Abstract: Disclosed herein are compositions and methods for treating diseases characterized by expanded microsatellite repeats by impeding or inhibiting transcription of expanded microsatellite repeats.

Abstract: The present disclosure provides an air duct structure to receive a processing component. The air duct structure includes an air inlet opening, an air outlet opening, a plurality of side walls, and a support surface. The air inlet opening is in direct fluid communication with an air inlet of the computer chassis. The air outlet opening is in direct fluid communication with an air inlet of a processing component. The plurality of side walls at least partially define a channel extending between the air inlet opening and the air outlet opening. The support surface receives the processing component on the air duct structure relative to the computer chassis. The processing component includes an air exhaust to diffuse air, and the plurality of side walls at least partially fluidly isolate the air inlet opening from an air diffused from the air exhaust.

Abstract: A method of manufacturing a particulate polymer includes introducing a polymer latex into a vessel; distributing the polymer latex in the vessel to a coagulator via a distribution member and a redistribution member; introducing a coagulant and steam into the coagulator; breaking the polymer latex; and separating the particulate polymer. The distribution member and the redistribution member are mounted on an agitator shaft of the coagulator, and are configured such that the polymer latex in the vessel enters the open top and exits the open bottom of the distribution member and flows into the redistribution member. The polymer latex in the redistribution member then overflows into the coagulator.

Abstract: A semiconductor device structure is provided. The semiconductor device structure includes a first substrate including a first face and a second face opposite the first face. A second substrate is bonded to the first face of the first substrate such that the second face of the first substrate faces away from the second substrate. One or more recesses are arranged in the second face of the first substrate and are configured to compensate for thermal expansion or thermal contraction.

Abstract: Methods, systems, and computer-readable storage media for receiving, through a set of user interfaces (UIs), user input including job configuration information and deployment information for an application, providing a CI/CD job for the application with a CI/CD service using the job configuration information and the deployment information, and triggering, in response to a commit of changes to the application in a repository, automated build of the application, and in response, automatically: generating a development descriptor file at least partially based on the user input, providing an archive file including the development descriptor file, and processing, by the CI/CD job executed by the CI/CD service, the archive file to deploy the application within the target environment.

Abstract: Methods and systems for improving fusion bonding are disclosed. Plasma treatment is performed on a substrate prior to the fusion bonding, which leaves residual charge on the substrate to be fusion bonded. The residual charge is usually dissipated through an electrically conductive silicone cushion on a loading pin. In the methods, the amount of residual voltage on a test silicon wafer is measured. If the residual voltage is too high, this indicates the usable lifetime of the silicone cushion has passed, and the electrically conductive silicone cushion is replaced. This ensures the continued dissipation of residual charge during use in production, improving the quality of fusion bonds between substrates.

Abstract: Disclosed herein are compositions and methods for treating diseases characterized by expanded microsatellite repeats by impeding or inhibiting transcription of expanded microsatellite repeats.

Abstract: Methods, systems, and computer-readable storage media for receiving, through a set of user interfaces (UIs), user input including job configuration information and deployment information for an application, providing a CI/CD job for the application with a CI/CD service using the job configuration information and the deployment information, and triggering, in response to a commit of changes to the application in a repository, automated build of the application, and in response, automatically: generating a development descriptor file at least partially based on the user input, providing an archive file including the development descriptor file, and processing, by the CI/CD job executed by the CI/CD service, the archive file to deploy the application within the target environment.

Abstract: Methods and compositions useful for delivering a protein to a plurality of nuclei in a cell. Fusion proteins comprising one or more signals useful for promoting delivery of the proteins to a plurality of nuclei in a multinucleate cell. Methods comprising administering isolated nucleic acids to a multinucleate cell, wherein the isolated nucleic acid comprises a sequence encoding a fusion protein, the fusion protein comprising, a protein of interest fused to at least the following migration signals: (a) at least one nuclear export signal (NFS); and (b) at least one nuclear localization signal (NLS) and/or at least one nucleolar localization signal (NoLS). Fusion proteins comprising: (a) a protein of interest; and (b) at least the following migration signals: (i) a nuclear export signal (NFS); (ii) a nuclear localization signal (NLS); and (iii) a nucleolar localization signal (NoLS). Methods of making and using the same. Methods of delivering recombinant genes and/or fusion proteins to multinucleate cells.

Abstract: An application development graphical user interface which includes a drag-and-drop canvas area is provided. User interface elements are configured to be dragged and dropped into the canvas area to design a client application graphical user interface including a filter or a sorter. A configuration panel of the application development user interface providing options and fields for configuring sorter or filter configuration options and for configuring machine learning service configuration options. Machine learning service metadata is generated for the client application. The client application metadata for the client application is deployed and the client application configured present recommendations based on inputs to the filter or sorter using the machine learning service.

Abstract: Methods, systems, and computer-readable storage media for retrieving, by a smart setup system, a component configuration metadata file corresponding to an application, the component configuration metadata file including component metadata representing components that the application uses during runtime, parsing, by a parser of the smart setup system, the component configuration metadata file to provide a set of data objects, each corresponding to a respective component in the set of components, providing, by an emitter of the smart setup system, a set of checking scripts and a set of installation scripts by, for each component in the set of components, providing a checking script and an installation script using a respective data object, and executing, by the smart setup system, each checking script in the set of checking scripts, and in response, receiving a set of check results, each check results indicating whether pre-requisites of a respective component are met.

Abstract: The present disclosure may provide a marking system for intestinal valve imaging. The marking system may obtain multiple intestinal images of an examined object. The marking system may perform intestinal valve segmentation on at least a portion of the multiple intestinal images to determine at least one independent intestinal valve. The marking system may also mark the at least one independent intestinal valve in the at least a portion of the multiple intestinal images.

Abstract: Methods, systems, and computer-readable storage media for receiving, by an application studio, user input indicating two or more artifacts of an enterprise application developed using the application studio, generating, by an enterprise application artifact composer of the application studio, an enterprise application artifact as a universal tag that provides an abstract representation of the enterprise application, and during deployment of the enterprise application: retrieving the enterprise application artifact, determining a target runtime that the enterprise application is to be deployed to, determining a set of dependencies for each artifact of the enterprise application, and for any dependency in the set of dependencies that is absent from the target runtime, retrieving binary code of the dependency from a library to deploy the dependency to the target runtime.

Abstract: Provided herein, in some embodiments, are nucleic acid constructs encoding therapeutic proteins of interest comprising one or more alternatively-spliced exons that regulate the expression of therapeutic proteins of interest. Such constructs may in some embodiments be useful for delivery in a recombinant viral vector.

Abstract: Methods, systems, and computer-readable storage media for retrieving, by a smart setup system, a component configuration metadata file corresponding to an application, the component configuration metadata file including component metadata representing components that the application uses during runtime, parsing, by a parser of the smart setup system, the component configuration metadata file to provide a set of data objects, each corresponding to a respective component in the set of components, providing, by an emitter of the smart setup system, a set of checking scripts and a set of installation scripts by, for each component in the set of components, providing a checking script and an installation script using a respective data object, and executing, by the smart setup system, each checking script in the set of checking scripts, and in response, receiving a set of check results, each check results indicating whether pre-requisites of a respective component are met.

Abstract: Methods, systems, and computer-readable storage media for integrating skills into computer-executable applications using a low-code/no-code (LCNC) development platform.

Abstract: A bonding tool includes a gas supply line that may extend directly between valves associated with one or more gas supply tanks and a processing chamber such that gas supply line is uninterrupted without any intervening valves or other types of structures that might otherwise cause a pressure buildup in the gas supply line between the processing chamber and the valves associated with the one or more gas supply tanks. The pressure in the gas supply line may be maintained at or near the pressure in the processing chamber so that gas provided to the processing chamber through the gas supply line does not cause a pressure imbalance in the processing chamber, which might otherwise cause early or premature contact between semiconductor substrates that are to be bonded in the processing chamber.

Abstract: Autoregulatory systems that have been implemented to control the expression and activity of Cast 3d, including the activity of Cast 3d in vivo, thereby reducing collateral damage in cells at off-target sites (e.g., non-target messenger RNA transcripts. The autoregulatory system is in the form of a nucleic acid molecule comprising a zinc finger binding site, a promoter, and a nucleotide sequence encoding a Cast 3d fusion protein, and a transcriptional repressor domain, and wherein the Cast 3d fusion protein binds to the zinc finger binding site and represses transcription of the nucleotide sequence encoding the Cast 3d fusion protein.

Abstract: Methods, systems, and computer-readable storage media for receiving initial input from a user of the application, the initial input indicating that a UI element is to be generated for the user, receiving context data representative of a context of the application when the input is received, the context data at least partially including a data schema definition of data accessed by the application, prompting the user for input at least partially based on the context data, receiving additional input responsive to the prompting, defining dynamic metadata based on at least a portion of the initial input, at least a portion of the additional input, and at least a portion of the data schema definition, the dynamic metadata including one or more actions that can be executed on data accessed through the UI element, and processing the dynamic metadata to generate the UI element for display in the application.

Abstract: Disclosed is an electrical control system for minimally invasive tumor therapies. The electrical control system for minimally invasive tumor therapies includes a control module, a perfusion module and a power box. The perfusion module includes a working medium storage tank, a tank liquid level meter, a tank pressure sensor, a tank deflation valve, a liquid charging valve and an external working medium container. The power box is configured to supply power to the control module and the perfusion module. The control module is configured to receive working medium parameters sent by the tank liquid level meter and the tank pressure sensor, and to control, when the work medium parameters meet a perfusion condition, the tank deflation valve and the liquid charging valve to open or close respectively so as to input working medium from the external working medium container into the working medium storage tank.