Patents by Inventor Shigeki Iwanaga

Shigeki Iwanaga has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11112404
    Abstract: Disclosed is a method for obtaining information of a test substance, the method including: forming a complex by causing a capture substance to bind to a test substance in a specimen; selectively collecting at least the complex from the specimen; immobilizing the complex collected from the specimen, onto a base plate; and obtaining information regarding a structure of the test substance from the complex immobilized on the base plate.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: September 7, 2021
    Assignee: SYSMEX CORPORATION
    Inventors: Kenji Akama, Toshihiro Watanabe, Masaya Okada, Kazuto Yamashita, Akshay Ganguly, Shigeki Iwanaga
  • Publication number: 20210255191
    Abstract: Disclosed is: a fluorescent dye comprising a compound, a tautomer of the compound, or a salt of the compound or the tautomer; a labeled composite substance comprising the fluorescent dye and a composite substance which are bonded to each other; a composition containing the fluorescent dye or the labeled composite substance; and a method for acquiring information about a substance of interest by a super-resolution microscopy.
    Type: Application
    Filed: February 1, 2021
    Publication date: August 19, 2021
    Applicants: Eisai R&D Management Co., Ltd., SYSMEX CORPORATION
    Inventors: Daiki HARA, Takafumi Motoki, Yuji Kazuta, Yoshihiko Norimine, Hiroyuki Amino, Masatoshi Suganuma, Shingo Fujiyama, Kazuto Yamashita, Masaya Okada, Yoichi Nishikawa, Shigeki Iwanaga
  • Patent number: 10904491
    Abstract: A method according to one or more aspects may control a microscope system including an imaging unit configured to image a sample, and a display unit including a first display region and a second display region. The method may include: sequentially displaying, in the first display region, first images sequentially captured by the imaging unit; and displaying, in the second display region, a second image generated based on information extracted from the sequentially captured first images.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: January 26, 2021
    Assignee: SYSMEX CORPORATION
    Inventors: Masaya Okada, Shigeki Iwanaga
  • Publication number: 20200264181
    Abstract: The present invention provides a method for determining a success or failure of a measurement of a target particle contained in a measurement sample. The method includes: detecting the target particle and other particle other than the target particle in the measurement sample; and determining the success or failure of the measurement of the target particle based on at least a detection result of the other particle.
    Type: Application
    Filed: February 18, 2020
    Publication date: August 20, 2020
    Applicant: SYSMEX CORPORATION
    Inventors: Yusuke TAKAHASHI, Masatoshi YANAGIDA, Kentaro SHIRAI, Yuichi IJIRI, Shigeki IWANAGA
  • Publication number: 20200264170
    Abstract: Disclosed is a method for acquiring information on an analyte, comprising the steps of: bringing a polypeptide that is the analyte into contact with a capture substance that binds to the polypeptide to form a complex comprising the polypeptide and the capture substance; bonding the capture substance in the complex to a first solid phase to immobilize the complex onto the first solid phase; collecting the first solid phase having the complex immobilized on the first solid phase; releasing the complex from the collected first solid phase, and then bonding the capture substance in the released complex to a second solid phase to immobilize the complex onto the second solid phase; and acquiring information on the polypeptide from the complex immobilized on the second solid phase, wherein a capture substance that binds to at least one of the first solid phase and the second solid phase binds to a C-terminal region of the polypeptide.
    Type: Application
    Filed: February 4, 2020
    Publication date: August 20, 2020
    Applicant: SYSMEX CORPORATION
    Inventors: Kazuto YAMASHITA, Akshay GANGULY, Naoya SAIKI, Shigeki IWANAGA
  • Patent number: 10732095
    Abstract: A particle imaging device comprises a flow cell, a light source, an irradiation optical system configured to form a light sheet on the flow cell, a light collecting optical system and an imaging element. The sheet surface of the light sheet is perpendicular to the exterior side surface of the flow cell to which the light is entered from the light source. The sheet surface of the light sheet is inclined at a predetermined angle that is not perpendicular to the flow direction of the sample.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: August 4, 2020
    Assignee: SYSMEX CORPORATION
    Inventors: Masaya Okada, Shigeki Iwanaga
  • Patent number: 10676784
    Abstract: A sample analyzing method includes: denaturing DNA by heating a measurement specimen; bleaching the measurement specimen to inhibit autofluorescence from the measurement specimen; binding a fluorescent dye to a test substance in the measurement specimen; and capturing an image of fluorescence originated from the fluorescent dye by irradiating the measurement specimen with light. The DNA denaturation treatment is performed before the bleaching.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: June 9, 2020
    Assignee: SYSMEX CORPORATION
    Inventors: Takuya Kubo, Shigeki Iwanaga
  • Publication number: 20200173980
    Abstract: A method of determining a quality of a cell separation, according to an aspect, includes: separating, by running a specimen containing a first particle and a second particle in a flow path, the specimen to a first specimen containing the first particle and a second specimen containing the second particle, based on a difference in magnitude of a force exerted on each particle contained in the specimen; measuring first information on an amount of the first specimen and second information on an amount of the second specimen; and determining a quality of the separating based on the first information and the second information.
    Type: Application
    Filed: November 27, 2019
    Publication date: June 4, 2020
    Applicant: SYSMEX CORPORATION
    Inventors: Yusuke TAKAHASHI, Kentaro SHIRAI, Masatoshi YANAGIDA, Shigeki IWANAGA, Yuichi IJIRI, Keiko YOSHIKAWA
  • Publication number: 20200106993
    Abstract: A method according to one or more aspects may control a microscope system including an imaging unit configured to image a sample, and a display unit including a first display region and a second display region. The method may include: sequentially displaying, in the first display region, first images sequentially captured by the imaging unit; and displaying, in the second display region, a second image generated based on information extracted from the sequentially captured first images.
    Type: Application
    Filed: September 23, 2019
    Publication date: April 2, 2020
    Applicant: SYSMEX CORPORATION
    Inventors: Masaya OKADA, Shigeki IWANAGA
  • Publication number: 20200103347
    Abstract: A microscope apparatus includes: a sample setting unit in which a sample is set; an imaging unit configured to image the sample set in the sample setting unit; a housing unit on which the sample setting unit is arranged, and which is configured to internally accommodate the imaging unit; a first light source configured to irradiate light for fluorescence excitation on the sample in the sample setting unit; a first cover configured to be movable to a first position that covers the sample setting unit and a second position that opens the sample setting unit; and a second cover configured to be movable within the first cover; and a second light source arranged in a space covered with the second cover and configured to irradiate light on the sample in the sample setting unit.
    Type: Application
    Filed: September 26, 2019
    Publication date: April 2, 2020
    Applicant: SYSMEX CORPORATION
    Inventors: Masaya OKADA, Shigeki IWANAGA
  • Patent number: 10604731
    Abstract: Provided is a cell analyzer including: a light source unit configured to apply light to test cells each containing first substances which are bound to first fluorescent dyes and which serve as an index for therapeutic strategy judgement; an image capturing unit configured to capture an image of fluorescence caused by the light; a processing unit configured to process the image obtained by the image capturing unit; and a display unit configured to display a process result obtained by the processing unit, wherein the processing unit obtains a first image by performing an inactivation process of quenching the first fluorescent dyes, an activation process of activating a part of the first fluorescent dyes that have been quenched, and an image capturing process of capturing, by means of the image capturing unit, an image of the fluorescence by applying light from the light source unit to each test cell; extracts bright points based on the first fluorescent dyes on the basis of the first image; classifies the extra
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: March 31, 2020
    Assignee: SYSMEX CORPORATION
    Inventors: Kanako Masumoto, Takuya Kubo, Shigeki Iwanaga, Masaya Okada
  • Publication number: 20200095631
    Abstract: A sample analyzing method includes: denaturing DNA by heating a measurement specimen; bleaching the measurement specimen to inhibit autofluorescence from the measurement specimen; binding a fluorescent dye to a test substance in the measurement specimen; and capturing an image of fluorescence originated from the fluorescent dye by irradiating the measurement specimen with light. The DNA denaturation treatment is performed before the bleaching.
    Type: Application
    Filed: October 21, 2019
    Publication date: March 26, 2020
    Applicant: SYSMEX CORPORATION
    Inventors: Takuya KUBO, Shigeki IWANAGA
  • Patent number: 10585275
    Abstract: Disclosed is a microscope device that includes: a sample placement unit on which a sample is set; an imaging unit configured to take an image of the sample that is set on the sample placement unit; a case in which the sample placement unit is provided and the imaging unit is disposed; a display unit configured to display the image taken by the imaging unit; and a moving unit, provided integrally with the display unit, configured to be movable relative to the sample placement unit.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: March 10, 2020
    Assignee: Sysmex Corporation
    Inventors: Masaya Okada, Shigeki Iwanaga
  • Patent number: 10533217
    Abstract: A sample analyzing method includes: denaturing DNA by heating a measurement specimen; bleaching the measurement specimen to inhibit autofluorescence from the measurement specimen; binding a fluorescent dye to a test substance in the measurement specimen; and capturing an image of fluorescence originated from the fluorescent dye by irradiating the measurement specimen with light. The DNA denaturation treatment is performed before the bleaching.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: January 14, 2020
    Assignee: SYSMEX CORPORATION
    Inventors: Takuya Kubo, Shigeki Iwanaga
  • Publication number: 20190162954
    Abstract: An optical device comprises a shared phase modulation mask configured to impart a first phase modulation to light of a first wavelength, and imparts a second phase modulation to light of a second wavelength, an irradiation optical system configured to cause the light of the first wavelength and the light of the second wavelength to enter the same incident region in the phase modulation mask, and a light collecting optical system configured to collect the light of the first phase-modulated first wavelength and the light of the second phase-modulated second wavelength to form an image corresponding to a point spread function.
    Type: Application
    Filed: January 14, 2019
    Publication date: May 30, 2019
    Inventors: Masaya OKADA, Shigeki IWANAGA
  • Publication number: 20190128793
    Abstract: A cell detection method and a cell detection system capable of performing target cell detection satisfactorily without interference and reducing the time required for detection of target cells are provided. The cell detection method includes a separation step of step S1 to obtain a sample containing target cells by removing at least a part of the non-target cells from a biological sample including target cells and non-target cells based on a difference in forces acting on target cells and non-target cells; a concentration step of step S3 of obtaining a measurement sample having a target cell concentration increased from the sample containing target cells; a detection of step S4 of detecting target cells by subjecting the measurement sample to an imaging flow cytometer.
    Type: Application
    Filed: November 1, 2018
    Publication date: May 2, 2019
    Inventors: Kentaro SHIRAI, Yusuke TAKAHASHI, Masatoshi YANAGIDA, Shigeki IWANAGA, Tomokazu YOSHIDA, Yuichi IJIRI
  • Patent number: 10222612
    Abstract: An optical device comprises a shared phase modulation mask configured to impart a first phase modulation to light of a first wavelength, and imparts a second phase modulation to light of a second wavelength, an irradiation optical system configured to cause the light of the first wavelength and the light of the second wavelength to enter the same incident region in the phase modulation mask, and a light collecting optical system configured to collect the light of the first phase-modulated first wavelength and the light of the second phase-modulated second wavelength to form an image corresponding to a point spread function.
    Type: Grant
    Filed: March 9, 2017
    Date of Patent: March 5, 2019
    Assignee: SYSMEX CORPORATION
    Inventors: Masaya Okada, Shigeki Iwanaga
  • Publication number: 20190033291
    Abstract: Disclosed is a cell imaging method including: forming a light sheet with respect to a flow cell; causing a measurement sample containing a plurality of cells to flow in the flow cell; and receiving lights generated from the plurality of cells passing through the light sheet, by an imaging device via an element configured to extend a depth of focus, and taking images of the plurality of cells by the imaging device.
    Type: Application
    Filed: January 30, 2018
    Publication date: January 31, 2019
    Inventors: Masaya OKADA, Shigeki IWANAGA
  • Publication number: 20180299437
    Abstract: Disclosed is a method for obtaining information of a test substance, the method including: forming a complex by causing a capture substance to bind to a test substance in a specimen; selectively collecting at least the complex from the specimen; immobilizing the complex collected from the specimen, onto a base plate; and obtaining information regarding a structure of the test substance from the complex immobilized on the base plate.
    Type: Application
    Filed: April 12, 2018
    Publication date: October 18, 2018
    Inventors: Kenji AKAMA, Toshihiro WATANABE, Masaya OKADA, Kazuto YAMASHITA, Akshay GANGULY, Shigeki IWANAGA
  • Patent number: D827008
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: August 28, 2018
    Assignee: SYSMEX CORPORATION
    Inventors: Masaya Okada, Fumie Shibata, Shigeki Iwanaga, Masayuki Seki