Abstract: An analysis threshold determination device includes a threshold determination unit for determining a pair of or plural pairs of thresholds used for analysis in accordance with a pair of thresholds generated by a calculation unit and a count value output from a pulse count unit. The calculation unit repeatedly generates a new pair of thresholds in which at least one of the pair of thresholds is changed every time the pulse count unit counts the pulse until reaching a predetermined value. The threshold determination unit chooses a class of a measure of central tendency according to a frequency distribution defining each pair of thresholds generated as a class and the count value output from the pulse count unit as a frequency. The threshold determination unit determines a pair of or plural pairs of thresholds corresponding to a class of a predetermined range from the class of measure of central tendency.

Abstract: An analysis device includes a controller configured to count a pulse derived from a particles as a plural particles when a light reception level signal includes the pulse having a first extreme value point, a second extreme value point, and a third extreme value point, and the pulse fulfils a condition in which the third extreme value point is present between the first extreme value point and the second extreme value point in a pulse width direction of the pulse, the third extreme value point is present between the first extreme value point and a threshold in a pulse amplitude direction, the first extreme value point and the second extreme value point are each an extreme value point of a waveform projecting in a common direction, and the third extreme value point is an extreme value point of a waveform in a direction opposite to the common direction.

Abstract: An analysis unit for quantitating detection target substances bound to antibodies includes wells and inclination parts. The wells each have a hole-like shape defined by an opening, an inner circumferential surface, and a bottom. The inclination parts each have an inclined surface connected to the inner circumferential surface and inclined downward such that whose height with respect to the bottom decreases as a distance from an outer circumferential side of the well increases.

Abstract: A nanoparticle measurement device includes a timing signal generation unit, a low-frequency component extraction unit, a low-frequency component calculation unit, a threshold correction unit, and a measurement unit. The timing signal generation unit generates timing signals. The low-frequency component extraction unit extracts low-frequency components according to the timing signals. The low-frequency component calculation unit calculates an interpolated low-frequency component in accordance with the low-frequency components. The threshold correction unit sets a corrected threshold in accordance with the interpolated low-frequency component. The measurement unit extracts and counts nanoparticle pulse signals from a light reception signal according to the timing signals and the corrected threshold.

Abstract: A washing apparatus includes a stage, a suction nozzle, and a control unit. On the stage, an analytical unit is mounted. In the analytical unit, a well having a hole shape including a bottom surface and an inner peripheral surface is formed. The suction nozzle sucks a solution in the well. The control unit, after controlling the suction nozzle to sucks the solution in the well, controls the stage to rotate the stage on which the analytical unit is mounted at a predetermined speed of rotation, and controls the suction nozzle to suck a residue of the solution existing in the well.

Abstract: An analysis device includes a turntable holding a substrate, an optical pickup driven in a direction perpendicular to a rotation axis of the turntable and configured to emit laser light to reaction regions and to receive reflected light from the respective reaction regions, an optical pickup drive circuit, and a controller. The reaction regions are formed at positions different from the center of the substrate. The center of the substrate is located on the rotation axis of the turntable. The optical pickup detects a reception level of the reflected light to generate a light reception level signal. The controller controls a turntable drive circuit to rotate the substrate, controls the optical pickup drive circuit to drive the optical pickup, and specifies the respective reaction regions in accordance with a positional information signal and the light reception level signal.

Abstract: A method of fabricating a substrate for analysis fixes antibodies that specifically react with specific antigens included in detection target substances to the substrate for analysis. The method subjects the substrate for analysis to immersion treatment with a predetermined treatment solution so as to form antibody aggregations in which the antibodies are aggregated at boundary regions between recesses and convex portions on the substrate for analysis. The method causes the antigens and the antibodies to react with each other so as to capture the detection target substances on the substrate for analysis by the antibody aggregations.

Abstract: An analysis device includes an optical disc drive, a gate information processing unit, a detection circuit, and a gate shift processing unit. The optical disc drive rotates a specimen analysis disc and detects a measurement radial position for an optical pickup. The detection circuit generates gate signals shifted by a gate shift amount in each measurement radial position in a rotating direction of the specimen analysis disc, and generates count values of the respective gate signals. The gate shift processing unit divides a gate signal-corresponding region of the corresponding gate signal by a unit gate shift amount in the rotating direction of the specimen analysis disc to define a plurality of divided regions and sets count values of the divided regions based on the count values of the gate signals.

Abstract: An analysis device includes a controller configured to count a pulse derived from a particles as a plural particles when a light reception level signal includes the pulse having a first extreme value point, a second extreme value point, and a third extreme value point, and the pulse fulfils a condition in which the third extreme value point is present between the first extreme value point and the second extreme value point in a pulse width direction of the pulse, the third extreme value point is present between the first extreme value point and a threshold in a pulse amplitude direction, the first extreme value point and the second extreme value point are each an extreme value point of a waveform projecting in a common direction, and the third extreme value point is an extreme value point of a waveform in a direction opposite to the common direction.

Abstract: An optical disc device capable of detecting a reference position of an optical disc in a rotating direction includes an optical disc rotation drive unit, an optical sensor, and a control circuit. The optical disc rotation drive unit rotates the optical disc provided with a rotation reference mark. The rotation reference mark is formed into a shape having a width changing in the radial direction of the optical disc. The optical sensor detects the rotation reference mark. The control circuit controls the optical disc rotation drive unit and the optical sensor, extracts a detection signal of the rotation reference mark as a pulse waveform from an output signal of the optical sensor with the optical disc being rotated, and specifies a rotation reference position of the optical disc in accordance with the pulse waveform.

Abstract: A first sample solution including exosomes including first to third detection target substances is mixed with a first buffer solution including first nanoparticles including first binding substances which bind to the first detection target substances. The first detection target substances and the first binding substances are bound together, so as to form first complexes of the exosomes and the first nanoparticles. The first complexes are isolated from a mixed solution of the first sample solution and the first buffer solution. The second detection target substances and the second binding substances are bound together, so as to capture the first complexes on a substrate. The second binding substances are fixed onto the substrate. A second buffer solution including second nanoparticles including third binding substances which bind to the third detection target substances is reacted with the first complexes.

Abstract: An analysis threshold generation device includes a threshold calculation unit for generating a pair of thresholds for a pulse width of a pulse included in a light reception level signal or a pair of thresholds for a pulse amplitude of the pulse. The analysis threshold generation device includes a threshold correction unit for generating a pair of thresholds used for analysis in accordance with the pair of thresholds generated by the threshold calculation unit and a count value output from a pulse count unit. The threshold calculation unit repeatedly generates a new pair of thresholds in which at least one of the pair of thresholds is changed every time the pulse count unit counts the pulse until reaching a predetermined value.

Abstract: An analysis threshold determination device includes a threshold determination unit for determining a pair of or plural pairs of thresholds used for analysis in accordance with a pair of thresholds generated by a calculation unit and a count value output from a. pulse count unit. The calculation unit repeatedly generates a new pair of thresholds in which at least one of the pair of thresholds is changed every time the pulse count unit counts the pulse until reaching a predetermined value. The threshold determination unit chooses a class of a measure of central tendency according to a frequency distribution defining each pair of thresholds generated as a class and the count value output from the pulse count unit as a frequency. The threshold determination unit determines a pair of or plural pairs of thresholds corresponding to a class of a predetermined range from the class of measure of central tendency.

Abstract: An analysis device includes a turntable, an optical pickup, and a controller. The turntable holds a specimen analysis disc having reaction regions on which nanoparticles binding to substances to be detected are captured. The optical pickup emits laser light to each reaction region, receives a reflected light from each reaction region, and generates a light reception level signal. The controller sequentially generates a plurality of measurement gate signals for counting the number of the nanoparticles captured on each reaction region, counts the number of the nanoparticles of each of the measurement gate signals based on the light reception level signal, specifies a measurement gate section in each reaction region according to a measurement result per measurement gate signal, and adds up the number of the nanoparticles of the respective measurement gate signals in the measurement gate section.

Abstract: An analysis device includes a turntable, an optical pickup, and a controller. The turntable holds a disc for specimen analysis having a reaction region on which fine particles binding to substances to be detected are captured per track. The optical pickup emits laser light to the reaction region, receives a reflected light from the reaction region, and generates a reception level signal of the light. The controller sequentially generates a plurality of measurement gate signals per track for counting the number of the fine particles captured on the reaction region, counts the number of the fine particles per measurement gate signal from the reception level signal, compares measurement results obtained in positions having a symmetric relation with each other in the reaction region, and defines a measurement-result-correction target region for correcting the number of the fine particles.

Abstract: An analysis unit for quantitating detection target substances bound to antibodies includes wells and inclination parts. The wells each have a hole-like shape defined by an opening, an inner circumferential surface, and a bottom. The inclination parts each have an inclined surface connected to the inner circumferential surface and inclined downward such that whose height with respect to the bottom decreases as a distance from an outer circumferential side of the well increases.

Abstract: A washing apparatus includes a stage, a suction nozzle, and a control unit. On the stage, an analytical unit is mounted. In the analytical unit, a well having a hole shape including a bottom surface and an inner peripheral surface is formed. The suction nozzle sucks a solution in the well. The control unit, after controlling the suction nozzle to sucks the solution in the well, controls the stage to rotate the stage on which the analytical unit is mounted at a predetermined speed of rotation, and controls the suction nozzle to suck a residue of the solution existing in the well.

Abstract: An optical disc device capable of detecting a reference position of an optical disc in a rotating direction includes an optical disc rotation drive unit, an optical sensor, and a control circuit. The optical disc rotation drive unit rotates the optical disc provided with a rotation reference mark. The rotation reference mark is formed into a shape having a width changing in the radial direction of the optical disc. The optical sensor detects the rotation reference mark. The control circuit controls the optical disc rotation drive unit and the optical sensor, extracts a detection signal of the rotation reference mark as a pulse waveform from an output signal of the optical sensor with the optical disc being rotated, and specifies a rotation reference position of the optical disc in accordance with the pulse waveform.

Abstract: A magnet structure includes first and second magnet units. The first magnet unit is provided with a first magnet fixing section that includes a first surface and a first magnet having a first polarity on the first surface's side. The second magnet unit is provided with a second magnet fixing section that includes a second surface and a second magnet having a second polarity on the second surface's side, the second polarity being an opposite polarity to the first polarity. The first and second surfaces are located next to one another on the same plane to form a magnetic attachment surface which is magnetically attached to a magnetically-attached object. The second magnet unit is supported by the first magnet unit so as to move in a predetermined range.

Abstract: An analysis method irradiates, with laser light, an analysis substrate made of a resin material and having a reaction region on which detection target substances and nanoparticles of a metal compound for labeling the detection target substances are captured. The analysis method extracts, as a substrate signal level, a signal level generated when receiving reflected light from the analysis substrate. The analysis method receives reflected light from the reaction region to generate a light reception level signal. The analysis method extracts a nanoparticle detection signal from the light reception level signal of the reflected light from the reaction region, the nanoparticle detection signal having a higher level than the signal level of the reflected light from the analysis substrate. The analysis method detects the nanoparticles in accordance with the extracted nanoparticle detection signal.