Abstract: Provided is an anti-human Tie2 antibody for preventing or treating diabetic macular edema, diabetic retinopathy, and critical limb ischemia by binding to a human Tie2 to activate the human Tie2. The present inventors have conducted investigations on an anti-human Tie2 antibody, and have thus provided an anti-human Tie2 antibody comprising four heavy chain variable regions and four light chain variable regions, in which the heavy chain variable region consists of the amino acid sequence of the amino acid numbers 1 to 122 of SEQ ID NO: 2, the light chain variable region consists of the amino acid sequence of the amino acid numbers 1 to 113 of SEQ ID NO: 4, the one heavy chain variable region and the one light chain variable region constitute one antigen-binding site, and the antibody comprises four antigen-binding sites.

Abstract: Provided is an anti-human Tie2 antibody for preventing or treating diabetic macular edema, diabetic retinopathy, and critical limb ischemia by binding to a human Tie2 to activate the human Tie2. The present inventors have conducted investigations on an anti-human Tie2 antibody, and have thus provided an anti-human Tie2 antibody comprising four heavy chain variable regions and four light chain variable regions, in which the heavy chain variable region consists of the amino acid sequence of the amino acid numbers 1 to 122 of SEQ ID NO: 2, the light chain variable region consists of the amino acid sequence of the amino acid numbers 1 to 113 of SEQ ID NO: 4, the one heavy chain variable region and the one light chain variable region constitute one antigen-binding site, and the antibody comprises four antigen-binding sites.

Abstract: Provided is an anti-human Tie2 antibody for preventing or treating diabetic macular edema, diabetic retinopathy, and critical limb ischemia by binding to a human Tie2 to activate the human Tie2. The present inventors have conducted investigations on an anti-human Tie2 antibody, and have thus provided an anti-human Tie2 antibody comprising four heavy chain variable regions and four light chain variable regions, in which the heavy chain variable region consists of the amino acid sequence of the amino acid numbers 1 to 122 of SEQ ID NO: 2, the light chain variable region consists of the amino acid sequence of the amino acid numbers 1 to 113 of SEQ ID NO: 4, the one heavy chain variable region and the one light chain variable region constitute one antigen-binding site, and the antibody comprises four antigen-binding sites.

Abstract: The present invention can provide a monoclonal antibody which comprises a heavy chain constant region which is IgG2 wherein valine at position 234, glutamine at position 237 and proline at position 331 are at least substituted with alanine, alanine and serine, respectively (numbering is based on the EU index of Kabat et al); has an agonist activity; and binds to human CD40.

Abstract: Provided is an anti-human Tie2 antibody for preventing or treating diabetic macular edema, diabetic retinopathy, and critical limb ischemia by binding to a human Tie2 to activate the human Tie2. The present inventors have conducted investigations on an anti-human Tie2 antibody, and have thus provided an anti-human Tie2 antibody comprising four heavy chain variable regions and four light chain variable regions, in which the heavy chain variable region consists of the amino acid sequence of the amino acid numbers 1 to 122 of SEQ ID NO: 2, the light chain variable region consists of the amino acid sequence of the amino acid numbers 1 to 113 of SEQ ID NO: 4, the one heavy chain variable region and the one light chain variable region constitute one antigen-binding site, and the antibody comprises four antigen-binding sites.

Abstract: The present invention can provide a monoclonal antibody which comprises a heavy chain constant region which is IgG2 wherein valine at position 234, glutamine at position 237 and proline at position 331 are at least substituted with alanine, alanine and serine, respectively (numbering is based on the EU index of Kabat et al); has an agonist activity; and binds to human CD40.

Abstract: The present invention can provide a monoclonal antibody which comprises a heavy chain constant region which is IgG2 wherein valine at position 234, glutamine at position 237 and proline at position 331 are at least substituted with alanine, alanine and serine, respectively (numbering is based on the EU index of Kabat et al); has an agonist activity; and binds to human CD40.

Abstract: The present invention can provide a monoclonal antibody which comprises a heavy chain constant region which is IgG2 wherein valine at position 234, glutamine at position 237 and proline at position 331 are at least substituted with alanine, alanine and serine, respectively (numbering is based on the EU index of Kabat et al); has an agonist activity; and binds to human CD40.

Abstract: An ozonizer has a flat plate-shaped low voltage electrode, flat plate-shaped first and second high voltage electrodes facing the low voltage electrode, a first dielectric, and a first spacer, located between the low voltage electrode and the first high voltage electrode, a second dielectric, and a second spacer between the electrode and the second high voltage electrode. The ozonizer also has a first electrode cooling sheet facing the first high voltage electrode at a side opposite a first discharge gap, a second electrode cooling sheet facing the second high voltage electrode, a first thermally conducting and electrically insulating sheet sandwiched between the first high voltage electrode and the first electrode cooling sheet, and a second thermally conducting and electrically insulating sheet sandwiched between the second high voltage electrode and the second electrode cooling sheet.

Abstract: An ozonizer has a flat plate-shaped low voltage electrode and a flat plate-shaped high voltage electrode facing a main surface of the low voltage electrode. The ozomzer also has a flat plate-shaped dielectric and a spacer forming a discharge gap in a laminating direction, located between the low voltage electrode and the high voltage electrode, a high voltage electrode cooling unit forming a cooling water passage insulated from the high voltage electrode inside the high voltage electrode. An alternating voltage is applied between the low voltage electrode and the high voltage electrode and a discharge is produced in the discharge gap, into which oxygen is injected, to produce ozone gas.

Abstract: The ozonizer of this present invention is small in size, and capable of generating highly concentrated ozone with a high (generating) efficiency. A low voltage electrode includes a disc-shaped low voltage electrode main body facing a high voltage electrode and an extension at one side of the low voltage electrode main body, and the extensions are laminated in layers on a base via blocks, and a coolant inlet portion for supplying coolant to a coolant passage, a coolant outlet portion for exhausting coolant from the coolant passage, and an ozone gas outlet portion for exhausting ozone gas from the ozone gas passage pass through the extensions and the blocks, respectively, in a laminating direction of the discharge cells.

Abstract: An ozonizer has a flat plate-shaped low voltage electrode 7, a flat plate-shaped high voltage electrode 3 facing a main surface of the low voltage electrode 7. The ozonizer also has a flat plate-shaped dielectric 5 and a spacer for forming a discharge gap 6 of a thin thickness in a laminating direction provided between the low voltage electrode 7 and the electrode 3, an electrode cooling sheet 1 provided facing a main surface of the electrode 3 at a side opposite the discharge gap 6 for cooling the electrode 3. The ozonizer also has a thermal conducting/electric insulating sheet 2 sandwiched between the electrode 3 and the electrode cooling sheet 1. An alternating voltage is applied between the low voltage electrode 7 and the electrode 3 and a discharge is produced in the discharge gap 6 injected with oxygen gas to produce ozone gas.

Abstract: An ozonizer has a flat plate-shaped low voltage electrode and a flat plate-shaped high voltage electrode facing a main surface of the low voltage electrode. The ozonizer also has a flat plate-shaped dielectric and a spacer for forming a discharge gap having a thickness in a laminating direction, provided between the low voltage electrode and the electrode, an electrode cooling sheet facing a main surface of the electrode at a side opposite the discharge gap for cooling the electrode. The ozonizer also has a thermally conducting and electrically insulating sheet sandwiched between the electrode and the electrode cooling sheet. An alternating voltage is applied between the low voltage electrode and the electrode and a discharge is produced in the discharge gap so that, when filled with oxygen, ozone gas is produced.

Abstract: The ozonizer of this present invention is small in size, and capable of generating highly concentrated ozone with a high (generating) efficiency. A low voltage electrode 29 includes a disc-shaped low voltage electrode main body 29a facing a high voltage electrode 8 and an extension 29b equipped at one side of the low voltage electrode main body 29a, and the extensions are laminated in a plurality of layers on a base 1 via blocks 30, and a coolant inlet portion 42 for supplying coolant to a coolant passage 34, a coolant outlet portion 35 for exhausting coolant from the coolant passage 34 and an ozone gas outlet portion 33 for exhausting ozone gas from the ozone gas passage 36 are formed passing through the extensions 29b and the blocks 30, respectively, in a laminating direction of the discharge cells 28.

Abstract: An ozonizer has a flat plate-shaped low voltage electrode 7, a flat plate-shaped high voltage electrode 3 facing a main surface of the low voltage electrode 7. The ozonizer also has a flat plate-shaped dielectric 5 and a spacer for forming a discharge gap 6 of a thin thickness in a laminating direction provided between the low voltage electrode 7 and the high voltage electrode 3, a high voltage electrode cooling unit 2 for forming a cooling water passage 2c insulated from the high voltage electrode 3 inside the high voltage electrode 3. An alternating voltage is applied between the low voltage electrode 7 and the high voltage electrode 3 and a discharge is produced in the discharge gap 6 injected with oxygen gas to produce ozone gas.

Abstract: An ozonizer has a flat plate-shaped low voltage electrode 7, a first and second high voltage electrode 3-1, 3-2 provided facing the low voltage electrode 7, a first dielectric 5-1 and first spacer provided between the low voltage electrode 7 and the electrode 3-1, a second dielectric 5-2 and a second spacer provided between the electrode 7 and the electrode 3-2. The ozonizer also has a first electrode cooling sheet 1-1 provided facing the electrode 3-1 at a side opposite a first discharge gap 6-1, a second electrode cooling sheet 1-2 provided facing the electrode 3-2 at a side opposite a second discharge gap 6-2, a first thermal conducting/electric insulating sheet 2-1 sandwiched between the first high voltage electrode 3-1 and the first electrode cooling sheet 1-1 and a second thermal conducting/electric insulating sheet 2-2 sandwiched between the second high voltage electrode 3-2 and the second electrode cooling sheet 1-2.

Abstract: There is provided a highly efficient and compact ozone generating apparatus in which a very short air gap of about 0.2 mm is formed at high accuracy. Non-discharge portions are dispersed and disposed to cover an entire discharge space, or a spacer is provided to form the non-discharge portion. Further, an elastic body is mounted on a back face of an electrode, thereby enhancing an air gap accuracy of the discharge space.

Abstract: There is provided a highly efficient and compact ozone generating apparatus in which a very short air gap of about 0.2 mm is formed at high accuracy. Non-discharge portions are dispersed and disposed to cover an entire discharge space, or a spacer is provided to form the non-discharge portion. Further, an elastic body is mounted on a back face of an electrode, thereby enhancing an air gap accuracy of the discharge space.

Abstract: There is provided a highly efficient and compact ozone generating apparatus in which a very short air gap of about 0.2 mm is formed at high accuracy. Non-discharge portions are dispersed and disposed to cover an entire discharge space, or a spacer is provided to form the non-discharge portion. Further, an elastic body is mounted on a back face of an electrode, thereby enhancing an air gap accuracy of the discharge space.

Abstract: An ozonizer has a flat plate-shaped low voltage electrode 7, a flat plate-shaped high voltage electrode 3 facing a main surface of the low voltage electrode 7. The ozonizer also has a flat plate-shaped dielectric 5 and a spacer for forming a discharge gap 6 of a thin thickness in a laminating direction provided between the low voltage electrode 7 and the electrode 3, an electrode cooling sheet 1 provided facing a main surface of the electrode 3 at a side opposite the discharge gap 6 for cooling the electrode 3. The ozonizer also has a thermal conducting/electric insulating sheet 2 sandwiched between the electrode 3 and the electrode cooling sheet 1. An alternating voltage is applied between the low voltage electrode 7 and the electrode 3 and a discharge is produced in the discharge gap 6 injected with oxygen gas to produce ozone gas.