use of stromal inducer cells. Additionally, the yield and/or purity can be greater than has been reported for prior methods of producing platelets from pluripotent stem cells. Also provided are compositions and pharmaceutical preparations comprising platelets, preferably produced from pluripotent stem cells.
    Type: Application
    Filed: May 8, 2018
    Publication date: November 8, 2018
    Applicant: Astellas Institute for Regenerative Medicine
    Inventors: Qiang Feng, Shi-Jiang Lu, Robert P. Lanza
  • Patent number: 9993503
    Abstract: Methods for production of platelets from pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) are provided. These methods may be performed without forming embryoid bodies or clusters of pluripotent stem cells, and may be performed without the use of stromal inducer cells. Additionally, the yield and/or purity can be greater than has been reported for prior methods of producing platelets from pluripotent stem cells. Also provided are compositions and pharmaceutical preparations comprising platelets, preferably produced from pluripotent stem cells.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: June 12, 2018
    Assignee: Astellas Institute for Regenerative Medicine
    Inventors: Qiang Feng, Shi-Jiang Lu, Robert P. Lanza