Patents by Inventor Shigenobu Nakayama

Shigenobu Nakayama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Catechol derivatives, and preventive and remedial preparations for regressive disorders in the central nervous system containing the same
    Patent number: 5214034
    Abstract: Catechol derivatives which relate to the production of nerve growth factor in particular tissues of brain are disclosed.Methods for the synthesis, data on the physiological activity, and data on the toxicity of these derivatives as well as examples of preparation for their administration are also disclosed.The disclosed derivatives provide preventive and remedial effect for regressive disorders in the central nervous system including senile dementia of Alzheimer type.
    Type: Grant
    Filed: December 3, 1991
    Date of Patent: May 25, 1993
    Assignee: Mitsui Toatsu Chemicals, Incorporated
    Inventors: Shigenobu Nakayama, Fumiaki Ikeda
  • Catechol derivatives, and preventive and remedial preparations for regressive disorders in the central nervous system containing the same
    Patent number: 5102906
    Abstract: Catechol derivatives which relate to the production of nerve growth factor in particular tissues of brain are disclosed.Methods for the synthesis, data on the physiological activity, and data on the toxicity of these derivatives as well as examples of preparation for their administration are also disclosed.The disclosed derivatives provide preventive and remedial effect for regressive disorders in the central nervous system including senile dementia of Alzheimer type.
    Type: Grant
    Filed: October 31, 1990
    Date of Patent: April 7, 1992
    Assignee: Mitsui Toatsu Chemicals, Incorporated
    Inventors: Shigenobu Nakayama, Fumiaki Ikeda
  • Catechol diacetate derivatives for inducing the production of nerve growth factor to treat degenerative diseases in the central nervous system
    Patent number: 4985458
    Abstract: A pharmaceutical composition for the treatment of regressive disorders of the central nervous system treatable by inducing the production and secretion of nerve growth factor, containing as an active ingredient a catechol derivative of the formula ##STR1## where R.sub.6 is a lower alkyl group having 2 to 5 carbon atoms. The catechol derivatives provide preventative and remedial effects for regressive disorders in the central nervous system including senile dementia of the alzheimer type.
    Type: Grant
    Filed: February 20, 1990
    Date of Patent: January 15, 1991
    Assignee: Mitsui Toatsu Chemicals, Incorporated
    Inventors: Shigenobu Nakayama, Fumiaki Ikeda
  • Process for producing 2-mercaptoethylamine hydrohalides
    Patent number: 4507500
    Abstract: A process for producing 2-mercaptoethylamine hydrohalides of the general formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are identical or different, and each represents a hydrogen atom, a lower alkyl group, a hydroxy-substituted lower alkyl group or a phenyl group, and X represents a halogen atom,which comprises reacting a 2-mercaptothiazoline of the general formula ##STR2## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined above, with a 2-halogenoethylamine hydrohalide of the general formula ##STR3## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and X are as defined above, in the presence of water.
    Type: Grant
    Filed: July 7, 1981
    Date of Patent: March 26, 1985
    Assignee: Mitsui Toatsu Chemicals, Inc.
    Inventors: Shigenobu Nakayama, Eiichi Noda, Yoshiaki Noguchi, Isamu Yamamoto, Noboru Kawasaki