Patents by Inventor Shigehisa Sugiyama

Shigehisa Sugiyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230332085
    Abstract: Provided is a cell culture apparatus including a culture vessel that stores a cell suspension containing cells; a first filter part that has a first filter membrane that performs membrane separation treatment on the cell suspension extracted from the culture vessel; a first circulation flow path that allows components blocked by the first filter membrane to return to the culture vessel; a second filter part that has a second filter membrane that performs membrane separation treatment on components of the cell suspension permeated through the first filter membrane; a second circulation flow path that allows components permeated through the second filter membrane to return to the culture vessel; and a recovery flow path that recovers components blocked by the second filter membrane. In the cell culture apparatus, an average hole diameter of the first filter membrane is 20 µm or smaller, and 0 < B/A ? 0.
    Type: Application
    Filed: June 19, 2023
    Publication date: October 19, 2023
    Inventors: Shinichi NAKAI, Yoichi NAGAI, Nobuyuki HARAGUCHI, Shigehisa SUGIYAMA
  • Patent number: 11725174
    Abstract: Provided is a cell culture apparatus including a culture vessel that stores a cell suspension containing cells; a first filter part that has a first filter membrane that performs membrane separation treatment on the cell suspension extracted from the culture vessel; a first circulation flow path that allows components blocked by the first filter membrane to return to the culture vessel; a second filter part that has a second filter membrane that performs membrane separation treatment on components of the cell suspension permeated through the first filter membrane; a second circulation flow path that allows components permeated through the second filter membrane to return to the culture vessel; and a recovery flow path that recovers components blocked by the second filter membrane. In the cell culture apparatus, an average hole diameter of the first filter membrane is 20 ?m or smaller, and 0<B/A?0.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: August 15, 2023
    Assignee: FUJIFILM CORPORATION
    Inventors: Shinichi Nakai, Yoichi Nagai, Nobuyuki Haraguchi, Shigehisa Sugiyama
  • Patent number: 11395999
    Abstract: Disclosed herein are a method for producing a liposome which is capable of reducing the facility costs and also capable of rapid desolvation, and an apparatus for producing a liposome which is for use in the above-mentioned method. Provided is a method for producing a liposome, including a stirring step of stirring a mixed liquid containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase, and an evaporating step of evaporating an organic solvent from the mixed liquid, in which the condensed organic solvent is removed by passing a gas having a temperature not higher than the dew point of the solvent in the evaporating step.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: July 26, 2022
    Assignee: FUJIFILM Corporation
    Inventors: Susumu Sugiyama, Naoki Yamada, Shigehisa Sugiyama, Yohei Okubo, Takashi Sasaki, Tetsu Ishiguro
  • Patent number: 11325091
    Abstract: Disclosed herein are a method for producing a liposome which is capable of reducing the facility costs and also capable of rapid desolvation, and an apparatus for producing a liposome which is for use in the above-mentioned method. Provided is a method for producing a liposome, including a stirring step of stirring a mixed liquid containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase, and an evaporating step of evaporating an organic solvent from the mixed liquid, in which the condensed organic solvent is removed by passing a gas having a temperature not higher than the dew point of the solvent in the evaporating step.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: May 10, 2022
    Assignee: FUJIFILM Corporation
    Inventors: Susumu Sugiyama, Naoki Yamada, Shigehisa Sugiyama, Yohei Okubo, Takashi Sasaki, Tetsu Ishiguro
  • Patent number: 10485760
    Abstract: Disclosed herein are a method for producing a miniaturized liposome on a large production scale, and an apparatus for producing a liposome which is to be used in the above-mentioned method. Provided is a method for producing a liposome, including a step of stirring a mixture containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase in a first tank of an apparatus having the first tank and a circulation path, in which the ratio of the capacity of the circulation path to the total capacity of the tank and the circulation path is 0.4 or less and/or the time required for the mixture to return to the first tank after being discharged therefrom is within 2.0 minutes.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: November 26, 2019
    Assignee: FUJIFILM Corporation
    Inventors: Susumu Sugiyama, Naoki Yamada, Shigehisa Sugiyama, Yohei Okubo
  • Publication number: 20190322975
    Abstract: Provided is a cell culture apparatus including a culture vessel that stores a cell suspension containing cells; a first filter part that has a first filter membrane that performs membrane separation treatment on the cell suspension extracted from the culture vessel; a first circulation flow path that allows components blocked by the first filter membrane to return to the culture vessel; a second filter part that has a second filter membrane that performs membrane separation treatment on components of the cell suspension permeated through the first filter membrane; a second circulation flow path that allows components permeated through the second filter membrane to return to the culture vessel; and a recovery flow path that recovers components blocked by the second filter membrane. In the cell culture apparatus, an average hole diameter of the first filter membrane is 20 ?m or smaller, and 0<B/A?0.
    Type: Application
    Filed: July 2, 2019
    Publication date: October 24, 2019
    Inventors: Shinichi NAKAI, Yoichi NAGAI, Nobuyuki HARAGUCHI, Shigehisa SUGIYAMA
  • Patent number: 10052807
    Abstract: A fiber manufacturing method includes the following steps of: dissolving a polymer in a solvent to obtain a polymer solution; spraying the polymer solution into a liquid heated to a boiling point of the solvent or higher, and evaporating the solvent to precipitate a fibrous polymer in a sealed precipitation tank, the liquid being immiscible with the polymer and the solvent; conveying the precipitated fibrous polymer in a liquid from the precipitation tank; water-rinsing the fibrous polymer conveyed in the liquid in the conveying step in a sealed water-rinsing tank; conveying the water-rinsed fibrous polymer in a liquid from the water-rinsing tank; and cooling and condensing solvent gas that is generated in the spraying step and the water-rinsing step.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: August 21, 2018
    Assignee: FUJIFILM Corporation
    Inventors: Yukihiro Katai, Shigehisa Sugiyama, Seiji Kasahara, Yasuhisa Shimoda, Masahiro Esaki
  • Publication number: 20180133676
    Abstract: Disclosed herein are a method for producing a liposome which is capable of reducing the facility costs and also capable of rapid desolvation, and an apparatus for producing a liposome which is for use in the above-mentioned method. Provided is a method for producing a liposome, including a stirring step of stirring a mixed liquid containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase, and an evaporating step of evaporating an organic solvent from the mixed liquid, in which the condensed organic solvent is removed by passing a gas having a temperature not higher than the dew point of the solvent in the evaporating step.
    Type: Application
    Filed: January 11, 2018
    Publication date: May 17, 2018
    Applicant: FUJIFILM Corporation
    Inventors: Susumu SUGIYAMA, Naoki YAMADA, Shigehisa SUGIYAMA, Yohei OKUBO, Takashi SASAKI, Tetsu ISHIGURO
  • Publication number: 20180133156
    Abstract: Disclosed herein are a method for producing a miniaturized liposome on a large production scale, and an apparatus for producing a liposome which is to be used in the above-mentioned method. Provided is a method for producing a liposome, including a step of stirring a mixture containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase in a first tank of an apparatus having the first tank and a circulation path, in which the ratio of the capacity of the circulation path to the total capacity of the tank and the circulation path is 0.4 or less and/or the time required for the mixture to return to the first tank after being discharged therefrom is within 2.0 minutes.
    Type: Application
    Filed: January 11, 2018
    Publication date: May 17, 2018
    Applicant: FUJIFILM Corporation
    Inventors: Susumu SUGIYAMA, Naoki YAMADA, Shigehisa SUGIYAMA, Yohei OKUBO
  • Publication number: 20170281543
    Abstract: Disclosed herein are a method for producing a miniaturized liposome on a large production scale, and an apparatus for producing a liposome which is to be used in the above-mentioned method. Provided is a method for producing a liposome, including a step of stirring a mixture containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase in a first tank of an apparatus having the first tank and a circulation path, in which the ratio of the capacity of the circulation path to the total capacity of the tank and the circulation path is 0.4 or less and/or the time required for the mixture to return to the first tank after being discharged therefrom is within 2.0 minutes.
    Type: Application
    Filed: June 16, 2017
    Publication date: October 5, 2017
    Applicant: FUJIFILM Corporation
    Inventors: Susumu SUGIYAMA, Naoki YAMADA, Shigehisa SUGIYAMA, Yohei OKUBO
  • Publication number: 20170282144
    Abstract: Disclosed herein are a method for producing a liposome which is capable of reducing the facility costs and also capable of rapid desolvation, and an apparatus for producing a liposome which is for use in the above-mentioned method. Provided is a method for producing a liposome, including a stirring step of stirring a mixed liquid containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase, and an evaporating step of evaporating an organic solvent from the mixed liquid, in which the condensed organic solvent is removed by passing a gas having a temperature not higher than the dew point of the solvent in the evaporating step.
    Type: Application
    Filed: June 16, 2017
    Publication date: October 5, 2017
    Applicant: FUJIFILM Corporation
    Inventors: Susumu SUGIYAMA, Naoki YAMADA, Shigehisa SUGIYAMA, Yohei OKUBO, Takashi SASAKI, Tetsu ISHIGURO
  • Publication number: 20160354964
    Abstract: A fiber manufacturing method includes the following steps of: dissolving a polymer in a solvent to obtain a polymer solution; spraying the polymer solution into a liquid heated to a boiling point of the solvent or higher, and evaporating the solvent to precipitate a fibrous polymer in a sealed precipitation tank, the liquid being immiscible with the polymer and the solvent; conveying the precipitated fibrous polymer in a liquid from the precipitation tank; water-rinsing the fibrous polymer conveyed in the liquid in the conveying step in a sealed water-rinsing tank; conveying the water-rinsed fibrous polymer in a liquid from the water-rinsing tank; and cooling and condensing solvent gas that is generated in the spraying step and the water-rinsing step.
    Type: Application
    Filed: August 8, 2016
    Publication date: December 8, 2016
    Applicant: FUJIFILM Corporation
    Inventors: Yukihiro KATAI, Shigehisa SUGIYAMA, Seiji KASAHARA, Yasuhisa SHIMODA, Masahiro ESAKI
  • Patent number: 8730453
    Abstract: An exposure apparatus includes a light emitting unit, a mask stage that holds a mask for forming a pattern on a workpiece and a moving stage that holds the workpiece and has a laser length measuring device. The apparatus further includes an XY? direction moving mechanism that moves the moving stage within a plane parallel to the workpiece face, and a Z direction moving mechanism that moves the moving stage in a vertical direction. The laser length measuring device measures a distance between the device and a reflection mirror using laser light. A control unit controls the XY? direction moving mechanism to move the moving stage based on the distance. The reflective mirror is fixed to a structural body that supports the mask stage.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: May 20, 2014
    Assignee: Ushio Denki Kabushiki Kaisha
    Inventor: Shigehisa Sugiyama
  • Publication number: 20130070228
    Abstract: An exposure apparatus includes a light emitting unit, a mask stage that holds a mask for forming a pattern on a workpiece and a moving stage that holds the workpiece and has a laser length measuring device. The apparatus further includes an XY? direction moving mechanism that moves the moving stage within a plane parallel to the workpiece face, and a Z direction moving mechanism that moves the moving stage in a vertical direction. The laser length measuring device measures a distance between the device and a reflection mirror using laser light. A control unit controls the XY? direction moving mechanism to move the moving stage based on the distance. The reflective mirror is fixed to a structural body that supports the mask stage.
    Type: Application
    Filed: September 13, 2012
    Publication date: March 21, 2013
    Applicant: USHIO DENKI KABUSHIKI KAISHA
    Inventor: Shigehisa Sugiyama