Abstract: A pneumatic tire comprises a tread portion, a pair of sidewall portions, a pair of bead portions, a carcass extending between the portions, and an inner rubber extending between the portions, on the inner side of the carcass. The inner rubber comprises a first portion extending through the tread portion with a first thickness and a second portion extending through the sidewall portions with a second thickness smaller than the first thickness. The land ratio of the tread portion 2 is 65% or more.

Abstract: A top emission organic EL element includes a substrate, an insulating layer including a hole portion, a lower electrode, a light emitting layer, a bank surrounding the lower electrode and the light emitting layer, and an upper transparent electrode. The insulating layer, the lower electrode, the light emitting layer, the bank, and the upper transparent electrode are disposed above the substrate. The bank is arranged on the insulating layer so as to surround the hole portion. The lower electrode is configured to cover an inner side of the hole portion and an area, where the bank is not arranged, of an upper surface of the insulating layer, and a thickness at a center area of the lower electrode is 150 nm or more.

Abstract: Provided is a labeling method for nucleic acid including a reaction step for hybridizing a nucleic acid probe that has a nucleotide sequence complementary to that of a nucleic acid to be labeled and contains a reactive nucleobase derivative incorporated at a position complementary to that of a target nucleobase as a target of labeling in the nucleic acid to be labeled, to the nucleic acid to be labeled; a transferring step for transferring a transfer group contained in the reactive nucleobase derivative to the nucleotide residue containing the target nucleobase in the nucleic acid to be labeled; and a labeling step for labeling the transfer group transferred to the nucleotide residue with a radioactive material.

Abstract: Provided is a labeling method for nucleic acid including a reaction step for hybridizing a nucleic acid probe that has a nucleotide sequence complementary to that of a nucleic acid to be labeled and contains a reactive nucleobase derivative incorporated at a position complementary to that of a target nucleobase as a target of labeling in the nucleic acid to be labeled, to the nucleic acid to be labeled; a transferring step for transferring a transfer group contained in the reactive nucleobase derivative to the nucleotide residue containing the target nucleobase in the nucleic acid to be labeled; and a labeling step for labeling the transfer group transferred to the nucleotide residue with a radioactive material.

Abstract: A top emission organic EL element includes a substrate, an insulating layer including a hole portion, a lower electrode, a light emitting layer, a bank surrounding the lower electrode and the light emitting layer, and an upper transparent electrode. The insulating layer, the lower electrode, the light emitting layer, the bank, and the upper transparent electrode are disposed above the substrate. The bank is arranged on the insulating layer so as to surround the hole portion. The lower electrode is configured to cover an inner side of the hole portion and an area, where the bank is not arranged, of an upper surface of the insulating layer, and a thickness at a center area of the lower electrode is 150 nm or more.

Abstract: There is provided a method for quantitatively detecting 8-oxo 2?-deoxyguanosine in an aqueous sample solution with high sensitivity. A method for quantitatively detecting 8-oxo 2?-deoxyguanosine in an aqueous sample solution, including the steps of 1) immobilizing a fluorescent probe molecule showing a fluorescence response specific to 8-oxo 2?-deoxyguanosine on surfaces of fine particles via a spacer unit and bringing the sample solution into contact with the fine particles, and 2) measuring a physical property of the fine particles before and after the contact with the sample solution to determine a change in the physical property.

Abstract: There is provided a method for quantitatively detecting 8-oxo 2?-deoxyguanosine in an aqueous sample solution with high sensitivity. A method for quantitatively detecting 8-oxo 2?-deoxyguanosine in an aqueous sample solution, including the steps of 1) immobilizing a fluorescent probe molecule showing a fluorescence response specific to 8-oxo 2?-deoxyguanosine on surfaces of fine particles via a spacer unit and bringing the sample solution into contact with the fine particles, and 2) measuring a physical property of the fine particles before and after the contact with the sample solution to determine a change in the physical property.

Abstract: The invention provides a conjugate of functional oligonucleotide with poly(ethylene oxide), polyion complex of the conjugate with cationic polymer, and micelle thereof. The micelle improves stability of the oligonucleotide in animal cells and its specific bindability to target gene.

Abstract: The present invention provides a thionucleoside-S-nitrosyl derivative of the following Formula I or a salt thereof: [wherein R1 represents ribose, 2-deoxyribose or a derivative of either, and R2 represents a hydrogen atom, an amino group, a hydroxyl group, a halogen atom, a R3-oxy group or a R3-amino group (wherein R3 represents an optionally substituted C1-15 alkyl group or an optionally substituted C1-15 acyl group)].

Abstract: The invention provides a conjugate of functional oligonucleotide with poly(ethylene oxide), polyion complex of the conjugate with cationic polymer, and micelle thereof. The micelle improves stability of the oligonucleotide in animal cells and its specific bindability to target gene.

Abstract: The present invention provides a thionucleoside-S-nitrosyl derivative of the following Formula I or a salt thereof: [wherein R1 represents ribose, 2-deoxyribose or a derivative of either, and R2 represents a hydrogen atom, an amino group, a hydroxyl group, a halogen atom, a R3-oxy group or a R3-amino group (wherein R3 represents an optionally substituted C1-15 alkyl group or an optionally substituted C1-15 acyl group)].

Abstract: There are provided 2-aminopurine derivatives represented by the following general formula (1): where R represents any species selected from the group consisting of hydrogen and acyl groups, X represents any species selected from the group consisting of phosphoramidite and oligonucleotides, Y represents any species selected from the group consisting of dimethyltrityl groups and oligonucleotides, and Z1, Z2, Z3, Z4 and Z5 are the same or different and represent any species selected from the group consisting of hydrogen and hydroxyl, amino, lower alkyl, alkoxy, carboxyl and sulfonic acid groups, provided that Z1, Z2, Z3, Z4 and Z5 are not all hydrogen, as well as gene expression-regulating compositions characterized by comprising the derivatives. By introducing the 2-aminopurine derivatives into oligonucleotides it is possible to achieve crosslinking reaction with high reactivity for target nucleic acids and notably high base sequence specificity.

Abstract: A constant-speed exhaust valve device has a valve body of a cylindrical shape opened at both axial ends, and a push means disposed to apply an axial compressive force to the valve body, whereby the exhaust speed of the device can be made steady and manufacturing yield of the device is made excellent.