Patents by Inventor Shibo Jiang

Shibo Jiang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11999806
    Abstract: Provided are a series of polypeptides with antiviral activity. The present invention provides a new strategy for preventing and controlling Enterovirus such as EV71, CVA16, CVA6, CVB3, and CVB5 viruses and provides a new theoretical basis for accelerating the research and development of a polypeptide small molecule drug against Enterovirus such as EV71, CVA16, CVA6, CVB3, and CVB5 viruses.
    Type: Grant
    Filed: January 21, 2019
    Date of Patent: June 4, 2024
    Assignees: WUHAN INSTITUTE OF VIROLOGY, CHINESE ACADEMY OF SCIENCES, FUDAN UNIVERSITY
    Inventors: Xi Zhou, Lu Lu, Yuan Fang, Shibo Jiang, Zezhong Liu, Chengfeng Qin, Yang Qiu, Jingfang Mu
  • Publication number: 20240002383
    Abstract: Provided herein are a series of compounds and their use as an adjuvant. Provided herein are the compounds, a composition comprising the compounds, and the use thereof. These compounds can be used as an adjuvant for a vaccine, and compared to the conventional aluminum adjuvant, the compounds can significantly improve the cellular and humoral immune responses to a vaccine. The compounds as an adjuvant can increase a broad-spectrum protection against various corona viruses such as SARS virus, influenza viruses, and HIV viruses, and significantly enhance persistence of immunoprotection of vaccines.
    Type: Application
    Filed: September 12, 2023
    Publication date: January 4, 2024
    Inventors: Lu LU, Shibo JIANG, Zezhong LIU, Ming HSEIH, Yilong ZHANG, Jie ZHOU, Qian WANG, Xinling WANG, Wei XU
  • Publication number: 20230346916
    Abstract: Disclosed herein are immunogenic compositions for the prevention of infection with SARS-CoV-2. The immunogenic compositions comprise polypeptides, RNA, or DNA and are capable of inducing a long-term and broad immune response in a subject.
    Type: Application
    Filed: March 4, 2021
    Publication date: November 2, 2023
    Inventors: Lanying DU, Wanbo TAI, Christopher HILLYER, Larry LUCHSINGER, Shibo JIANG
  • Publication number: 20230192769
    Abstract: Provided are a series of polypeptides with antiviral activity. The present invention provides a new strategy for preventing and controlling Enterovirus such as EV71, CVA16, CVA6, CVB3, and CVB5 viruses and provides a new theoretical basis for accelerating the research and development of a polypeptide small molecule drug against Enterovirus such as EV71, CVA16, CVA6, CVB3, and CVB5 viruses.
    Type: Application
    Filed: January 21, 2019
    Publication date: June 22, 2023
    Inventors: Xi ZHOU, Lu LU, Yuan FANG, Shibo JIANG, Zezhong LIU, Chengfeng QIN, Yang QIU, Jingfang MU
  • Publication number: 20220409694
    Abstract: Provided is a polypeptide containing the amino acid sequence as shown in SEQ ID NO. 1, and the present invention belongs to the field of biomedicine. The polypeptide can inhibit the infection with novel coronavirus 2019-nCoV (SARS-CoV-2) and SARS-like viruses, and can thus provide good candidate drugs for the prevention and treatment of 2019-nCoV and SARS-like viruses which may break out in the future. Further provided is a polypeptide derivative having palmic acid or cholesterol modifications.
    Type: Application
    Filed: January 11, 2021
    Publication date: December 29, 2022
    Inventors: Lu LU, Shibo JIANG, Shuai XIA, Xia YANG
  • Publication number: 20220313651
    Abstract: The present specification provides methods of treatment of flavivirus infection, such as Zika or dengue vims infection, by administration of gossypol, a gossypol derivative, digitonin, or conessine. These compounds may be used alone, in combination with each other, or in combination with curcumin or bortezomib.
    Type: Application
    Filed: August 20, 2020
    Publication date: October 6, 2022
    Inventors: Lanying DU, Asim Kumar DEBNATH, Shibo JIANG, Yaning GAO
  • Publication number: 20220112177
    Abstract: A ketoamide compound and a preparation method, a pharmaceutical composition, and a use thereof. Specifically, the ketoamide compound shown in formula (A), a racemate, an enantiomer, or a diastereoisomer thereof, or any mixture of same, or a pharmaceutically active metabolite thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof. The ketoamide compound can effectively inhibit coronavirus or Ebola virus, and thereby implement the prevention or treatment of diseases related to coronavirus or diseases related to Ebola virus.
    Type: Application
    Filed: August 9, 2019
    Publication date: April 14, 2022
    Inventors: Hong Liu, Shibo Jiang, Wenhao Dai, Lu Lu, Jingjing Peng, Shuai Xia, Jiang Wang, Jian Li, Hualiang Jiang, Kaixian Chen
  • Patent number: 11103575
    Abstract: Described herein are immunogenic compositions for preventing infection with Middle East respiratory syndrome coronavirus (MERS-CoV) wherein the immunogenic compositions comprise at least a portion of the MERS-CoV S protein and an immunopotentiator.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: August 31, 2021
    Assignee: The New York Blood Center, Inc.
    Inventors: Lanying Du, Fang Li, Shibo Jiang, Yusen Zhou
  • Publication number: 20190328865
    Abstract: Described herein are immunogenic compositions for preventing infection with Middle East respiratory syndrome coronavirus (MERS-CoV) wherein the immunogenic compositions comprise at least a portion of the MERS-CoV S protein and an immunopotentiator.
    Type: Application
    Filed: November 17, 2017
    Publication date: October 31, 2019
    Inventors: Lanying Du, Fang Li, Shibo Jiang, Yusen Zhou
  • Patent number: 9943589
    Abstract: Disclosed herein are immunogenic compositions for preventing infection with influenza viruses wherein the immunogenic compositions comprises an immunogen such as a hemagglutinin of an influenza virus, and an immunopotentiator such as an Fc fragment of human IgG and optionally a stabilization sequence. The immunogen is linked to the stabilization sequence which in turn is linked to the immunopotentiator.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: April 17, 2018
    Assignee: NEW YORK BLOOD CENTER, INC.
    Inventors: Shibo Jiang, Lanying Du
  • Patent number: 9889194
    Abstract: Described herein are immunogenic compositions for preventing infection with Middle East respiratory syndrome coronavirus (MERS-CoV) wherein the immunogenic compositions comprise at least a portion of the MERS-CoV S protein and an immunopotentiator.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: February 13, 2018
    Assignee: New York Blood Center, Inc.
    Inventors: Shibo Jiang, Lanying Du, Yusen Zhou, Guangyu Zhao
  • Patent number: 9724383
    Abstract: Disclosed herein are trimeric polypeptide pharmaceutical compositions comprising three monomers, each monomer comprising a polypeptide having the amino acid sequence of the N-terminal heptad repeat (NHR or HR1) or C-terminal heptad repeat (CHR or HR2) of the transmembrane glycoprotein of human immunodeficiency virus (HIV) and a trimerization motif.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: August 8, 2017
    Assignee: New York Blood Center, Inc.
    Inventors: Shibo Jiang, Zhi Qi, Xi Chen, Chungen Pan
  • Patent number: 9701736
    Abstract: Disclosed herein are neutralizing antibodies with cross-neutralizing activity and cross-protective effects against divergent stains of influenza virus, which are specific for an epitope having at least 90% homology to amino acids +72-115 of the HA1 domain of H5N1 influenza virus hemagglutinin.
    Type: Grant
    Filed: October 9, 2014
    Date of Patent: July 11, 2017
    Assignee: New York Blood Center, Inc.
    Inventors: Shibo Jiang, Lanying Du, Yusen Zhou
  • Publication number: 20170182148
    Abstract: Disclosed herein are immunogenic compositions for preventing infection with influenza viruses wherein the immunogenic compositions comprises an immunogen such as a hemagglutinin of an influenza virus, and an immunopotentiator such as an Fc fragment of human IgG and optionally a stabilization sequence. The immunogen is linked to the stabilization sequence which in turn is linked to the immunopotentiator.
    Type: Application
    Filed: January 26, 2017
    Publication date: June 29, 2017
    Inventors: Shibo Jiang, Lanying Du
  • Patent number: 9592287
    Abstract: Disclosed herein are immunogenic compositions for preventing infection with influenza viruses wherein the immunogenic compositions comprises an immunogen such as a hemagglutinin of an influenza virus, and an immunopotentiator such as an Fc fragment of human IgG and optionally a stabilization sequence. The immunogen is linked to the stabilization sequence which in turn is linked to the immunopotentiator.
    Type: Grant
    Filed: October 5, 2010
    Date of Patent: March 14, 2017
    Assignee: New York Blood Center, Inc.
    Inventors: Shibo Jiang, Lanying Du
  • Publication number: 20160296617
    Abstract: Described herein are immunogenic compositions for preventing infection with Middle East respiratory syndrome coronavirus (MERS-CoV) wherein the immunogenic compositions comprise at least a portion of the MERS-CoV S protein and an immunopotentiator.
    Type: Application
    Filed: February 28, 2014
    Publication date: October 13, 2016
    Inventors: Shibo Jiang, Lanying Du, Yusen Zhou, Guangyu Zhao
  • Publication number: 20160000900
    Abstract: Embodiments are provided for network resource allocation considering user experience, satisfaction, and operator interest. An embodiment method by a network component for allocating network resources includes evaluating, for a user, a QoE for each flow of a plurality of flows in network traffic in according with a QoE model, and further evaluating, for an operator, a revenue associated with the flows in accordance with a revenue model. A plurality of priorities that correspond to the flows are calculated in accordance with the QoE for the user and the revenue for the operator. The method further includes identifying a flow of the flows with a highest value of the priorities, and allocating a network resource for the flow. In an embodiment, the QoE model is a satisfaction model that provides a measure of user satisfaction for each flow in accordance with a subscription or behavior class of the user.
    Type: Application
    Filed: February 14, 2014
    Publication date: January 7, 2016
    Inventors: Yusen Zhou, Guangyu Zhao, Shibo Jiang, Lanying Du
  • Publication number: 20150306174
    Abstract: Disclosed herein are trimeric polypeptide pharmaceutical compositions comprising three monomers, each monomer comprising a polypeptide having the amino acid sequence of the N-terminal heptad repeat (NHR or HR1) or C-terminal heptad repeat (CHR or HR2) of the transmembrane glycoprotein of human immunodeficiency virus (HIV) and a trimerization motif.
    Type: Application
    Filed: July 10, 2015
    Publication date: October 29, 2015
    Inventors: Shibo Jiang, Zhi Qi, Xi Chen, Chungen Pan
  • Patent number: 9115186
    Abstract: Disclosed herein are trimeric polypeptide pharmaceutical compositions comprising three monomers, each monomer comprising a polypeptide having the amino acid sequence of the N-terminal heptad repeat (NHR or HR1) or C-terminal heptad repeat (CHR or HR2) of the transmembrane glycoprotein of human immunodeficiency virus (HIV) and a trimerization motif.
    Type: Grant
    Filed: February 8, 2010
    Date of Patent: August 25, 2015
    Assignee: New York Blood Center
    Inventors: Shibo Jiang, Zhi Qi, Xi Chen, Chungen Pan
  • Publication number: 20150030607
    Abstract: Disclosed herein are neutralizing antibodies with cross-neutralizing activity and cross-protective effects against divergent stains of influenza virus, which are specific for an epitope having at least 90% homology to amino acids +72-115 of the HA1 domain of H5N1 influenza virus hemagglutinin.
    Type: Application
    Filed: October 9, 2014
    Publication date: January 29, 2015
    Inventors: Shibo Jiang, Lanying DU, Yusen Zhou