Patents by Inventor Shigeomi Higuchi

Shigeomi Higuchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for induction of differentiation of osteoclasts
    Publication number: 20030198939
    Abstract: The present invention provides a simple method of producing osteoclasts from monocytes, a agent comprising monoclonal antibody to be used for the method, and a method for screening a ligand that induces differentiation of monocytes to osteoclasts. Differentiation of monocytes to osteoclasts can be induced in vitro by culturing isolated human peripheral blood monocytes in the presence of monoclonal antibody that binds to a portion of FRP-1 protein exposed on the surface of monocytes. Such a differentiation system can be utilized to isolate a ligand that binds to FRP-1 protein and induces differentiation of monocytes to osteoclasts.
    Type: Application
    Filed: May 21, 2003
    Publication date: October 23, 2003
    Inventors: Yasuhiko Ito, Shigeomi Higuchi
  • Method for induction of differentiation of osteoclasts
    Patent number: 6589528
    Abstract: The present invention provides a simple method of producing osteoclasts from monocytes, a agent comprising monoclonal antibody to be used for the method, and a method for screening a ligand that induces differentiation of monocytes to osteoclasts. Differentiation of monocytes to osteoclasts can be induced in vitro by culturing isolated human peripheral blood monocytes in the presence of monoclonal antibody that binds to a portion of FRP-1 protein exposed on the surface of monocytes. Such a differentiation system can be utilized to isolate a ligand that binds to FRP-1 protein and induces differentiation of monocytes to osteoclasts.
    Type: Grant
    Filed: November 6, 2001
    Date of Patent: July 8, 2003
    Assignee: DNAVEC Research Inc.
    Inventors: Yasuhiko Ito, Shigeomi Higuchi
  • Method for induction of differentiation of osteoclasts
    Publication number: 20020031514
    Abstract: The present invention provides a simple method of producing osteoclasts from monocytes, a agent comprising monoclonal antibody to be used for the method, and a method for screening a ligand that induces differentiation of monocytes to osteoclasts. Differentiation of monocytes to osteoclasts can be induced in vitro by culturing isolated human peripheral blood monocytes in the presence of monoclonal antibody that binds to a portion of FRP-1 protein exposed on the surface of monocytes. Such a differentiation system can be utilized to isolate a ligand that binds to FRP-1 protein and induces differentiation of monocytes to osteoclasts.
    Type: Application
    Filed: November 6, 2001
    Publication date: March 14, 2002
    Inventors: Yasuhiko Ito, Shigeomi Higuchi