Patents by Inventor Shigenari Hirokawa

Shigenari Hirokawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of identifying abnormal cells by expression levels of ETFB
    Patent number: 9562912
    Abstract: Provided is a method for identifying and suppressing abnormal growth of fibroblasts at an early stage. Provided is a method for identifying the growth state of fibroblasts using as an index the level of expression of ETFB (electron transfer flavoprotein beta subunit), comprising: judging, in cases where the level of expression of ETFB is high, that there is a high probability that fibroblasts are abnormally growing; and judging, in cases where the level of expression of ETFB is low, that there is a high probability that fibroblasts are normally growing. Further, by inhibition of ETFB, abnormal growth of fibroblasts can be suppressed.
    Type: Grant
    Filed: December 27, 2011
    Date of Patent: February 7, 2017
    Assignee: POLA PHARMA INC.
    Inventors: Shigenari Hirokawa, Hiroyuki Kitajima, Tomomasa Shimanuki
  • METHOD OF APPLYING ETFB TO ABNORMAL PROLIFERATION OF CELL, AND ABNORMAL PROLIFERATION INHIBITOR
    Publication number: 20140235491
    Abstract: Provided is a method for identifying and suppressing abnormal growth of fibroblasts at an early stage. Provided is a method for identifying the growth state of fibroblasts using as an index the level of expression of ETFB (electron transfer flavoprotein beta subunit), comprising: judging, in cases where the level of expression of ETFB is high, that there is a high probability that fibroblasts are abnormally growing; and judging, in cases where the level of expression of ETFB is low, that there is a high probability that fibroblasts are normally growing. Further, by inhibition of ETFB, abnormal growth of fibroblasts can be suppressed.
    Type: Application
    Filed: December 27, 2011
    Publication date: August 21, 2014
    Applicant: POLA PHARMA INC.
    Inventors: Shigenari Hirokawa, Hiroyuki Kitajima, Tomomasa Shimanuki
  • Triterpenic acid derivative and preparation for external application for skin comprising the same
    Patent number: 7718635
    Abstract: In a triterpenic acid having hydroxyl groups, at least one of the hydroxyl groups is phosphorylated to produce a phosphorylated triterpenic acid and/or a salt thereof, thereby improving the solubility of the triterpenic acid in a preparation for external application for the skin and allowing the physiological activity of the triterpenic acid to be exerted satisfactorily. The phosphorylated triterpenic acid is preferably, for example, ursolic acid phosphate and/or a salt thereof. The preparation for external application for the skin is preferably a cosmetic, particularly preferably a quasi-drug.
    Type: Grant
    Filed: April 13, 2006
    Date of Patent: May 18, 2010
    Assignee: Pola Chemical Industries Inc.
    Inventors: Michio Ochiai, Kenichi Goto, Yoshihiro Tokudome, Shigenari Hirokawa
  • NOVEL TRITERPENIC ACID DERIVATIVE AND PREPARATION FOR EXTERNAL APPLICATION FOR SKIN COMPRISING THE SAME
    Publication number: 20090075946
    Abstract: In a triterpenic acid having hydroxyl groups, at least one of the hydroxyl groups is phosphorylated to produce a phosphorylated triterpenic acid and/or a salt thereof, thereby improving the solubility of the triterpenic acid in a preparation for external application for the skin and allowing the physiological activity of the triterpenic acid to be exerted satisfactorily. The phosphorylated triterpenic acid is preferably, for example, ursolic acid phosphate and/or a salt thereof. The preparation for external application for the skin is preferably a cosmetic, particularly preferably a quasi-drug.
    Type: Application
    Filed: April 13, 2006
    Publication date: March 19, 2009
    Applicant: Pola Chemical Industries Inc.
    Inventors: Michio Ochiai, Kenichi Goto, Yoshihiro Tokudome, Shigenari Hirokawa