Patents by Inventor Shigenori Nozawa
Shigenori Nozawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10835643Abstract: A drug coating layer on a non-porous nylon elastomer balloon substrate surface comprising a plurality of elongated bodies with long axes wherein each elongated body is formed of a crystal of a water-insoluble drug and is independently formed on the substrate surface, wherein the long axes of the elongated bodies are substantially linear in shape, and the long axes of the elongated bodies form an angle in a predetermined range with respect to a substrate plane with which the long axis of the elongated body intersects. The drug coating layer can provide low toxicity and a high intravascular stenosis inhibitory effect.Type: GrantFiled: January 12, 2018Date of Patent: November 17, 2020Assignee: TERUMO KABUSHIKI KAISHAInventors: Keiko Yamashita, Hiroshi Goto, Shigenori Nozawa, Katsumi Morimoto
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Patent number: 10188771Abstract: A method of treating peripheral artery diseases in lower limbs by providing a medical device having an expandable member having a drug coating layer which has a crystalline morphological form including a plurality of crystal particles of a water-insoluble drug regularly arranged and uniformly sized on the surface of the medical device, inserting the medical device in peripheral blood vessels, expanding the expandable member, pressing the drug coating layer to a blood vessel wall such that at least part of the plurality of crystals are transferred to the blood vessel wall, and deflating the expandable member such that a pharmacokinetics profile is presented in which a drug concentration in the blood vessels is kept for the inhibition of smooth muscle cell proliferation in a high drug-concentration period of time, and for the non-inhibition of endothelial cell growth in a later low drug-concentration period of time.Type: GrantFiled: August 12, 2014Date of Patent: January 29, 2019Assignee: TERUMO KABUSHIKI KAISHAInventors: Keiko Yamashita, Shigenori Nozawa, Katsumi Morimoto
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Patent number: 10149925Abstract: A method of reducing the risk of embolization of peripheral blood vessels by providing a medical device having an expandable member having a drug coating layer which has a crystalline morphological form including a plurality of crystal particles of a water-insoluble drug regularly arranged and uniformly sized on the surface of the medical device, inserting the medical device in peripheral blood vessels, expanding the expandable member, pressing the drug coating layer to a blood vessel wall such that at least part of the plurality of crystal particles are transferred to the blood vessel wall, and deflating the expandable member such that the generation of microparticulates having a size that causes embolization of peripheral blood vessels is suppressed.Type: GrantFiled: August 12, 2014Date of Patent: December 11, 2018Assignee: TERUMO KABUSHIKI KAISHAInventors: Keiko Yamashita, Shigenori Nozawa, Katsumi Morimoto, Kyoko Shimamura
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Patent number: 10143779Abstract: A method of inhibiting thickening of vascular intima by providing a medical device having an expandable member having a drug coating layer which has a crystalline morphological form including a plurality of crystal particles of a water-insoluble drug regularly arranged and uniformly sized on the surface of the medical device, inserting the medical device in peripheral blood vessels, expanding the expandable member, pressing the drug coating layer to a blood vessel wall such that at least part of the plurality of crystals are transferred to the blood vessel wall, and deflating the expandable member such that a vascular intima thickening is inhibited uniformly in an entire treated lesion of stenosis to uniformly cause patency of the lesion.Type: GrantFiled: August 12, 2014Date of Patent: December 4, 2018Assignee: TERUMO KABUSHIKI KAISHAInventors: Keiko Yamashita, Shigenori Nozawa, Katsumi Morimoto
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Patent number: 10045960Abstract: A coating composition for drug-eluting medical devices, which enables a medical device to be delivered to a target tissue for the purpose of treating an affected blood vessel part such as restenosis, without easy separation of a drug from the medical device during the delivery process is provided. The coating composition for drug-eluting medical devices contains a water-insoluble drug and at least one selected from the group consisting of ester compounds of amino acids, which have a hydropathy index of the amino acid of zero or less than zero, and salts thereof. A drug coating layer, a drug-eluting medical device and a method of treatment are also provided.Type: GrantFiled: February 1, 2017Date of Patent: August 14, 2018Assignee: TERUMO KABUSHIKI KAISHAInventors: Keiko Yamashita, Shigenori Nozawa
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Publication number: 20180154049Abstract: A drug coating layer on a non-porous nylon elastomer balloon substrate surface comprising a plurality of elongated bodies with long axes wherein each elongated body is formed of a crystal of a water-insoluble drug and is independently formed on the substrate surface, wherein the long axes of the elongated bodies are substantially linear in shape, and the long axes of the elongated bodies form an angle in a predetermined range with respect to a substrate plane with which the long axis of the elongated body intersects. The drug coating layer can provide low toxicity and a high intravascular stenosis inhibitory effect.Type: ApplicationFiled: January 12, 2018Publication date: June 7, 2018Applicant: Terumo Kabushiki KaishaInventors: Keiko Yamashita, Hiroshi Goto, Shigenori Nozawa, Katsumi Morimoto
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Patent number: 9981070Abstract: A coating composition capable of forming a drug coating layer insusceptible to peeling in the process of delivery of a water-insoluble drug to a target tissue is provided. The coating composition contains the water-insoluble drug and a basic compound which is positively charged at physiological pH. A medical device coated with the coating composition is further provided.Type: GrantFiled: September 21, 2015Date of Patent: May 29, 2018Assignee: TERUMO KABUSHIKI KAISHAInventors: Keiko Yamashita, Shigenori Nozawa
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Patent number: 9877918Abstract: A liposome composition, which is obtained by mixing a water-miscible organic solution in which a phospholipid and cholesterol are contained in a total concentration of 100 to 200 w/v % in a water-miscible organic solvent with a first aqueous phase solution in an amount of 3/1 to 12/1 in terms of volume ratio to the water-miscible organic solution, thereby obtaining an emulsion in which the total concentration of the phospholipid and cholesterol in the resulting mixed phase is 15 to 50 w/v %, followed by subjecting the emulsion to external solution exchange with a second aqueous phase solution, wherein an ion gradient is formed between an aqueous phase in an internal region of a liposome membrane, including the first aqueous phase solution, and an aqueous phase in an external region of the liposome membrane, including the second aqueous phase solution, and a drug can be introduced in a high encapsulation amount.Type: GrantFiled: July 22, 2013Date of Patent: January 30, 2018Assignee: TERUMO KABUSHIKI KAISHAInventors: Keiko Yamashita, Shigenori Nozawa, Naoki Otomo
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Patent number: 9872940Abstract: A drug coating layer which is a drug coating layer having a morphological form including a plurality of elongated bodies having long axes that each crystal of a water-insoluble drug independently has on a substrate surface, in which the long axes of the elongated bodies are nearly linear in shape, and the long axes of the elongated bodies form an angle in a predetermined range with respect to a substrate plane with which the long axis of the elongated body intersects. The drug coating layer can provide low toxicity and a high intravascular stenosis inhibitory effect.Type: GrantFiled: March 28, 2014Date of Patent: January 23, 2018Assignee: TERUMO KABUSHIKI KAISHAInventors: Keiko Yamashita, Hiroshi Goto, Shigenori Nozawa, Katsumi Morimoto, Hiroaki Kasukawa
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Publication number: 20170143663Abstract: A coating composition for drug-eluting medical devices, which enables a medical device to be delivered to a target tissue for the purpose of treating an affected blood vessel part such as restenosis, without easy separation of a drug from the medical device during the delivery process is provided. The coating composition for drug-eluting medical devices contains a water-insoluble drug and at least one selected from the group consisting of ester compounds of amino acids, which have a hydropathy index of the amino acid of zero or less than zero, and salts thereof. A drug coating layer, a drug-eluting medical device and a method of treatment are also provided.Type: ApplicationFiled: February 1, 2017Publication date: May 25, 2017Applicant: TERUMO KABUSHIKI KAISHAInventors: Keiko YAMASHITA, Shigenori NOZAWA
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Patent number: 9603974Abstract: A coating composition for drug-eluting medical devices, which enables a medical device to be delivered to a target tissue for the purpose of treating an affected blood vessel part such as restenosis, without easy separation of a drug from the medical device during the delivery process is provided. The coating composition for drug-eluting medical devices contains a water-insoluble drug and at least one selected from the group consisting of ester compounds of amino acids, which have a hydropathy index of the amino acid of zero or less than zero, and salts thereof. A drug coating layer, a drug-eluting medical device and a method of treatment are also provided.Type: GrantFiled: September 25, 2014Date of Patent: March 28, 2017Assignee: TERUMO KABUSHIKI KAISHAInventors: Keiko Yamashita, Shigenori Nozawa
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Patent number: 9592322Abstract: A coating composition for drug eluting medical devices, which is capable of forming a drug coating layer that is not susceptible to peeling during delivery to a target tissue is provided. This coating composition contains: a water-insoluble drug; at least one selected from the group consisting of hyaluronic acid, alkanoyl hyaluronic acids obtained by substituting at least part of hydrogen atoms in the hydroxyl groups of hyaluronic acid with an alkanoyl group, and salts of hyaluronic acid and the alkanoyl hyaluronic acids; and at least one selected from the group consisting of amino-acid esters and salts thereof. A drug coating layer, a medical device and a method of treatment are also provided.Type: GrantFiled: September 25, 2014Date of Patent: March 14, 2017Assignee: TERUMO KABUSHIKI KAISHAInventors: Keiko Yamashita, Shigenori Nozawa, Masashi Isozaki
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Publication number: 20160015864Abstract: A coating composition capable of forming a drug coating layer unsusceptible to peeling in the process of delivery of a water-insoluble drug to a target tissue is provided. The coating composition contains the water-insoluble drug and a basic compound which is positively charged at physiological pH. A medical device coated with the coating composition is further provided.Type: ApplicationFiled: September 21, 2015Publication date: January 21, 2016Applicant: TERUMO KABUSHIKI KAISHAInventors: Keiko YAMASHITA, Shigenori NOZAWA
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Publication number: 20160015861Abstract: Provided are a drug coating layer which has low toxicity and a high intravascular stenosis inhibitory effect, when delivering medical device coated with a drug into the body and medical device using the same. The drug coating layer is a drug coating layer having a morphological form including a plurality of elongated bodies having long axes that each crystal of a water-insoluble drug independently has on a substrate surface, in which the long axes of the elongated bodies are nearly linear in shape, and the long axes of the elongated bodies form an angle in a predetermined range with respect to a substrate plane with which the long axis of the elongated body intersects.Type: ApplicationFiled: September 29, 2015Publication date: January 21, 2016Applicant: TERUMO KABUSHIKI KAISHAInventors: Keiko YAMASHITA, Hiroshi GOTOU, Shigenori NOZAWA, Katsumi MORIMOTO, Hiroaki KASUKAWA
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Publication number: 20150328369Abstract: A method of treating peripheral artery diseases in lower limbs by providing a medical device having an expandable member having a drug coating layer which has a crystalline morphological form including a plurality of crystal particles of a water-insoluble drug regularly arranged and uniformly sized on the surface of the medical device, inserting the medical device in peripheral blood vessels, expanding the expandable member, pressing the drug coating layer to a blood vessel wall such that at least part of the plurality of crystals are transferred to the blood vessel wall, and deflating the expandable member such that a pharmacokinetics profile is presented in which a drug concentration in the blood vessels is kept for the inhibition of smooth muscle cell proliferation in a high drug-concentration period of time, and for the non-inhibition of endothelial cell growth in a later low drug-concentration period of time.Type: ApplicationFiled: August 12, 2014Publication date: November 19, 2015Applicant: Terumo Kabushiki KaishaInventors: Keiko YAMASHITA, Shigenori NOZAWA, Katsumi MORIMOTO
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Publication number: 20150328372Abstract: A method of inhibiting thickening of vascular intima by providing a medical device having an expandable member having a drug coating layer which has a crystalline morphological form including a plurality of crystal particles of a water-insoluble drug regularly arranged and uniformly sized on the surface of the medical device, inserting the medical device in peripheral blood vessels, expanding the expandable member, pressing the drug coating layer to a blood vessel wall such that at least part of the plurality of crystals are transferred to the blood vessel wall, and deflating the expandable member such that a vascular intima thickening is inhibited uniformly in an entire treated lesion of stenosis to uniformly cause patency of the lesion.Type: ApplicationFiled: August 12, 2014Publication date: November 19, 2015Applicant: Terumo Kabushiki KaishaInventors: Keiko YAMASHITA, Shigenori NOZAWA, Katsumi MORIMOTO
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Publication number: 20150328371Abstract: A method of reducing the risk of embolization of peripheral blood vessels by providing a medical device having an expandable member having a drug coating layer which has a crystalline morphological form including a plurality of crystal particles of a water-insoluble drug regularly arranged and uniformly sized on the surface of the medical device, inserting the medical device in peripheral blood vessels, expanding the expandable member, pressing the drug coating layer to a blood vessel wall such that at least part of the plurality of crystal particles are transferred to the blood vessel wall, and deflating the expandable member such that the generation of microparticulates having a size that causes embolization of peripheral blood vessels is suppressed.Type: ApplicationFiled: August 12, 2014Publication date: November 19, 2015Applicant: Terumo Kabushiki KaishaInventors: Keiko YAMASHITA, Shigenori NOZAWA, Katsumi MORIMOTO, Kyoko SHIMAMURA
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Publication number: 20150056265Abstract: A coating composition for drug-eluting medical devices, which enables a medical device to be delivered to a target tissue for the purpose of treating an affected blood vessel part such as restenosis, without easy separation of a drug from the medical device during the delivery process is provided. The coating composition for drug-eluting medical devices contains a water-insoluble drug and at least one selected from the group consisting of ester compounds of amino acids, which have a hydropathy index of the amino acid of zero or less than zero, and salts thereof. A drug coating layer, a drug-eluting medical device and a method of treatment are also provided.Type: ApplicationFiled: September 25, 2014Publication date: February 26, 2015Applicant: TERUMO KABUSHIKI KAISHAInventors: Keiko YAMASHITA, Shigenori NOZAWA
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Publication number: 20150057746Abstract: A coating composition for drug eluting medical devices, which is capable of forming a drug coating layer that is not susceptible to peeling during delivery to a target tissue is provided. This coating composition contains: a water-insoluble drug; at least one selected from the group consisting of hyaluronic acid, alkanoyl hyaluronic acids obtained by substituting at least part of hydrogen atoms in the hydroxyl groups of hyaluronic acid with an alkanoyl group, and salts of hyaluronic acid and the alkanoyl hyaluronic acids; and at least one selected from the group consisting of amino-acid esters and salts thereof. A drug coating layer, a medical device and a method of treatment are also provided.Type: ApplicationFiled: September 25, 2014Publication date: February 26, 2015Applicant: TERUMO KABUSHIKI KAISHAInventors: Keiko YAMASHITA, Shigenori NOZAWA, Masashi ISOZAKI
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Patent number: 8945526Abstract: The present invention provides a novel amphiphilic substance, a nanoparticle using the novel amphiphilic substance, which can be used as a nanocarrier having high biocompatibility, a drug delivery system and a probe useful for the system, and, a molecular imaging system and a probe useful for the system. An amphiphilic block polymer comprising a hydrophilic block; and a hydrophobic block, wherein the hydrophilic block is a hydrophilic polypeptide chain having 10 or more sarcosine units, and the hydrophobic block is a hydrophobic molecular chain comprising units selected from the group consisting of amino acid units and hydroxyl acid units as essential structural units, and having 5 or more of the essential structural units.Type: GrantFiled: June 15, 2007Date of Patent: February 3, 2015Assignees: Shimadzu Corporation, Kyoto UniversityInventors: Hitoshi Akitsu, Eiichi Ozeki, Ryoji Fushimi, Shunsaku Kimura, Masashi Isozaki, Shigenori Nozawa