Abstract: The invention provides a composition for inhibiting proline-directed protein kinase FA/glycogen synthase kinase 3? (PDPK FA/GSK-3?), experiments verified that the composition can effectively inhibit the PDPK FA/GSK-3?. In addition, inhibition of PDPK FA/GSK-3? can improve the clinical efficacy of cancer treatment and cure rate.

Abstract: Provided herein is a method for detecting the presence of a unique subset of unhealthy bone marrow-derived cell (BMDC) by co-staining the cytoplasmic and/or nuclear expression of PDPK FA/GSK-3?, and specific BMDC markers as the diagnostic indicator for disease predispositions from very early-stage aberrant wound healing, chronic inflammations, immune disorder towards end-stage fibrotic disease and neoplasia in cancer-free human subjects.

Abstract: The present invention relates to methods and compositions for identifying and detecting lethal cell useful for monitoring disease status and therapy response in various types of cancer patients regardless of the etiological origin of the cancer and uses thereof.

Abstract: Provided herein is a method for detecting the presence of lethal system in a patient using the expression of nuclear factor A (NFA) in marker cell. In another aspect, provided herein is a method for predicting if a patient has metastatic potential and is at risk of developing metastasis and for determining a prognosis for the patient.

Abstract: The present invention provides methods and compositions for targeting the pathologically relevant bipolar actions of these master integrators without affecting the basal physiologically relevant functions. NFA can be used as marker of vicious cycles. Partial inhibition of NFA will be less toxic (in most cases) and more efficient for simultaneous partial inhibitions of all key mediators to terminate this vicious cycles for prevention and treatment of the long-term stresses and chronic inflammation-related diseases without causing any side effects and complications. Aberrant expression of NFA, master stress, and inflammation integrators play a role in orchestrating of vicious cycles. Aspects of the invention provide core technology for simultaneously targeting 12 hallmarks of cancer.

Abstract: The present invention relates to methods and compositions for identifying and detecting lethal cell useful for monitoring disease status and therapy response in various types of cancer patients regardless of the etiological origin of the cancer and uses thereof.

Abstract: Provided herein is a method for detecting the presence of unhealthy cell in a subject using the expression of PDPK FA/GSK-3? in cell and uses thereof. In another aspect, provided herein is a method for predicting if a subject is systemically unhealthy and at risk of developing systemic diseases and syndromes.