Abstract: The present application relates to a modified immune effector cell, wherein the functions of a T cell antigen receptor (TCR) and major histocompatibility complexes (MHCI, MHCII) in the modified immune effector cell are inhibited in a T cell, and the modified immune effector cell comprises a chimeric antigen receptor (CAR) targeting IL13R?2. The modified immune effector cell of the present application knocks out TCR and HLA-A genes expressed by the cell while recognizing surface antigens of tumor cells, so that multiple effects of improving the anti-tumor effect of CAR-T cells, prolonging the survival time of the cells, and reducing the immune rejection response caused by allogeneic cell therapy are achieved.

Abstract: A system synchronization method includes: connecting synchronization modules of a plurality of devices together through a synchronization bus. The synchronization modules include a signal generation module, a switch control module, a synchronization bus monitoring module, and a switch S1. A signal output terminal of the signal generation module is connected to a first terminal of the switch S1, and a timing overflow terminal of the signal generation module is connected to the switch control module configured to control the switch S1. The switch control module is connected to the synchronization bus monitoring module. A second terminal of the switch S1 is connected to the switch control module and the synchronization bus monitoring module. The system synchronization method has the advantages of simple structure, low cost, high reliability, and good practicability.

Abstract: A system synchronization method includes: connecting synchronization modules of a plurality of devices together through a synchronization bus. The synchronization modules include a signal generation module, a switch control module, a synchronization bus monitoring module, and a switch S1. A signal output terminal of the signal generation module is connected to a first terminal of the switch S1, and a timing overflow terminal of the signal generation module is connected to the switch control module configured to control the switch S1. The switch control module is connected to the synchronization bus monitoring module. A second terminal of the switch S1 is connected to the switch control module and the synchronization bus monitoring module. The system synchronization method has the advantages of simple structure, low cost, high reliability, and good practicability.