Abstract: A liquid crystal display (LCD), a controller and a driving method of a panel thereof are provided. Before the controller drives each data line, the driving polarity of the data lines is adjusted according to the display property of the sub-frame data signal. A first inversion driving method is employed for adjusting the data lines when the display property of the sub-frame data signal is a black frame, and a second inversion driving method is employed for adjusting when the display property of the sub-frame data signal is a color frame. Accordingly, power consumption can be lowered during the process of driving pixels, thereby achieving the purpose of power saving while not affecting the display quality.