Abstract: The present invention aims to provide a composition for the prevention or treatment of TDP-43 proteinopathy using a microRNA targeting the TDP-43 gene. A prophylactic or therapeutic composition for TDP-43 proteinopathy, comprising: one or more nucleic adds selected from the group consisting of isolated RNAs and isolated nucleic acids encoding the RNAs, wherein the RNAs consist of human miR-33 represented by SEQ ID NO: 1, variants of the human miR-33 having one or more mutations, and precursors of the human miR-33 and the variants.

Abstract: The present invention aims to provide a composition for the prevention or treatment of TDP-43 proteinopathy using a microRNA targeting the TDP-43 gene. A prophylactic or therapeutic composition for TDP-43 proteinopathy, comprising: one or more nucleic adds selected from the group consisting of isolated RNAs and isolated nucleic acids encoding the RNAs, wherein the RNAs consist of human miR-33 represented by SEQ ID NO: 1, variants of the human miR-33 having one or more mutations, and precursors of the human miR-33 and the variants.

Abstract: The present invention provides a tissue regeneration substrate that has the ability to release a basic fibroblast growth factor (bFGF) and like cell growth factors in a sustained manner, into which cells can easily enter, and that is suitably used for regeneration of tissues. Specifically, the present invention provides a tissue regeneration substrate that comprises a cell growth factor adsorbed in a bioabsorbable porous substrate that contains collagen and gelatin, and a method for producing the same.

Abstract: An effective therapeutic agent for keloids and/or hypertrophic scars is provided. Specifically, an elastic fiber regenerating agent consisting of chondroitinase ABC derived from Proteus vulgaris and a therapeutic agent for keloids and/or hypertrophic scars comprising the regenerating agent as an active ingredient are provided.

Abstract: The present invention provides a tissue regeneration substrate that has the ability to release a basic fibroblast growth factor (bFGF) and like cell growth factors in a sustained manner, into which cells can easily enter, and that is suitably used for regeneration of tissues. Specifically, the present invention provides a tissue regeneration substrate that comprises a cell growth factor adsorbed in a bioabsorbable porous substrate that contains collagen and gelatin, and a method for producing the same.

Abstract: A tire (18) includes a pair of beads (24), a carcass (26), a belt (28), and a band (30). The carcass (26) includes a carcass ply (44) having a carcass cord. The carcass cord is constituted by a rayon fiber or an aramid fiber. The belt 28 includes belt plies (46) and (48) having belt cords. The belt cord is constituted by an aramid fiber. The belt cord has a fineness which is equal to or greater than 1400 dtex and is equal to or smaller than 1600 dtex. The belt cord has a density which is equal to or higher than 20 ends/5 cm and is equal to or lower than 30 ends/5 cm. The band (30) includes a band ply (50) having a band cord. The band cord is wound spirally in a substantially circumferential direction.

Abstract: An external preparation which contains acetylsalicylic acid or its salt as an active ingredient and has an effect of inhibiting keloid and/or hypertrophic scar formation as well as an analgesic and antipruritic effect.

Abstract: An information reference apparatus includes: a reference information storage part storing predetermined reference information; a reference range defining information storage part storing predetermined reference range defining information; and a reference range defining part referring to the reference range defining information stored for a user by the reference range defining information storage part and defining a range of the reference information stored by the reference information storage part, in which range the reference information is available for the user to refer to.

Abstract: A telecommunication network based on distributed control, comprising a plurality of switch nodes having switch fabric devices containing switches for exchanging user information between subscriber lines and trunk lines, and signal devices for sending and receiving control signals through the subscriber lines and the trunk lines; a plurality of control nodes for controlling the switch nodes by sending and receiving control messages with the switch nodes; a control network for performing mutual message communications between the switch nodes and the control nodes; and an user information network for transferring the user information; wherein the control network connects the switch nodes and the control nodes by connection-type or connectionless communications, the control nodes and the switch nodes send and receive messages for communicating with other nodes through the control network, and each of the control nodes controls a plurality of switch nodes based on the control network routing messages to specified

Abstract: A pneumatic motorcycle tire provided with a spiral belt and a pair of axially spaced reinforcing layers radially inside of the belt to improve the cornering stability and straight running stability of a motorcycle.

Abstract: A motorcycle tire in which the tread face is curved convexly so that the maximum cross-section width of the tire lies between axial edges of the tread portion includes a belt, and the belt comprises at least three plies, wherein the radially inner ply and radially outer ply are made of the same strip of rubberized parallel cords having a strip width of from 85 to 105% the tread width, and the middle ply is made of a strip of rubberized cords having a strip width which is different from that of the inner and outer plies.

Abstract: A pneumatic motorcycle tire provided with a spiral belt and a pair of axially spaced reinforcing layers radially inside of the belt to improve the cornering stability and straight running stability of a motorcycle.

Abstract: A radial tire for motorcycles which comprises: a carcass ply of organic fiber cords arranged radially at an angle of 70 to 90 degrees to the tire equator and turned up around bead cores to form two turned up portions and a main portion therebetween; and a belt disposed radially outside the carcass and inside a tread, wherein the radial height Ht of the radially outer edge of each carcass turned up portion is 0.5 to 1.2 times the radial height of the tread edge, both from the bead base. The belt is composed of three pieces, two lateral pieces and a central piece therebetween, each piece being made of at least one spirally wound cord having an elastic modulus of not less than 600 kgf/sq. mm and formed by winding spirally a ribbon of rubber in which the at least one cord is embedded. The width of the central piece of the belt is 0.1 to 0.6 times the tread width. The central piece is differed from at least one of the lateral pieces in respect of cord specification and/or cord arrangement.

Abstract: A pneumatic motorcycle tire provided with a spiral belt and a pair of axially spaced reinforcing layers radially inside of the belt to improve the cornering stability and straight running stability of a motorcycle.

Abstract: A radial tire for motorcycles which comprises: a carcass ply of organic fiber cords arranged radially at an angle of 70 to 90 degrees to the tire equator and turned up around bead cores to form two turned up portions and a main portion therebetween; and a belt disposed radially outside the carcass and inside a tread, wherein the radial height Ht of the radially outer edge of each carcass turned up portion is 0.5 to 1.2 times the radial height of the tread edge, both from the bead base. The belt is composed of three pieces, two lateral pieces and a central piece therebetween, each piece being made of at least one spirally wound cord having an elastic modulus of not less than 600 kgf/sq.mm and formed by winding spirally a ribbon of rubber in which the at least one cord is embedded. The width of the central piece of the belt is 0.1 to 0.6 times the tread width. The central piece is differed from at least one of the lateral pieces in respect of cord specification and/or cord arrangement.

Abstract: A radial tire comprises a toroidal carcass extending between beads and turned up around bead cores, and a belt reinforcement disposed radially outside the carcass and inside a tread, wherein the belt reinforcement comprises a band layer formed by plural ribbons of rubber in which one cord or two parallel cords are embedded, the ribbons are wound spirally and continuously from one edge to the other edge of the tread to be arranged side by side, the ends of the ribbons are located at the edges of the band layer, and at each of the edges of the band layer the ends of the ribbons are shifted equiangularly in the circumferential direction of the tire.

Abstract: A motorcycle radial tire includes a carcass having at least one ply of radially arranged organic fiber cords turned up around a pair of bead cores, the radial height (Ht) of the radially outer edge of the carcass turned up portions being more than 0.6 times and less than 1.2 times the radial height (Hs) of tread edges, a first belt having one cord or a plurality of parallel cords wound spirally so that the windings thereof are laid at small angles with respect to the tire equator, a second belt having one ply of parallel organic fiber cords laid at at angle of 10 to 30 degrees with respect to the tire equator, a bead apex made of rubber having a JIS(A) hardness of 65 to 75 disposed between the main portion and each turned up portion of the carcass, and the radial height (Ha) of the radially outer edge of the bead apex from the bead base line being more than 0.5 times and less than 1.2 times the radial height (Hs) of the tread edges.

Abstract: A belted radial tire for motorcycles which comprises: a pair of bead cores disposed one in each bead portion of the tire; a carcass extending between the bead portions through sidewall portions and a tread portion of the tire, the carcass having at least one ply of organic fiber cords arranged radially at an angle of 60 to 90 degrees to the tire equator; a tread disposed radially outside the carcass to define the tread portion; and a belt disposed radially outside the carcass and inside the tread and comprising two ply pieces made of at least one spirally wound cord having an elastic modulus of not less than 600 kgf/sq.mm, the above-mentioned tread curved so that the maximum cross section width of the tire lies between the tread edges, each of the two belt ply pieces formed by winding a ribbon of rubber, in which the belt cord is embedded, spirally around the carcass from the axially outer edge thereof toward the tire equator.