Patents by Inventor Shigeru Ibaragi

Shigeru Ibaragi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8443799
    Abstract: A dry powder inhalation system suitable for transpulmonary administration characterized by using a combination of: (1) A vessel housing a freeze-dried composition that contains a single dose of an active ingredient, and has: (i) a non-powder cake-like form, (ii) a disintegration index of 0.015 or more, and (iii) a property of becoming fine particles having a mean particle diameter of 10 microns or less or a fine particle fraction of 10% or more upon receipt of an air impact having an air speed of at least 1 m/sec and an air flow rate of at least 17 ml/sec; and (2) A device capable of applying said air impact to the freeze-dried composition in said vessel and for discharging the powder-form freeze-dried composition that has been made into fine particles.
    Type: Grant
    Filed: August 30, 2008
    Date of Patent: May 21, 2013
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Chikamasa Yamashita, Shigeru Ibaragi, Yuichiro Fukunaga, Akitsuna Akagi
  • Patent number: 8333193
    Abstract: The present invention provides a novel dry powder inhalation system suitable for transpulmonary administration. The dry powder inhalation system of the invention characterized by using a combination of: (1) a vessel housing a freeze-dried composition that contains a single dose of an active ingredient, and has: (i) a non-powder cake-like form, (ii) a disintegration index of 0.015 or more, and (iii) a property of becoming fine particles having a mean particle diameter of 10 microns or less or a fine particle fraction of 10% or more upon receipt of an air impact having an air speed of at least 1 m/sec and an air flow rate of at least 17 ml/sec; and (2) a device comprising means capable of applying said air impact to the freeze-dried composition in said vessel, and means for discharging the powder-form freeze-dried composition that has been made into fine particles.
    Type: Grant
    Filed: August 30, 2008
    Date of Patent: December 18, 2012
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Chikamasa Yamashita, Shigeru Ibaragi, Yuichiro Fukunaga, Akitsuna Akagi
  • Patent number: 7708014
    Abstract: An inhalation device for transpulmonary administration comprises: a chamber (16) for containing a pharmaceutical composition which is pulverized into fine particles by an air-generated impact for dispersal in air; an air inlet flow path (2) for introducing to the chamber (16) outside air to apply the air-generated impact to the pharmaceutical composition and for injecting the outside air toward the pharmaceutical composition; an inhalation flow path (1) for inhaling the pulverized pharmaceutical composition; a housing (9) for accommodating the chamber (16), the air inlet flow path (2), and the inhalation flow path (1); a mouthpiece (10) provided at one end of the housing (9), the mouthpiece (9) being provided with a mouth-side flow path (11) which communicates with the inhalation flow path (1), and an auxiliary flow path (12).
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: May 4, 2010
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Chikamasa Yamashita, Hitoshi Matsushita, Shigeru Ibaragi, Akitsuna Akagi
  • Publication number: 20090126732
    Abstract: The present invention provides a novel dry powder inhalation system suitable for transpulmonary administration. The dry powder inhalation system of the invention characterized by using a combination of: (1) a vessel housing a freeze-dried composition that contains a single dose of an active ingredient, and has: (i) a non-powder cake-like form, (ii) a disintegration index of 0.015 or more, and (iii) a property of becoming fine particles having a mean particle diameter of 10 microns or less or a fine particle fraction of 10% or more upon receipt of an air impact having an air speed of at least 1 m/sec and an air flow rate of at least 17 ml/sec; and (2) a device comprising means capable of applying said air impact to the freeze-dried composition in said vessel, and means for discharging the powder-form freeze-dried composition that has been made into fine particles.
    Type: Application
    Filed: August 30, 2008
    Publication date: May 21, 2009
    Inventors: Chikamasa Yamashita, Shigeru Ibaragi, Yuichiro Fukunaga, Akitsuna Akagi
  • Publication number: 20090095293
    Abstract: The present invention provides a novel dry powder inhalation system suitable for transpulmonary administration. The dry powder inhalation system of the invention characterized by using a combination of: (1) a vessel housing a freeze-dried composition that contains a single dose of an active ingredient, and has: (i) a non-powder cake-like form, (ii) a disintegration index of 0.015 or more, and (iii) a property of becoming fine particles having a mean particle diameter of 10 microns or less or a fine particle fraction of 10% or more upon receipt of an air impact having an air speed of at least 1 m/sec and an air flow rate of at least 17 ml/sec; and (2) a device comprising means capable of applying said air impact to the freeze-dried composition in said vessel, and means for discharging the powder-form freeze-dried composition that has been made into fine particles.
    Type: Application
    Filed: October 10, 2008
    Publication date: April 16, 2009
    Inventors: Chikamasa YAMASHITA, Shigeru Ibaragi, Yuichiro Fukunaga, Akitsuna Akagi
  • Patent number: 7448379
    Abstract: A non-powder-form freeze-dried composition for transpulmonary administration has a disintegration index greater than or equal to 0.015 and contains at least one active ingredient. The composition becomes fine particles upon receiving air impact at an air speed greater than or equal to 1 meter/second and an air flow rate greater than or equal to 17 milliliters/second. The fine particles have a mean particle diameter less than or equal to 1×10?5 meters and/or a fine particle fraction greater than or equal to 10%. A method of making the composition, a vessel containing the composition, a method of administering the composition, a dry powder inhalation system for transpulmonary administration, and a method of transpulmonary administration are also disclosed.
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: November 11, 2008
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Chikamasa Yamashita, Shigeru Ibaragi, Yuichiro Fukunaga, Akitsuna Akagi
  • Publication number: 20060169280
    Abstract: An inhalation device for transpulmonary administration comprises: a chamber (16) for containing a pharmaceutical composition which is pulverized into fine particles by an air-generated impact for dispersal in air; an air inlet flow path (2) for introducing to the chamber (16) outside air to apply the air-generated impact to the pharmaceutical composition and for injecting the outside air toward the pharmaceutical composition; an inhalation flow path (1) for inhaling the pulverized pharmaceutical composition; a housing (9) for accommodating the chamber (16), the air inlet flow path (2), and the inhalation flow path (1); a mouthpiece (10) provided at one end of the housing (9), the mouthpiece (9) being provided with a mouth-side flow path (11) which communicates with the inhalation flow path (1), and an auxiliary flow path (12).
    Type: Application
    Filed: December 12, 2003
    Publication date: August 3, 2006
    Inventors: Chikamasa Yama, Hitoshi Matsushita, Shigeru Ibaragi, Akitsuna Akagi
  • Publication number: 20060057106
    Abstract: The present invention provides a freeze-dried interferon-? composition for transpulmonary administration which can maintain IFN-? stably, and can be prepared into fine particles in a vessel at the time of use. A freeze-dried interferon-? composition for transpulmonary administration of the present invention has the following properties (i) to (iv): (i) containing at least one hydrophobic stabilizer selected from the group consisting of hydrophobic amino acids, dipeptides of hydrophobic amino acids, tripeptides of hydrophobic amino acids and derivatives of hydrophobic amino acids and salts thereof; at least one hydrophilic stabilizer selected from the group consisting of hydrophilic amino acids, dipeptides of hydrophilic amino acids, tripeptides of hydrophilic amino acids, derivatives of hydrophilic amino acids and salts thereof; and interferon-?(ii) a non-powder cake-like form; (iii) a disintegration index of 0.
    Type: Application
    Filed: December 12, 2003
    Publication date: March 16, 2006
    Inventors: Chikamasa Yamashita, Shigeru Ibaragi
  • Publication number: 20030101995
    Abstract: The present invention provides a novel dry powder inhalation system suitable for transpulmonary administration.
    Type: Application
    Filed: June 14, 2002
    Publication date: June 5, 2003
    Applicant: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Chikamasa Yamashita, Shigeru Ibaragi, Yuichiro Fukunaga, Akitsuna Akagi