Abstract: Disclosed are a biomarkers composition related to diagnosis and prognosis of immunoglobulin A nephropathy (IgAN) and application thereof, belonging to the field of biomedicine. The biomarkers composition includes at least one of cytokines of FCAR, MBL and MMP-9. It is found after screening and analysis that FCAR, MBL and MMP-9 are associated with the diagnosis of IgAN, especially with severe IgAN. With protein microarray, patients of mild IgAN and severe IgAN, and healthy people are distinguished with high specificity and sensitivity according to the present disclosure.

Abstract: The present disclosure relates to a device configured to move within a body cavity, such as the gastrointestinal tract, in particular, the small intestine, and methods of using the device. The presently disclosed device may be self-driving, e.g., through the use of one or more traction-motion element, and the articulation of a tip of the device may be controlled and fine tuned. The presently disclosed device may be used in a variety of body cavities such as a vascular body lumen, a digestive body lumen, a respiratory body lumen, or a urinary body lumen, for example, for endoscopic purposes, for delivering a substance into the body cavity, for removing a substance or tissue from the body cavity, for capturing an image of the body cavity, and/or for performing an operation of a tissue or organ using the device.

Abstract: Provided herein are systems, methods and computer readable media for facilitating pricing. An example method may include determining a price adjustable promotion from a plurality of promotions, the price adjustable promotion having a first promotional price, a forecasted demand that provides an indication of a promotion inventory exhaustion period and a plurality of redemption parameters that comprise at least a promotional period, a promotional value and a redemption expiration and causing the price adjustable promotion to be offered at the second promotional price while at least one of the plurality of redemption parameters for the price adjustable promotion remain constant.

Abstract: The present disclosure relates to a device configured to move within a body cavity, such as the gastrointestinal tract, in particular, the small intestine, and methods of using the device. The presently disclosed device may be self-driving, e.g., through the use of one or more traction-motion element, and the articulation of a tip of the device may be controlled and fine tuned. The presently disclosed device may be used in a variety of body cavities such as a vascular body lumen, a digestive body lumen, a respiratory body lumen, or a urinary body lumen, for example, for endoscopic purposes, for delivering a substance into the body cavity, for removing a substance or tissue from the body cavity, for capturing an image of the body cavity, and/or for performing an operation of a tissue or organ using the device.

Abstract: Provided herein are systems, methods and computer readable media for dynamically determining a value of one component of a data set to achieve a target characteristic. An example method may include providing, at a user interface of a user device, an initial data comprising a fixed component representative of an icon and an adjustable component representative of the size of the icon, collecting, via a communications interface, consumer interaction information, representative of consumer interaction during display of the initial data set at the user interface of the user device, and subsequent to the determination that the difference in the value of the predefined metric measured during the time period and the previously measured value of the predefined metric measured during the previous time period meets the predefined threshold value, providing a second data set comprising the fixed component and the adjustable component set at a second value.

Abstract: The present disclosure relates to a device configured to move within a body cavity, such as the gastrointestinal tract, in particular, the small intestine, and methods of using the device. The presently disclosed device may be self-driving, and the articulation of a tip of the device may be controlled and fine tuned. The presently disclosed device may be used in a variety of body cavities such as a vascular body lumen, a digestive body lumen, a respiratory body lumen, or a urinary body lumen, for example, for endoscopic purposes, for delivering a substance into the body cavity, for removing a substance or tissue from the body cavity, for capturing an image of the body cavity, and/or for performing an operation of a tissue or organ using the device.

Abstract: Provided herein are systems, methods and computer readable media for facilitating pricing. An example method may include determining a price adjustable promotion from a plurality of promotions, the price adjustable promotion having a first promotional price, a forecasted demand that provides an indication of a promotion inventory exhaustion period and a plurality of redemption parameters that comprise at least a promotional period, a promotional value and a redemption expiration and causing the price adjustable promotion to be offered at the second promotional price while at least one of the plurality of redemption parameters for the price adjustable promotion remain constant.

Abstract: Provided herein are systems, methods and computer readable media for facilitating pricing. An example method may include determining a price adjustable promotion from a plurality of promotions, the price adjustable promotion having a first promotional price, a forecasted demand that provides an indication of a promotion inventory exhaustion period and a plurality of redemption parameters that comprise at least a promotional period, a promotional value and a redemption expiration and causing the price adjustable promotion to be offered at the second promotional price while at least one of the plurality of redemption parameters for the price adjustable promotion remain constant.

Abstract: The integrity of an end-to-end message sent from a source to a destination in a distributed data pipeline is improved by tracking the number of messages sent to and received by each of the intermediate components and sink components of the pipeline as the messages move through the distributed data pipeline.

Abstract: Novel heterocyclo compounds represented by Formula I wherein X, R1, R2, R3, R4, R5, R6 and n are as described herein are provided. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of cancer conditions in mammals including humans, including prostate, colon, bladder, melanoma, liver, breast, cervical, ovarian, esophagi, glialblastoma, pancreatic and lung cancer.

Abstract: Methods and systems of performing data mining may include receiving a plurality of web log records and a plurality of call log records; associating one or more web log records with a call log record, wherein the associated user for each of the associated one or more web log records and the call log record are the same; identifying one or more patterns among the web log records for the plurality of call log records, wherein each pattern comprises one or more web accesses, a time stamp at which each of the one or more web accesses is performed and the call topic for the call log record; identifying one or more web log records associated with a new call, and predicting a call topic for the new call based on at least one pattern and the one or more web log records.

Abstract: Disclosed are heterocyclo compounds that have a formula represented by the following: and wherein X, R1, R2, R3, R4, R5, R6 and n are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of cancer conditions in mammals including humans, including by way of non-limiting example, prostate, colon, bladder, melanoma, liver, breast, cervical, ovarian, esophagi, glialblastoma, pancreatic and lung cancer.

Abstract: A method and system for processing informational items originating from a plurality of information sources into a derived document for topical analysis thereof. Informational items are collated from a one of the sources in accordance with a predetermined plurality of relevant attributes and a key property value of common to select ones of the relevant attributes. Informational items are then grouped from the plurality of sources associated with the key common property value to form a document, wherein the informational items therein are marked on the informational source thereof. The document is then analyzed for topical identification.

Abstract: A nonvolatile memory device includes a bottom electrode on a semiconductor substrate, a data storage layer on the bottom electrode, the data storage layer including a transition metal oxide, and a switching layer provided on a top surface and/or a bottom surface of the data storage layer, wherein a bond energy of material included in the switching layer and oxygen is more than a bond energy of a transition metal in the transition metal oxide and oxygen.

Abstract: A method of managing a call center that includes a plurality of agents may include receiving functional data associated with the plurality of call center agents over a time period, for each data curve, normalizing the data points to create a plurality of normalized functional data points, determining a variation associated with each normalized functional data point, determining one or more threshold values associated with each normalized functional data point, determining whether one or more of the normalized functional data points have a value that exceeds the associated threshold value, and identifying each of the normalized functional data points having a value that exceeds the associated threshold value as an outlier. The method may include identifying the call center agent associated with each curve that has an outlier and presenting information pertaining to one or more identified call center agents to a user.

Abstract: In some aspects of the present application, a method for identifying significant events related to machine problems. The method includes receiving one or more machine problems; determining one or more machine problem classifications based on the one or more machine problems; generating a probability distribution that the one or more machines problems are related to the one more machine problem classifications; determining if one or more events are associated with the one or more machine problems during a predetermined time interval; and determining if the one or more events are significantly related to the one or more machine problem classifications using a statistical algorithm.

Abstract: A method and system for processing informational items originating from a plurality of information sources into a derived document for topical analysis thereof. Informational items are collated from a one of the sources in accordance with a predetermined plurality of relevant attributes and a key property value of common to select ones of the relevant attributes. Informational items are then grouped from the plurality of sources associated with the key common property value to form a document, wherein the informational items therein are marked on the informational source thereof. The document is then analyzed for topical identification.

Abstract: A method of managing a call center that includes a plurality of agents may include receiving functional data associated with the plurality of call center agents over a time period, for each data curve, normalizing the data points to create a plurality of normalized functional data points, determining a variation associated with each normalized functional data point, determining one or more threshold values associated with each normalized functional data point, determining whether one or more of the normalized functional data points have a value that exceeds the associated threshold value, and identifying each of the normalized functional data points having a value that exceeds the associated threshold value as an outlier. The method may include identifying the call center agent associated with each curve that has an outlier and presenting information pertaining to one or more identified call center agents to a user.

Abstract: A system implements a method of assessing performance of a call center agent that includes identifying a set of the one-time caller calls that the agent has handled. A first issue resolution rate is determined for the calls in the set that were released by the customer, and a second issue resolution rate is determined for the calls in the set that were released by the call center agent. The method also includes determining a difference between the first issue resolution rate and the second issue resolution rate. The determined difference is used to generate a performance assessment for the call center agent.

Abstract: A system implements a method of assessing performance of a call center agent that includes identifying a set of the one-time caller calls that the agent has handled. A first issue resolution rate is determined for the calls in the set that were released by the customer, and a second issue resolution rate is determined for the calls in the set that were released by the call center agent. The method also includes determining a difference between the first issue resolution rate and the second issue resolution rate. The determined difference is used to generate a performance assessment for the call center agent.