Patents by Inventor Shian-Jy Wang

Shian-Jy Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11931456
    Abstract: A pharmaceutical composition containing a mixed polymeric micelle and a drug enclosed in the micelle, in which the mixed polymeric micelle, 1 to 1000 nm in size, includes an amphiphilic block copolymer and a lipopolymer. Also disclosed are preparation of the pharmaceutical composition and use thereof for treating cancer.
    Type: Grant
    Filed: November 16, 2022
    Date of Patent: March 19, 2024
    Assignee: MegaPro Biomedical Co. Ltd.
    Inventors: Ming-Cheng Wei, Yuan-Hung Hsu, Wen-Yuan Hsieh, Chia-Wen Huang, Chih-Lung Chen, Jhih-Yun Jian, Shian-Jy Wang
  • Publication number: 20240000978
    Abstract: A method of tracking immune cells to detect immune response. The method including steps of identifying a patient having a disease associated with an organ; administering biocompatible magnetic nanoparticles into the blood stream of the patient; and obtaining a magnetic resonance image of the organ. The presence of hyperintense or hypointense spots in the magnetic resonance image indicates immune response in the patient.
    Type: Application
    Filed: August 7, 2023
    Publication date: January 4, 2024
    Inventors: Chih-Lung Chen, Wen-Yuan Hsieh, Chen-Hsuan Lin, Shian-Jy Wang
  • Publication number: 20230078391
    Abstract: A pharmaceutical composition containing a mixed polymeric micelle and a drug enclosed in the micelle, in which the mixed polymeric micelle, 1 to 1000 nm in size, includes an amphiphilic block copolymer and a lipopolymer. Also disclosed are preparation of the pharmaceutical composition and use thereof for treating cancer.
    Type: Application
    Filed: November 16, 2022
    Publication date: March 16, 2023
    Inventors: Ming-Cheng Wei, Yuan-Hung Hsu, Wen-Yuan Hsieh, Chia-Wen Huang, Chih-Lung Chen, Jhih-Yun Jian, Shian-Jy Wang
  • Patent number: 11541007
    Abstract: A pharmaceutical composition containing a mixed polymeric micelle and a drug enclosed in the micelle, in which the mixed polymeric micelle, 1 to 1000 nm in size, includes an amphiphilic block copolymer and a lipopolymer. Also disclosed are preparation of the pharmaceutical composition and use thereof for treating cancer.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: January 3, 2023
    Assignee: MegaPro Biomedical Co., Ltd.
    Inventors: Ming-Cheng Wei, Yuan-Hung Hsu, Wen-Yuan Hsieh, Chia-Wen Huang, Chih-Lung Chen, Jhih-Yun Jian, Shian-Jy Wang
  • Publication number: 20220080057
    Abstract: A biocompatible magnetic material containing an iron oxide nanoparticle and one or more biocompatible polymers, each having formula (I) below, covalently bonded to the iron oxide nanoparticle: in which each of variables R, L, x, and y is defined herein, the biocompatible magnetic material contains 4-15% Fe(II) ions relative to the total iron ions. Also disclosed in a method of preparing the biocompatible magnetic material.
    Type: Application
    Filed: November 24, 2021
    Publication date: March 17, 2022
    Inventors: Wen-Yuan Hsieh, Yuan-Hung Hsu, Chia-Wen Huang, Ming-Cheng Wei, Chih-Lung Chen, Shian-Jy Wang
  • Publication number: 20200360287
    Abstract: A pharmaceutical composition containing a mixed polymeric micelle and a drug enclosed in the micelle, in which the mixed polymeric micelle, 1 to 1000 nm in size, includes an amphiphilic block copolymer and a lipopolymer. Also disclosed are preparation of the pharmaceutical composition and use thereof for treating cancer.
    Type: Application
    Filed: May 16, 2019
    Publication date: November 19, 2020
    Inventors: Ming-Cheng Wei, Yuan-Hung Hsu, Wen-Yuan Hsieh, Chia-Wen Huang, Chih-Lung Chen, Jhih-Yun Jian, Shian-Jy Wang
  • Publication number: 20190247522
    Abstract: A biocompatible magnetic material containing an iron oxide nanoparticle and one or more biocompatible polymers, each having formula (I) below, covalently bonded to the iron oxide nanoparticle: in which each of variables R, L, x, and y is defined herein, the biocompatible magnetic material contains 4-15% Fe(II) ions relative to the total iron ions. Also disclosed in a method of preparing the biocompatible magnetic material.
    Type: Application
    Filed: November 29, 2018
    Publication date: August 15, 2019
    Inventors: Wen-Yuan Hsieh, Yuan-Hung Hsu, Chia-Wen Huang, Ming-Cheng Wei, Chih-Lung Chen, Shian-Jy Wang
  • Patent number: 9492399
    Abstract: A method of treating a condition related to iron deficiency. The method includes steps of identifying a patient having a condition related to iron deficiency and administering an effective amount of biocompatible iron oxide nanoparticles to the patient. The biocompatible iron oxide nanoparticles each contains an iron oxide core that is covered by one or more biocompatible polymers, each of which has a polyethylene glycol group, a silane group, and a linker linking, via a covalent bond, the polyethylene glycol group and the silane group.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: November 15, 2016
    Assignee: MegaPro Biomedical Co., Ltd.
    Inventors: Chih-Lung Chen, Wen-Yuan Hsieh, Chen-Hsuan Lin, Su-Yo Lin, Shin-Yi Huang, Yuan-Hung Hsu, Shian-Jy Wang, Hsin Jung Huang
  • Publication number: 20160008292
    Abstract: A method of treating a condition related to iron deficiency. The method includes steps of identifying a patient having a condition related to iron deficiency and administering an effective amount of biocompatible iron oxide nanoparticles to the patient. The biocompatible iron oxide nanoparticles each contains an iron oxide core that is covered by one or more biocompatible polymers, each of which has a polyethylene glycol group, a silane group, and a linker linking, via a covalent bond, the polyethylene glycol group and the silane group.
    Type: Application
    Filed: July 10, 2015
    Publication date: January 14, 2016
    Inventors: Chih-Lung Chen, Wen-Yuan Hsieh, Chen-Hsuan Lin, Su-Yo Lin, Shin-Yi Huang, Yuan-Hung Hsu, Shian-Jy Wang, Hsin Jung Huang
  • Publication number: 20160008491
    Abstract: A method of tracking immune cells to detect immune response. The method including steps of identifying a patient having a disease associated with an organ; administering biocompatible magnetic nanoparticles into the blood stream of the patient; and obtaining a magnetic resonance image of the organ. The presence of hyperintense or hypointense spots in the magnetic resonance image indicates immune response in the patient.
    Type: Application
    Filed: July 10, 2015
    Publication date: January 14, 2016
    Inventors: Chih-Lung Chen, Wen-Yuan Hsieh, Chen-Hsuan Lin, Shian-Jy Wang
  • Publication number: 20140199349
    Abstract: Disclosed is a pH-sensitive hyaluronic acid derivative, comprising at least one repeat unit as shown in the following formula (I), wherein HA represents a unit comprising N-acetyl-D-glucosamine and D-glucuronic acid, q represents an integer of 2 to 10,000; A represents a biocleavable linkage comprising at least one of hydrazone, acetal, ketal and imine; M represents at least one of a hydrophobic fragment, a hydrophilic fragment, and an amphiphilic fragment, and p represents the number of [A-M] directly grafted onto each HA unit, p represents an integer of 0 to 4, and the p of each HA unit is not 0 at the same time.
    Type: Application
    Filed: December 29, 2011
    Publication date: July 17, 2014
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Jean-Dean Yang, Ayi-Man Chou, Jui-Hsiang Chen, Hsia-Wei Liu, Shian-Jy Wang, Tse-Min Teng, Hsiang-Fa Liang, Ming-Cheng Wei, Maggie J.M. Lu
  • Patent number: 8586095
    Abstract: A thermosensitive nanostructure for hyperthermia treatment. Magnetic nanoparticles are encapsulated in a thermosensitive polymer nanostructure having a lower critical solution temperature (LCST) of about 40-45° C. The thermosensitive polymer nanostructure may carry a drug. When the magnetic nanoparticles are heated to 40-45° C. by application of an alternating magnetic field in hyperthermia treatment, the thermosensitive polymer nanostructure collapses to release the drug, thus providing concurrent drug treatment.
    Type: Grant
    Filed: August 29, 2006
    Date of Patent: November 19, 2013
    Assignee: Industrial Technology Research Institute
    Inventors: Wen Hsiang Chang, Chao-Hung Kao, Chin-I Lin, Shian-Jy Wang
  • Patent number: 8562953
    Abstract: A dendritic polymer and a magnetic resonance imaging contrast agent employing the same. The magnetic resonance contrast agent includes the dendritic polymer according to the structure of SP-DZ-L)i)j or SP-DX-Z-L)i)j, wherein, S is cyclosilane moiety with j silicon oxygen residual groups, and j is not less than 2; P is CH2CH2Ol, and l is not less than 1; D is a C3-30 dendritic moiety having n oxygen residue, and n is not less than 3; X is C3-30 moiety having bi-functional groups; Z is a C3-20 moiety having a plurality of functional group; and L is a metal cation.
    Type: Grant
    Filed: October 2, 2012
    Date of Patent: October 22, 2013
    Assignee: Industrial Technology Research Institute
    Inventors: Dhakshanamurthy Thirumalai, Chin-I Lin, Shian-Jy Wang
  • Patent number: 8486299
    Abstract: The invention provides phosphors composed of Eu(1-x-w)MaxMbwMgMc10O17, wherein Ma is Yb, Sn, Ce, Tb, Dy, or combinations thereof, and 0<x<0.5, Mb is Ca, Sr, Ba, or combinations thereof, and 0?w?0.5, and Mc is Al, Ga, Sc, In, or combinations thereof. The blue phosphors emit blue light under the excitation of ultraviolet light or blue light, and the phosphors may be further collocated with different colored phosphors to provide a white light illumination device. The blue phosphors of the invention can efficiently utilize light in solar cells.
    Type: Grant
    Filed: July 21, 2010
    Date of Patent: July 16, 2013
    Assignee: Industrial Technology Research Institute
    Inventors: Tien-Heng Huang, Fang-Ching Chang, Yao-Tsung Yeh, Shian-Jy Wang
  • Patent number: 8303937
    Abstract: A dendritic polymer and a magnetic resonance imaging contrast agent employing the same. The magnetic resonance contrast agent includes the dendritic polymer according to the structure of SP-DZ-L)i)j or SP-DX-Z-L)i)j, wherein, S is cyclosilane moiety with j silicon oxygen residual groups, and j is not less than 2; P is and l is not less than 1; D is a C3-30 dendritic moiety having n oxygen residue, and n is not less than 3; X is C3-30 moiety having bi-functional groups; Z is a C3-20 moiety having a plurality of functional group; and L is a metal cation.
    Type: Grant
    Filed: July 16, 2008
    Date of Patent: November 6, 2012
    Assignee: Industrial Technology Research Institute
    Inventors: Dhakshanamurthy Thirumalai, Chin-I Lin, Shian-Jy Wang
  • Publication number: 20120107246
    Abstract: Methotrexate-modified nanoparticles that target tumors, compositions that include the nanoparticles, methods of imaging tissues using the nanoparticles, and methods for treating tissues using the nanoparticles.
    Type: Application
    Filed: June 18, 2010
    Publication date: May 3, 2012
    Applicant: WASHINGTON, UNIVERSITY OF
    Inventors: Miqin Zhang, Shian-Jy Wang, Nathan Kohler, Yuh-Jiuan Lin, Conroy Sun
  • Publication number: 20110226314
    Abstract: The invention provides phosphors composed of Eu(1-x-w)MaxMbwMgMc10O17, wherein Ma is Yb, Sn, Ce, Tb, Dy, or combinations thereof, and 0<x<0.5, Mb is Ca, Sr, Ba, or combinations thereof, and 0?w?0.5, and Mc is Al, Ga, Sc, In, or combinations thereof. The blue phosphors emit blue light under the excitation of ultraviolet light or blue light, and the phosphors may be further collocated with different colored phosphors to provide a white light illumination device. The blue phosphors of the invention can efficiently utilize light in solar cells.
    Type: Application
    Filed: July 21, 2010
    Publication date: September 22, 2011
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Tien-Heng Huang, Fang-Ching Chang, Yao-Tsung Yeh, Shian-Jy Wang
  • Publication number: 20110084594
    Abstract: The invention provides a phosphor emitting UV and visible light, which may be collocated with other phosphors to provide a white light illumination device, composed of (M1-xREx)9M?(PO4)7 or M9(M?1-yRE?y)(PO4)7 , wherein M is Mg, Ca, Sr, Ba, Zn or combinations thereof, M? is Sc, Y, La, Gd, Al, Ga, In or combinations thereof, RE is Pr, Nd, Eu, Gd, Tb, Ce, Dy, Yb, Er, Sc, Mn, Zn or combinations thereof, RE? is Pr, Nd, Gd, Tb, Ce, Dy, Yb, Er, Bi or combinations thereof, 0.001?x?0.8, and 0.001?y<1.0.
    Type: Application
    Filed: February 15, 2010
    Publication date: April 14, 2011
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Shian-Jy Wang, Shyue-Ming Jang, Yi-Chen Chiu, Wei-Jen Liu, Teng-Ming Chen, Chien-Hao Huang, Yao-Tsung Yeh
  • Patent number: 7648783
    Abstract: A cadmium tin oxide (Cd1?xSnxO) multi-layer laminate is disclosed. The laminate comprises: a substrate; and a layer of Cd1?xSnxO which is not an epitaxial structure; wherein, the composition of Sn/(Cd+Sn) is 1˜20%. The method for producing the Cd1?xSnxO multi-layer laminate is also described here. The method comprises steps of: (a) providing metal or oxide targets for sputtering films of Cd1?xSnxO; and (b) sputtering films of Cd1?xSnxO from the targets onto the substrate; wherein the composition of Sn/(Cd+Sn) is 1˜20%.
    Type: Grant
    Filed: December 20, 2005
    Date of Patent: January 19, 2010
    Assignees: Industrial Research Technology Institute, Toth Information System, Inc.
    Inventors: Tien-Heng Huang, Ren-Jye Wu, Wen-Hsuan Chao, Lih-Ping Wang, Hung-Chiao Cheng, Jassy Shian-Jy Wang, Shu-Hei Wang, John R. Rodgers
  • Patent number: 7633219
    Abstract: The invention provides a red phosphor composed of M(Eu1-x-yLaxBiy)4Si3O13, wherein M is Ca, Sr, Ba, or combinations thereof, 0<x<1, and 0<y<1. Under excitation of blue light or ultraviolet light, the red phosphor emits red light having a major emission peak of about 613 nm. The red phosphor of the invention may be collocated with green and blue phosphors to provide a white light illumination device.
    Type: Grant
    Filed: July 5, 2007
    Date of Patent: December 15, 2009
    Assignee: Industrial Technology Research Institute
    Inventors: Teng-Ming Chen, Yi-Chen Chiu, Shian-Jy Wang, Yao-Tsung Yeh, Shyue-Ming Jang