Patents by Inventor Shigeki Hibi
Shigeki Hibi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5635519Abstract: A benzothiazole derivative or a pharmacologically acceptable salt thereof of the following formula, as defined in the claims, which is useful as a preventive or therapeutic agent for diseases on which functions of suppressing leukotrienes and thromboxanes production are effective: ##STR1##Type: GrantFiled: February 15, 1995Date of Patent: June 3, 1997Assignee: Eisai Co., Ltd.Inventors: Yasushi Okamoto, Katsuya Tagami, Shigeki Hibi, Hirotoshi Numata, Naoki Kobayashi, Masanobu Shinoda, Tetsuya Kawahara, Manabu Murakami, Kiyoshi Oketani, Takashi Inoue, Takashi Yamanaka, Isao Yamatsu
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Patent number: 5631402Abstract: An aminobenzoic acid derivative represented by the following general formulas (I), (I-2) or (I-3), or a pharmacologically acceptable salt thereof, which exhibits a serotonin antagonism and an acetylcholine release accelerating activity at a well-balanced activity ratio and which is efficacious as a drug for patients with gastrointestinal unindentified complaints: ##STR1## wherein R.sup.1 represents a group such as an alkynyl or cyanoalkyl group; R.sup.2 represents a group such as an amino or acylamino group; R.sup.3 represents a halogen atom; X represents --O-- or --NH--; and A represents an oxygen or sulfur atom.Type: GrantFiled: June 7, 1995Date of Patent: May 20, 1997Assignee: Eisai Co., Ltd.Inventors: Shuhei Miyazawa, Shigeki Hibi, Hiroyuki Yoshimura, Takashi Mori, Yorihisa Hoshino, Mitsuo Nagai, Kouichi Kikuchi, Hisashi Shibata, Kazuo Hirota, Takashi Yamanaka, Isao Yamatsu, Masanori Mizuno
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Patent number: 5612356Abstract: A heterocycle-containing carbonic acid derivative represented by the following general formula (I): ##STR1## or a physiologically acceptable salt thereof which exhibits an excellent preventive and therapeutic effect against various diseases, and an intermediate which is useful for the production of the heterocycle-containing carbonic acid derivative.Type: GrantFiled: April 25, 1995Date of Patent: March 18, 1997Assignee: Eisai Co., Ltd.Inventors: Hiroyuki Yoshimura, Mitsuo Nagai, Shigeki Hibi, Koichi Kikuchi, Ieharu Hishinuma, Junichi Nagakawa, Makoto Asada, Norimasa Miyamoto, Takayuki Hida, Aichi Ogasawara, Isao Yamatsu
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Patent number: 5599972Abstract: An aminobenzoic acid derivative represented by the following general formulas (I), (I-2) or (I-3), or a pharmacologically acceptable salt thereof, which exhibits a serotonin antagonism and an acetylcholine release accelerating activity at a well-balanced activity ratio and which is efficacious as a drug for patients with gastrointestinal unindentified complaints: ##STR1## wherein R.sup.1 represents a group such as an alkynyl or cyanoalkyl group; R.sup.2 represents a group such as an amino or acylamino group; R.sup.3 represents a halogen atom; X represents --O-- or --NH--; and A represents an oxygen or sulfur atom.Type: GrantFiled: June 7, 1995Date of Patent: February 4, 1997Assignee: Eisai Co., Ltd.Inventors: Shuhei Miyazawa, Shigeki Hibi, Hiroyuki Yoshimura, Takashi Mori, Yorihisa Hoshino, Mitsuo Nagai, Kouichi Kikuchi, Hisashi Shibata, Kazuo Hirota, Takashi Yamanaka, Isao Yamatsu, Masanori Mizuno
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Patent number: 5578603Abstract: An aminobenzoic acid derivative represented by the following formulas (I-2) or (I-3), or a pharmacologically acceptable salt thereof, which exhibits a serotonin antagonism and an acetylcholine release accelerating activity at a well-balanced activity ratio and which is efficacious as a drug for patients with gastrointestinal unindentified complaints: ##STR1## wherein R.sup.1 represents a group such as an alkynyl or cyanoalkyl group; R.sup.2 represents a group such as an amino or acylamino group; R.sup.3 represents a halogen atom; X represents --O-- or --N--; and A represents an oxygen or sulfur atom.Type: GrantFiled: November 8, 1994Date of Patent: November 26, 1996Assignee: Eisai Co., Ltd.Inventors: Shuhei Miyazawa, Shigeki Hibi, Hiroyuki Yoshimura, Takashi Mori, Yorihisa Hoshino, Mitsuo Nagai, Kouichi Kikuchi, Hisashi Shibata, Kazuo Hirota, Takashi Yamanaka, Isao Yamatsu, Masanori Mizuno
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Patent number: 5527948Abstract: Naphthalene derivatives of the formula: ##STR1## wherein R.sup.1, represents a hydrogen atom, a lower alkyl group or an acyl group; R.sup.2 independently represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a cycloalkyl group, a cycloalkylalkyl group, a hydroxyl group, an aryl group which may be substituted, an arylalkyl group whose aryl group may be substituted, a heteroaryl group, or a heteroaryllakyl group; R.sup.3 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, an aryl group which may have a substituent, an arylalkyl group whose aryl group may be substituted, an arylalkenyl group whose aryl group may be substituted, a cycloalkyl group, an alkoxyalkyl group, a heteroaryl group, a heteroarylalkyl group, a carboxyl group, a carboxyalkyl group, an aminoalkyl group, or a cyano group; R.sup.6 is C.sub.1-6 alkyl; and m is 0 or an integer of from 1 to 2 useful in treating autoimmune diseases are disclosed.Type: GrantFiled: March 13, 1995Date of Patent: June 18, 1996Assignee: Eisai Corp. Ltd.Inventors: Makoto Okita, Hiroshi Shirota, Masayuki Tanaka, Toshihiko Kaneko, Katsuya Tagami, Shigeki Hibi, Yasushi Okamoto, Seiichiro Nomoto, Takeshi Suzuki, Kenichi Chiba, Masaki Goto, Ryoichi Hashida, Hideki Ono, Hideto Ohhara, Hideki Sakurai, Shigeru Souda, Yoshimasa Machida, Kouichi Katayama, Isao Yamatsu
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Patent number: 5420144Abstract: A benzothiazole derivative or a pharmacologically acceptable salt thereof which is useful as a preventive or therapeutic agent for diseases on which functions of suppressing leukotrienes and thromboxanes production are effective.Type: GrantFiled: November 5, 1993Date of Patent: May 30, 1995Assignee: Eisai Co., Ltd.Inventors: Yasushi Okamoto, Katsuya Tagami, Shigeki Hibi, Hirotoshi Numata, Naoki Kobayashi, Masanobu Shinoda, Tetsuya Kawahara, Manabu Murakami, Kiyoshi Oketani, Takashi Inoue, Takashi Yamanaka, Isao Yamatsu
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Patent number: 5389643Abstract: An aminobenzoic acid derivative represented by the following general formulas (I), (I-2) or (I-3), or a pharmacologically acceptable salt thereof, which exhibits a serotonin antagonism and an acetylcholine release accelerating activity at a well-balanced activity ratio and which is efficacious as a drug for patients with gastrointestinal unindentified complaints: ##STR1## wherein R.sup.1 represents a group such as an alkynyl or cyanoalkyl group; R.sup.2 represents a group such as an amino or acylamino group;R.sup.3 represents a halogen atom;X represents --O-- or --NH--; andA represents an oxygen or sulfur atom.Type: GrantFiled: February 3, 1993Date of Patent: February 14, 1995Assignee: Eisai Co., Ltd.Inventors: Shuhei Miyazawa, Shigeki Hibi, Hiroyuki Yoshimura, Takashi Mori, Yorihisa Hoshino, Mitsuo Nagai, Kouichi Kikuchi, Hisashi Shibata, Kazuo Hirota, Takashi Yamanaka, Isao Yamatsu, Masanori Mizuno
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Patent number: 5385942Abstract: A quinone derivative useful in the treatment of hepatic diseases defined by the general formula: ##STR1## where X and Y may be the same or different from each other and are each a hydroxyl group, a group represented by the formula --(--OCH.sub.2 --).sub.n --OR.sup.6, wherein n is 0 or 1 and R.sup.6 is a lower alkyl group, or an acyl group.Type: GrantFiled: March 1, 1993Date of Patent: January 31, 1995Assignee: Eisai Co., Ltd.Inventors: Shinya Abe, Yasushi Okamoto, Katsuya Tagami, Shigeki Hibi, Junichi Nagakawa, Kazuo Hirota, Ieharu Hishinuma, Kaname Miyamoto, Takashi Yamanaka, Hiromitsu Yokohama, Tsutomu Yoshimura, Tohru Horie, Yasunori Akita, Koichi Katayama, Isao Yamatsu
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Patent number: 5329010Abstract: The present invention is a quinone derivative which exhibits excellent therapeutic activity represented by the general formula (I) or a pharmacologically acceptable salt thereof: ##STR1## wherein A stands for a group represented by the formula: ##STR2## (wherein R.sup.3, R.sup.4 and R.sup.5 is the same or different from each other and each stand for a hydrogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, an alkoxyalkyl group, an alkoxyalkoxy group, a cycloalkylalkoxy group, a thiol group or a thioalkyl group, with the proviso that R.sup.3 and R.sup.4 are each a lower alkoxy groupR.sup.1 stands for a heteroarylalkyl group; andB stands for a carboxyl group or a protected carboxyl group.Type: GrantFiled: February 25, 1992Date of Patent: July 12, 1994Assignee: Eisai Co., Ltd.Inventors: Yasushi Okamoto, Katsuya Tagami, Shigeki Hibi, Hirotoshi Numata, Tetsuya Kawahara, Naoki Kobayashi, Masanobu Shinoda, Koukichi Harada, Kaname Miyamoto, Koichi Abe
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Patent number: 5300518Abstract: A benzothiazole derivative or a pharmacologically acceptable salt thereof which is useful as a preventive or therapeutic agent for diseases on which functions of suppressing leukotrienes and thromboxanes production are effective.A benzothiazole derivative represented by the following general formula (I): ##STR1## wherein R.sup.1 and R.sup.3 are either the same or different and represents a hydrogen atom, a lower alkyl group or a lower alkoxy group; R.sup.4 represents a group represented by the formula --(CH.sub.x)--.sub.q wherein q is a integer of from 1 to 4;R.sup.2 represents a hydrogen atom and;R.sup.5 and R.sup.6 are the same or different and each represent a hydrogen atom or a lower alkyl group; or a pharmacologically acceptable salt thereof.Type: GrantFiled: March 31, 1992Date of Patent: April 5, 1994Assignee: Eisai Co., Ltd.Inventors: Yasushi Okamoto, Katsuya Tagami, Shigeki Hibi, Hirotoshi Numata, Naoki Kobayashi, Masanobu Shinoda, Tetsuya Kawahara, Manabu Murakami, Kiyoshi Oketani, Takashi Inoue, Takashi Yamanaka, Isao Yamatsu
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Patent number: 5298649Abstract: A naphthalene derivative having the formula is new and useful for medicine. ##STR1## wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or an acyl group;R.sup.2 independently represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a cycloalkyl group, a cycloalkylalkyl group, a hydroxyl group, an aryl group which may be substituted, an arylalkyl group whose aryl group may be substituted, a heteroaryl group, or a heteroarylalkyl group;R.sup.3 and R.sup.4 are the same or different and represent a hydrogen atom, a lower alkyl group, a lower alkenyl group, an aryl group which may have a substituent, an arylalkyl group whose aryl group may be substituted, an arylalkenyl group whose aryl group may be substituted, a cycloalkyl group, an alkoxyalkyl group, a heteroaryl group, a heteroarylalkyl group, a carboxyl group, a carboxyalkyl group, an aminoalkyl group, or a cyano group;R.sup.5 represents a group of the formula, --OR.sup.7, (wherein R.sup.Type: GrantFiled: October 10, 1991Date of Patent: March 29, 1994Assignee: Eisai Co., Ltd.Inventors: Makoto Okita, Hiroshi Shirota, Masayuki Tanaka, Toshihiko Kaneko, Katsuya Tagami, Shigeki Hibi, Yasushi Okamoto, Seiichiro Nomoto, Takeshi Suzuki, Kenichi Chiba, Masaki Goto, Ryoichi Hashida, Hideki Ono, Hideto Ohhara, Hideki Sakurai, Shigeru Souda, Yoshimasa Machida, Kouichi Katayama, Isao Yamatsu
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Patent number: 5210239Abstract: A quinone derivative useful in the treatment of hepatic diseases defined by the general formula: ##STR1## where R1 is selected from the group consisting of alkyl, alkenly, alkynyl or heterocycle, R2 is a substituted nitrogen containing radical wherein the substituents on said nitrogen are selected from the group consisting of hydrogen, substituted or unsubstituted lower alkyl or heterocycles, and where said nitrogen may be a ring heteroatom, and R3, R4 and R5, may be the same or different and each are hydrogen, lower alkyl or lower alkoxy groups.Type: GrantFiled: August 31, 1990Date of Patent: May 11, 1993Assignee: Eisai Co., Ltd.Inventors: Shinya Abe, Yasushi Okamoto, Katsuya Tagami, Shigeki Hibi, Junichi Nagakawa, Kazuo Hirota, Ieharu Hishinuma, Kaname Miyamoto, Takashi Yamanaka, Hiromitsu Yokohama, Tsutomu Yoshimura, Tohru Horie, Yasunori Akita, Koichi Katayama, Isao Yamatsu
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Patent number: 5134111Abstract: A naphthalene derivative having the formula is new and useful for medicine. ##STR1## [wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or an acyl group;R.sup.2 independently represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a cycloalkyl group, a cycloalkylalkyl group, a hydroxyl group, an aryl group which may be substituted, an arylalkyl group whose aryl group may be substituted, a heteroaryl group, or a heteroarylalkyl group;R.sup.3 and R.sup.4 are the same or different and represent a hydrogen atom, a lower alkyl group, a lower alkenyl group, an aryl group which may have a substituent, an arylalkyl group whose aryl group may be substituted, an arylalkenyl group whose aryl group may be substituted, a cycloalkyl group, an alkoxyalkyl group, a heteroaryl group, a heteroarylalkyl group, a carboxy group, a carboxyalkyl group, an aminoalkyl group, or a cyano group;R.sup.5 represents a group of the formula, --OR.sup.7, (wherein R.sup.Type: GrantFiled: December 15, 1989Date of Patent: July 28, 1992Assignee: Eisai Co., Ltd.Inventors: Makoto Okita, Hiroshi Shirota, Masayuki Tanaka, Toshihiko Kaneko, Katsuya Tagami, Shigeki Hibi, Yasushi Okamoto, Seiichiro Nomoto, Takeshi Suzuki, Kenichi Chiba, Masaki Goto, Ryoichi Hashida, Hideki Ono, Hideto Ohhara, Hideki Sakurai, Shigeru Souda, Yoshimasa Machida, Kouichi Katayama, Isao Yamatsu