Patents by Inventor Shigeaki Maruo

Shigeaki Maruo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5612203
    Abstract: Disclosed is a method for producing saccarides of definite chain length, such as glucose, maltose, malto-oligosaccharides and isomalto-oligosaccharides with a high purity. Saccharides such as starch, dextran and cellulose, and hydrolyzates thereof, are subjected to modification of the anomeric carbon at the reducing end of the molecule without modification of the non-reducing end of the molecule. The modification may be oxidation, for example by bromine to produce a carboxylic acid at the anomeric carbon, or amination, for example by phenylhydrazine to produce an osazone or osone of the saccharide. After modification, the modified saccharide can be adsorbed on an ion exchange resin and then repeatedly cleaved with a suitable enzyme, such as .beta.-amylase, to produce the desired saccharide of definite chain length.
    Type: Grant
    Filed: August 8, 1994
    Date of Patent: March 18, 1997
    Assignee: Nippon Shinyaku Co. Ltd.
    Inventors: Shigeaki Maruo, Noriyuke Tachikake, Yohji Ezure
  • Patent number: 5364794
    Abstract: A simplified process is provided for producing saccharides of definite chain length, such as glucose, maltose and maltooligosaccharides, each in an isolated state and with a high purity.The process comprises transferring a saccharide chain, using a saccharide chain transferase, from a saccharide chain source to a substance substantially separable from the saccharides mentioned above and treating the thus-obtained oligosaccharide with an enzyme capable of excising the saccharide chain of definite chain length in an exo manner.
    Type: Grant
    Filed: February 4, 1993
    Date of Patent: November 15, 1994
    Assignee: Nippon Shinyaku Company Limited
    Inventors: Yohji Ezure, Shigeaki Maruo, Katsunori Miyazaki, Naoyoshi Yamada
  • Patent number: 5256788
    Abstract: The present invention relates to stabilizing agents for enzymes which comprises an enzyme stabilizing amount of an N-substituted moranoline derivative of the formula (III): ##STR1## wherein R.sup.1 is phenyl lower alkynyl, phenoxy lower alkenyl or phenoxy lower alkynyl, wherein the phenyl moiety is unsubstituted, or a glucose oligomer thereof.
    Type: Grant
    Filed: February 5, 1990
    Date of Patent: October 26, 1993
    Assignee: Nippon Shinyaku Co. Ltd.
    Inventors: Yohji Ezure, Shigeaki Maruo, Hiroshi Yamashita, Katsunori Miyazaki, Makoto Sugiyama
  • Patent number: 4970214
    Abstract: A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof, wherein Y is S or O;R is hydrogen or alkyl having from about 1 to about 4 carbon atoms;R.sup.1 is hydrogen, alkyl having from about 1 to about 4 carbon atoms, alkoxy having from about 1 to about 4 carbon atoms, halogen or trifluoromethyl;R.sup.2 is hydrogen or unsubstituted or substituted alkyl having from about 1 to about 4 carbon atoms; andR.sup.3 is hydrogen, alkyl having from about 1 to about 6 carbon atoms, cycloalkyl having from about 3 to about 6 carbon atoms, alkoxy having from about 1 to about 4 carbon atoms, aryloxy having from about 6 to about 10 carbon atoms, alkylthio having from about 1 to about 4 carbon atoms, hydroxyalkoxy having from about 1 to about 4 carbon atoms, or unsubstituted or substituted phenyl is useful to obtain inhibition of aldose reduction in animals, including humans.
    Type: Grant
    Filed: December 8, 1988
    Date of Patent: November 13, 1990
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Masao Murase, Shigeaki Maruo
  • Patent number: 4806633
    Abstract: A method of preparing a molecular compound of glucosylmoranoline of the formula I ##STR1## with methanol, which comprises stirring an aqueous solution comprising (I) and other moranoline derivatives with methanol, whereupon crystals of the molecular compound of (I) with methanol are formed.
    Type: Grant
    Filed: April 15, 1987
    Date of Patent: February 21, 1989
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Yoji Ezure, Masashi Yamamoto, Shigeaki Maruo, Makoto Sugiyama
  • Patent number: 4785018
    Abstract: A compound of the formula (I): ##STR1## wherein R is hydrogen or unsubstituted or substituted 1-naphthyl. These compounds are useful to obtain inhibition of aldose reductase in animals, including humans.
    Type: Grant
    Filed: June 25, 1987
    Date of Patent: November 15, 1988
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Masao Murase, Shigeaki Maruo
  • Patent number: 4363802
    Abstract: Bisglucosyl moranoline of the formula (I) ##STR1## is useful in inhibiting increase of blood sugar in sugar-loaded animals and humans, and particularly for treatment of diabetes mellitus.
    Type: Grant
    Filed: November 30, 1981
    Date of Patent: December 14, 1982
    Assignee: Nippon Shinyaku Co. Ltd.
    Inventors: Shingo Matsumura, deceased, Hiroshi Enomoto, Yoshiaki Aoyagi, Yoji Ezure, Yoshiaki Yoshikuni, Shigeaki Maruo, Nobutoshi Ojima, Kiyotaka Konno