Patents by Inventor Shian-Jan Shiuey

Shian-Jan Shiuey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
    Patent number: 5753638
    Abstract: Compounds of the formula ##STR1## wherein R is hydrogen, hydroxy, or fluorine are useful as agents for the treatment of hyperproliferative disorders of the skin such as psoriasis, as agents for the treatment of leukemia, and as agents for the treatment of sebaceous gland diseases, such as, acne and seborrheic dermatitis.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: May 19, 1998
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Enrico Giuseppe Baggiolini, deceased, Shian-Jan Shiuey, Milan Radoje Uskokovic
  • Method of treating sebaceous gland diseases with vitamin D.sub.3 fluorinated analogs
    Patent number: 5750517
    Abstract: Compounds of the formula ##STR1## wherein R is hydrogen, hydroxy, or fluorine are useful as agents for the treatment of hyperproliferative disorders of the skin such as psoriasis, as agents for the treatment of leukemia, and as agents for the treatment of sebaceous gland diseases, such as, acne and seborrheic dermatitis.
    Type: Grant
    Filed: March 1, 1996
    Date of Patent: May 12, 1998
    Assignee: Hoffman-La Roche Inc.
    Inventors: Enrico Giuseppe Baggiolini, deceased, Shian-Jan Shiuey, Milan Radoje Uskokovic
  • Vitamin D3 fluorinated analogs
    Patent number: 5612328
    Abstract: Compounds of the formula ##STR1## wherein R is hydrogen, hydroxy, or fluorine, and X is H.sub.2 or .dbd.CH.sub.2 are useful as agents for the treatment of hyperproliferative disorders of the skin such as psoriasis, as agents for the treatment of cancer, such as, leukemia, and as agents for the treatment of sebaceous gland diseases, such as, acne and seborrheic dermatitis.
    Type: Grant
    Filed: February 1, 1996
    Date of Patent: March 18, 1997
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Barbara J. Baggiolini, Shian-Jan Shiuey, Milan R. Uskokovic
  • Method of treating hyperproliferative skin diseases with fluorinated vitamin D.sub.3 analogs
    Patent number: 5512554
    Abstract: Compounds of the formula ##STR1## wherein R is hydrogen, hydroxy, or fluorine, and X is H.sub.2 or .dbd.CH.sub.2 are useful as agents for the treatment of hyperproliferative disorders of the skin such as psoriasis, as agents for the treatment of cancer, such as, leukemia, and as agents for the treatment of sebaceous gland diseases, such as, acne and seborrheic dermatitis.
    Type: Grant
    Filed: April 11, 1995
    Date of Patent: April 30, 1996
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Enrico G. Baggiolini, deceased, Shian-Jan Shiuey, Milan R. Uskokovic
  • Vitamin D3 Flourinated Analogs
    Patent number: 5451574
    Abstract: Compounds of the formula ##STR1## wherein R is hydrogen, hydroxy, or fluorine, and X is H.sub.2 are useful as agents for the treatment of hyperproliferative disorders of the skin such as psoriasis, as agents for the treatment of cancer, such as, leukemia, and as agents for the treatment of sebaceous gland diseases, such as, acne and seborrheic dermatitis.
    Type: Grant
    Filed: January 18, 1994
    Date of Patent: September 19, 1995
    Assignee: Hoffman-La Roche Inc.
    Inventors: Enrico G. Baggiolini, deceased, Barbara J. Baggiolini, Shian-Jan Shiuey, Milan R. Uskokovic
  • 1.alpha.-fluoro-25-hydroxy-16-ene-23-yne-cholecalciferol
    Patent number: 5384314
    Abstract: This invention is for 1.alpha.-fluoro-25-hydroxy-16-ene-23-yne-cholecalciferol, which can be further characterized by the formula: ##STR1## and which is useful as an agent for the treatment of sebaceous gland diseases such as acne and sebhorreic dermatitis.
    Type: Grant
    Filed: March 11, 1994
    Date of Patent: January 24, 1995
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Thomas I. Doran, Shian-Jan Shiuey, Milan R. Uskokovic
  • Vitamin D3 analogs
    Patent number: 5145846
    Abstract: Compounds of the formula ##STR1## wherein R is hydrogen or hydroxy, R.sub.5 is hydrogen, and A is ##STR2## with the proviso that when A is --C.tbd.C--, R.sub.5 may also be deuterium, are described.The compounds of formula I are useful as agents for the treatment of hyperproliferative disorders of the skin such as psoriasis, as agents for the treatment of neoplastic diseases such as leukemia, and as agents for the treatment of sebaceous gland diseases such as acne or seborrheic dermatitis.
    Type: Grant
    Filed: April 10, 1991
    Date of Patent: September 8, 1992
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Enrico G. Baggiolini, deceased, Bernard M. Hennessy, Shian-Jan Shiuey, Gary A. Truitt, Milan R. Uskokovic
  • CCK analogs with appetite regulating activity
    Patent number: 5128448
    Abstract: The invention is directed to novel CCK analogs wherein Tryptophan and/or Phenylalamine are substituted with a radical which provides enhanced appetite suppressant activity to the peptide.
    Type: Grant
    Filed: January 10, 1990
    Date of Patent: July 7, 1992
    Assignee: Hoffman-La Roche Inc.
    Inventors: Waleed Danho, David J. Nelson, Gary L. Olson, Shian-Jan Shiuey, Jefferson W. Tilley, Rolf Wagner
  • Vitamin D.sub.3 analogs
    Patent number: 5087619
    Abstract: Compounds of the formula ##STR1## wherein R is hydrogen or hydroxy, R.sub.5 is hydrogen, and A is --C.tbd.C--, ##STR2## or --CH.sub.2 --CH.sub.2 --, with the proviso that when A is --C.tbd.C--, R.sub.5 may also be deuterium, are described.The compounds of formula I are useful as agents for the treatment of hyperproliferative disorders of the skin such as psoriasis, as agents for the treatment of neoplastic diseases such as leukemia, and as agents for the treatment of sebaceous gland diseases such as acne or seborrheic dermatitis.
    Type: Grant
    Filed: March 23, 1990
    Date of Patent: February 11, 1992
    Assignee: Hoffman-La Roche Inc.
    Inventors: Enrico G. Baggiolini, deceased, Barbara J. Baggiolini, Bernard M. Hennessy, Shian-Jan Shiuey, Gary A. Truitt, Milan R. Uskokovic
  • Vitamin D compounds
    Patent number: 4804502
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or hydroxy and R.sub.2 is hydrogen or fluorine are described. The compounds of formula I are useful as agents in the treatment of disease states characterized by metabolic calcium deficiencies. Examplary of such disease states are osteoporosis and renal osteodystrophy.
    Type: Grant
    Filed: January 20, 1988
    Date of Patent: February 14, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Enrico G. Baggiolini, John J. Partridge, Shian-Jan Shiuey, Gary A. Truitt, Milan R. Uskokovic
  • Synthesis of 1.alpha.,25-dihydroxy-24R-fluorocholecalciferol and 1.alpha.,25-dihydroxy-24S-fluorocholecalciferol
    Patent number: 4652405
    Abstract: 1.alpha.,25-Dihydroxy-24R-fluorocholecalciferol and 1.alpha.,25-dihydroxy-24S-fluorocholecalciferol, analogs of 1.alpha.,25-dihydroxy-cholecalciferol which is physiologically the most active metabolite of vitamin D.sub.3, are synthesized in a multistep process from the known substance 1.alpha.,3.beta.-dihydroxyandrost-5-en-17-one. The new analogs are characterized by the ability to increase intestinal calcium transport, increase serum calcium and phosphate concentrations and to increase the deposition of these minerals in bones. These compounds will find a ready application as substitutes for natural 1.alpha.,25-dihydroxycholecalciferol in the treatment of disease states characterized by metabolic calcium and phosphate deficiencies.
    Type: Grant
    Filed: August 6, 1982
    Date of Patent: March 24, 1987
    Assignee: Hoffman-La Roche Inc.
    Inventors: John J. Partridge, Shian-Jan Shiuey, Milan R. Uskokovic
  • Synthesis of 1.alpha.,25-dihydroxy-24R-fluorocholecalciferol and 1.alpha.,25-dihydroxy-24S-fluorocholecalciferol
    Patent number: 4634692
    Abstract: 1.alpha.,25-Dihydroxy-24R-fluorocholecalciferol and 1.alpha.,25-dihydroxy-24S-fluorocholecalciferol, analogs of 1.alpha.,25-dihydroxy-cholecalciferol which is physiologically the most active metabolite of vitamin D.sub.3, are synthesized in a multistep process from the known substance 1.alpha.,3.beta.-dihydroxyandrost-5-en-17-one. The new analogs are characterized by the ability to increase intestinal calcium transport, increase serum calcium and phosphate concentrations and to increase the deposition of these minerals in bones. These compounds will find a ready application as substitutes for natural 1.alpha.,25-dihydroxycholecalciferol in the treatment of disease states characterized by metabolic calcium and phosphate deficiencies.
    Type: Grant
    Filed: April 11, 1984
    Date of Patent: January 6, 1987
    Assignee: Hoffmann-La Roche Inc.
    Inventors: John J. Partridge, Shian-Jan Shiuey, Milan R. Uskokovic
  • 25,26-dehydro-1.alpha.,24R-dihydroxycholecalciferol and 25,26-dehydro-1.alpha.,24S-dihydroxycholecalciferol and the epimeric mixture
    Patent number: 4594340
    Abstract: The syntheses of 25,26-dehydro-1.alpha.,24R-dihydroxycholecalciferol and 25,26-dehydro-1.alpha.,24S-dihydroxycholecalciferol and the epimeric mixture which are useful as differentiation inducing agent and anti-proliferation agents are described. 25,26-dehydro-1.alpha.,24R-dihydroxycholecalciferol, 25,26-dehydro-1.alpha.,24S-dihydroxycholecalciferol, and the epimeric mixture are useful in treating osteoporosis, tumors and leukemia.
    Type: Grant
    Filed: November 29, 1984
    Date of Patent: June 10, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: John J. Partridge, Shian-Jan Shiuey, Gary A. Truitt, Milan R. Uskokovic
  • Process for the preparation of 24,24-difluoro-1.alpha.,25-dihydroxy vitamin D.sub.3 and intermediates obtained therefrom
    Patent number: 4421690
    Abstract: The present invention relates to a process and intermediates for the preparation of 24,24-difluoro-1.alpha.,25-dihydroxycholecalciferol from the readily-available 1.alpha.,3.beta.-dihydroxyandrost-5-en-17-one which is made by a known microbiological process from 3.beta.-hydroxyandrost-5-en-17-one [R. M. Dodson, A. H. Goldkamp and R. D. Muir, J. Amer. Chem. Soc. 82 4026 (1960)].
    Type: Grant
    Filed: May 17, 1982
    Date of Patent: December 20, 1983
    Assignee: Hoffmann-La Roche Inc.
    Inventors: John J. Partridge, Shian-Jan Shiuey, Milan R. Uskokovic