Abstract: The present disclosure provides a method of monitoring, evaluating and early-warning pollution for key pollution sources in an industrial park. The method comprises: a multi-index on-line early-warning monitoring method for pollution from key pollution sources, a hierarchical pollution risk evaluating method, and a pollution early-warning grade evaluating method, which are in line with the environmental management solution that pollution prevention is the priority in an industrial park in China.

Abstract: Disclosed is a high-precision dynamic real-time 360-degree omnidirectional point cloud acquisition method based on fringe projection. The method comprises: firstly, by means of the fringe projection technology based on a stereoscopic phase unwrapping method, and with the assistance of an adaptive dynamic depth constraint mechanism, acquiring high-precision three-dimensional (3D) data of an object in real time without any additional auxiliary fringe pattern; and then, after a two-dimensional (2D) matching points optimized by the means of corresponding 3D information is rapidly acquired, by means of a two-thread parallel mechanism, carrying out coarse registration based on Simultaneous Localization and Mapping (SLAM) technology and fine registration based on Iterative Closest Point (ICP) technology.

Abstract: Provided herein are methods of treating certain cancers comprising administering to the subject in need there of an effective amount of a compound of Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, Ra, and Rb are as defined herein.

Abstract: A high-speed remote landslide simulation test device with a variable angle includes a support adjustment component, slide plates, and loose leaves. The device first transmits the operation paths of adjusting the slide plate at different angles to the controller, and the personnel operates the control panel to control the support jack, the motor, and the electromagnet to start and stop through the controller, the output shaft of the motor drives the stainless steel threaded rod to rotate, the controller first energizes one electromagnet and disconnects the other three electromagnets, which can only make the stainless steel threaded rod rotate in a fixed position inside the inner threaded pipe, and the three inner threaded pipes follow the rotation direction of the stainless steel threaded rod, thus, the position of the support jack can be moved separately.

Abstract: The present invention relates to a method of building a dynamic overlay network topology based on cross-chain interaction between blockchains, at least comprising: selecting at least one gateway node and at least one ordinary node from at least one cross-chain interaction node; clustering the ordinary nodes into ordinary node clusters based on a clustering algorithm; building a structured network topology and cross-chain connections between the cross-chain interaction nodes based on the gateway node; performing topology building on the ordinary node clusters based on a breadth-first spanning tree algorithm.

Abstract: The present invention relates to a network transmission optimization device for a graph-type blockchain, at least comprising a transaction processing module, a node managing module, and a route managing module, wherein the transaction processing module performs compression on a transaction, and transaction data obtained through the compression are transmitted among different clusters through a routing node selected by the route managing module from at least one cluster, wherein the at least one cluster is obtained through dividing plural nodes by the node managing module. The network transmission optimization method provides a transaction coding scheme to the existing graph-type blockchain systems, and improve use efficiency of network bandwidth by means of parallelized broadcast. The structured network topology of the network transmission optimization method is made to address delay among nodes, and is adaptive to dynamic joining and exit of nodes, thereby improving network transmission efficiency.

Abstract: The present application relates to a method for preparing a substantially and diastereomerically pure crystalline ethanol solvate of Compound IIa and its use for synthesizing Ivosidenib.

Abstract: The present invention relates to a lightweight data storage apparatus for graphic blockchains, at least comprising a common transaction construction module for a user to initiate new transactions and a network broadcast module for broadcasting the transactions, wherein the apparatus further comprises a combined-transaction constructing module and a transaction deleting module, wherein the combined-transaction constructing module serves to determine whether number of transactions initiated by an account satisfies a first predetermined condition, and if yes, execute a first lightening procedure on the transactions, and the transaction deleting module serves to execute a second lightening procedure on the transactions that have been processed by the first lightening procedure and now have validation references satisfying a second predetermined condition, after which the network broadcast module broadcasts the transactions obtained after the second lightening procedure.

Abstract: The present invention relates to an implementation method for graphic-blockchain-orientated hybrid consensus, at least comprising: calling at least one module to generate a new data block and broadcast it; calling at least one module to check and validate the received new block based on predetermined rules; calling at least one module to generate a void block; and calling at least one module to update a committee member list. The existing graphic blockchain can only achieve probabilistic consensus, yet the present invention achieves deterministic consensus on graphic blockchain for the first time, thereby reaching consensus faster. The present invention decouples generation and consensus of blocks for the first time, so that the two parts can be designed separately in a modularized manner. The present invention provides the first totally decentralized hybrid consensus algorithm in the graphic blockchain. This is unachievable to many existing graphic blockchain such as IOTA and Obyte.

Abstract: The present invention relates to a highly flexible, scalable multi-blockchain, hierarchical data-sharing and data-storing system, at least comprising a third-party blockchain system, a data-sharing blockchain system, and an application-layer client, wherein the data-sharing blockchain system performs data aggregation and hierarchical storage on shared data uploaded by the third-party blockchain system through accessing the data-sharing blockchain system, so as to allow the application-layer client to require the shared data from the data-sharing blockchain system. The disclosure herein creates a single reliable data-sharing blockchain apparatus based on blockchain systems, so as to facilitate aggregation of data coming from different blockchain systems, reduce node complexity and block data redundancy when data are acquired from multiple parties, and define different sharing rules for different data contents, thereby being adaptive to scenarios where data are shared among parties.

Abstract: The present invention relates to a method of building a dynamic overlay network topology based on cross-chain interaction between blockchains, at least comprising: selecting at least one gateway node and at least one ordinary node from at least one cross-chain interaction node; clustering the ordinary nodes into ordinary node clusters based on a clustering algorithm; building a structured network topology and cross-chain connections between the cross-chain interaction nodes based on the gateway node; performing topology building on the ordinary node clusters based on a breadth-first spanning tree algorithm.

Abstract: Provided herein are various salts, including tris(hydroxymethyl)aminomethane salts and sodium salts, as well as various crystalline forms of the compound represented by the structural formula: Also provided are pharmaceutical compositions comprising these salts and crystalline forms, methods for their manufacture, and uses thereof for treating conditions, including but not limited to conditions that would benefit from inhibition of dihydroorotate dehydrogenase (DHODH).

Abstract: The present disclosure provides a white-light block polymer, an ink composition, and a manufacturing method thereof. The white-light block polymer makes it only necessary to print one ink when using inkjet printing, thereby simplifying inkjet printing processing and meanwhile preventing a crosstalk problem of pixels having different colors of light. The present disclosure makes the ink composition suitable for inkjet printing by properly mixing the white-light block polymer, an organic solvent, a surface tension modifier, and a viscosity modifier in a suitable ratio.

Abstract: Provided are formulations of ivosidenib including a number of polymorphs. Further provided are formulations of ivosidenib containing a number of known impurities. Still further provided are stable compositions of ivosidenib.

Abstract: Provided are compounds useful for treating cancer and methods of making the compounds and intermediates described herein.

Abstract: Provided are compounds useful for treating cancer and methods of making the compounds and intermediates described herein.

Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a pharmaceutical composition comprising such a compound.

Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.