Patents by Inventor Shigeho Inaba
Shigeho Inaba has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4010154Abstract: Novel 1-substituted benzodiazepine derivatives and salt thereof having the formula, ##STR1## wherein R.sub.1 is a hydrogen atom, a halogen atom, a nitro group, a cyano group, a lower alkoxy group or a trifluoromethyl group; R.sub.2 is a pyridyl group or a group of the formula ##STR2## wherein R.sub.5 and R.sub.6 represent individually a hydrogen atom, a halogen atom, a lower alkyl group or a trifluoromethyl group); R.sub.3 is a hydrogen atom or a lower alkyl group; R.sub.4 is a lower alkyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl group; m is 1 or 2; and n is an integer of 1 to 4, and a process for preparation thereof and pharmaceutical use of the same.Type: GrantFiled: August 16, 1974Date of Patent: March 1, 1977Assignee: Sumitomo Chemical Company, LimitedInventors: Hisao Yamamoto, Shigeho Inaba, Toshiyuki Hirohashi, Michihiro Yamamoto, Kikuo Ishizumi, Mitsuhiro Akatsu, Isamu Maruyama, Kazuo Mori, Yoshiharu Kume, Takahiro Izumi
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Patent number: 4010280Abstract: A phenoxyalkylamine derivative of the formula: ##STR1## and its pharmaceutically acceptable salts, which are useful as neuroleptic agents and a process for their preparation by reacting a compound of the formula: ##STR2## with a compound of the formula: ##STR3## wherein R.sub.1 and R.sub.2 are each hydrogen, halogen, C.sub.1 -C.sub.7 alkyl or C.sub.1 -C.sub.7 alkoxy, X is oxygen, sulfur, sulfinyl or NR (in which R is hydrogen or C.sub.1 -C.sub.7 alkyl), m and n are each an integer of 2, 3 or 4, and Y and Y' are each amino or halogen but they are different from each other.Type: GrantFiled: September 27, 1974Date of Patent: March 1, 1977Assignee: Sumitomo Chemical Company, LimitedInventors: Isamu Maruyama, Masaru Nakao, Kikuo Sasajima, Shigeho Inaba, Hisao Yamamoto
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Patent number: 4009173Abstract: Novel butyrophenone derivatives of the formula: ##STR1## wherein R.sub.1 represents a hydroxyl group or ##STR2## (wherein R.sub.6 and R.sub.7 are each a hydrogen atom or a lower alkyl group or, when taken together with the adjacent nitrogen atom, may form a heterocyclic group), R.sub.2 represents an optionally substituted phenyl group or ##STR3## (wherein R.sub.8 and R.sub.9 are each a hydrogen atom or a lower alkyl group or, when taken together with the adjacent nitrogen atom, may form a heterocyclic group), R.sub.4 represents a hydrogen atom, a lower alkyl group or an optionally substituted phenyl group, R.sub.5 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or a trifluoromethyl group, R.sub.10 represents a hydrogen atom or an acyl group represented by R.sub.3 CO- (wherein R.sub.3 is a hydrogen atom, a lower alkyl group or an optionally substituted phenyl group) and Z represents two hydrogen atoms or an oxygen atom, provided that when Z is an oxygen atom and R.sub.Type: GrantFiled: September 29, 1975Date of Patent: February 22, 1977Assignee: Sumitomo Chemical Company, LimitedInventors: Kikuo Sasajima, Masaru Nakao, Isamu Maruyama, Keiichi Ono, Shigenari Katayama, Shigeho Inaba, Hisao Yamamoto
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Patent number: 4009275Abstract: Phenoxypropylamine derivatives of the formula: ##STR1## (in which R.sub.2 is a halogen atom or a trifluoromethyl group) and R.sub.1 is a halogen atom or a C.sub.1 -C.sub.4 alkyl or C.sub.2 -C.sub.4 alkenyl group, and their pharmaceutically acceptable salts, which are useful as neuroleptic agents and can be prepared by reacting a compound of the formula: ##STR2## wherein X is a halogen atom and R.sub.1 is as defined above with a compound of the formula:H-Ywherein Y is as defined above.Type: GrantFiled: February 28, 1975Date of Patent: February 22, 1977Assignee: Sumitomo Chemical Company, LimitedInventors: Isamu Maruyama, Masaru Nakao, Kikuo Sasajima, Shigeho Inaba, Hisao Yamamoto
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Patent number: 4002755Abstract: Triazoloquinazolines of the formula, ##STR1## wherein R.sub.1 is C.sub.1.sub.-4 alkyl or aryl; R.sub.2 and R.sub.3 are independently hydrogen, halogen, trifluoromethyl, nitro, C.sub.1.sub.-4 alkyl or C.sub.1.sub.-4 alkoxy, or R.sub.2 and R.sub.3 together may form methylenedioxy; and R.sub.4 is hydrogen, C.sub.1.sub.-4 alkyl, aralkyl, C.sub.1.sub.-4 haloalkyl, or C.sub.3.sub.-6 cycloalkyl; and pharmaceutically acceptable acid addition salts thereof are prepared by (a) reacting a 2-hydrazinoquinazoline derivative with a carboxylic acid or reactive derivative thereof, (b) cyclizing a 2-acylhydrazinoquinazoline derivative with heating or (c) reacting a triazolylbenzophenone derivative with ammonia. Said triazoloquinazolines and pharmaceutically acceptable acid addition salts thereof show excellent anti-inflammatory and analgesic activities.Type: GrantFiled: February 25, 1975Date of Patent: January 11, 1977Assignee: Sumitomo Chemical Company, LimitedInventors: Michihiro Yamamoto, Shigeaki Morooka, Masao Koshiba, Shigeho Inaba, Hisao Yamamoto
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Patent number: 4002611Abstract: A 1-alkyl-1,2,4,5-tetrahydro-3H-1,4-benzodiazepine derivative is produced by contacting a 1-aminoethyl-indole derivative with a suitable oxidizing agent and then reducing the resulting 1-acyl-2,3-dihydro-1H-1,4-benzodiazepine derivative. The starting 1-aminoethyl-indole derivative is prepared by subjecting a 3-phenyl-indole derivative to cyanomethylation (or carbamoylemethylation) and then reducing the resulting 1-cyanomethyl- (or 1-carbamoylmethyl)-indole derivative. The 1-acyl-1,2,4,5-tetrahydro-3H-1,4-benzodiazepine derivative is useful as a tranquillizer, muscle-relaxant, etc.Type: GrantFiled: February 7, 1969Date of Patent: January 11, 1977Assignee: Sumitomo Chemical Company, LimitedInventors: Hisao Yamamoto, Shigeho Inaba, Tadashi Okamoto, Toshiyuki Hirohashi, Kikuo Ishizumi, Michihiro Yamamoto, Isamu Maruyama, Kazuo Mori, Tsuyoshi Kobayashi
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Patent number: 4001412Abstract: 1-Substituted-1,2-dihydrothieno[2,3-d]-pyrimidin-2-ones of the formula, ##STR1## wherein R is lower alkyl or cyclopropylmethyl, R.sub.1 is halogen, lower alkyl or nitro, R.sub.2 is hydrogen or lower alkyl and R.sub.3 is hydrogen or halogen, are obtained by treating a trihaloacetamidothiophene derivative with ammonia. These compounds have excellent pharmacological activities such as uricosuric activity.Type: GrantFiled: May 6, 1975Date of Patent: January 4, 1977Assignee: Sumitomo Chemical Company, LimitedInventors: Toshiyuki Hirohashi, Hiromi Sato, Shigeho Inaba, Hisao Yamamoto
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Patent number: 3991048Abstract: A 1,4-benzodiazepine derivative, or a pharmaceutically acceptable acid salt thereof, of the formula, ##SPC1##Wherein R.sub.1 is hydrogen, halogen, nitro or trifluoromethyl; R.sub.2 and R.sub.3 are independently hydrogen, halogen, lower alkyl or trifluoromethyl; R.sub.4 is lower alkyl, alkenyl, trihaloalkyl, alkoxyalkyl, alkenyloxyalkyl, alkoxyalkoxyalkyl, alkanoyloxyalkyl, cycloalkylalkyl, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl or a group of the formula ##EQU1## in which R.sub.6 and R.sub.7 are independently lower alkyl, and n is an integer of 1 to 4; and R.sub.5 is hydrogen or lower alkyl, is obtained by reacting a benzophenone derivative of the formula, ##SPC2##Wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined above, with a 2-isocyanatoacetyl chloride derivative of the formula ##EQU2## wherein R.sub.5 is as defined above.Type: GrantFiled: February 25, 1975Date of Patent: November 9, 1976Assignee: Sumitomo Chemical Company, LimitedInventors: Kikuo Ishizumi, Kazuo Mori, Shigeho Inaba, Hisao Yamamoto
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Patent number: 3989829Abstract: Benzodiazepine derivatives of the formula, ##SPC1##Wherein R.sub.1 is a C.sub.2-4 alkenyl group, R.sub.2 is a halogen atom and R.sub.3 is a hydrogen or halogen atom, which are useful as minor tranquilizer and anticonvulsant. These compounds are prepared by reacting a compound of the formula, ##SPC2##Wherein R.sub.1, R.sub.2, and R.sub.3 are as defined above, with a compound of the formula, ##EQU1## wherein X is an oxygen or sulfur atom.Type: GrantFiled: July 10, 1975Date of Patent: November 2, 1976Assignee: Sumitomo Chemical Company, LimitedInventors: Hisao Yamamoto, Shigeho Inaba, Toshiyuki Hirohashi, Michihiro Yamamoto, Kikuo Ishizumi, Mitsuhiro Akatsu, Isamu Maruyama, Yoshiharu Kume, Kazuo Mori, Takahiro Izumi
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Patent number: 3980645Abstract: Fused quinazolinone derivatives of the formula, ##SPC1##Wherein R.sub.1 and R.sub.2 are individually hydrogen, C.sub.1.sub.-4 alkyl, C.sub.1.sub.-4 alkoxy, nitro, C.sub.1.sub.-4 alkylsulfonyl or halogen; R.sub.3 is pyridyl, thienyl or a group of the formula ##SPC2##Wherein R.sub. 4 is hydrogen or halogen; R is hydrogen, C.sub.1.sub.-4 alkyl, C.sub.2.sub.-5 alkenyl, aralkyl, (C.sub.3.sub.-6 cycloalkyl)C.sub.1.sub.-4 alkyl, (C.sub.1.sub.-4 alkoxy)C.sub.1.sub.-4 alkyl, (C.sub.1.sub.-4 alkylthio)C.sub.1.sub.-4 alkyl, hydroxy-C.sub.1.sub.-4 alkyl or C.sub.2.sub.-5 alkanoyloxy-C.sub.1.sub.-4 alkyl; Y is oxygen, or a group of the formula N - R.sub.5, wherein R.sub.5 is hydrogen or C.sub.1.sub.-4 alkyl; and Z is C.sub.2.sub.-5 alkylene or alkenylene, are prepared by reacting a trihaloacetamidophenyl ketone derivative of the formula, ##SPC3##Wherein R.sub.1, R.sub.2, R.sub. 3 and R are as defined above; and X.sub.1, X.sub.2 and X.sub.3 are halogen, with an amine of the formula, HY - Z - NH.sub.Type: GrantFiled: November 7, 1974Date of Patent: September 14, 1976Assignee: Sumitomo Chemical Company, LimitedInventors: Shigeho Inaba, Michihiro Yamamoto, Kikuo Ishizumi, Kazuo Mori, Masao Koshiba, Hisao Yamamoto
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Patent number: 3979390Abstract: A process for producing butyrophenone derivatives of the formula: ##EQU1## which comprises reacting a compound of the formula: ##SPC1##With an amine of the formulaH-W(wherein Ar represents a group of either one of the formulas: ##SPC2##Z is a secondary amino group and W is the residue of an amine excluding a hydrogen atom therefrom). The said butyrophenone derivatives and their salts exhibit a variety of beneficial pharmacological activities including a central and autonomic nervous system depressing activity.Type: GrantFiled: March 16, 1973Date of Patent: September 7, 1976Assignee: Sumitomo Chemical Company, LimitedInventors: Kikuo Sasajima, Keiichi Ono, Masaru Nakao, Isamu Maruyama, Masaharu Takayama, Shigenari Katayama, Junki Katsube, Shigeho Inaba, Hisao Yamamoto
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Patent number: 3974145Abstract: Novel indolylacetic acid derivatives, which have excellent anti-inflammatory, antipyretic and analgesic activities, represented by the formula, ##SPC1##Wherein X.sub.1 and X.sub.2 each is a member selected from the group consisting of oxygen and methylene; A is a member selected from the group consisting of unsubstituted saturated hydrocarbon chain having up to 5 carbon atoms, unsubstituted unsaturated hydrocarbon chain having up to 5 carbon atoms and substituted saturated or substituted ethylenically unsaturated hydrocarbon chain having up to 5 carbon atoms, in which the substituents are selected from the group consisting of halogen or phenyl, the hydrocarbon chain being straight or blanched one; m is 0 or 1; n is 1 or 2; R.sub.1 and R.sub.2 each is a member selected from the group consisting of hydrogen and alkyl having up to 4 carbon atoms; R.sub.Type: GrantFiled: February 4, 1974Date of Patent: August 10, 1976Assignee: Sumitomo Chemical Company, LimitedInventors: Michio Kimura, Shigeho Inaba, Hisao Yamamoto
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Patent number: 3970654Abstract: Quinazolinone derivatives of the formula, ##SPC1##Wherein R is a polyalicyclic hydrocarbon group; R.sup.1 and R.sup.2 are independently a hydrogen atom, a nitro group, a trifluoromethyl group or a methylsulfonyl group; R.sup.3 is a phenyl group, a substituted phenyl group, a pyridyl group or a thienyl group; and n is 0 or an integer of 1 to 3, have potent antiviral activity with low toxicities. These compounds can be prepared using a variety of processes analogous to known methods, for example, by oxidizing a 3,4-dihydro-2(1H)-quinazolinone having a polyalicyclic hydrocarbon group bonded through an alkylene group at the 1 position.Type: GrantFiled: July 30, 1974Date of Patent: July 20, 1976Assignee: Sumitomo Chemical Company, LimitedInventors: Michihiro Yamamoto, Shigeaki Morooka, Masao Koshiba, Shigeho Inaba, Hisao Yamamoto
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Patent number: 3966939Abstract: Novel 2-substituted 6,7-benzomorphan derivatives of the formula: ##SPC1##And acid addition salts thereof, which are useful as non-addicting analgesics, pain relieving agents and antitussives and can be prepared by reacting 6,7-benzomorphan derivatives of the formula: ##SPC2##With the reactive derivatives of alcohols of the formula: ##EQU1## [wherein R is a hydrogen atom, a hydroxyl group, an alkoxy group or an alkanoyloxy group; R.sub.1 is a hydrogen atom, an alkyl group, an alkoxyalkyl group or a substituted or unsubstituted aryl group; R.sub.3 is a hydrogen atom or a hydroxyl group; R.sub.4 is a hydrogen atom, an alkyl group or a substituted or unsubstituted aryl group, or R.sub.3 and R.sub.4 may form an alkylidene group or a carbonyl group together with the carbon atom to which these substituents are bonded; R.sub.2, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and R.sub.10 are each a hydrogen atom or an alkyl group; A is an alkylene group; and m is an integer of 0 to 2].Type: GrantFiled: March 17, 1975Date of Patent: June 29, 1976Assignee: Sumitomo Chemical Company, LimitedInventors: Kenji Kobayashi, Toshitsugu Fukumaru, Hiroyuki Mizote, Shigeho Inaba, Hisao Yamamoto
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Patent number: 3965106Abstract: A 3-phenoxypropylamine derivative of the formula: ##SPC1##Wherein Y is ##SPC2##(wherein R.sub.1 is a halogen atom or a trifluoromethyl group) or ##SPC3##(wherein R.sub.2 is a lower alkyl group) and its pharmaceutically acceptable salts which are useful as central nervous system depressing agents.Type: GrantFiled: December 12, 1973Date of Patent: June 22, 1976Assignee: Sumitomo Chemical Company, LimitedInventors: Isamu Maruyama, Masaru Nakao, Kikuo Sasajima, Shigeho Inaba, Hisao Yamamoto
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Patent number: 3960873Abstract: Novel N-substituted heterocyclic derivatives represented by the formula, ##SPC1##Wherein R.sub.1 is hydrogen atom, lower alkyl, lower alkoxy, nitro, halogen or trifluoromethyl group; R.sub.2 is hydrogen atom or lower alkyl group; X is sulfur atom, sulfinyl or sulfonyl group; Y is ##EQU1## group (wherein R.sub.3 is phenyl or substituted phenyl group; R.sub.4 is hydrogen atom, hydroxy, lower alkyl, lower alkoxy, lower alkanoyl, lower alkanoyloxy, carbamoyl, N-(lower alkyl)-carbamoyl or N,N-di(lower akyl)-carbamoyl group; R.sub.5 is hydrogen atom, morpholino, pyrrolidinyl, piperidinyl, hexamethylenimino, lower alkyl, cyclo(lower alkyl), cyclo(lower alkyl)-(lower alkyl), hydroxy-(lower alkyl), (lower alkoxy)-(lower alkyl), phenyl or substituted phenyl group; k is 0 or 1 and m is 0, 1 or 2); and n is 3 or 4, and pharmaceutically acceptable salts thereof, which have excellent tranquillizing, anti-psychotonic, anti-emotional, anti-convulsive, anti-psychosis, sedative, analgesic or anti-hypertensive activities.Type: GrantFiled: June 21, 1974Date of Patent: June 1, 1976Assignee: Sumitomo Chemical Co., Ltd.Inventors: Isamu Maruyama, Hisao Yamamoto, Masaru Nakao, Shigeru Sakai, Kikuo Sasajima, Sumio Kitagawa, Shigeho Inaba
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Patent number: 3961066Abstract: A novel 2-substituted-6,7-benzomorphan derivative of the formula: ##SPC1##And its acid addition salts, which are useful as non-addicting analgesics and antitussives and can be prepared by reacting a 2-unsubstituted-6,7-benzomorphan derivative of the formula: ##SPC2##With the reactive derivative of an alcohol of the formula:HOA',optionally followed by elimination of the protective group in the resulting product, wherein R.sub.1 is hydrogen, lower alkyl or acyl; R.sub.2 and R.sub.3 are each lower alkyl; A is lower alkyl, cyano(lower)alkyl, benzoyl(lower)alkyl, ar(lower)alkyl, lower alkenyl or cyclo(lower)alkyl(lower)alkyl; and A' is a group as mentioned in A or benzoyl(lower)alkyl of which the carbonyl group is masked with a suitable protective group.Type: GrantFiled: March 29, 1974Date of Patent: June 1, 1976Assignee: Sumitomo Chemical Company, LimitedInventors: Toshitsugu Fukumaru, Kenji Kobayashi, Hiroyuki Mizote, Shigeho Inaba, Hisao Yamamoto
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Patent number: 3957783Abstract: Novel thienopyrimidine derivatives which have excellent pharmacological uricosuric activity are prepared by reacting a thiophene derivative with cyanic acid or a salt thereof, urea or a reactive ester of carbamic acid. If desired, alkylated, halogenated or nitrated thienopyrimidine derivatives are produced by reacting thienopyrimidine derivatives with an alkylating, halogenating or nitrating agent, respectively.Type: GrantFiled: May 7, 1973Date of Patent: May 18, 1976Assignee: Sumitomo Chemical Company, LimitedInventors: Toshiyuki Hirohashi, Hiromi Sato, Shigeho Inaba, Hisao Yamamoto
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Patent number: 3953446Abstract: Quinazoline derivatives which have anti-inflammatory, antiviral, uricosuric activities are prepared by reacting an indole-2-carbonylazide derivative with an oxidizing agent under mild conditions.Type: GrantFiled: August 5, 1974Date of Patent: April 27, 1976Assignee: Sumitomo Chemical Company, LimitedInventors: Kikuo Ishizumi, Kazuo Mori, Michihiro Yamamoto, Masao Koshiba, Shigeho Inaba, Hisao Yamamoto
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Patent number: 3951986Abstract: 2-Propanol derivatives of the formula: ##SPC1##And their pharmaceutically acceptable acid addition salts, which are useful as medicaments and can be produced by reacting a compound of the formula: A-CH.sub.2 -Z with a compound of the formula: A'-H [wherein R is hydrogen or lower alkanoyl; R.sub.1 is hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl; W is oxygen, sulfur, sulfinyl or sulfonyl; Y is a group of either one of the formulae: ##SPC2##(wherein R.sub.2 is hydrogen, halogen, lower alkyl or lower alkoxy and R.sub.3 is hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl); A and A' are each a group of either one of the formulae: ##SPC3##(wherein R.sub.1, W and Y are each as defined above), provided that A and A' are different each other; and Z is a group of either one of the formulae: ##EQU1## (wherein X is halogen, alkylsulfonyloxy or arylsulfonyloxy and R is as defined above)].Type: GrantFiled: June 18, 1973Date of Patent: April 20, 1976Assignee: Sumitomo Chemical Company, LimitedInventors: Isamu Maruyama, Masaru Nakao, Kikuo Sasajima, Shigeho Inaba, Hisao Yamamoto