Patents by Inventor Shibin Zhou

Shibin Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human fast-1 gene
    Publication number: 20060281078
    Abstract: hFAST-1 is a human forkhead activin signal transducer gene. The hFAST-1 protein has the ability to bind to human Smad2 and activate an activin response element (ARE). The hFAST-1-dependent activation of ARE is dependent on endogenous Smad4 and stimulation of the TGF-? receptor. The hFAST-1 protein binds to a novel DNA motif, TGT(G/T)(T/G)ATT, which is present within the ARE. This motif is important for the activation of genes responsive to ligands of the TGF-? family. The invention includes tools for investigating the TGF-? signaling pathway and screening for compounds which modulate the action of TGF-?.
    Type: Application
    Filed: February 6, 2001
    Publication date: December 14, 2006
    Inventors: Shibin Zhou, Leigh Zawel, Bert Vogelstein, Kenneth Kinzler
  • Human fast-1 protein
    Patent number: 6225441
    Abstract: hFAST-1 is a human forkhead activin signal transducer gene. The hFAST-1 protein has the ability to bind to human Smad2 and activate an activin response element (ARE). The hFAST-1-dependent activation of ARE is dependent on endogenous Smad4 and stimulation of the TGF-&bgr; receptor. The hFAST-1 protein binds to a novel DNA motif, TGT(G/T)(T/G)ATT, which is present within the ARE. This motif is important for the activation of genes responsive to ligands of the TGF-&bgr; family. The invention includes tools for investigating the TGF-&bgr; signaling pathway and screening for compounds which modulate the action of TGF-&bgr;.
    Type: Grant
    Filed: March 7, 2000
    Date of Patent: May 1, 2001
    Assignee: The Johns Hopkins University
    Inventors: Shibin Zhou, Leigh Zawel, Bert Vogelstein, Kenneth W. Kinzler
  • Human fast-1 gene
    Patent number: 6110738
    Abstract: hFAST-1 is a human forkhead activin signal transducer gene. The hFAST-1 protein has the ability to bind to human Smad2 and activate an activin response element (ARE). The hFAST-1-dependent activation of ARE is dependent on endogenous Smad4 and stimulation of the TGF-.beta. receptor. The hFAST-1 protein binds to a novel DNA motif, TGT(G/T)(T/G)ATT, which is present within the ARE. This motif is important for the activation of genes responsive to ligands of the TGF-.beta. family. The invention includes tools for investigating the TGF-.beta. signaling pathway and screening for compounds which modulate the action of TGF-.beta..
    Type: Grant
    Filed: July 10, 1998
    Date of Patent: August 29, 2000
    Assignee: The Johns Hopkins University
    Inventors: Shibin Zhou, Leigh Zawel, Bert Vogelstein, Kenneth W. Kinzler