Abstract: The present invention relates to the field of fluid heat transfer, and discloses a heat transfer enhancement pipe as well as a cracking furnace and an atmospheric and vacuum heating furnace including the same. The heat transfer enhancement pipe (1) includes a pipe body (10) of tubular shape having an inlet (100) for entering of a fluid and an outlet (101) for said fluid to flow out; internal wall of the pipe body (10) is provided with a fin (11) protruding towards interior of the pipe body (10), the fin (11) spirally extends in an axial direction of the pipe body (10), wherein a height of the fin (11) gradually increases from one end in at least a part extension of the fin. The heat transfer enhancement pipe can reduce thermal stress of itself, thereby increasing service life of the heat transfer enhancement pipe.

Abstract: The present invention relates to the field of fluid heat transfer, and discloses a heat transfer enhancement pipe as well as a cracking furnace and an atmospheric and vacuum heating furnace including the same. The heat transfer enhancement pipe (1) includes a pipe body (10) of tubular shape having an inlet (100) for entering of a fluid and an outlet (101) for said fluid to flow out; internal wall of the pipe body (10) is provided with a fin (11) protruding towards interior of the pipe body (10), wherein the fin (11) has one or more fin sections extending spirally in the axial direction of the pipe body (10), and each fin section has a first end surface facing the inlet (100) and a second end surface facing the outlet (101), at least one of the first end surface and the second end surface of at least one of the rib sections is formed as a transition surface along spirally extending direction.

Abstract: The present invention relates to the field of fluid heat transfer, and discloses a heat transfer enhancement pipe as well as a cracking furnace and an atmospheric and vacuum heating furnace including the same. The heat transfer enhancement pipe (1) includes a pipe body (10) of tubular shape having an inlet (100) for entering of a fluid and an outlet (101) for said fluid to flow out; the internal wall of the pipe body (10) is provided with a fin (11) protruding towards the interior of the pipe body (10), the fin (11) spirally extends in an axial direction of the pipe body (10), wherein at least one of a heat insulator (14) and a heat insulating layer (17) is provided at the outside of the pipe body (10). The heat transfer enhancement pipe can reduce thermal stress of itself, thereby increasing service life of the heat transfer enhancement pipe.

Abstract: The present invention relates to the field of fluid heat transfer, and discloses a heat transfer enhancement pipe as well as a cracking furnace and an atmospheric and vacuum heating furnace including the same. The heat transfer enhancement pipe (1) includes a pipe body (10) of tubular shape having an inlet (100) for entering of a fluid and an outlet (101) for said fluid to flow out; internal wall of the pipe body (10) is provided with a fin (11) protruding towards interior of the pipe body (10), the fin (11) spirally extends in an axial direction of the pipe body (10), wherein a height of the fin (11) gradually increases from one end in at least a part extension of the fin. The heat transfer enhancement pipe can reduce thermal stress of itself, thereby increasing service life of the heat transfer enhancement pipe.

Abstract: An online multiphase measuring method of concentration and diameter distribution of dispersed phase particles in a multiphase reactor is provided in the present invention. The method is based on an online multiphase measuring instrument. The method described herein includes the following steps: (1) the online multiphase measuring instrument is placed in a multiphase system, and an image of the particles in the multiphase system is obtained; (2) valid particles are determined as: the particle that its Grad(?) is greater than or equal to Grad(?l/2) is labeled as a valid one; (3) the particle diameter is calculated by di=10×ni/N10; according to the equation ? = V c V = ? i n ? 1 6 ? ? ? ? d i 3 S × l , the concentration of the valid particles is calculated. The concentration and diameter of bubbles, droplets or solid particles can be obtained in real time and online measurement. The accuracy of this method is high.

Abstract: Provided are an immersion-type online multiphase measuring instrument and method. The instrument includes a package tube; a viewport; LED lamps and a brightness-adjustable light source system including a power supply, a signal generator and an oscilloscope; a telecentric lens and an image sensor; a controller; a signal processing and outputting system; and a display system. The LED lamps, the telecentric lens and the image sensor are located in the package tube. The exposure period of the image sensor is less than the pulse period of the signal generator. The photographic probe used in this measuring instrument has the advantages of online quantitative measurement, small size, portability, less-impact of fluid temperature and the surrounding environment, adaptability to transparent and opaque reactors with two-phase, three-phase and more than three-phase.

Abstract: An online multiphase measuring method of concentration and diameter distribution of dispersed phase particles in a multiphase reactor is provided in the present invention. The method is based on an online multiphase measuring instrument. The method described herein includes the following steps: (1) the online multiphase measuring instrument is placed in a multiphase system, and an image of the particles in the multiphase system is obtained; (2) valid particles are determined as: the particle that its Grad(?) is greater than or equal to Grad(?l/2) is labeled as a valid one; (3) the particle diameter is calculated by di=10×ni/N10; according to the equation ? = V c V = ? i n ? 1 6 ? ? ? ? d i 3 S × l , the concentration of the valid particles is calculated. The concentration and diameter of bubbles, droplets or solid particles can be obtained in real time and online measurement. The accuracy of this method is high.

Abstract: The present invention provides an immersion-type online multiphase measuring instrument and method. The instrument comprises a package tube; a viewport; LED lamps and a brightness-adjustable light source system including a power supply, a signal generator and an oscilloscope; a telecentric lens and an image sensor; a controller; a signal processing and outputting system; and a display system. The LED lamps, the telecentric lens and the image sensor are located in the package tube. The exposure period of the image sensor is less than the pulse period of the signal generator. The photographic probe used in this measuring instrument has the advantages of online quantitative measurement, small size, portability, less-impact of fluid temperature and the surrounding environment, adaptability to transparent and opaque reactors with two-phase, three-phase and more than three-phase. It can capture the high contrast images of local fluid flow in multiphase reactor.

Abstract: Provided is a fusion protein comprising circularly permuted form of TRAIL, and the fusion protein contains circularly permuted form of TRAIL and oligopeptides located at the N-terminus and/or C-terminus of the permuted form. The oligopeptides contain a repeating sequence consisting of 3-10 histidines. The components of the circularly permuted form of TRAIL from N-terminus to C-terminus are: (a) amino acids 135-281 of TRAIL, (b) a linker, and (c) amino acids 121-135 of TRAIL or amino acids 114-135 of TRAIL or amino acids 95-135 of TRAIL or any fragments of amino acids 95-135 of TRAIL containing amino acids 121-135 of TRAIL. Also provided is a method for treating cancer by using the fusion protein.

Abstract: Provided is a fusion protein comprising circularly permuted form of TRAIL, and the fusion protein contains circularly permuted form of TRAIL and oligopeptides located at the N-terminus and/or C-terminus of the permuted form. The oligopeptides contain a repeating sequence consisting of 3-10 histidines. The components of the circularly permuted form of TRAIL from N-terminus to C-terminus are: (a) amino acids 135-281 of TRAIL, (b) a linker, and (c) amino acids 121-135 of TRAIL or amino acids 114-135 of TRAIL or amino acids 95-135 of TRAIL or any fragments of amino acids 95-135 of TRAIL containing amino acids 121-135 of TRAIL. Also provided is a method for treating cancer by using the fusion protein.

Abstract: The present invention relates to a method for early evaluation of clinical efficacy of antitumor intervention measure, comprising evaluating the efficacy of the antitumor intervention measure by assaying whether the content of a tumor-damaging biomarker(s) in the blood of a patient having tumor rises as compared to the baseline level before treatment within a time window after the patients receives at least one antitumor intervention measure. In preferable embodiments, the tumor-damaging biomarker(s) is selected from a group consisting of Alanine Aminotransferase (ALT), Aspartate Transaminase (AST), Lactate Dehydrogenase (LDH); said tumor is multiple myeloma; said antitumor intervention measure is the administration of CPT alone or the administration of CPT in combination with thalidomide.

Abstract: The present invention provides a fusion protein comprising an immunostimulatory polypeptide and a mutant E7 protein of a human papilloma virus. The present invention also provides a gene encoding the fusion protein, expression vectors containing the gene, a pharmaceutical composition comprising the fusion protein, a method for treating or preventing a human papilloma virus related disease by using the fusion protein and uses of the fusion protein in the preparation of a medicament for the treatment or prevention of the human papilloma virus related disease.

Abstract: The present invention provides a fusion protein comprising an immunostimulatory polypeptide and a mutant E7 protein of a human papilloma virus. The present invention also provides a gene encoding the fusion protein, expression vectors containing the gene, a pharmaceutical composition comprising the fusion protein, a method for treating or preventing a human papilloma virus related disease by using the fusion protein and uses of the fusion protein in the preparation of a medicament for the treatment or prevention of the human papilloma virus related disease.

Abstract: The present invention provides a method for applying external counterpulsation to a patient, including detecting a blood-flow impedance signal, self-adaptive filter processing the detected blood-flow impedance signal, and adjusting inflation of an inflatable member based on the self-adaptive filter processing in order to optimize counterpulsation timing. A computer processes the signals and controls a fluid distribution device to distribute compressed fluid to a plurality of inflatable members based on said processed signals.

Abstract: The present invention provides a method for applying external counterpulsation to a patient, including detecting a blood-flow impedance signal, self-adaptive filter processing the detected blood-flow impedance signal, and adjusting inflation of an inflatable member based on the self-adaptive filter processing in order to optimize counterpulsation timing. The present invention further includes an external counterpulsation apparatus providing a high-frequency current source applied to the patient to produce an electrocardiographic signal and a blood flow impedance signal, as well as an amplifier-filter circuit to operably condition the electrocardiographic signal and a heart impedance signal amplifier receiving the blood flow impedance signal. A computer processes the signals and controls a fluid distribution device to distribute compressed fluid to a plurality of inflatable members based on said processed signals.

Abstract: The present invention provides a method for applying external counterpulsation to a patient, including detecting a blood-flow impedance signal, self-adaptive filter processing the detected blood-flow impedance signal, and adjusting inflation of an inflatable member based on the self-adaptive filter processing in order to optimize counterpulsation timing. The present invention further includes an external counterpulsation apparatus providing a high-frequency current source applied to the patient to produce an electrocardiographic signal and a blood flow impedance signal, as well as an amplifier-filter circuit to operably condition the electrocardiographic signal and a heart impedance signal amplifier receiving the blood flow impedance signal. A computer processes the signals and controls a fluid distribution device to distribute compressed fluid to a plurality of inflatable members based on said processed signals.

Abstract: The present invention provides a high efficiency external counterpulsation apparatus having accurate and reliable timing of inflation and deflation and reduced temperature of the pressurized gas, such that the gas flow temperature of the balloons is near to room temperature. The external counterpulsation apparatus also has a new gas distribution device and devices for monitoring the blood pressure and oxygen levels in the blood of a patient for improving safety. The present invention further provides a method for controlling the external counterpulsation apparatus.

Abstract: The present invention provides a high efficiency external counterpulsation apparatus having accurate and reliable timing of inflation and deflation and reduced temperature of the pressurized gas, such that the gas flow temperature of the balloons is near to room temperature. The external counterpulsation apparatus also has a new gas distribution device and devices for monitoring the blood pressure and oxygen levels in the blood of a patient for improving safety. The present invention further provides a method for controlling the external counterpulsation apparatus.

Abstract: The present invention provides a high efficiency external counterpulsation apparatus having accurate and reliable timing of inflation and deflation and reduced temperature of the pressurized gas, such that the gas flow temperature of the balloons is near to room temperature. The external counterpulsation apparatus also has a new gas distribution device and devices for monitoring the blood pressure and oxygen levels in the blood of a patient for improving safety. The present invention further provides a method for controlling the external counterpulsation apparatus.