Abstract: To provide a compound having an inhibitory activity for an androgen receptor. A fused pyrimidine compound represented by the following formula (I) or a pharmaceutically acceptable thereof (in the formula, X, Y, Z, R1, and R2 are as defined in the specification).

Abstract: To improve the user friendliness of switching a map display between the real world and a virtual world while also improving the entertainment value of the game and avoiding the danger arising from using a smartphone while walking.

Abstract: A method for inhibiting androgen activity, including administering an effective amount of a tetrahydropyridopyrimidine compound of formula (I) or a pharmaceutically acceptable salt thereof to a subject in need thereof, and a method for treating tumor, including administering an effective amount of a tetrahydropyridopyrimidine compound of formula (I) or a pharmaceutically acceptable salt thereof to a subject in need thereof

Abstract: To improve the user friendliness of switching a map display between the real world and a virtual world while also improving the entertainment value of the game and avoiding the danger arising from using a smartphone while walking.

Abstract: To improve the user friendliness of switching a map display between the real world and a virtual world while also improving the entertainment value of the game and avoiding the danger arising from using a smartphone while walking.

Abstract: To improve the user friendliness of switching a map display between the real world and a virtual world while also improving the entertainment value of the game and avoiding the danger arising from using a smartphone while walking.

Abstract: To improve the user friendliness of switching a map display between the real world and a virtual world while also improving the entertainment value of the game and avoiding the danger arising from using a smartphone while walking.

Abstract: To improve the user friendliness of switching a map display between the real world and a virtual world while also improving the entertainment value of the game and avoiding the danger arising from using a smartphone while walking.

Abstract: To provide a compound having an inhibitory activity for an androgen receptor. A fused pyrimidine compound represented by the following formula (I) or a pharmaceutically acceptable thereof (in the formula, X, Y, Z, R1, and R2 are as defined in the specification).

Abstract: A method for inhibiting androgen activity, including administering an effective amount of a tetrahydropyridopyrimidine compound of formula (I) or a pharmaceutically acceptable salt thereof to a subject in need thereof, and a method for treating tumor, including administering an effective amount of a tetrahydropyridopyrimidine compound of formula (I) or a pharmaceutically acceptable salt thereof to a subject in need thereof

Abstract: A method for inhibiting androgen activity, including administering an effective amount of a tetrahydropyridopyrimidine compound of formula (I) or a pharmaceutically acceptable salt thereof to a subject in need thereof, and a method for treating tumor, including administering an effective amount of a tetrahydropyridopyrimidine compound of formula (I) or a pharmaceutically acceptable salt thereof to a subject in need thereof

Abstract: A tetrahydropyridopyrimidine compound represented by formula (I) or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition including the tetrahydropyridopyrimidine compound or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier:

Abstract: A method for inhibiting androgen activity, including administering an effective amount of a tetrahydropyridopyrimidine compound of formula (I) or a pharmaceutically acceptable salt thereof to a subject in need thereof, and a method for treating tumor, including administering an effective amount of a tetrahydropyridopyrimidine compound of formula (I) or a pharmaceutically acceptable salt thereof to a subject in need thereof

Abstract: To provide a compound having an inhibitory activity for an androgen receptor. A tetrahydropyridopyrimidine compound represented by the following general formula (I) or a pharmaceutically acceptable thereof (in the formula, X and R are as defined in the specification).

Abstract: Game software for getting a computer to execute a procedure for computing and producing a mesh being comprised of a plurality of small partitions on a projecting plane of a virtual camera, a procedure for projecting the mesh produced on the projecting plane onto a position of the surface of a big surface object in a three dimensional virtual space, the position being shown by object data, so as to set a projecting mesh, a procedure for partially modeling the surface of the big surface object on each of small partitions comprising the projecting mesh, a procedure for rendering the surface of the big surface object partially modeled so as to compute and produce an image of the surface on the projecting plane, and a procedure for displaying the image of the surface computed and produced on a monitor

Abstract: A method of manufacturing substance GM-95 having general formula [I], comprising (a) deprotecting a macrocyclic compound having general formula [II] (wherein, R1's are the same or different and each represents a lower alkyl group, and R2 represents a thiol protecting group) by removing acetal protecting groups (the R1's) thereof, and forming an oxazole ring through an intramolecular cyclization reaction between produced formyl group and an amide group, and (b) deprotecting a resulting macrocyclic compound having general formula [III] (wherein, R2 is as mentioned above) by removing the thiol protecting group (R2) thereof, and forming a thiazoline ring through an intramolecular cyclization reaction between a thiol group thus produced and an amide group.

Abstract: At respective positions spaced from each other on an optic axis of illumination light, a plurality of polygons, each of which corresponds to the shape of a transverse cross section at each position of a virtual region gradually expanded as the illumination light advances from a light source 1 in an optic axis direction are disposed so that the normal of each polygon orients toward a view point in a virtual three-dimensional space. The position of each polygon on the optic axis is set so that at least adjacent polygons are partially superimposed. A texture expressing divergence of illumination light is mapped to each polygon. The size in a direction orthogonal to the optic axis of a virtual region is changed based on a distance from the view point to the light source. The magnification of the virtual region to the distance from the light source is differentiated based on a relationship between an optic axis direction and a direction in which the light source is viewed from the view point.

Abstract: A method of manufacturing substance GM-95 having general formula [I], comprising (a) deprotecting a macrocyclic compound having general formula [II] (wherein, R1's are the same or different and each represents a lower alkyl group, and R2 represents a thiol protecting group) by removing acetal protecting groups (the R1's) thereof, and forming an oxazole ring through an intramolecular cyclization reaction between produced formyl group and an amide group, and (b) deprotecting a resulting macrocyclic compound having general formula [III] (wherein, R2 is as mentioned above) by removing the thiol protecting group (R2) thereof, and forming a thiazoline ring through an intramolecular cyclization reaction between a thiol group thus produced and an amide group.

Abstract: At respective positions spaced from each other on an optic axis of illumination light, a plurality of polygons, each of which corresponds to the shape of a transverse cross section at each position of a virtual region gradually expanded as the illumination light advances from a light source 1 in an optic axis direction are disposed so that the normal of each polygon orients toward a viewpoint in a virtual three-dimensional space. The position of each polygon on the optic axis is set so that at least adjacent polygons are partially superimposed. A texture expressing divergence of illumination light is mapped to each polygon. The size in a direction orthogonal to the optic axis of a virtual region is changed based on a distance from the view point to the light source. The magnification of the virtual region to the distance from the light source is differentiated based on a relationship between an optic axis direction and a direction in which the light source is viewed from the view point.

Abstract: The invention relates an epoxysuccinamide derivative represented by a formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom, an alkyl or aminoalkyl group, R.sup.2 represents an aminoalkyl group which May be substituted, an aryl group which may be substituted, a heterocyclic group which may be substituted, an aralkyl group which may be substituted, or an alkyl group substituted by a heterocyclic ring which may be substituted, or R.sup.1 and R.sup.2 may form a nitrogen-containing heterocyclic ring, which may be substituted, together with the adjacent nitrogen atoms, and R.sup.3 and R.sup.4 are the same or different from each other and independently represent a hydrogen atom, or an alkyl or aralkyl group, or a salt thereof, a preparation process thereof, and a medicine comprising such a derivative or salt as an active ingredient.