Patents by Inventor Shigeharu Fukuda

Shigeharu Fukuda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20030194762
    Abstract: The object of the present invention is to provide an &agr;-isomaltosylglucosaccharide-forming enzyme, process of the same, cyclotetrasaccharide, and saccharide composition comprising the saccharide which are obtainable by using the enzyme; and is solved by establishing an &agr;-isomaltosylglucosaccharide-forming enzyme which forms a saccharide, having a glucose polymerization degree of at least three and having both the &agr;-1,6 glucosidic linkage as a linkage at the non-reducing end and the &agr;-1,4 glucosidic linkage other than the linkage at the non-reducing end, by catalyzing the &agr;-glucosyl-transfer from a saccharide having a glucose polymerization degree of at least two and having the &agr;-1,4 glucosidic linkage as a linkage at the non-reducing end without substantially increasing the reducing power; &agr;-isomaltosyl-transferring method using the enzyme; method for forming &agr;-isomaltosylglucosaccharide; process for producing a cyclotetrasaccharide having the structure of cyclo{→6)-&a
    Type: Application
    Filed: April 1, 2002
    Publication date: October 16, 2003
    Inventors: Michio Kubota, Keiji ` Tsusaki, Takanobu Higashiyama, Shigeharu Fukuda, Toshio Miyake
  • Publication number: 20030108593
    Abstract: A reduction inhibitory agent for active oxygen eliminating activity which comprises cyclotetrasaccharide, i.e., cyclo{→6}-&agr;-D-glucopyranosyl-(1→3)-&agr;-D-glucopyranosyl-(1→6)-&agr;-D-glucopyranosyl-(1→3)-&agr;-D-glucopyranosyl-(1→), as an effective ingredient, a method for inhibiting the reduction of active oxygen eliminating activity which comprises incorporating either cyclotetrasaccharide or the reduction inhibitory agent into plant edible products and/or plant antioxidants, and a composition where the reduction of active oxygen eliminating activity of the plant edible products and/or plant antioxidants has been satisfactorily inhibited by the method.
    Type: Application
    Filed: November 20, 2002
    Publication date: June 12, 2003
    Applicant: KABUSHIKI KAISHA HAY ASHIBARA SEIBUTSU KAGAKU KENKYUJO
    Inventors: Kazuyuki Oku, Michio Kubota, Shigeharu Fukuda, Toshio Miyake
  • Patent number: 6524625
    Abstract: A physiologically active extract comprising an ethyl acetate-soluble ingredient of an indigo plant, which is obtainable by soaking a raw indigo plant in an organic solvent used for extraction. The ethyl acetate-soluble ingredient includes tryptanthrin, 3,5,4′-trihydroxy-6,7-methylenedioxy-flavone, kaempferol, 3,5,7,4′-tetrahydroxy-6-methoxy-flavone, gallic acid, caffeic acid, indirubin, pheophorbide a, and methylpheophorbide a.
    Type: Grant
    Filed: June 25, 1999
    Date of Patent: February 25, 2003
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyuto
    Inventors: Hajime Aga, Shigeyuki Arai, Shigeharu Fukuda, Toshio Kunikata, Masashi Kurimoto
  • Patent number: 6497862
    Abstract: Disclosed are a composition for inhibiting body odor which comprises trehalose and/or maltitol as an effective ingredient, a method for inhibiting body odor by using the composition, and an article incorporated with the composition.
    Type: Grant
    Filed: March 1, 2001
    Date of Patent: December 24, 2002
    Assignees: Kabushiki Kaisha Hayashibara, Seibutsu Kagaku Kenkyujo
    Inventors: Kazuyuki Oku, Michio Kubota, Shigeharu Fukuda, Toshio Miyake
  • Publication number: 20020055620
    Abstract: A reduction inhibitory agent for active oxygen eliminating activity comprises trehalose as an active ingredient. This agent can be incorporated into plant edible products and/or plant antioxidants.
    Type: Application
    Filed: October 30, 2001
    Publication date: May 9, 2002
    Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO
    Inventors: Hajime Aga, Takashi Shibuya, Shigeharu Fukuda, Toshio Miyake
  • Publication number: 20010031249
    Abstract: Disclosed are a composition for inhibiting body odor which comprises trehalose and/or maltitol as an effective ingredient, a method for inhibiting body odor by using the composition, and an article incorporated with the composition.
    Type: Application
    Filed: March 1, 2001
    Publication date: October 18, 2001
    Inventors: Kazuyuki Oku, Michio Kubota, Shigeharu Fukuda, Toshio Miyake
  • Patent number: 6294360
    Abstract: A saccharide composition containing trehalulose, which is obtainable by allowing a maltose/trehalose converting enzyme to act on a sucrose solution to produce trehalulose, and collecting the resulting trehalulose-containing mixture. Since the enzyme converts sucrose into trehalulose in a relatively high yield and the conversion rate is controllable, a saccharide composition rich in trehalulose is readily obtained on an industrial scale.
    Type: Grant
    Filed: March 4, 1997
    Date of Patent: September 25, 2001
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Tomoyuki Nishimoto, Hiroto Chaen, Shigeharu Fukuda, Toshio Miyake
  • Patent number: 6232294
    Abstract: A neuro-function regulatory agent with lesser side effects, comprising glycosyl vitamin P as an effective ingredient. When administered to patients with nerve diseases, the agent exerts a remarkable effect on the relief of patients' symptoms accompanied by nerve diseases.
    Type: Grant
    Filed: December 7, 1998
    Date of Patent: May 15, 2001
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Shigeharu Fukuda, Toshio Miyake
  • Patent number: 6224872
    Abstract: A composition which comprises a flavonoid and a processed product of a plant of the genus Pfaffia. The composition effectively maintains and promotes the health, treats and prevents diseases, and exerts immunoenhancement, antiallergic, psychotropic, and/or tonic activities.
    Type: Grant
    Filed: July 20, 1998
    Date of Patent: May 1, 2001
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Takashi Shibuya, Takeshi Ario, Shigeharu Fukuda
  • Patent number: 6207641
    Abstract: An agent for susceptive diseases, which contains a polypeptide that has a molecular weight of 18,500±3,000 daltons on SDS-PAGE and a pI of 4.9±1.0 on chromatofocusing, strongly induces the IFN-&ggr; production by immunocompetent cells with only a small amount, and does not cause serious side effects even when administered to human at a relatively-high dose. The agent treats and/or prevents malignant tumors, viral diseases, bacterial infectious diseases, and immune diseases including atopies.
    Type: Grant
    Filed: November 20, 1997
    Date of Patent: March 27, 2001
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Kakuji Torigoe, Tadao Tanimoto, Shigeharu Fukuda, Masashi Kurimoto
  • Patent number: 6200783
    Abstract: A process for producing or separating trehalose and/or sugar alcohols from hydrogenated saccharide mixtures containing trehalose and sugar alcohols selected from the group consisting of sorbitol, maltitol, and maltotriitol, which comprises the steps of subjecting hydrogenated saccharide mixtures containing trehalose and the sugar alcohols to column chromatography using strong-acid cation exchange resins, and successively eluting and collecting a trehalose-rich fraction and a sugar alcohol-rich fraction in this order.
    Type: Grant
    Filed: September 18, 1998
    Date of Patent: March 13, 2001
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Hiroto Chaen, Takashi Shibuya, Shigeharu Fukuda
  • Patent number: 6153227
    Abstract: Disclosed are a propolis extract where the peculiar odor of propolis is reduced by decreasing the odorizing ingredients, a process to produce the propolis extract which comprises soaking propolis in a hydrophilic organic solvent to effect extraction and treating the liquid layer in the resultant extract with an anion-exchange resin, and a biologically active composition comprising the propolis extract.
    Type: Grant
    Filed: July 30, 1999
    Date of Patent: November 28, 2000
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Takashi Shibuya, Kazuyuki Oku, Hajime Aga, Shigeharu Fukuda
  • Patent number: 6153228
    Abstract: A propolis extract having a reduced peculiar odor is prepared by deceasing the amount of odorizing ingredients. This propolis extract can be used to prepare biologically active compositions.
    Type: Grant
    Filed: March 1, 2000
    Date of Patent: November 28, 2000
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Takashi Shibuya, Kazuyuki Oku, Hajime Aga, Shigeharu Fukuda
  • Patent number: 5981498
    Abstract: An agent for improving the blood circulation, which contains as an effective ingredient glycosyl vitamin P such as glycosyl hesperidin and glycosyl rutin. The agent improves the blood circulation in humans to effectively relieve muscular rigidity.
    Type: Grant
    Filed: November 10, 1998
    Date of Patent: November 9, 1999
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Shigeharu Fukuda, Toshio Miyake
  • Patent number: 5863771
    Abstract: A saccharide composition comprising maltooligosyl derivatives of turanose and palatinose which can be readily produced, separated, and purified in a relatively-high yield from maltooligosylsucrose by allowing non-reducing saccharide-forming enzymes to act on aqueous solutions containing maltooligosylsucrose. These saccharides are reducing oligosaccharides with a mild and high-quality sweetness and can be used orally and parenterally, as well as being readily metabolized and used by living bodies.
    Type: Grant
    Filed: March 3, 1997
    Date of Patent: January 26, 1999
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Hajime Aga, Takashi Shibuya, Shigeharu Fukuda, Toshio Miyake
  • Patent number: 5824521
    Abstract: A saccharide composition containing trehalulose, which is obtainable by allowing a maltose/trehalose converting enzyme to act on a sucrose solution to produce trehalulose, and collecting the resulting trehalulose-containing mixture. Since the enzyme converts sucrose into trehalulose in a relatively high yield and the conversion rate is controllable, a saccharide composition rich in trehalulose is readily obtained on an industrial scale.
    Type: Grant
    Filed: April 9, 1998
    Date of Patent: October 20, 1998
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Tomoyuki Nishimoto, Hiroto Chaen, Shigeharu Fukuda, Toshio Miyake
  • Patent number: 5331091
    Abstract: A novel melanin formation-inhibitory protein, which has a molecular weight of 90,000.+-.20,000 and a pI of 5.5.+-.0.5, exerts a tyrosinase formation-inhibitory activity in pigment cells but does not substantially inhibit the inherent tyrosinase activity. Thus, the protein is advantageously used as a pharmaceutical and as a cosmetic in the prevention and/or treatment for local chromatosises such as chloasma, ephelis and sunburn, as well as for systemic chromatosises such as addisonism.
    Type: Grant
    Filed: August 20, 1993
    Date of Patent: July 19, 1994
    Assignee: Kabushiki Kaisha Hayashibara Seitbutsu Kagaku Kenkyujo
    Inventors: Shigeharu Fukuda, Yasuo Suemoto, Masashi Kurimoto