Patents by Inventor Shigeo Hirasawa

Shigeo Hirasawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Azide group-containing Fc protein
    Patent number: 11149074
    Abstract: The present invention provides a means capable of efficiently manufacturing a fused substance of an Fc protein and a substance of interest (for example, a peptide). Specifically, the present invention provides an azide group-containing Fc protein represented by formula (1): N3-La-Phe-Lb-Fc??(1) wherein N3 represents an azide group; La represents a bond or a divalent group; Phe represents a residue of phenylalanine or a derivative thereof; Lb represents a lysine residue or an arginine residue, or a peptide linker containing two or more amino acid residues having a lysine residue or an arginine residue at/on the N-terminus; and Fc represents an Fc protein; and the like.
    Type: Grant
    Filed: November 1, 2018
    Date of Patent: October 19, 2021
    Assignee: Ajinomoto Co., Inc.
    Inventors: Shigeo Hirasawa, Masumi Taki
  • COMPOUND HAVING AFFINITY SUBSTANCE TO ANTIBODY AND BIOORTHOGONAL FUNCTIONAL GROUP, OR SALT THEREOF
    Publication number: 20210139541
    Abstract: Compounds having an affinity substance to an antibody and a bioorthogonal functional group, represented by the following Formula (I): A-L-E-B??(I) wherein A is an affinity substance to an antibody, L is a divalent group comprising a leaving group, E is a divalent group comprising an electrophilic group (i) coupled with the leaving group and (ii) having ability to react with a nucleophilic group in the antibody, B is a bioorthogonal functional group, and the leaving group has ability to be cleaved and eliminated from E by a reaction between the nucleophilic group and the electrophilic group, or a salt thereof, and the like are useful for labelling antibodies.
    Type: Application
    Filed: December 11, 2020
    Publication date: May 13, 2021
    Applicant: Ajinomoto Co., Inc.
    Inventors: Yutaka MATSUDA, Noriko HATADA, Kei YAMADA, Natsuki SHIKIDA, Kazutaka SHIMBO, Tomohiro FUJII, Shigeo HIRASAWA
  • AZlDE GROUP-CONTAINING Fc PROTEIN
    Publication number: 20190055300
    Abstract: The present invention provides a means capable of efficiently manufacturing a fused substance of an Fc protein and a substance of interest (for example, a peptide). Specifically, the present invention provides an azide group-containing Fc protein represented by formula (1): N3-La-Phe-Lb-Fc??(1) wherein N3 represents an azide group; La represents a bond or a divalent group; Phe represents a residue of phenylalanine or a derivative thereof; Lb represents a lysine residue or an arginine residue, or a peptide linker containing two or more amino acid residues having a lysine residue or an arginine residue at/on the N-terminus; and Fc represents an Fc protein; and the like.
    Type: Application
    Filed: November 1, 2018
    Publication date: February 21, 2019
    Applicant: Ajinomoto Co., Inc.
    Inventors: Shigeo HIRASAWA, Masumi Taki
  • Dihydrodiaryloxazepine derivative and pharmaceutical composition containing the same
    Patent number: 7320973
    Abstract: The present invention provides dihydrodiaryloxazepine derivative represented by the following formula [1], analogs thereof and pharmaceutical compositions containing them.
    Type: Grant
    Filed: December 1, 2003
    Date of Patent: January 22, 2008
    Assignee: Ajinomoto Co., Inc.
    Inventors: Katsutoshi Sakata, Takashi Tsuji, Munetaka Tokumasu, Kazuyoshi Takahashi, Shigeo Hirasawa, Junko Ezaki
  • Dihydrodiaryloxazepine derivative and pharmaceutical composition containing the same
    Publication number: 20040110742
    Abstract: The present invention provides dihydrodiaryloxazepine derivative represented by the following formula [1], analogs thereof and pharmaceutical compositions containing them. Those compounds have an excellent effect of improving functional diseases of gastrointestinal tracts.
    Type: Application
    Filed: December 1, 2003
    Publication date: June 10, 2004
    Applicant: Ajinomoto Co., Inc.
    Inventors: Katsutoshi Sakata, Takashi Tsuji, Munetaka Tokumasu, Kazuyoshi Takahashi, Shigeo Hirasawa, Junko Ezaki