Abstract: The present invention relates to a monoclonal antibody having excellent immunosuppressive activity or an antigen binding fragment thereof. More specifically, the present invention relates to a monoclonal antibody or an antigen binding fragment thereof, which binds to a peptide consisting an amino acid sequence represented by SSVLYGGPPSAA (SEQ ID NO: 1) or a conjugate of the peptide and a pharmaceutically acceptable carrier, the monoclonal antibody or an antigen binding fragment thereof having a higher binding affinity for core histone than for histone H1.

Abstract: There is provided a method for producing dipropylene glycol (DPG) and/or tripropylene glycol (TPG) including: (A) reacting a raw material liquid including propylene oxide and water to obtain a reaction liquid including unreacted water, propylene glycol (PG), DPG and/or TPG, and an alcohol compound excluding PG, DPG, and TPG; (B) separating, from the reaction liquid, a first liquid containing water and the alcohol compound and a second liquid containing the PG, DPG and/or TPG and optionally the alcohol compound; (C) removing a part of the alcohol compound from the first liquid to obtain a third liquid containing water and optionally a part of the alcohol compound; (D) separating, from the second liquid, a fourth liquid containing the PG and optionally the alcohol compound, and a fifth liquid containing the DPG and/or TPG and optionally the alcohol compound; and (E) recycling a part of the third liquid to step (A).

Abstract: A method for producing propylene oxide in which the concentration of an organic peroxide in a reaction solution after an epoxidation step is from 20 to 5,000 ppm by weight based on the amount excluding propylene in the reaction solution, the method comprising an epoxidation step of reacting an organic peroxide with propylene in the presence of a catalyst to obtain propylene oxide and an alcohol, a propylene recovery step of recovering the unreacted propylene in the epoxidation step and recycling the resulting propylene as a raw material of the epoxidation step, and a propylene oxide purification step of distilling the propylene oxide obtained in the epoxidation step to obtain purified propylene oxide.

Abstract: There is provided a method for producing dipropylene glycol (DPG) and/or tripropylene glycol (TPG) including: (A) reacting a raw material liquid including propylene oxide and water to obtain a reaction liquid including unreacted water, propylene glycol (PG), DPG and/or TPG, and an alcohol compound excluding PG, DPG, and TPG; (B) separating, from the reaction liquid, a first liquid containing water and the alcohol compound and a second liquid containing the PG, DPG and/or TPG and optionally the alcohol compound; (C) removing a part of the alcohol compound from the first liquid to obtain a third liquid containing water and optionally a part of the alcohol compound; (D) separating, from the second liquid, a fourth liquid containing the PG and optionally the alcohol compound, and a fifth liquid containing the DPG and/or TPG and optionally the alcohol compound; and (E) recycling a part of the third liquid to step (A).

Abstract: A signal processing section included in a semiconductor testing circuit supplies a test signal inputted from a tester via a signal line to a plurality of DUTs and generates a test result by synthesizing response signals transmitted from the plurality of DUTs on the basis of the test signal. A test result output section included in the semiconductor testing circuit makes a voltage level of the test result differ from a voltage level of the test signal inputted and outputs the test result to the tester via the signal line.

Abstract: The present invention relates to a monoclonal antibody having excellent immunosuppressive activity or an antigen binding fragment thereof. More specifically, the present invention relates to a monoclonal antibody or an antigen binding fragment thereof, which binds to a peptide consisting an amino acid sequence represented by SSVLYGGPPSAA (SEQ ID NO: 1) or a conjugate of the peptide and a pharmaceutically acceptable carrier, the monoclonal antibody or an antigen binding fragment thereof having a higher binding affinity for core histone than for histone H1.

Abstract: A purification method of dihydroxybenzene comprising the following steps, for obtaining purified dihydroxybenzene from crude dihydroxybenzene containing at least isopropenylphenol and hydroxyacetophenone as impurities: first extraction step, distillation step, second extraction step, and recovery step.

Abstract: A mold forming and molding technology operable to produce a silicon ingot suitable for obtaining a solar cell substrate is disclosed. A slurry is prepared comprising particles with surface oxide layers operable to bond the particles to each other. An external force is applied to the slurry to eliminate cohesion of the particles to form a de-cohesive slurry, and an inner surface of a mold base is coated with the de-cohesive slurry to form a releasing layer that reduces defects in the silicon ingot.

Abstract: There is provided a method for handling an aqueous solution containing a water-soluble substance that changes into a water-insoluble substance over time, including a step of bringing the aqueous solution to be treated containing the water-soluble substance that changes into the water-insoluble substance over time into contact with a water-insoluble organic solvent, and extracting the water-soluble substance into the water-insoluble organic solvent. Preferably, the water-soluble substance is alkylbenzene hydroperoxide, and the water-insoluble substance is alkylbenzene hydroperoxide-derived alcohol. Preferably, the aqueous solution to be treated is an alkaline aqueous phase separated in a water-washing step in a process of manufacturing the alkylbenzene hydroperoxide that has an alkali extraction step, the water-washing step, an oxidation step, and a reaction solution separation step.

Abstract: The present invention discloses anti-histone H1 monoclonal antibodies, hybridomas for the production thereof, and polypeptides, which are useful for suppressing, predicting, or diagnosing transplant rejection in organ transplantation.

Abstract: A testing device of a semiconductor device includes a first board having a plurality of openings; a frame body provided in the openings, the frame body having a frame in which a plurality of probe needles is provided; and a plurality of second boards provided perpendicular to the first board in the periphery of the openings, the second boards being connected to the first board; wherein the probe needles pierce the frame so as to be connected to the second boards from the periphery of the frame body via the openings.

Abstract: A purification method of dihydroxybenzene comprising the following steps, for obtaining purified dihydroxybenzene from crude dihydroxybenzene containing at least isopropenylphenol and hydroxyacetophenone as impurities: first extraction step: water is added to crude dihydroxybenzene to prepare a dihydroxybenzene aqueous solution A, then, the solution is subjected to extraction by allowing it to contact with an extraction solvent (1), to be separated into a first fraction containing dihydroxybenzene, hydroxyacetophenone and water and a second fraction containing isopropenylphenol and the extraction solvent (1), distillation step: the first fraction obtained in the first extraction step is subjected to distillation, to be separated into a third fraction containing water and a fourth fraction containing dihydroxybenzene and hydroxyacetophenone, then, the fourth fraction is subjected to distillation, to be separated into a fifth fraction as purified dihydroxybenzene and a sixth fraction as dihydroxybenzene contain

Abstract: The present invention discloses anti-histone H1 monoclonal antibodies, hybridomas for the production thereof, and polypeptides, which are useful for suppressing, predicting, or diagnosing transplant rejection in organ transplantation.

Abstract: A signal processing section included in a semiconductor testing circuit supplies a test signal inputted from a tester via a signal line to a plurality of DUTs and generates a test result by synthesizing response signals transmitted from the plurality of DUTs on the basis of the test signal. A test result output section included in the semiconductor testing circuit makes a voltage level of the test result differ from a voltage level of the test signal inputted and outputs the test result to the tester via the signal line.

Abstract: The present invention discloses anti-histone H1 monoclonal antibodies, hybridomas for the production thereof, and polypeptides, which are useful for suppressing, predicting, or diagnosing transplant rejection in organ transplantation.

Abstract: A method for collecting an object material from a solution, which comprises the following steps: a step of adding a second solvent to a solution composed of an object material to be collected and a first solvent, then mixing therewith to form an emulsion containing the object material in a state under which the emulsion is not uniformly dissolved in the second solvent, in the second solvent; and a step of separating thus obtained emulsion from the solution.

Abstract: A method for producing propylene oxide in which the concentration of an organic peroxide in a reaction solution after an epoxidation step is from 20 to 5,000 ppm by weight based on the amount excluding propylene in the reaction solution, the method comprising an epoxidation step of reacting an organic peroxide with propylene in the presence of a catalyst to obtain propylene oxide and an alcohol, a propylene recovery step of recovering the unreacted propylene in the epoxidation step and recycling the resulting propylene as a raw material of the epoxidation step, and a propylene oxide purification step of distilling the propylene oxide obtained in the epoxidation step to obtain purified propylene oxide.

Abstract: A testing device of a semiconductor device includes a first board having a plurality of openings; a frame body provided in the openings, the frame body having a frame in which a plurality of probe needles is provided; and a plurality of second boards provided perpendicular to the first board in the periphery of the openings, the second boards being connected to the first board; wherein the probe needles pierce the frame so as to be connected to the second boards from the periphery of the frame body via the openings.

Abstract: A mold forming and molding technology operable to produce a silicon ingot suitable for obtaining a solar cell substrate is disclosed. A slurry is prepared comprising particles with surface oxide layers operable to bond the particles to each other. An external force is applied to the slurry to eliminate cohesion of the particles to form a de-cohesive slurry, and an inner surface of a mold base is coated with the de-cohesive slurry to form a releasing layer that reduces defects in the silicon ingot.

Abstract: The present invention discloses anti-histone H1 monoclonal antibodies, hybridomas for the production thereof, and polypeptides, which are useful for suppressing, predicting, or diagnosing transplant rejection in organ transplantation.