Patents by Inventor Shigefumi Takeda

Shigefumi Takeda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5234951
    Abstract: The present invention relates to an anti-ulcer agent comprising a compound represented by the following general formula I as the effective ingredient, and a novel chalcone derivative included in the compound represented by this general formula I: ##STR1## wherein X and Y independently stand for a hydrogen atom or together form a single bond, R.sub.1 stands for a hydroxyl group, an acetoxy group, a carboxymethoxy group or a methoxycarbonylmethoxy group, R.sub.2 stands for a hydrogen atom, an isoprenyl group, isopentyl group or a propyl group, R.sub.3 stands for a hydroxyl group or a methoxy group, R.sub.4 stands for a hydrogen atom, a hydroxyl group or a methoxy group, R.sub.5 stands for a hydrogen atom, a hydroxyl group, a methoxy group or an isopentyl group, R.sub.6 stands for a hydroxyl group, a methoxy group or a carboxymethoxy group, and R.sub.7 stands for a hydrogen atom or a methoxy group.
    Type: Grant
    Filed: November 25, 1991
    Date of Patent: August 10, 1993
    Assignee: Tsumura Juntendo, Inc.
    Inventors: Yukio Komazawa, Shigefumi Takeda, Kunio Hosaka, Hiroshi Mitsuhashi, Toshihiko Watanabe
  • Patent number: 5227398
    Abstract: Hepatopathy improvers contain as an effective ingredient one or more of benzodioxole derivatives represented by the following formula: ##STR1## wherein A means a particular N- or S-containing group. Most of these benzodioxole derivatives are novel.
    Type: Grant
    Filed: November 26, 1991
    Date of Patent: July 13, 1993
    Assignee: Tsumura & Co.
    Inventors: Masayuki Kimura, Shouichi Nishida, Shigefumi Takeda, Kunio Hosaka
  • Patent number: 5106871
    Abstract: The present invention relates to an anti-ulcer agent comprising a compound represented by the following general formula I as the effective ingredient, and a novel chalcone derivative included in the compound represented by this general formula I: ##STR1## wherein X and Y independently stand for a hydrogen atom or together form a single bond, R.sub.1 stands for a hydroxyl group, an acetoxy group, a carboxymethoxy group or a methoxycarbonylmethoxy group, R.sub.2 stands for a hydrogen atom, an isoprenyl group, isopentyl group or a propyl group, R.sub.3 stands for hydroxyl group or a methoxy group, R.sub.4 stands for a hydrogen atom, a hydroxyl group or a methoxy group, R.sub.5 stands for a hydrogen atom, a hydroxyl group, a methoxy group or an isopentyl group, R.sub.6 stands for a hydroxyl group, a methoxy group or a carboxymethoxy group, and R.sub.7 stands for a hydrogen atom or a methoxy group.
    Type: Grant
    Filed: July 19, 1991
    Date of Patent: April 21, 1992
    Assignee: Tsumura & Co.
    Inventors: Yukio Komazawa, Shigefumi Takeda, Kunio Hosaka, Hiroshi Mitsuhashi, Toshihiko Watanabe
  • Patent number: 5032685
    Abstract: The present invention relates to a novel biphenyl derivative having a liver ailment-moderating action, which is effective for the remedy of liver diseases such as acute hepatitis and chronic hepatitis, a process for the preparation of this derivative and a liver ailment-moderating agent comprising this derivative as an active ingredient. Moreover, the present invention relates to a compound valuable as the intermediate compound for the synthesis of this derivative and a process for efficiently preparing this intermediate compound.
    Type: Grant
    Filed: November 21, 1989
    Date of Patent: July 16, 1991
    Assignee: Tsumura Juntendo, Inc.
    Inventors: Yoshiyuki Matsuoka, Kunio Hosaka, Shigefumi Takeda, Hiroshi Mitsuhashi
  • Patent number: 4987240
    Abstract: The present invention relates to a novel biphenyl derivative having a liver ailment-moderating action, which is effective for the remedy of liver diseases such as acute hepatitis and chronic hepatitis, a process for the preparation of this derivative and a liver ailment-moderating agent comprising this derivative as an active ingredient. Moreover, the present invention relates to a compound valuable as the intermediate compound for the synthesis of this derivative and a process for efficiently preparing this intermediate compound.
    Type: Grant
    Filed: November 21, 1989
    Date of Patent: January 22, 1991
    Assignee: Tsumura & Co.
    Inventors: Yoshiyuki Matsuoko, Kunio Hosaka, Shigefumi Takeda, Hiroshi Mitsuhashi
  • Patent number: 4962211
    Abstract: The present invention relates to a novel biphenyl derivative having a liver ailment-moderating action, which is effective for the remedy of liver diseases such as acute hepatitis and chronic hepatitis, a process for the preparation of this derivative and a liver ailment-moderating agent comprising this derivative as an active ingredient. Moreover, the present invention relates to a compound valuable as the intermediate compound for the synthesis of this derivative and a process for efficiently preparing this intermediate compound.
    Type: Grant
    Filed: November 21, 1989
    Date of Patent: October 9, 1990
    Assignee: Tsumura & Co.
    Inventors: Yoshiyuki Matsuoka, Kunio Hosaka, Shigefumi Takeda, Hiroshi Mitsuhashi
  • Patent number: 4904694
    Abstract: The present invention relates to a novel biphenyl derivative having a liver ailment-moderating action, which is effective for the remedy of liver diseases such as acute hepatitis and chronic hepatitis, a process for the preparation of this derivative and a liver ailment-moderating agent comprising this derivative as an active ingredient. Moreover, the present invention relates to a compound valuable as the intermediate compound for the synthesis of this derivative and a process for efficiently preparing this intermediate compound.
    Type: Grant
    Filed: February 10, 1988
    Date of Patent: February 27, 1990
    Assignee: Tsumura & Co.
    Inventors: Yoshiyuki Matsuoka, Kunio Hosaka, Shigefumi Takeda, Hiroshi Mitsuhashi
  • Patent number: 4618495
    Abstract: A composition for reducing cancer symptoms by improving lipid metabolism and eliminating or reducing anorexia in tumor-bearing patients through inhibition of the lipid degradation-promoting action of toxohormone L which comprises an aqueous or aqueous organic solvent extract of one or more crude preparations selected from the group consisting of Astragali radix, Cinnamomi cortex, Rehmanniae radix, Paeoniae radix, Cnidii rhizoma, Atractylodis lanceae rhizoma, Angelicae radix, Ginseng radix, Hoelen and Glycyrrhizae radix, a method for preparing such a composition, and a method for reducing cancer symptoms using the composition.
    Type: Grant
    Filed: February 14, 1985
    Date of Patent: October 21, 1986
    Assignee: Tsumura Juntendo Inc.
    Inventors: Hiromichi Okuda, Hiroshi Masuno, Masaki Aburada, Shigefumi Takeda, Eiko Itoh, Moe Matsushita, Eikichi Hosoya
  • Patent number: 4613591
    Abstract: Adminiculum increasing the antitumor activities of mitomycin C and doxorubicin hydrochloride and decreasing the side effects associated with their use comprising an aqueous or aqueous organic solvent extract of a crude preparation of Astragali radix, Cinnamomi cortex, Rehmanniae radix, Paeoniae radix, Cnidii rhizoma, Atractylodis lanceae rhizoma, Angelicae radix, Ginseng radix, Hoelen and Glycyrrhizae radix, a method for preparing said adminiculum and a method for its use. In addition, compositions and methods for treating tumor-bearing patients are disclosed.
    Type: Grant
    Filed: June 29, 1983
    Date of Patent: September 23, 1986
    Assignee: Tsumura Juntendo Inc.
    Inventors: Masaki Aburada, Shigefumi Takeda, Eiko Itoh, Moe Matsushita, Eikichi Hosoya