Abstract: An object of the present invention is to provide a composition for prevention or treatment for mild cognitive impairment or dementia. The present invention is a composition for prevention or treatment for mild cognitive impairment or dementia, comprising hydrogen as an active ingredient.

Abstract: Provided is a preventive and/or therapeutic agent for dementia. The preventive and/or therapeutic agent for dementia comprises hydrogen gas as an active ingredient.

Abstract: An object of the present invention is to provide a composition for prevention or treatment for mild cognitive impairment or dementia. The present invention is a composition for prevention or treatment for mild cognitive impairment or dementia, comprising hydrogen as an active ingredient.

Abstract: A pressure-sensitive adhesive tape package is provided. The pressure-sensitive adhesive tape package accommodates an adhesive tape having a support and an adhesive agent layer provided on one surface of the support, the adhesive tape being bent into a first portion and a second portion such that the adhesive agent layer faces outward. Moreover, the pressure-sensitive adhesive tape package can include a first release sheet releasably attached to the adhesive agent layer of the first portion of the adhesive tape, and a second release sheet releasably attached to the adhesive agent layer of the second portion of the adhesive tape to seal the adhesive tape with the first release sheet between the first and second release sheets. In this configuration, the conventionally existing package can be eliminated. Moreover, when the second release sheet is removed from the adhesive agent layer of the second portion of the adhesive tape, half of the adhesive agent layer is exposed.

Abstract: An object of the present invention is to provide a scavenger of in vivo harmful reactive oxygen species and/or free radicals, which is capable of effectively reducing the concentrations of in vivo reactive oxygen species and/or free radicals and exhibiting given effects such as the suppression of aging process, the prevention of geriatric or lifestyle-related disease, health promotion, and the inhibition of oxidative stress by virtue of this reduction in the concentrations of reactive oxygen species and/or free radicals. The scavenger of in vivo harmful reactive oxygen species and/or free radicals of the present invention comprises a liquid or gas comprising at least a hydrogen molecule. This medium may further comprise an oxygen molecule. Furthermore, this medium may comprise water or an aqueous solution or may be a gas. The scavenger of reactive oxygen species and/or free radicals can be used in the treatment or prevention of a disorder attributed to reactive oxygen species and/or free radicals.

Abstract: A bottle made of polyethylene terephthalate does likely undergo that a gas having a small molecular weight or volatile component escapes from the bottle in a short time in comparison with a glass bottle, steel can, and aluminum can. For a countermeasure, a simple operation prevents hydrogen molecules, helium gas, and volatile component from scattering and being lost. A container filled with gas, or liquid or viscous fluid in which gas is dissolved, or metal granules adsorbing gas is given a cap, and then, the whole of the container including the cap is packed with a metal foil laminated film superior in gas-barrier properties to be vacuum packaged.

Abstract: An object of the present invention is to provide a scavenger of in vivo harmful reactive oxygen species and/or free radicals, which is capable of effectively reducing the concentrations of in vivo reactive oxygen species and/or free radicals and exhibiting given effects such as the suppression of aging process, the prevention of geriatric or lifestyle-related disease, health promotion, and the inhibition of oxidative stress by virtue of this reduction in the concentrations of reactive oxygen species and/or free radicals. The scavenger of in vivo harmful reactive oxygen species and/or free radicals of the present invention comprises a liquid or gas comprising at least a hydrogen molecule. This medium may further comprise an oxygen molecule. Furthermore, this medium may comprise water or an aqueous solution or may be a gas. The scavenger of reactive oxygen species and/or free radicals can be used in the treatment or prevention of a disorder attributed to reactive oxygen species and/or free radicals.

Abstract: A method for manufacturing a tubular body, includes: attaching a first member to an outer or inner peripheral surface of one end in an axial direction of a cylindrical core, along a circumferential direction of the peripheral surface thereof; applying a first resin solution on the peripheral surface, to cover it and the peripheral surface of one end of the first member closer to the center of the core, and to form a coating (first coat film); attaching a second member to the peripheral surface of the end of the first coat film on the side where the first member has been attached; applying a second resin solution on the peripheral surface of the first coat film, to cover it and the peripheral surface of the end of the second member closer to the center, and to form a coating (second coat film); peeling off the first and second members.

Abstract: Provided is an adhesive patch including a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a woven fabric knitted in stockinette stitch on both sides having two or more rows of crimped polyethylene terephthalate multifilament yarns, the adhesive layer contains 25 to 50% by mass of a liquid organic ingredient and 25 to 50% by mass of a thermoplastic elastomer based on the total mass of the layer and contains 10% by mass or more of methyl salicylate as the liquid organic ingredient based on the total mass of the layer, and the storage elastic modulus (G?) of the adhesive layer is 30000 to 75000 Pa at 10 rad/s and 37° C.

Abstract: A pressure-sensitive adhesive tape package is provided. The pressure-sensitive adhesive tape package accommodates an adhesive tape having a support and an adhesive agent layer provided on one surface of the support, the adhesive tape being bent into a first portion and a second portion such that the adhesive agent layer faces outward. Moreover, the pressure-sensitive adhesive tape package can include a first release sheet releasably attached to the adhesive agent layer of the first portion of the adhesive tape, and a second release sheet releasably attached to the adhesive agent layer of the second portion of the adhesive tape to seal the adhesive tape with the first release sheet between the first and second release sheets. In this configuration, the conventionally existing package can be eliminated. Moreover, when the second release sheet is removed from the adhesive agent layer of the second portion of the adhesive tape, half of the adhesive agent layer is exposed.

Abstract: A method for manufacturing a tubular body, includes: attaching a first member to an outer or inner peripheral surface of one end in an axial direction of a cylindrical core, along a circumferential direction of the peripheral surface thereof; applying a first resin solution on the peripheral surface, to cover it and the peripheral surface of one end of the first member closer to the center of the core, and to form a coating (first coat film); attaching a second member to the peripheral surface of the end of the first coat film on the side where the first member has been attached; applying a second resin solution on the peripheral surface of the first coat film, to cover it and the peripheral surface of the end of the second member closer to the center, and to form a coating (second coat film); peeling off the first and second members.

Abstract: Provided is an adhesive patch including a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a woven fabric knitted in stockinette stitch on both sides having two or more rows of crimped polyethylene terephthalate multifilament yarns, the adhesive layer contains 25 to 50% by mass of a liquid organic ingredient and 25 to 50% by mass of a thermoplastic elastomer based on the total mass of the layer and contains 10% by mass or more of methyl salicylate as the liquid organic ingredient based on the total mass of the layer, and the storage elastic modulus (G?) of the adhesive layer is 30000 to 75000 Pa at 10 rad/s and 37° C.

Abstract: An object of the present invention is to provide a scavenger of in vivo harmful reactive oxygen species and/or free radicals, which is capable of effectively reducing the concentrations of in vivo reactive oxygen species and/or free radicals and exhibiting given effects such as the suppression of aging process, the prevention of geriatric or lifestyle-related disease, health promotion, and the inhibition of oxidative stress by virtue of this reduction in the concentrations of reactive oxygen species and/or free radicals. The scavenger of in vivo harmful reactive oxygen species and/or free radicals of the present invention comprises a liquid or gas comprising at least a hydrogen molecule. This medium may further comprise an oxygen molecule. Furthermore, this medium may comprise water or an aqueous solution or may be a gas. The scavenger of reactive oxygen species and/or free radicals can be used in the treatment or prevention of a disorder attributed to reactive oxygen species and/or free radicals.

Abstract: The present invention provides an genetically engineered cDNA of the rat bcl-x gene, which has at least one substitution selected from the substitutions that change residues 22 Tyr to Phe, residues 26 Gln to Asn and residues 165 Arg to Lys, in the coding region of rat bcl-x cDNA of SEQ ID NO: 1, a recombinant vector containing the engineered cDNA, a cell into which the recombinant vector was introduced, and an improved protein of Bcl-xL. The improved protein of Bcl-xL is useful as an ingredient for remedies for various diseases accompanied with cell death since it effectively inhibit cell death such as apoptosis.

Abstract: According to the present invention, a lipid metabolism improving agent containing hydrogen molecules that is in a liquid or gas state is provided. The lipid metabolism improving agent of the present invention comprises a liquid or gas containing at least hydrogen molecules. It may comprise a medium containing oxygen molecules. Further, such medium may comprise water, an aqueous solution, or a gas. The lipid metabolism improving agent has effects of suppressing body fat accumulation, arteriosclerosis, and the like.

Abstract: An endless belt including a belt main body in which a ten-point average roughness (Rz) of an inner peripheral surface thereof is in a range of 2.0 ?m or higher and 10.0 ?m or lower and an average distance (Sm) between projections and depressions of the inner peripheral surface is in a range of 50 ?m or higher and 200 ?m or lower, and a guide portion in which an average distance (Sm?) between projections and depressions on an adhesive surface thereof adhered to the inner peripheral surface of the belt main body along an edge of the belt main body is two times or higher and six times or lower the average distance (Sm) between projections and depressions in the inner peripheral surface.

Abstract: A process for producing a resin composition having a high adhesion between a resin layer and a metallic layer as well as an excellent durability includes providing a porous structure at least on the surface of the resin layer; and forming the metallic layer on the surface of the resin layer.

Abstract: The present invention provides a protein having a potent cell-death inducing activity that is, a fused protein is in which a modified Bax protein fused with GFP at the N-terminus and is further fused with a homing signal peptide having a homing activity specific for endothelial cells in tumor angiogenesis; a gene coding the fused protein; and a cancer cell growth inhibitor containing the fused protein. Namely, a fused gene containing a cell death-inducing gene acting specially on cancer tissue, which is a fused gene having a gene encoding a homing signal peptide sequence specific for endothelial cells undergoing angiogenesis, a gene encoding a green fluorescent protein (GFP) and a gene encoding ?NBax protein, which is human Bax with a deletion of the N-terminal sequence containing the BH3 domain in this order, and a fusion protein encoded by the fused gene.

Abstract: An object of the present invention is to provide a scavenger of in vivo harmful reactive oxygen species and/or free radicals, which is capable of effectively reducing the concentrations of in vivo reactive oxygen species and/or free radicals and exhibiting given effects such as the suppression of aging process, the prevention of geriatric or lifestyle-related disease, health promotion, and the inhibition of oxidative stress by virtue of this reduction in the concentrations of reactive oxygen species and/or free radicals. The scavenger of in vivo harmful reactive oxygen species and/or free radicals of the present invention comprises a liquid or gas comprising at least a hydrogen molecule. This medium may further comprise an oxygen molecule. Furthermore, this medium may comprise water or an aqueous solution or may be a gas. The scavenger of reactive oxygen species and/or free radicals can be used in the treatment or prevention of a disorder attributed to reactive oxygen species and/or free radicals.

Abstract: The present invention provides an genetically engineered cDNA of the rat bcl-x gene, which has at least one substitution selected from the substitutions that change residues 22 Tyr to Phe, residues 26 Gln to Asn and residues 165 Arg to Lys, in the coding region of rat bcl-x cDNA of SEQ ID NO: 1, a recombinant vector containing the engineered cDNA, a cell into which the recombinant vector was introduced, and an improved protein of Bcl-xL. The improved protein of Bcl-xL is useful as an ingredient for remedies for various diseases accompanied with cell death since it effectively inhibit cell death such as apoptosis.