Abstract: A device for measuring alternating current (AC) magnetic susceptibility and the method for measuring the same are provided. The device comprises an AC magnetic susceptibility coil set, a signal capturing unit, and a signal processing unit. The device detects AC magnetic susceptibility signals from under testing particles in the magnetic field with variable AC frequencies, and extracts the AC magnetic susceptibility intensity variation and phase difference and/or the real part and the imaginary part of the AC magnetic susceptibility by the signal processing unit.

Abstract: A method of examining cardiac electromagnetic activity over a heart for diagnosing the cardiac functions of the heart is disclosed. The method includes collecting a plurality of sets of spatially distributed, time-varying magnetic field signals of the heart of a subject, wherein the magnetic field signals exhibit features of at least a wave, identifying a time corresponding to a local maximum intensity of the magnetic field signals of the wave at each measurement position and plotting a temporal evolution of the local maximum intensity of the magnetic field signals during a time interval of the wave.

Abstract: Present invention relates to a device magnetically separating a sample. The preferred material for the device is plastic. The device is a cuboid plate, which consists of one or two bottom sides and at least two lateral sides. The bottom side has wells on it to accommodate magnetic elements, and the magnetic element which is suitable to be accommodated into the wells comprising column shape, half-column shape, or half circular column shape magnetic elements. The magnetic element comprises permanent magnet or electromagnet, and the permanent magnet is selected from the group consisting of alnico, samarium cobalt, neodymium iron boron, or magnetic ceramic materials. The magnetic elements can adsorb the magnetic samples in the micro plate.

Abstract: The present invention provides a probe-type SQUID system to detect magnetic particles stored in the living organisms or magnetic-labeling indicators for immunoassays and tumor or other applications. The probe-type SQUID system comprises a probe union, a SQUID union and a connecting electrically conducting wires such as copper wires, wherein the probe union is coupled with a cooling module such as TE cooler module to avoid power heating so that the probe can approach to the living organism to detect magnetic particles with high-sensitivity.

Abstract: A method of examining cardiac electromagnetic activity over a heart for diagnosing the cardiac functions of the heart is disclosed. The method may include constructing a phase diagram of electromagnetic signals over a heart by collecting sets of time-dependent magnetic signals, determining the zeroth and the first derivations of each set of the magnetic signals at a given time, and categorizing the zeroth and the first derivations of the magnetic signals in either of the four phases: (+, +), (?, ?), (+, ?), (?, +). The method may also include monitoring a wave propagation of the magnetic signals.

Abstract: The invention provides a high resolution proton nuclear magnetic reonance and imaging (NMR/MRI) in microtesla magnetic fields by using high critical temperature (high-Tc) superconducting quantum interference device (SQUID) magnetometer via a flux transformer. Both the SQUID and the input coupling coil are installed inside a superconducting vessel which shields environmental noise and set the SQUID in a stable operation condition. The present invention also offers the advantages of preserving the NMR signal even if the sample is far away from the SQUID detector.

Abstract: A method of examining cardiac electromagnetic activity over a heart for diagnosing the cardiac functions of the heart is disclosed. The method may include constructing a phase diagram of electromagnetic signals over a heart by collecting sets of time-dependent magnetic signals, determining the zeroth and the first derivations of each set of the magnetic signals at a given time, and categorizing the zeroth and the first derivations of the magnetic signals in either of the four phases: (+, +), (?, ?), (+, ?), (?, +). The method may also include monitoring a wave propagation of the magnetic signals.

Abstract: A method for suppressing non-specific bindings between molecules includes providing magnetic particles dispersed in a liquid, wherein each of the magnetic particles has a magnetization. The magnetic particles are coated with coating molecules. Binding molecules mixed of first-type binding molecules and second-type binding molecules are applied to the liquid, wherein the coating molecules are specifically binding with the first-type binding molecules and non-specifically binding with the second-type binding molecules. An alternating current (ac) magnetic field is applied at an axis with a frequency level, wherein the frequency level causes suppression of the second-type binding molecules in binding with the coating molecules.

Abstract: The present invention is directed to methods for quantitatively measuring biomolecules by using magnetic nanoparticles. Through the use of the magnetic nanoparticles and the bioprobes coated to the magnetic nanoparticles, the biomolecules conjugated with the bioprobes result in the formation of particle clusters. By measuring the changes in magnetic properties resulting from the existence of the bio-targets, the amount of the bio-targets in a sample to be tested can be measured.

Abstract: A method to quantitatively measure an amount of bio-molecules in a sample includes providing a solution having magnetic nanoparticles; coating bioprobe molecules to surfaces of the magnetic nanoparticles in the solution; measuring a first alternating current (ac) magnetization of the solution at a mixture frequency (?f1+?f2), wherein ? or ? is independently an integer larger than zero; adding a sample containing the bio-molecules to be detected to the solution, so that the biomolecules in the sample conjugate with the bioprobe molecules coated on the nanoparticles; and measuring a second ac magnetization of the solution at the mixture frequency (?f1+?f2) after adding the sample and incubation, so as to obtain an ac magnetization reduction at the mixture frequency (?f1+?f2) between the first and the second magnetization to determine the amount of the bio-molecules.

Abstract: A method for measuring a concentration of nucleic acids is described. The method includes providing bioprobe molecules that include single-stranded nucleic acids, wherein the bioprobe molecules are conjugated with magnetic beads in a solution. A sample of single-stranded target nucleic acids is added to solution, where the single-stranded target nucleic acids hybridize with the single-stranded nucleic acids of the bioprobe molecules. A reduction of the ac (alternating current) magnetic susceptibility of the solution prior and after the addition of the sample to the solution is determined.

Abstract: A method of examining cardiac electromagnetic activity over a heart for diagnosing the cardiac functions of the heart is disclosed. The method includes collecting a plurality of sets of spatially distributed, time-varying magnetic field signals of the heart of a subject, wherein the magnetic field signals exhibit features of at least a wave, identifying a time corresponding to a local maximum intensity of the magnetic field signals of the wave at each measurement position and plotting a temporal evolution of the local maximum intensity of the magnetic field signals during a time interval of the wave.

Abstract: A method of examining cardiac electromagnetic activity over a heart for diagnosing the cardiac functions of the heart is disclosed. The method may include constructing a phase diagram of electromagnetic signals over a heart by collecting sets of time-dependent magnetic signals, determining the zeroth and the first derivations of each set of the magnetic signals at a given time, and categorizing the zeroth and the first derivations of the magnetic signals in either of the four phases: (+, +), (?, ?), (+, ?), (?, +). The method may also include monitoring a wave propagation of the magnetic signals.

Abstract: A superconductive quantum interference device (SQUID) system is provided for measuring the alternating current (AC) magnetic susceptibility of material at a single frequency or a mixing frequency from multiple frequencies, such as mf1+nf2, where f1 and f2 are two excitation frequencies of two primary coils. The system includes a magnetic-flux sourcing unit for producing an AC magnetic flux on a sample and a magnetic-flux reading unit for reading the induced magnetic flux from the sample via a magnetic flux transformer. The magnetic-flux reading unit includes a SQUID set for detecting the induced magnetic flux, so as to obtain the magnetic susceptibility of the sample in converting calculation.

Abstract: A superconductive quantum interference device (SQUID) system is provided for measuring the alternating current (AC) magnetic susceptibility of material at a single frequency or a mixing frequency from multiple frequencies, such as mf1+nf2, where f1 and f2 are two excitation frequencies of two primary coils. The system includes a magnetic-flux sourcing unit for producing an AC magnetic flux on a sample and a magnetic-flux reading unit for reading the induced magnetic flux from the sample via a magnetic flux transformer. The magnetic-flux reading unit includes a SQUID set for detecting the induced magnetic flux, so as to obtain the magnetic susceptibility of the sample in converting calculation.

Abstract: A composition for magnetofecting genetic materials into cells with the assistant of an external magnetic force is described. The composition includes hydrophilic vectors, magnetic nanoparticles, and genetic materials, wherein the magnetic nanoparticles and the genetic materials are enveloped inside the hydrophilic vectors.

Abstract: An ultra-sensitive SQUID-based magnetoreduction measurement system for performing an assay is provided, wherein the system is capable of measuring the concentration of multiple-active-epitope biomolecules, single-active-epitope biomolecules, or small biomolecules with high sensitivity. The sensitivity of the ultra-sensitive magnetoreduction measurement system is 1 ppt or below. The system includes a sample unit and a sensor unit. The sample unit includes excitation coils and a pick up coil, and a sample housed inside the pick up coil, wherein the sample contains at least magnetic nanoparticles coated with bio-receptors that are conjugated with to-be-detected biomolecules. The sensor unit includes a SQUID magnetometer and a couple coil, wherein the magnetization of the sample sensed by the pick-up coil is transferred to the magnetometer at the sensor unit via the couple coil.

Abstract: The invention is about cascading high-transition-temperature superconducting quantum interference devices (SQUIDs) for sensing magnetic fields. These SQUIDs in series are connected with coils for picking up detected magnetic signals. Depending on the patterns of pick-up coils, magnetometers or gradiometers, which sense the magnetic field intensity and magnetic field gradient respectively, are achieved. Examples of magnetometers and gradiometers includes cascading high-Tc SQUIDs in series are provided.

Abstract: The present invention is designed as the diagnostic methods using magnetic nanoparticles to quantitatively measure the ligands or biomolecules for assessing/evaluating the status or risks of diseases, such as atherosclerosis, infection/inflammatory diseases, and tumors. Through the use of the magnetic nanoparticles and the bio-receptors coated to the magnetic nanoparticles, the ligands conjugated with the bio-receptors can be detected or marked, and the amount of the ligands in a sample can be determined by measuring the changes in magnetic properties resulting from the existence of the ligands.

Abstract: The present invention is directed to methods for quantitatively measuring biomolecules by using magnetic nanoparticles. Through the use of the magnetic nanoparticles and the bioprobes coated to the magnetic nanoparticles, the biomolecules conjugated with the bioprobes result in the formation of particle clusters. By measuring the changes in magnetic properties resulting from the existence of the bio-targets, the amount of the bio-targets in a sample to be tested can be measured.