Abstract: A method includes detecting a nucleotide sequence in genomic DNA obtained from a sample; and evaluating a content of mesenchymal stem cells in the sample. The nucleotide sequence comprises at least one CpG site selected from the group consisting of: a CpG site consisting of C at position 157 and G at position 158 of SEQ ID NO: 1; and a CpG site complementary to the CpG site of SEQ ID NO: 1 in a nucleotide sequence complementary to the nucleotide sequence of SEQ ID NO: 1. The sample is an adipose tissue or a cell-containing fraction obtained from an adipose tissue.

Abstract: A method includes detecting a nucleotide sequence in genomic DNA obtained from a sample; and evaluating a content of mesenchymal stem cells in the sample. The nucleotide sequence comprises at least one CpG site selected from the group consisting of: a CpG site consisting of C at position 157 and G at position 158 of SEQ ID NO: 1; and a CpG site complementary to the CpG site of SEQ ID NO: 1 in a nucleotide sequence complementary to the nucleotide sequence of SEQ ID NO: 1. The sample is an adipose tissue or a cell-containing fraction obtained from an adipose tissue.

Abstract: The invention aims at providing an adsorbent for bacterial toxins, a method for removal of such toxins by adsorption, and an adsorber packed with said adsorbent. Provided are an adsorbent for bacterial toxins, which comprises a water-insoluble porous material having a mode of pore radius of 20 angstroms to 1,000 angstroms, a method for removal of bacterial toxins using said adsorbent, and an adsorber packed with said adsorbent.

Abstract: The invention aims at providing an adsorbent for bacterial toxins, a method for removal of such toxins by adsorption, and an adsorber packed with said adsorbent. Provided are an adsorbent for bacterial toxins, which comprises a water-insoluble porous material having a mode of pore radius of 20 angstroms to 1,000 angstroms, a method for removal of bacterial toxins using said adsorbent, and an adsorber packed with said adsorbent.

Abstract: An adsorbent for cardiac glycoside contained in body fluid, comprising a compound having a log P value of at least 6 immobilized on a water-insoluble carrier is provided. A process for adsorbing and removing cardiac glycoside contained in body fluid efficiently, which comprises contacting body fluid with this adsorbent for cardiac glycoside is provided.

Abstract: A safe and practically useful body fluid processor whereby blood taken out from a patient can be directly processed, characterized by having a favorable passage of the blood cell and showing an extremely low risk of the generation and leakage of microparticles. Namely, a body fluid processor enabling direct hemoperfusion wherein the ratio of sedimented particles to the volume of the space in which the particles for processing body fluid are to be packed is 100% or less and the space in which the particles for processing body fluid are to be packed in the body fluid processor is filled with the particles for processing body fluid and a filling liquid at a ratio of 95% or more but not more than 100%.

Abstract: An adsorbent which comprises a water-insoluble carrier and a compound, which is immobilized on said carrier, having a binding affinity for an antibody against ?1-adrenoceptor and/or an antibody against M2 muscarinic receptor exhibits a remarkably large adsorptive capacity.

Abstract: A device for body fluid purification, comprising a container having an inlet and an outlet for a fluid and a means for preventing an adsorbent from flowing out of the container and an adsorbent charged in the container, the adsorbent comprising a spherical hydrogel, the spherical hydrogel having an average particle size in a range of from about 460 to 600 ?m and having a substantially uniform particle size and comprising an epoxidated cellulose having hexadecylamine immobilized thereon in an amount of 100 to 300 ?mol per gram of dry weight of said epoxidated cellulose, and water, wherein the weight ratio of said epoxidated cellulose having hexadecylamine immobilized thereon to the water is 2:8.

Abstract: The present invention provides an adsorbent, adsorption unit, and an adsorption method which make it possible to selectively adsorb an immunoglobulin and/or an immune complex present in a body fluid (for example, blood, plasma, etc.) efficiently without pretreating the body fluid. By immobilizing a compound having binding activity for an immunoglobulin and/or an immune complex on a water-insoluble carrier, an adsorbent having remarkably excellent adsorption capacity may be obtained.

Abstract: The present invention provides an adsorbent, adsorption unit, and an adsorption method which make it possible to selectively adsorb an immunoglobulin and/or an immune complex present in a body fluid (for example, blood, plasma, etc.) efficiently without pretreating the body fluid. By immobilizing a compound having binding activity for an immunoglobulin and/or an immune complex on a water-insoluble carrier, an adsorbent having remarkably excellent adsorption capacity may be obtained.

Abstract: The present invention provides an adsorbent, an adsorption method, and an adsorber for efficiently adsorbing low-density lipoproteins and fibrinogen directly from a body fluid, particularly whole blood, to decrease the concentrations of these components in the body fluid with minimizing losses of useful substances such as HDL and albumin. The adsorbent includes a tryptophan derivative and a polyanionic compound which are immobilized on a water-insoluble porous carrier, wherein the amount of the immobilized polyanionic compound is 0.10 ?mol to 1.5 ?mol per milliliter of wet volume of the adsorbent, and the molar ratio of the amount of the immobilized tryptophan derivative to the amount of the immobilized polyanionic compound is 1 to 70. The adsorbent is capable of whole blood treatment for safely and efficiently adsorbing low-density lipoproteins and fibrinogen.

Abstract: The present invention is directed to an enterotoxin adsorbent comprising a compound having a log P (P denotes a partition coefficient in an octanol-water system) value of not less than 2.50 as immobilized on a water-insoluble carrier.

Abstract: An adsorbent for peptidoglycan which comprises an water-insoluble porous material having an amino group and having a molecular weight of exclusion limit of at least 50,000, and a method for removing peptidoglycan by adsorption, which comprises a step of contacting the adsorbent to a liquid containing peptidoglycan.

Abstract: A device for body fluid purification, comprising a container having an inlet and an outlet for a fluid and a means for preventing an adsorbent from flowing out of the container and an adsorbent charged in the container, the adsorbent comprising a spherical hydrogel, the spherical hydrogel having an average particle size in a range of from about 460 to 600 ?m and having a substantially uniform particle size and comprising an epoxidated cellulose having hexadecylamine immobilized thereon in an amount of 100 to 300 ?mol per gram of dry weight of said epoxidated cellulose, and water, wherein the weight ratio of said epoxidated cellulose having hexadecylamine immobilized thereon to the water is 2:8.

Abstract: A device for body fluid purification, comprising a container having an inlet and an outlet for a fluid and a means for preventing an adsorbent from flowing out of the container and an adsorbent charged in the container, the adsorbent comprising a spherical hydrogel, the spherical hydrogel having an average particle size in a range of from about 460 to 600 ?m and having a substantially uniform particle size and comprising an epoxidated cellulose having hexadecylamine immobilized thereon in an amount of 100 to 300 ?mol per gram of dry weight of said epoxidated cellulose, and water, wherein the weight ratio of said epoxidated cellulose having hexadecylamine immobilized thereon to the water is 2:8.

Abstract: The present invention provides an adsorbent for efficiently adsorbing and removing cytokine in liquid and a method for removing cytokine in liquid by the adsorbent. Also, the present invention provides an adsorber for removing cytokine in liquid. Specifically, an adsorbent for cytokine is obtained by immobilizing a compound having a log P value of at least 2.50 (P is the partition coefficient in an octanol-water system) on a water-insoluble carrier. By contacting a liquid containing cytokine with the adsorbent for cytokine, the cytokine in the liquid can be effectively adsorbed and removed. Furthermore, cytokine can be efficiently adsorbed and removed by an adsorber comprising a container having an inlet and an outlet for liquid and a means for preventing the adsorbent from flowing out of the container, which is filled with the adsorbent.

Abstract: The present invention provides an adsorbent, adsorption unit, and an adsorption method which make it possible to selectively adsorb an immunoglobulin and/or an immune complex present in a body fluid (for example, blood, plasma, etc.) efficiently without pretreating the body fluid. By immobilizing a compound having binding activity for an immunoglobulin and/or an immune complex on a water-insoluble carrier, an adsorbent having remarkably excellent adsorption capacity may be obtained.

Abstract: An adsorbent suitable for adsorption of a transforming growth factor-? (TGF-?) comprising a compound which has a log P value of at least 2.50 wherein P is a partition coefficient in an octanol-water system and which is immobilized on a water-insoluble carrier. TGF-? present in a body fluid can be efficiently removed by bringing the body fluid into contact with the adsorbent.

Abstract: The present invention provides an intra-corporeal artificial kidney having a function of metabolizing protein and a method of constructing the same.

Abstract: A device for body fluid purification, comprising a container having an inlet and an outlet for a fluid and a means for preventing an adsorbent from flowing out of the container and an adsorbent charged in the container, the adsorbent comprising a spherical hydrogel, the spherical hydrogel having an average particle size in a range of from about 460 to 600 &mgr;m and having a substantially uniform particle size and comprising an epoxidated cellulose having hexadecylamine immobilized thereon in an amount of 100 to 300 &mgr;mol per gram of dry weight of said epoxidated cellulose, and water, wherein the weight ratio of said epoxidated cellulose having hexadecylamine immobilized thereon to the water is 2:8.