Patents by Inventor Shibo Xu

Shibo Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparative method and application of Zn(II)-curcumin complex and Zn(II)-curcumin solid dispersions
    Patent number: 8759562
    Abstract: This invention revealed the preparative method and applications of a Zn(II)-curcumin complex and its solid dispersions. The mass ration of Zn(II)-curcumin complex and polyvinylpyrrolidone (PVP) K30 was 1:1˜1:28. The Zn(II)-curcumin complex was synthesized by mixing equimolar amounts of zinc acetate and curcumin in dry ethanol and refluxing the mixture under a nitrogen atmosphere. The Zn(II)-curcumin complex precipitated, and the solid was separated by filtration and washed several times by water and ethanol to remove any unreacted curcumin and zinc acetate. Zn(II)-curcumin and PVP-k30 were added to absolute ethanol to produce a suspension by cryo-grinding under a nitrogen atmosphere. SDs of Zn(II)-curcumin/PVP were produced with a spray dryer. Zn(II)-curcumin SDs showed predominant effects in curing various senile diseases by tackling disadvantages of curcumin and surmounted the problems of monoindication and unideal therapeutic efficacy general existed in drugs for senile disease treatment.
    Type: Grant
    Filed: June 4, 2008
    Date of Patent: June 24, 2014
    Inventors: Xueting Mei, Donghui Xu, Shibo Xu
  • PREPARATIVE METHOD AND APPLICATION OF ZN(II)-CURCUMIN COMPLEX AND ZN(II)-CURCUMIN SOLID DISPERSIONS
    Publication number: 20100261923
    Abstract: This invention revealed the preparative method and applications of a Zn(II)-curcumin complex and its solid dispersions. The mass ration of Zn(II)-curcumin complex and polyvinylpyrrolidone (PVP) K30 was 1:1˜1:28. The Zn(II)-curcumin complex was synthesized by mixing equimolar amounts of zinc acetate and curcumin in dry ethanol and refluxing the mixture under a nitrogen atmosphere. The Zn(II)-curcumin complex precipitated, and the solid was separated by filtration and washed several times by water and ethanol to remove any unreacted curcumin and zinc acetate. Zn(II)-curcumin and PVP-k30 were added to absolute ethanol to produce a suspension by cryo-grinding under a nitrogen atmosphere. SDs of Zn(II)-curcumin/PVP were produced with a spray dryer. Zn(II)-curcumin SDs showed predominant effects in curing various senile diseases by tackling disadvantages of curcumin and surmounted the problems of monoindication and unideal therapeutic efficacy general existed in drugs for senile disease treatment.
    Type: Application
    Filed: June 4, 2008
    Publication date: October 14, 2010
    Inventors: Xueting Mei, Donghui Xu, Shibo Xu
  • Use of bis-acid(5-androsten-17-one-3beta-hydroxyl)diester for manufacture pharmaceuticals
    Publication number: 20040171594
    Abstract: The invention relates to the application of diacid-(5-androsten-17-one-3&bgr;-ol)-diester (formula I) as drug manufacture for arrhythmia, myocardial ischemia, cerebral ischemia, osteoporosis, renal failure and so on.
    Type: Application
    Filed: December 9, 2003
    Publication date: September 2, 2004
    Inventors: Donghui Xu, Shibo Xu