Patents by Inventor Shigeki Nunomura
Shigeki Nunomura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6835720Abstract: In order to provide the anti-retrovirus active compound with low anti-coagulant action and low cytotoxicity, compounds comprising glycoside or the salt thereof wherein lipid is linked to position 2 of sialic acid having all hydroxyl groups at positions 4, 7, 8 and 9 completely sulfated, or KDN (2-keto-3-deoxy-D-glycero-2-nononic acid) having all hydroxyl groups at positions 4, 5, 7, 8 and 9 completely sulfated are provided.Type: GrantFiled: September 23, 2002Date of Patent: December 28, 2004Assignee: Nissin Food Products Co., Ltd.Inventors: Shuji Fujita, Masaaki Numata, Kazuo Suzuki, Shigeki Nunomura, Mamoru Sugimoto, Masaki Terada
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Publication number: 20030073664Abstract: In order to provide the anti-retrovirus active compound with low anti-coagulant action and low cytotoxicity, compounds comprising glycoside or the salt thereof wherein lipid is linked to position 2 of sialic acid having all hydroxyl groups at positions 4, 7, 8 and 9 completely sulfated, or KDN (2-keto-3-deoxy-D-glycero-2-nononic acid) having all hydroxyl groups at positions 4, 5, 7, 8 and 9 completely sulfated are provided.Type: ApplicationFiled: September 23, 2002Publication date: April 17, 2003Applicant: Nissin Food Products Co., Ltd.Inventors: Shuji Fujita, Masaaki Numata, Kazuo Suzuki, Shigeki Nunomura, Mamoru Sugimoto, Masaki Terada
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Patent number: 6541461Abstract: In order to provide the anti-retrovirus active compound with low anti-coagulant action and low cytotoxicity, compounds comprising glycoside or the salt thereof wherein lipid is linked to position 2 of sialic acid having all hydroxyl groups at positions 4, 7, 8 and 9 completely sulfated, or KDN (2-keto-3-deoxy-D-glycero-2-nononic acid) having all hydroxyl groups at positions 4, 5, 7, 8 and 9 completely sulfated are provided.Type: GrantFiled: October 31, 2001Date of Patent: April 1, 2003Assignee: Nissin Food Products Co., Ltd.Inventors: Shuji Fujita, Masaaki Numata, Kazuo Suzuki, Shigeki Nunomura, Mamoru Sugimoto, Masaki Terada
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Publication number: 20020077472Abstract: In order to provide the anti-retrovirus active compound with low anti-coagulant action and low cytotoxicity, compounds comprising glycoside or the salt thereof wherein lipid is linked to position 2 of sialic acid having all hydroxyl groups at positions 4, 7, 8 and 9 completely sulfated, or KDN (2-keto-3-deoxy-D-glycero-2-nononic acid) having all hydroxyl groups at positions 4, 5, 7, 8 and 9 completely sulfated are provided.Type: ApplicationFiled: October 31, 2001Publication date: June 20, 2002Applicant: Nissin Food Products Co., Ltd.Inventors: Shuji Fujita, Masaaki Numata, Kazuo Suzuki, Shigeki Nunomura, Mamoru Sugimoto, Masaki Terada
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Patent number: 6337390Abstract: In order to provide the anti-retrovirus active compound with low anti-coagulant action and low cytotoxicity, compounds comprising glycoside or the salt thereof wherein lipid is linked to position 2 of sialic acid having all hydroxyl groups at positions 4, 7, 8 and 9 completely sulfated, or KDN (2-keto-3-deoxy-D-glycero-2-nononic acid) having all hydroxyl groups at positions 4, 5, 7, 8 and 9 completely sulfated are provided.Type: GrantFiled: January 19, 1999Date of Patent: January 8, 2002Assignee: Nissan Food Products Co., Ltd.Inventors: Shuji Fujita, Masaaki Numata, Kazuo Suzuki, Shigeki Nunomura, Mamoru Sugimoto, Masaki Terada
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Patent number: 5763413Abstract: A Lewis-associated compound, represented by general formula (I), a process for producing the same, and an anti-inflammatory, wherein R.sup.1 and R.sup.3 represent each hydrogen, m SO.sub.3 H or CH.sub.2 COOH; R.sup.2 represents hydrogen, SO.sub.3 H, CH.sub.2 COOH or N-acetyl-neutraminic acid residue; R.sup.4 represents hydrogen; R.sup.5 represents O-lower alkyl, O-lower alkenyl, O-ceramide residue, O-mannose residue, O-galactose residue or O-lactose residue; R.sup.6 represents acetylamine; and R.sup.7 and R.sup.8 represent each hydrogen.Type: GrantFiled: August 30, 1995Date of Patent: June 9, 1998Assignee: MECT CorporationInventors: Masaaki Numata, Shigeki Nunomura, Shuji Fujita, Masami Iida, Akira Endo, Takayuki Ishii, Tomoya Ogawa, Mamoru Sugimoto, Ryoichi Osawa, Masamichi Fujita
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Patent number: 5470962Abstract: An oligosialyl-1,2-dialkyl-sn-glycerol represented by the following formula (I): ##STR1## wherein each R.sup.1 independently represents a group selected from the group consisting of a hydrogen atom and alkali metal atoms, each R.sup.2 independently represents an alkyl group having 14 to 18 carbon atoms, Ac represents an acetyl group, and n represents an integer of from 0 to 20, and synthetic intermediates for their preparation useful as an immuno-stimulating agent, an antitumor agent, and a diagnostic and therapeutic agent for cancers.Type: GrantFiled: September 7, 1993Date of Patent: November 28, 1995Assignees: Rikagaku Kenkyusho, Mect CorporationInventors: Tomoya Ogawa, Shigeki Nunomura, Mamoru Sugimoto
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Patent number: 5101026Abstract: The present invention relates to ganglioside related compounds having, for example, the following formula: ##STR1## where R.sub.1 represents H or COCH.sub.3 (hereinafter abbreviated to "AC"); R.sub.2 represents H or CH.sub.3 ; and R.sub.3 represents --OH, ##STR2## These ganglioside related compounds are useful as membrane receptors, tumor markers, cell growth controlling substances, etc., and useful for immunotherapy for cancer, etc.Type: GrantFiled: August 6, 1987Date of Patent: March 31, 1992Assignee: MECT CorporationInventors: Tomoya Ogawa, Mamoru Sugimoto, Masaaki Numata, Masayoshi Ito, Yoshiyasu Shitori, Shigeki Nunomura
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Patent number: 4820730Abstract: Amidine compounds of formula (I) ##STR1## and the pharmaceutically acceptable acid addition salts thereof are novel and are of use as anti-trypsin, anti-plasmin, anti-kallikrein, anti-thrombin and anti-complement agents which may be administered orally. These amidine compounds can be produced by the reaction between a carboxylic acid compound of formula (II) ##STR2## or a reactive intermediate thereof and 6-amidino-2-naphthol of formula (III) ##STR3## or preferably an acid addition salt thereof.Type: GrantFiled: July 11, 1988Date of Patent: April 11, 1989Assignee: Torii & Co., Ltd.Inventors: Setsurou Fujii, Toshiyuki Okutome, Toyoo Nakayama, Shigeki Nunomura, Kimio Sudo, Shinichi Watanabe, Masateru Kurumi, Takuo Aoyama
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Patent number: 4777182Abstract: Amidine compounds of formula (I) ##STR1## and the pharmaceutically acceptable acid addition salts thereof are novel and are of use as anti-trypsin, anti-plasmin, anti-kallikrein, anti-thrombin and anti-complement agents which may be administered orally. These amidine compounds can be produced by the reaction between a carboxylic acid compound of formula (II) ##STR2## or a reactive intermediate thereof and 6-amidino-2-naphthol of formula (III) ##STR3## or preferably an acid addition salt thereof.Type: GrantFiled: February 24, 1986Date of Patent: October 11, 1988Assignee: Torii & Co., Ltd.Inventors: Setsurou Fujii, Toshiyuki Okutome, Toyoo Nakayama, Shigeki Nunomura, Kimio Sudo, Shinichi Watanabe, Masateru Kurumi, Takuo Aoyama
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Patent number: 4634783Abstract: Amidine compounds of the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful anti-trypsin, anti-plasmin, anti-kallikrein and anti-thrombin agents. They are also useful as a powerful anti-complement agent.Type: GrantFiled: January 23, 1984Date of Patent: January 6, 1987Assignee: Torii & Co. Ltd.Inventors: Setsuro Fujii, Toyoo Nakayama, Shigeki Nunomura, Ryoji Matsui, Shin-ichi Watanabe, Kimio Sudo, Toshiyuki Okutome, Masateru Kurumi, Yojiro Sakurai, Takuo Aoyama
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Patent number: 4570006Abstract: Amidino compounds represented by the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful anti-trypsine, anti-plasmin, anti-kallikrein and anti-thrombin agents. Having strong anti-Cl (Clr, Cls) activities and an anticomplement activity, they are also useful as anticomplement agents. These amidino compounds are prepared by usual esterification of carboxylic acid compounds represented by the formula (II)R.sub.1 --COOH (II)with amidinophenol compound (III) and, if necessary, can be transformed into pharmaceutically acceptable acid addition salts thereof.Type: GrantFiled: October 24, 1984Date of Patent: February 11, 1986Assignee: Torii & Co. Ltd.Inventors: Setsuro Fujii, Takashi Yaegashi, Toyoo Nakayama, Yojiro Sakurai, Shigeki Nunomura, Toshiyuki Okutome
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Patent number: 4563527Abstract: Amidine compounds of the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful anti-trypsin, anti-plasmin, anti-kallikrein and anti-thrombin agents. They are also useful as a powerful anti-complement agent.Type: GrantFiled: July 19, 1984Date of Patent: January 7, 1986Assignee: Torii & Co., Ltd.Inventors: Setsuro Fujii, Toyoo Nakayama, Shigeki Nunomura, Kimio Sudo, Shin-ichi Watanabe, Toshiyuki Okutome, Yojiro Sakurai, Masateru Kurumi, Takuo Aoyama
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Patent number: 4514416Abstract: Amidino compounds represented by the formula (I) ##STR1## and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful antitrypsine, antiplasmin, antikallikrein and anti-thrombin agents. Having strong anti-Cl (Clr, Cls) activities and an anticomplement activity, they are also useful as anticomplement agents. These amidino compounds are prepared by usual esterification of carboxylic acid compounds represented by the formula (II)R.sub.1 --COOH (II)with amidinophenol compound (III) and, if necessary, can be transformed into pharmaceutically acceptable acid addition salts thereof.Type: GrantFiled: May 21, 1984Date of Patent: April 30, 1985Assignee: Torii & Co. Ltd.Inventors: Setsuro Fujii, Takashi Yaegashi, Toyoo Nakayama, Yojiro Sakurai, Shigeki Nunomura, Toshiyuki Okutome
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Patent number: 4496584Abstract: Amidino compounds represented by the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful antitrypsin, antiplasmin, antikallikrein and antithrombin agents. Having strong anti-Cl activity and anti-complement activity, they are also useful as anti-complement agents. These amidino compounds are prepared by reacting carboxylic compounds represented by the formulaR.sub.1 --COOHor their reactive intermediates with amidinonaphthol represented by the formula ##STR2## and, if necessary, can be transformed into pharmaceutically acceptable acid addition salts thereof.Type: GrantFiled: April 21, 1982Date of Patent: January 29, 1985Assignee: Torii & Co. Ltd.Inventors: Setsuro Fujii, Takashi Yaegashi, Toyoo Nakayama, Shigeki Nunomura, Yojiro Sakurai, Toshiyuki Okutome
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Patent number: 4490388Abstract: Amidino compounds represented by the formula (I) ##STR1## and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful antitrypsine, antiplasmin, antikallikrein and anti-thrombin agents. Having strong anti-Cl (Clr, Cls) activities and an anticomplement activity, they are also useful as anticomplement agents. These amidino compounds are prepared by usual esterification of carboxylic acid compounds represented by the formula (II)R.sub.1 --COOH (II)with 4-(.beta.-amidinoethenyl)phenol represented by the formula (III) ##STR2## and, if necessary, can be transformed into pharmaceutically acceptable acid addition salts thereof.Type: GrantFiled: February 22, 1982Date of Patent: December 25, 1984Assignee: Torii & Co., Ltd.Inventors: Setsuro Fujii, Takuo Aoyama, Yojiro Sakurai, Toyoo Nakayama, Shigeki Nunomura, Takashi Yaegashi, Toshiyuki Okutome