Patents by Inventor Shiah-yun Chen

Shiah-yun Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multivalent indole compounds and use thereof as phospholipase-A2 inhibitors
    Patent number: 7666898
    Abstract: Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject.
    Type: Grant
    Filed: November 3, 2006
    Date of Patent: February 23, 2010
    Assignee: Ilypsa, Inc.
    Inventors: Han-Ting Chang, Dominique Charmot, Tomasz Glinka, Michael James Cope, Elizabeth Goka, Jun Shao, Damien Cartigny, Shiah-yun Chen, Jerry M. Buysse
  • INDOLE COMPOUNDS HAVING C4-ACIDIC SUBSTITUENTS AND USE THEREOF AS PHOSPHOLIPASE-A2 INHIBITORS
    Publication number: 20090318492
    Abstract: Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject.
    Type: Application
    Filed: November 3, 2006
    Publication date: December 24, 2009
    Inventors: Han-Ting Chang, Dominique Charmot, Tomasz Glinka, Michael James Cope, Elizabeth Goka, Jun Shao, Shiah-yun Chen, Jerry M. Buysse
  • INDOLE COMPOUNDS HAVING C4-AMIDE SUBSTITUENTS AND USE THEREOF AS PHOSPHOLIPASE-A2 INHIBITORS
    Publication number: 20090306171
    Abstract: Indole and indole-related compounds according to the formula (I) or (II) optionally having additional heteroatoms, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject. Formula (I), formula (II). R4 being a moiety represented by formula (C4-II-C), R3 being a moiety represented by formula (C3-I or C3-II).
    Type: Application
    Filed: November 3, 2006
    Publication date: December 10, 2009
    Inventors: Han-Ting Chang, Dominique Charmot, Tomasz Glinka, Michael James Cope, Elizabeth Goka, Jun Shao, Shiah-yun Chen, Jerry M. Buysse
  • AZAINDOLE COMPOUNDS AND USE THEREOF AS PHOSPHOLIPASE-A2 INHIBITORS
    Publication number: 20090239896
    Abstract: Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject. The compounds include azaindoles of the formula below [insert FIG. 6c] in which at least one of CR4, CR5, CR6 and CR7 is replaced by N, and the groups R1-R7 are defined as in claim 1.
    Type: Application
    Filed: November 3, 2006
    Publication date: September 24, 2009
    Inventors: Han-Ting Chang, Dominique Charmot, Tomasz Glinka, Michael James Cope, Elizabeth Goka, Jun Shao, Tony Kwok-Kong Mong, Shiah-yun Chen, Jerry M. Buysse
  • Phospholipase inhibitors, including multi-valent phospholipase inhibitors, and use thereof, including as lumen-localized phospholipase inhibitors
    Publication number: 20070135383
    Abstract: The present invention provides methods and compositions for the treatment of phospholipase-related conditions. In particular, the invention provides a method of treating insulin-related, weight-related conditions and/or cholesterol-related conditions in an animal subject. The method generally involves the administration of a non-absorbed and/or effluxed phospholipase A2 inhibitor that is localized in a gastrointestinal lumen.
    Type: Application
    Filed: November 3, 2006
    Publication date: June 14, 2007
    Inventors: Han-Ting Chang, Dominque Charmot, Tomasz Glinka, Michael Cope, Elizabeth Goka, Jun Shao, Damien Cartigny, Shiah-yun Chen, Jerry Buysse
  • Multivalent indole compounds and use thereof as phospholipase-A2 inhibitors
    Publication number: 20070135385
    Abstract: Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject.
    Type: Application
    Filed: November 3, 2006
    Publication date: June 14, 2007
    Inventors: Han-Ting Chang, Dominique Charmot, Tomasz Glinka, Michael Cope, Elizabeth Goka, Jun Shao, Damien Cartigny, Shiah-yun Chen, Jerry Buysse
  • Polymer-modified synthetic proteins
    Publication number: 20060233747
    Abstract: The present invention relates to methods and compositions for modifying peptides, polypeptides and proteins with polymers, especially glyco-mimetic polymers, so as to improve their biological activity or pharmacokinetic properties. The invention further provides methods and uses for such polymer-modified peptides, polypeptides and proteins. The invention is particularly suitable for use in the synthesis of polymer-modified, synthetic bioactive proteins, and of pharmaceutical compositions that contain such proteins.
    Type: Application
    Filed: June 5, 2006
    Publication date: October 19, 2006
    Applicant: Amylin Pharmaceuticals, Inc.
    Inventors: Gerd Kochendoerfer, Paolo Botti, James Bradburne, Shiah -yun Chen, Sonya Cressman, Christie Hunter, Stephen Kent, Donald Low, Jill Wilken
  • Polymer-modified synthetic proteins
    Patent number: 7118737
    Abstract: The present invention relates to methods and compositions for modifying peptides, polypeptides and proteins with polymers, especially glyco-mimetic polymers, so as to improve their biological activity or pharmacokinetic properties. The invention further provides methods and uses for such polymer-modified peptides, polypeptides and proteins. The invention is particularly suitable for use in the synthesis of polymer-modified synthetic bioactive proteins (FIG. 1D), and of pharmaceutical compositions that contain such proteins.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: October 10, 2006
    Assignee: Amylin Pharmaceuticals, Inc.
    Inventors: Gerd G. Kochendoerfer, Paolo Botti, James A. Bradburne, Shiah-yun Chen, Sonya Cressman, Christie L. Hunter, Stephen B. H. Kent, Donald W. Low, Jill G. Wilken
  • Pseudo-native chemical ligation
    Publication number: 20060149039
    Abstract: The present invention concerns methods and compositions for extending the technique of native chemical ligation to permit the ligation of a wider range of peptides, polypeptides, other polymers and other molecules via an amide bond. The invention further provides methods and uses for such proteins and derivatized proteins. The invention is particularly suitable for use in the synthesis of optionally polymer-modified, synthetic bioactive proteins, and of pharmaceutical compositions that contain such proteins.
    Type: Application
    Filed: January 27, 2006
    Publication date: July 6, 2006
    Applicant: Amylin Pharmaceuticals, Inc.
    Inventors: Christie Hunter, Paolo Botti, James Bradburne, Shiah-yun Chen, Sonya Cressman, Stephen Kent, Gerd Kochendoerfer, Donald Low
  • Pseudo native chemical ligation
    Patent number: 7030218
    Abstract: The present invention concerns methods and compositions for extending the technique of native chemical ligation of a wider range of peptides, polypeptides, other polymers and other molecules via an amide bond (see FIG. 1). The invention further provides methods and uses for such proteins and derivatized proteins. The invention is particularly suitable for use in the synthesis of optionally polymer-modified, synthetic bioactive proteins, and of pharmaceutical compositions that contain such proteins.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: April 18, 2006
    Assignee: Gryphon Therapeutics
    Inventors: Christie L. Hunter, Paolo Botti, James A. Bradburne, Shiah-yun Chen, Sonya Cressman, Stephen B. H. Kent, Gerd G. Kochendoerfer, Donald W. Low
  • Polymer-modified synthetic proteins
    Publication number: 20040115774
    Abstract: The present invention relates to methods and compositions for modifying peptides, polypeptides and proteins with polymers, especially glyco-mimetic polymers, so as to improve their biological activity or pharmacokinetic properties. The invention further provides methods and uses for such polymer-modified peptides, polypeptides and proteins. The invention is particularly suitable for use in the synthesis of polymer-modified synthetic bioactive proteins (FIG. 1D), and of pharmaceutical compositions that contain such proteins.
    Type: Application
    Filed: January 8, 2003
    Publication date: June 17, 2004
    Inventors: Gerd G Kochendoerfer, Paolo Botti, James A Bradburne, Shiah-yun Chen, Sonya Cressman, Christie L Hunter, Stephen B H Kent, Donald W Low, Jill G Wilken
  • Pseudo native chemical ligation
    Publication number: 20030208046
    Abstract: The present invention concerns methods and compositions for extending the technique of native chemical ligation of a wider range of peptides, polypeptides, other polymers and other molecules via an amide bond (see FIG. 1). The invention further provides methods and uses for such proteins and derivatized proteins. The invention is particularly suitable for use in the synthesis of optionally polymer-modified, synthetic bioactive proteins, and of pharmaceutical compositions that contain such proteins.
    Type: Application
    Filed: January 8, 2003
    Publication date: November 6, 2003
    Inventors: Christie L. Hunter, Paolo Botti, James A. Bradburne, Shiah-yun Chen, Sonya Cressman, Stephen B.H. Kent, Gerd G. Kochendoerfer, Donald W. Low
  • Synthetic erythropoiesis stimulating proteins
    Publication number: 20030191291
    Abstract: Synthetic erythropoiesis stimulating proteins are provided. Also provided are methods for synthesizing the proteins. The invention further relates to derivatives of such synthetic erythropoiesis stimulating proteins that are polymer-modified in a defined manner. Methods and uses for such proteins and derivatized proteins are also provided.
    Type: Application
    Filed: January 13, 2003
    Publication date: October 9, 2003
    Inventors: Gerd G. Kochendoerfer, Paolo Botti, James A. Bradburne, Shiah-yun Chen, Sonya Cressman, Christine L. Hunter, Stephen B.H. Kent, Donald W. Low