Patents by Inventor Shigehisa Sugiyama
Shigehisa Sugiyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230332085Abstract: Provided is a cell culture apparatus including a culture vessel that stores a cell suspension containing cells; a first filter part that has a first filter membrane that performs membrane separation treatment on the cell suspension extracted from the culture vessel; a first circulation flow path that allows components blocked by the first filter membrane to return to the culture vessel; a second filter part that has a second filter membrane that performs membrane separation treatment on components of the cell suspension permeated through the first filter membrane; a second circulation flow path that allows components permeated through the second filter membrane to return to the culture vessel; and a recovery flow path that recovers components blocked by the second filter membrane. In the cell culture apparatus, an average hole diameter of the first filter membrane is 20 µm or smaller, and 0 < B/A ? 0.Type: ApplicationFiled: June 19, 2023Publication date: October 19, 2023Inventors: Shinichi NAKAI, Yoichi NAGAI, Nobuyuki HARAGUCHI, Shigehisa SUGIYAMA
-
Patent number: 11725174Abstract: Provided is a cell culture apparatus including a culture vessel that stores a cell suspension containing cells; a first filter part that has a first filter membrane that performs membrane separation treatment on the cell suspension extracted from the culture vessel; a first circulation flow path that allows components blocked by the first filter membrane to return to the culture vessel; a second filter part that has a second filter membrane that performs membrane separation treatment on components of the cell suspension permeated through the first filter membrane; a second circulation flow path that allows components permeated through the second filter membrane to return to the culture vessel; and a recovery flow path that recovers components blocked by the second filter membrane. In the cell culture apparatus, an average hole diameter of the first filter membrane is 20 ?m or smaller, and 0<B/A?0.Type: GrantFiled: July 2, 2019Date of Patent: August 15, 2023Assignee: FUJIFILM CORPORATIONInventors: Shinichi Nakai, Yoichi Nagai, Nobuyuki Haraguchi, Shigehisa Sugiyama
-
Patent number: 11395999Abstract: Disclosed herein are a method for producing a liposome which is capable of reducing the facility costs and also capable of rapid desolvation, and an apparatus for producing a liposome which is for use in the above-mentioned method. Provided is a method for producing a liposome, including a stirring step of stirring a mixed liquid containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase, and an evaporating step of evaporating an organic solvent from the mixed liquid, in which the condensed organic solvent is removed by passing a gas having a temperature not higher than the dew point of the solvent in the evaporating step.Type: GrantFiled: January 11, 2018Date of Patent: July 26, 2022Assignee: FUJIFILM CorporationInventors: Susumu Sugiyama, Naoki Yamada, Shigehisa Sugiyama, Yohei Okubo, Takashi Sasaki, Tetsu Ishiguro
-
Patent number: 11325091Abstract: Disclosed herein are a method for producing a liposome which is capable of reducing the facility costs and also capable of rapid desolvation, and an apparatus for producing a liposome which is for use in the above-mentioned method. Provided is a method for producing a liposome, including a stirring step of stirring a mixed liquid containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase, and an evaporating step of evaporating an organic solvent from the mixed liquid, in which the condensed organic solvent is removed by passing a gas having a temperature not higher than the dew point of the solvent in the evaporating step.Type: GrantFiled: June 16, 2017Date of Patent: May 10, 2022Assignee: FUJIFILM CorporationInventors: Susumu Sugiyama, Naoki Yamada, Shigehisa Sugiyama, Yohei Okubo, Takashi Sasaki, Tetsu Ishiguro
-
Patent number: 10485760Abstract: Disclosed herein are a method for producing a miniaturized liposome on a large production scale, and an apparatus for producing a liposome which is to be used in the above-mentioned method. Provided is a method for producing a liposome, including a step of stirring a mixture containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase in a first tank of an apparatus having the first tank and a circulation path, in which the ratio of the capacity of the circulation path to the total capacity of the tank and the circulation path is 0.4 or less and/or the time required for the mixture to return to the first tank after being discharged therefrom is within 2.0 minutes.Type: GrantFiled: June 16, 2017Date of Patent: November 26, 2019Assignee: FUJIFILM CorporationInventors: Susumu Sugiyama, Naoki Yamada, Shigehisa Sugiyama, Yohei Okubo
-
Publication number: 20190322975Abstract: Provided is a cell culture apparatus including a culture vessel that stores a cell suspension containing cells; a first filter part that has a first filter membrane that performs membrane separation treatment on the cell suspension extracted from the culture vessel; a first circulation flow path that allows components blocked by the first filter membrane to return to the culture vessel; a second filter part that has a second filter membrane that performs membrane separation treatment on components of the cell suspension permeated through the first filter membrane; a second circulation flow path that allows components permeated through the second filter membrane to return to the culture vessel; and a recovery flow path that recovers components blocked by the second filter membrane. In the cell culture apparatus, an average hole diameter of the first filter membrane is 20 ?m or smaller, and 0<B/A?0.Type: ApplicationFiled: July 2, 2019Publication date: October 24, 2019Inventors: Shinichi NAKAI, Yoichi NAGAI, Nobuyuki HARAGUCHI, Shigehisa SUGIYAMA
-
Fiber manufacturing method, non-woven fabric manufacturing method, and fiber manufacturing equipment
Patent number: 10052807Abstract: A fiber manufacturing method includes the following steps of: dissolving a polymer in a solvent to obtain a polymer solution; spraying the polymer solution into a liquid heated to a boiling point of the solvent or higher, and evaporating the solvent to precipitate a fibrous polymer in a sealed precipitation tank, the liquid being immiscible with the polymer and the solvent; conveying the precipitated fibrous polymer in a liquid from the precipitation tank; water-rinsing the fibrous polymer conveyed in the liquid in the conveying step in a sealed water-rinsing tank; conveying the water-rinsed fibrous polymer in a liquid from the water-rinsing tank; and cooling and condensing solvent gas that is generated in the spraying step and the water-rinsing step.Type: GrantFiled: August 8, 2016Date of Patent: August 21, 2018Assignee: FUJIFILM CorporationInventors: Yukihiro Katai, Shigehisa Sugiyama, Seiji Kasahara, Yasuhisa Shimoda, Masahiro Esaki -
Publication number: 20180133676Abstract: Disclosed herein are a method for producing a liposome which is capable of reducing the facility costs and also capable of rapid desolvation, and an apparatus for producing a liposome which is for use in the above-mentioned method. Provided is a method for producing a liposome, including a stirring step of stirring a mixed liquid containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase, and an evaporating step of evaporating an organic solvent from the mixed liquid, in which the condensed organic solvent is removed by passing a gas having a temperature not higher than the dew point of the solvent in the evaporating step.Type: ApplicationFiled: January 11, 2018Publication date: May 17, 2018Applicant: FUJIFILM CorporationInventors: Susumu SUGIYAMA, Naoki YAMADA, Shigehisa SUGIYAMA, Yohei OKUBO, Takashi SASAKI, Tetsu ISHIGURO
-
Publication number: 20180133156Abstract: Disclosed herein are a method for producing a miniaturized liposome on a large production scale, and an apparatus for producing a liposome which is to be used in the above-mentioned method. Provided is a method for producing a liposome, including a step of stirring a mixture containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase in a first tank of an apparatus having the first tank and a circulation path, in which the ratio of the capacity of the circulation path to the total capacity of the tank and the circulation path is 0.4 or less and/or the time required for the mixture to return to the first tank after being discharged therefrom is within 2.0 minutes.Type: ApplicationFiled: January 11, 2018Publication date: May 17, 2018Applicant: FUJIFILM CorporationInventors: Susumu SUGIYAMA, Naoki YAMADA, Shigehisa SUGIYAMA, Yohei OKUBO
-
Publication number: 20170281543Abstract: Disclosed herein are a method for producing a miniaturized liposome on a large production scale, and an apparatus for producing a liposome which is to be used in the above-mentioned method. Provided is a method for producing a liposome, including a step of stirring a mixture containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase in a first tank of an apparatus having the first tank and a circulation path, in which the ratio of the capacity of the circulation path to the total capacity of the tank and the circulation path is 0.4 or less and/or the time required for the mixture to return to the first tank after being discharged therefrom is within 2.0 minutes.Type: ApplicationFiled: June 16, 2017Publication date: October 5, 2017Applicant: FUJIFILM CorporationInventors: Susumu SUGIYAMA, Naoki YAMADA, Shigehisa SUGIYAMA, Yohei OKUBO
-
Publication number: 20170282144Abstract: Disclosed herein are a method for producing a liposome which is capable of reducing the facility costs and also capable of rapid desolvation, and an apparatus for producing a liposome which is for use in the above-mentioned method. Provided is a method for producing a liposome, including a stirring step of stirring a mixed liquid containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase, and an evaporating step of evaporating an organic solvent from the mixed liquid, in which the condensed organic solvent is removed by passing a gas having a temperature not higher than the dew point of the solvent in the evaporating step.Type: ApplicationFiled: June 16, 2017Publication date: October 5, 2017Applicant: FUJIFILM CorporationInventors: Susumu SUGIYAMA, Naoki YAMADA, Shigehisa SUGIYAMA, Yohei OKUBO, Takashi SASAKI, Tetsu ISHIGURO
-
FIBER MANUFACTURING METHOD, NON-WOVEN FABRIC MANUFACTURING METHOD, AND FIBER MANUFACTURING EQUIPMENT
Publication number: 20160354964Abstract: A fiber manufacturing method includes the following steps of: dissolving a polymer in a solvent to obtain a polymer solution; spraying the polymer solution into a liquid heated to a boiling point of the solvent or higher, and evaporating the solvent to precipitate a fibrous polymer in a sealed precipitation tank, the liquid being immiscible with the polymer and the solvent; conveying the precipitated fibrous polymer in a liquid from the precipitation tank; water-rinsing the fibrous polymer conveyed in the liquid in the conveying step in a sealed water-rinsing tank; conveying the water-rinsed fibrous polymer in a liquid from the water-rinsing tank; and cooling and condensing solvent gas that is generated in the spraying step and the water-rinsing step.Type: ApplicationFiled: August 8, 2016Publication date: December 8, 2016Applicant: FUJIFILM CorporationInventors: Yukihiro KATAI, Shigehisa SUGIYAMA, Seiji KASAHARA, Yasuhisa SHIMODA, Masahiro ESAKI -
Patent number: 8730453Abstract: An exposure apparatus includes a light emitting unit, a mask stage that holds a mask for forming a pattern on a workpiece and a moving stage that holds the workpiece and has a laser length measuring device. The apparatus further includes an XY? direction moving mechanism that moves the moving stage within a plane parallel to the workpiece face, and a Z direction moving mechanism that moves the moving stage in a vertical direction. The laser length measuring device measures a distance between the device and a reflection mirror using laser light. A control unit controls the XY? direction moving mechanism to move the moving stage based on the distance. The reflective mirror is fixed to a structural body that supports the mask stage.Type: GrantFiled: September 13, 2012Date of Patent: May 20, 2014Assignee: Ushio Denki Kabushiki KaishaInventor: Shigehisa Sugiyama
-
Publication number: 20130070228Abstract: An exposure apparatus includes a light emitting unit, a mask stage that holds a mask for forming a pattern on a workpiece and a moving stage that holds the workpiece and has a laser length measuring device. The apparatus further includes an XY? direction moving mechanism that moves the moving stage within a plane parallel to the workpiece face, and a Z direction moving mechanism that moves the moving stage in a vertical direction. The laser length measuring device measures a distance between the device and a reflection mirror using laser light. A control unit controls the XY? direction moving mechanism to move the moving stage based on the distance. The reflective mirror is fixed to a structural body that supports the mask stage.Type: ApplicationFiled: September 13, 2012Publication date: March 21, 2013Applicant: USHIO DENKI KABUSHIKI KAISHAInventor: Shigehisa Sugiyama