Abstract: The present disclosure provides use of Clostridium ghonii combined with a tumor angiogenesis inhibitor in preparing a pharmaceutical product for treating a tumor. The present disclosure further provides a drug for treating a tumor, where the drug includes active ingredients of Clostridium ghonii and a tumor angiogenesis inhibitor.

Abstract: The present disclosure relates to use of a Clostridium ghonii spore combined with pembrolizumab in cancer treatment. It is found for the first time that the Clostridium ghonii spore combined with pembrolizumab can significantly improve a curative effect of colon cancer and reduce a dose of the pembrolizumab, and thus is efficient and low-toxic. Oncolysis by Clostridium ghonii can affect immunogenicity of a tumor microenvironment (TME) by various ways, converts an immunosuppressive state of the TME into an immune-activated state, adjusts the immunosuppressive TME, and breaks an immune tolerance. An optimal combination of the Clostridium ghonii spore and the pembrolizumab thoroughly removes about 20% of mouse tumor tissues. A benefit range of patients with tumors treated by a PD-1 antibody is expanded. The combination even has an obvious curative effect on patients failed the treatment by the PD-1 antibody.

Abstract: An internal combustion engine piston having an internal cooling cavity structure is provided, which includes a piston body, and a ring body fitted with the piston body to form the internal cooling cavity structure. The ring body and the top of the piston body form a first fitting region, and the ring body and a top end of a skirt portion of the piston body form a second fitting region. The first fitting region includes a body fitting portion and a ring body fitting portion arranged at the top of the ring body. Compared with the conventional technology, the ring body welding cylindrical surface in the present application is fitted with the body welding cylinder surface, and the welding seam formed by the welding does not extend into the cooling cavity.

Abstract: A method for manufacturing a piston with a re-molten reinforced combustion chamber throat is provided. The manufacturing steps includes: a) piston rough machining: machining allowances of the combustion chamber throat and the combustion chamber bottom are 1-3 mm; b) piston washing and degreasing treatment; c) coating or spraying a surfactant on the combustion chamber throat and the combustion chamber bottom that need to be re-molten, wherein the surfactant formula comprises the components TiO2, SiO2, CuCl2 and MnCl2 that are mixed in percentage: 1-30% of TiO2, 1-30% of SiO2, 1-40% of CuCl2 and 1-50% of MnCl2; after the four components are uniformly mixed, a suspension is prepared by using acetone as a solvent a mass ratio of 1:(3-8); d) re-melting the piston by using an A-TIG welding method; and f) after re-melting, processing the piston into a finished product.

Abstract: A method for manufacturing a piston with a re-molten reinforced combustion chamber throat is provided. The manufacturing steps includes: a) piston rough machining: machining allowances of the combustion chamber throat and the combustion chamber bottom are 1-3 mm; b) piston washing and degreasing treatment; c) coating or spraying a surfactant on the combustion chamber throat and the combustion chamber bottom that need to be re-molten, wherein the surfactant formula comprises the components TiO2, SiO2, CuCl2 and MnCl2 that are mixed in percentage: 1-30% of TiO2, 1-30% of SiO2, 1-40% of CuCl2 and 1-50% of MnCl2; after the four components are uniformly mixed, a suspension is prepared by using acetone as a solvent a mass ratio of 1: (3-8); d) re-melting the piston by using an A-TIG welding method; and f) after re-melting, processing the piston into a finished product.