Patents by Inventor Shigeki MUKOUBATA

Shigeki MUKOUBATA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High-affinity anti-VEGF antibody KLHa505
    Patent number: 11872271
    Abstract: An object of the present invention is to provide an antibody having significantly high affinity for VEGF compared to the prior art. The present invention provides a monoclonal antibody against VEGF, which binds to a vascular endothelial growth factor (VEGF) with a dissociation constant of 1×10?11 mol/L or less.
    Type: Grant
    Filed: April 13, 2021
    Date of Patent: January 16, 2024
    Assignees: ORDER-MADE MEDICAL RESEARCH INC., SANTEN PHARMACEUTICAL CO., LTD.
    Inventors: Yasufumi Murakami, Shigeki Mukoubata, Hirotada Akiyama, Koji Konomi
  • HIGH-AFFINITY ANTI-VEGF ANTIBODY
    Publication number: 20210228700
    Abstract: An object of the present invention is to provide an antibody having significantly high affinity for VEGF compared to the prior art. The present invention provides a monoclonal antibody against VEGF, which binds to a vascular endothelial growth factor (VEGF) with a dissociation constant of 1×10?11 mol/L or less.
    Type: Application
    Filed: April 13, 2021
    Publication date: July 29, 2021
    Applicants: ORDER-MADE MEDICAL RESEARCH INC., SANTEN PHARMACEUTICAL CO., LTD.
    Inventors: Yasufumi MURAKAMI, Shigeki MUKOUBATA, Hirotada AKIYAMA, Koji KONOMI
  • High-affinity anti-VEGF antibody
    Patent number: 11007259
    Abstract: An object of the present invention is to provide an antibody having significantly high affinity for VEGF compared to the prior art. The present invention provides a monoclonal antibody against VEGF, which binds to a vascular endothelial growth factor (VEGF) with a dissociation constant of 1×10?11 mol/L or less.
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: May 18, 2021
    Assignees: ORDER-MADE MEDICAL RESEARCH INC., SANTEN PHARMACEUTICAL CO., LTD.
    Inventors: Yasufumi Murakami, Shigeki Mukoubata, Hirotada Akiyama, Koji Konomi
  • Antibody inhibiting binding of VEGF to NRP1
    Patent number: 11008387
    Abstract: An object of the present invention is to provide an antibody against VEGF that inhibits binding of a vascular endothelial growth factor (VEGF) to neuropilin-1 (NRP1). The present invention provides an antibody against VEGF that inhibits binding of VEGF to NRP1.
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: May 18, 2021
    Assignees: ORDER-MADE MEDICAL RESEARCH INC., SANTEN PHARMACEUTICAL CO., LTD.
    Inventors: Yasufumi Murakami, Hiroyuki Satofuka, Shigeki Mukoubata, Hirotada Akiyama, Tatsuji Kurose, Sae Akao
  • HIGH-AFFINITY ANTI-VEGF ANTIBODY
    Publication number: 20200165330
    Abstract: An object of the present invention is to provide an antibody having significantly high affinity for VEGF compared to the prior art. The present invention provides a monoclonal antibody against VEGF, which binds to a vascular endothelial growth factor (VEGF) with a dissociation constant of 1×10?11 mol/L or less.
    Type: Application
    Filed: January 5, 2017
    Publication date: May 28, 2020
    Applicants: ORDER-MADE MEDICAL RESEARCH INC., SANTEN PHARMACEUTICAL CO., LTD.
    Inventors: Yasufumi MURAKAMI, Shigeki MUKOUBATA, Hirotada AKIYAMA, Koji KONOMI
  • ANTIBODY INHIBITING BINDING OF VEGF TO NRP1
    Publication number: 20190322732
    Abstract: An object of the present invention is to provide an antibody against VEGF that inhibits binding of a vascular endothelial growth factor (VEGF) to neuropilin-1 (NRP1). The present invention provides an antibody against VEGF that inhibits binding of VEGF to NRP1.
    Type: Application
    Filed: January 5, 2017
    Publication date: October 24, 2019
    Applicants: ORDER-MADE MEDICAL RESEARCH INC., SANTEN PHARMACEUTICAL CO., LTD.
    Inventors: Yasufumi MURAKAMI, Hiroyuki SATOFUKA, Shigeki MUKOUBATA, Hirotada AKIYAMA, Tatsuji KUROSE, Sae AKAO