Patents by Inventor Shigeki Iwanaga
Shigeki Iwanaga has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11598952Abstract: An optical device comprises a shared phase modulation mask configured to impart a first phase modulation to light of a first wavelength, and imparts a second phase modulation to light of a second wavelength, an irradiation optical system configured to cause the light of the first wavelength and the light of the second wavelength to enter the same incident region in the phase modulation mask, and a light collecting optical system configured to collect the light of the first phase-modulated first wavelength and the light of the second phase-modulated second wavelength to form an image corresponding to a point spread function.Type: GrantFiled: January 14, 2019Date of Patent: March 7, 2023Assignee: SYSMEX CORPORATIONInventors: Masaya Okada, Shigeki Iwanaga
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Patent number: 11473130Abstract: A sample analyzing method includes: denaturing DNA by heating a measurement specimen; bleaching the measurement specimen to inhibit autofluorescence from the measurement specimen; binding a fluorescent dye to a test substance in the measurement specimen; and capturing an image of fluorescence originated from the fluorescent dye by irradiating the measurement specimen with light. The DNA denaturation treatment is performed before the bleaching.Type: GrantFiled: October 21, 2019Date of Patent: October 18, 2022Assignee: SYSMEX CORPORATIONInventors: Takuya Kubo, Shigeki Iwanaga
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Publication number: 20220283083Abstract: Disclosed is an analytical method for analyzing a test substance contained in a measurement sample, the method comprising: generating a data set based on a plurality of optical spectra acquired from a plurality of locations in the measurement sample; inputting the data set into a deep learning algorithm having a neural network structure; and outputting information on the test substance, on the basis of an analytical result from the deep learning algorithm.Type: ApplicationFiled: March 4, 2022Publication date: September 8, 2022Applicants: SYSMEX CORPORATION, OSAKA UNIVERSITY, NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGYInventors: Masaya OKADA, Yuki SHIMAOKA, Shigeki IWANAGA, Kazuki BANDO, Katsumasa FUJITA, Yasunori NAWA, Satoshi FUJITA
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Publication number: 20220283154Abstract: Disclosed is a preparation method for preparing a measurement sample comprising an aggregate of metal nanoparticles having an analyte bound thereto, the preparation method comprising: contacting the analyte with a linker to bind the analyte to the linker; and contacting the linker that has been bound to the analyte with the metal nanoparticles to bind the linker to the metal nanoparticles.Type: ApplicationFiled: March 4, 2022Publication date: September 8, 2022Applicants: SYSMEX CORPORATION, OSAKA UNIVERSITY, NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGYInventors: Yuki SHIMAOKA, Masaya Okada, Shigeki Iwanaga, Kazuki Bando, Katsumasa Fujita, Yasunori Nawa, Satoshi Fujita
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Patent number: 11385448Abstract: A microscope apparatus includes: a sample setting unit in which a sample is set; an imaging unit configured to image the sample set in the sample setting unit; a housing unit on which the sample setting unit is arranged, and which is configured to internally accommodate the imaging unit; a first light source configured to irradiate light for fluorescence excitation on the sample in the sample setting unit; a first cover configured to be movable to a first position that covers the sample setting unit and a second position that opens the sample setting unit; and a second cover configured to be movable within the first cover; and a second light source arranged in a space covered with the second cover and configured to irradiate light on the sample in the sample setting unit.Type: GrantFiled: September 26, 2019Date of Patent: July 12, 2022Assignee: SYSMEX CORPORATIONInventors: Masaya Okada, Shigeki Iwanaga
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Cell imaging method, cell imaging apparatus, particle imaging method, and particle imaging apparatus
Patent number: 11366097Abstract: Disclosed is a cell imaging method including: forming a light sheet with respect to a flow cell; causing a measurement sample containing a plurality of cells to flow in the flow cell; and receiving lights generated from the plurality of cells passing through the light sheet, by an imaging device via an element configured to extend a depth of focus, and taking images of the plurality of cells by the imaging device.Type: GrantFiled: January 30, 2018Date of Patent: June 21, 2022Assignee: SYSMEX CORPORATIONInventors: Masaya Okada, Shigeki Iwanaga -
Patent number: 11285077Abstract: A blood collection device including a flow path to flow blood by capillary action capable of collecting a large amount of blood is provided. The blood collection device includes an introduction inlet 23 for introducing the blood of the subject M, a substrate 20 connected to the introduction inlet 23 and including a flow path 25 to flow the blood by capillary action, and a cooling body 30 for cooling the flow path 25.Type: GrantFiled: July 19, 2017Date of Patent: March 29, 2022Assignee: SYSMEX CORPORATIONInventors: Ayato Tagawa, Junko Kojima, Nobuyasu Hori, Kenji Akama, Masaya Okada, Kunpeng Cai, Samiko Hosoya, Shigeki Iwanaga
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Patent number: 11112404Abstract: Disclosed is a method for obtaining information of a test substance, the method including: forming a complex by causing a capture substance to bind to a test substance in a specimen; selectively collecting at least the complex from the specimen; immobilizing the complex collected from the specimen, onto a base plate; and obtaining information regarding a structure of the test substance from the complex immobilized on the base plate.Type: GrantFiled: April 12, 2018Date of Patent: September 7, 2021Assignee: SYSMEX CORPORATIONInventors: Kenji Akama, Toshihiro Watanabe, Masaya Okada, Kazuto Yamashita, Akshay Ganguly, Shigeki Iwanaga
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Publication number: 20210255191Abstract: Disclosed is: a fluorescent dye comprising a compound, a tautomer of the compound, or a salt of the compound or the tautomer; a labeled composite substance comprising the fluorescent dye and a composite substance which are bonded to each other; a composition containing the fluorescent dye or the labeled composite substance; and a method for acquiring information about a substance of interest by a super-resolution microscopy.Type: ApplicationFiled: February 1, 2021Publication date: August 19, 2021Applicants: Eisai R&D Management Co., Ltd., SYSMEX CORPORATIONInventors: Daiki HARA, Takafumi Motoki, Yuji Kazuta, Yoshihiko Norimine, Hiroyuki Amino, Masatoshi Suganuma, Shingo Fujiyama, Kazuto Yamashita, Masaya Okada, Yoichi Nishikawa, Shigeki Iwanaga
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Patent number: 10904491Abstract: A method according to one or more aspects may control a microscope system including an imaging unit configured to image a sample, and a display unit including a first display region and a second display region. The method may include: sequentially displaying, in the first display region, first images sequentially captured by the imaging unit; and displaying, in the second display region, a second image generated based on information extracted from the sequentially captured first images.Type: GrantFiled: September 23, 2019Date of Patent: January 26, 2021Assignee: SYSMEX CORPORATIONInventors: Masaya Okada, Shigeki Iwanaga
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Publication number: 20200264181Abstract: The present invention provides a method for determining a success or failure of a measurement of a target particle contained in a measurement sample. The method includes: detecting the target particle and other particle other than the target particle in the measurement sample; and determining the success or failure of the measurement of the target particle based on at least a detection result of the other particle.Type: ApplicationFiled: February 18, 2020Publication date: August 20, 2020Applicant: SYSMEX CORPORATIONInventors: Yusuke TAKAHASHI, Masatoshi YANAGIDA, Kentaro SHIRAI, Yuichi IJIRI, Shigeki IWANAGA
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Publication number: 20200264170Abstract: Disclosed is a method for acquiring information on an analyte, comprising the steps of: bringing a polypeptide that is the analyte into contact with a capture substance that binds to the polypeptide to form a complex comprising the polypeptide and the capture substance; bonding the capture substance in the complex to a first solid phase to immobilize the complex onto the first solid phase; collecting the first solid phase having the complex immobilized on the first solid phase; releasing the complex from the collected first solid phase, and then bonding the capture substance in the released complex to a second solid phase to immobilize the complex onto the second solid phase; and acquiring information on the polypeptide from the complex immobilized on the second solid phase, wherein a capture substance that binds to at least one of the first solid phase and the second solid phase binds to a C-terminal region of the polypeptide.Type: ApplicationFiled: February 4, 2020Publication date: August 20, 2020Applicant: SYSMEX CORPORATIONInventors: Kazuto YAMASHITA, Akshay GANGULY, Naoya SAIKI, Shigeki IWANAGA
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Patent number: 10732095Abstract: A particle imaging device comprises a flow cell, a light source, an irradiation optical system configured to form a light sheet on the flow cell, a light collecting optical system and an imaging element. The sheet surface of the light sheet is perpendicular to the exterior side surface of the flow cell to which the light is entered from the light source. The sheet surface of the light sheet is inclined at a predetermined angle that is not perpendicular to the flow direction of the sample.Type: GrantFiled: September 16, 2016Date of Patent: August 4, 2020Assignee: SYSMEX CORPORATIONInventors: Masaya Okada, Shigeki Iwanaga
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Patent number: 10676784Abstract: A sample analyzing method includes: denaturing DNA by heating a measurement specimen; bleaching the measurement specimen to inhibit autofluorescence from the measurement specimen; binding a fluorescent dye to a test substance in the measurement specimen; and capturing an image of fluorescence originated from the fluorescent dye by irradiating the measurement specimen with light. The DNA denaturation treatment is performed before the bleaching.Type: GrantFiled: March 21, 2016Date of Patent: June 9, 2020Assignee: SYSMEX CORPORATIONInventors: Takuya Kubo, Shigeki Iwanaga
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Publication number: 20200173980Abstract: A method of determining a quality of a cell separation, according to an aspect, includes: separating, by running a specimen containing a first particle and a second particle in a flow path, the specimen to a first specimen containing the first particle and a second specimen containing the second particle, based on a difference in magnitude of a force exerted on each particle contained in the specimen; measuring first information on an amount of the first specimen and second information on an amount of the second specimen; and determining a quality of the separating based on the first information and the second information.Type: ApplicationFiled: November 27, 2019Publication date: June 4, 2020Applicant: SYSMEX CORPORATIONInventors: Yusuke TAKAHASHI, Kentaro SHIRAI, Masatoshi YANAGIDA, Shigeki IWANAGA, Yuichi IJIRI, Keiko YOSHIKAWA
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Publication number: 20200103347Abstract: A microscope apparatus includes: a sample setting unit in which a sample is set; an imaging unit configured to image the sample set in the sample setting unit; a housing unit on which the sample setting unit is arranged, and which is configured to internally accommodate the imaging unit; a first light source configured to irradiate light for fluorescence excitation on the sample in the sample setting unit; a first cover configured to be movable to a first position that covers the sample setting unit and a second position that opens the sample setting unit; and a second cover configured to be movable within the first cover; and a second light source arranged in a space covered with the second cover and configured to irradiate light on the sample in the sample setting unit.Type: ApplicationFiled: September 26, 2019Publication date: April 2, 2020Applicant: SYSMEX CORPORATIONInventors: Masaya OKADA, Shigeki IWANAGA
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Publication number: 20200106993Abstract: A method according to one or more aspects may control a microscope system including an imaging unit configured to image a sample, and a display unit including a first display region and a second display region. The method may include: sequentially displaying, in the first display region, first images sequentially captured by the imaging unit; and displaying, in the second display region, a second image generated based on information extracted from the sequentially captured first images.Type: ApplicationFiled: September 23, 2019Publication date: April 2, 2020Applicant: SYSMEX CORPORATIONInventors: Masaya OKADA, Shigeki IWANAGA
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Patent number: 10604731Abstract: Provided is a cell analyzer including: a light source unit configured to apply light to test cells each containing first substances which are bound to first fluorescent dyes and which serve as an index for therapeutic strategy judgement; an image capturing unit configured to capture an image of fluorescence caused by the light; a processing unit configured to process the image obtained by the image capturing unit; and a display unit configured to display a process result obtained by the processing unit, wherein the processing unit obtains a first image by performing an inactivation process of quenching the first fluorescent dyes, an activation process of activating a part of the first fluorescent dyes that have been quenched, and an image capturing process of capturing, by means of the image capturing unit, an image of the fluorescence by applying light from the light source unit to each test cell; extracts bright points based on the first fluorescent dyes on the basis of the first image; classifies the extraType: GrantFiled: September 5, 2017Date of Patent: March 31, 2020Assignee: SYSMEX CORPORATIONInventors: Kanako Masumoto, Takuya Kubo, Shigeki Iwanaga, Masaya Okada
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Publication number: 20200095631Abstract: A sample analyzing method includes: denaturing DNA by heating a measurement specimen; bleaching the measurement specimen to inhibit autofluorescence from the measurement specimen; binding a fluorescent dye to a test substance in the measurement specimen; and capturing an image of fluorescence originated from the fluorescent dye by irradiating the measurement specimen with light. The DNA denaturation treatment is performed before the bleaching.Type: ApplicationFiled: October 21, 2019Publication date: March 26, 2020Applicant: SYSMEX CORPORATIONInventors: Takuya KUBO, Shigeki IWANAGA
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Patent number: 10585275Abstract: Disclosed is a microscope device that includes: a sample placement unit on which a sample is set; an imaging unit configured to take an image of the sample that is set on the sample placement unit; a case in which the sample placement unit is provided and the imaging unit is disposed; a display unit configured to display the image taken by the imaging unit; and a moving unit, provided integrally with the display unit, configured to be movable relative to the sample placement unit.Type: GrantFiled: September 12, 2017Date of Patent: March 10, 2020Assignee: Sysmex CorporationInventors: Masaya Okada, Shigeki Iwanaga