Patents by Inventor Shigebumi Hashimoto

Shigebumi Hashimoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dipeptide derivatives and antihypertensive drugs containing them
    Patent number: 4971993
    Abstract: There are disclosed dipeptide derivatives represented by the general formula: ##STR1## wherein R.sup.1 is a radical selected from the group consisting of alkyl, aralkyl and aryl groups optionally containing one or more substituent groups, R.sup.2 is a radical selected from the group consisting of hydrogen atoms and alkyl, aralkyl and aryl groups optionally containing one or more substituent groups, R.sup.3 is a radical selected from the group consisting of hydrogen atoms and alkyl, aralkyl and aryl groups optionally containing one or more substituent groups, R.sup.4 is a radical selected from the group consisting of hydrogen atoms and alkyl, aralkyl and aryl groups optionally containing one or more substituent groups, and R.sup.
    Type: Grant
    Filed: September 1, 1988
    Date of Patent: November 20, 1990
    Assignee: Ajinomoto Co., Inc.
    Inventors: Masahiko Kurauchi, Chikahiko Eguchi, Shigebumi Hashimoto
  • Amino acid derivatives, methods of preparing said derivatives and antihypertensive drugs containing them
    Patent number: 4590178
    Abstract: The present invention relates to an amino acid derivative represented by the formula ##STR1## wherein R.sub.1 and R.sub.2 represent hydroxyl, alkyloxy, aryloxy, arylkyloxy, alkyl, aryl, or aralkyl; R.sub.3, R.sub.5, R.sub.8 and R.sub.11 are hydrogen or alkyl; R.sub.4, R.sub.7 and R.sub.10 are hydrogen, or substituted or unsubstituted alkyl, aryl or aralkyl; R.sub.6 and R.sub.9 are hydrogen, alkyl, aryl, or aralkyl; R.sub.12 is hydroxyl, alkyloxy, aryloxy, aralkyloxy, amino, mono- or di-alkyl-, aryl- or aralkyl amino; and R.sub.6 and R.sub.7 combined together, and R.sub.9 and R.sub.10 combined together independently may form a substituted or unsubstituted alkylene bridge. The present invention also relates to a method of preparing said amino acid derivatives, and to anti-hypertensive drugs containing them.
    Type: Grant
    Filed: March 16, 1984
    Date of Patent: May 20, 1986
    Assignee: Ajinomoto Company, Incorporated
    Inventors: Shumpei Sakakibara, Yasumi Yugari, Shigebumi Hashimoto
  • Amino acid derivatives and antihypertensive drugs containing them
    Patent number: 4536395
    Abstract: N-terminal phosphorus dipeptides having antihypertensive properties are disclosed.
    Type: Grant
    Filed: July 14, 1983
    Date of Patent: August 20, 1985
    Assignee: Ajinomoto Co., Inc.
    Inventors: Shumpei Sakakibara, Yasumi Yugari, Shigebumi Hashimoto
  • Amino acid derivatives, methods of preparing said derivatives and antihypertensive drugs containing them
    Patent number: 4472381
    Abstract: The present invention relates to an amino acid derivative represented by the formula ##STR1## wherein R.sub.1 and R.sub.2 represent hydroxyl, alkyloxy, aryloxy, arylkyloxy, alkyl, aryl, or aralkyl; R.sub.3, R.sub.5, R.sub.8 and R.sub.11 are hydrogen or alkyl; R.sub.4, R.sub.7 and R.sub.10 are hydrogen, or substituted or unsubstituted alkyl, aryl or aralkyl; R.sub.6 and R.sub.9 are hydrogen, alkyl, aryl, or aralkyl; R.sub.12 is hydroxyl, alkyloxy, aryloxy, aralkyloxy, amino, mono- or di-alkyl-, aryl- or aralkyl amino; and R.sub.6 and R.sub.7 combined together, and R.sub.9 and R.sub.10 combined together independently may form a substituted or unsubstituted alkylene bridge. The present invention also relates to a method of preparing said amino acid derivatives, and to anti-hypertensive drugs containing them.
    Type: Grant
    Filed: January 18, 1983
    Date of Patent: September 18, 1984
    Assignee: Ajinomoto Company Incorporated
    Inventors: Shumpei Sakakibara, Yasumi Yugari, Shigebumi Hashimoto