Abstract: There has been a need for a neutralizing monoclonal antibody which is useful for antibody therapy effective against ebolavirus. The present invention provides a monoclonal antibody or an antigen-binding fragment thereof, which recognizes an internal fusion loop of ebolavirus GP and is capable of neutralizing the biological activity of ebolavirus.

Abstract: There has been a need for a neutralizing monoclonal antibody which is useful for antibody therapy effective against ebolavirus. The present invention provides a monoclonal antibody or an antigen-binding fragment thereof, which recognizes an internal fusion loop of ebolavirus GP and is capable of neutralizing the biological activity of ebolavirus.

Abstract: Disclosed is a novel method for altering the depth of flower color for the lighter or deeper. Specifically disclosed is a method for altering the depth of flower color of a plant for the lighter or deeper by varying the anthocyanin content in petals of the plant, which comprises a step of regulating the expression of type IV chalcone isomerase in the plant.

Abstract: An anti-ganglioside GM2 antibody composition having enhanced effector function which is useful as a medicament has been desired. The present invention provides an antibody composition comprising an antibody molecule which specifically binds to ganglioside GM2 and has complex type N-glycoside-linked sugar chains in the Fc region, wherein the complex type N-glycoside-linked sugar chains have a structure in which fucose is not bound to N-acetylglucosamine in the reducing end in the sugar chains; a transformant which produces the antibody composition; a process for producing the antibody composition; and a pharmaceutical composition comprising the antibody composition.

Abstract: The present invention provides an antibody composition comprising an antibody molecule which specifically binds to human CC chemokine receptor 4 (CCR4) and has complex type N-glycoside-linked sugar chains in the Fc region, wherein the complex type N-glycoside-linked sugar chains have a structure in which fucose is not bound to N-acetylglucosamine in the reducing end in the sugar chains; a transformant which produces the antibody composition; a process for producing the antibody composition; and a pharmaceutical composition comprising the antibody composition.

Abstract: Preparation of Braille books and audio books by man has a problem that a great deal of costs including the work cost for recitation or translation (printing) of Braille, composition, examination and the like and the distribution cost are required as compared with general books. Further, there is a problem that books that visually handicapped people wish to read cannot be delivered immediately at an inexpensive price. The user (reader) himself participates in editing or correction in processing for producing an audio book which reads an electronic book aloud using the speech synthesis technique and pronunciation symbol text constituting the basis of the audio book to thereby reduce the cost required for the production processing of the audio book and the pronunciation symbol text and improve the quality of the audio book and the pronunciation symbol text.

Abstract: Development of a host cell capable of producing a glycoprotein composition such as an antibody composition which is useful in development of medicaments is desired. The present invention provides a cell in which a genomic gene encoding an enzyme relating to a sugar chain modification in which 1-position of fucose is bound to 6-position of N-acetylglucosamine in the reducing end through ?-bond in a complex type N-glycoside-linked sugar chain is knocked out, wherein the cell is naturalized in a serum-free medium and a process for producing a glycoprotein composition using the cell.

Abstract: The present inventors identified the causative gene of pyl mutant, which is mutable and shows a lowered chlorophyll accumulation, and discovered that a new type of transposon classified to Ac/Ds type is involved in the mutation. It is confirmed for the first time that the Ac/Ds type transposon nDart (SEQ ID NO: 1) in rice has transposon activity under normal cultivation conditions. Furthermore, an autonomous element Dart was discovered by analyzing said Ac/Ds type transposon.

Abstract: The present invention provides a cell capable of controlling the sugar chain structure of a glycoprotein which is a producing protein, that is, a cell capable of producing a glycoprotein having high physiological activity; a process for producing a glycoprotein using the cell; a glycoprotein produced by the process; and use thereof.

Abstract: The present invention provides an antibody composition comprising an antibody molecule which specifically binds to human CC chemokine receptor 4 (CCR4) and has complex type N-glycoside-linked sugar chains in the Fc region, wherein the complex type N-glycoside-linked sugar chains have a structure in which fucose is not bound to N-acetylglucosamine in the reducing end in the sugar chains; a transformant which produces the antibody composition; a process for producing the antibody composition; and a pharmaceutical composition comprising the antibody composition.

Abstract: An efficient contents search service is provided according to a particular contents purchase or contract history of the user.

Abstract: The present invention provides an antibody composition comprising an antibody molecule which specifically binds to human interleukin-5 receptor ? chain and has complex type N-glycoside-linked sugar chains in the Fc region, wherein the complex type N-glycoside-linked sugar chains have a structure in which fucose is not bound to N-acetylglucosamine in the reducing end in the sugar chains; a transformant which produces the antibody composition; a process for producing the antibody composition; and a pharmaceutical composition comprising the antibody composition.

Abstract: The invention is directed to correcting of a lower end level of a suction nozzle during manufacturing running based on the lower end level of the suction nozzle measured after a mounting operation. An electronic component mounting apparatus for picking electronic components up from component feeding units by suction nozzles and mounting the electronic component on a printed board is provided with a line sensor unit for measuring a lower end level of the suction nozzle after a component mounting operation on a printed board. A CPU calculates a descending amount of the suction nozzle at a pickup station and a mounting station based on a value measured by the line sensor unit, and rotates a stroke motor to move a moving body to a position where the suction nozzle can descend by the amount. Therefore, the electronic component can be picked up and mounted on the printed board properly even if the suction nozzle is worn with time.

Abstract: A genome-modification technique based on homologous recombination was established for partial modification of genomic sequences into desired sequences. The use of such a technique to achieve high efficiency and reproducibility in higher plants has been regarded as difficult. According to the present invention, endogenous genome sequences of higher plants can be targeted to efficiently and reproducibly yield homologous recombinants without changing their original loci. Moreover, the present invention enables the production of a transformed plant in which a specific gene is modified without any restrictions, and it can also contribute to the analysis of gene functions as well as to the analysis of gene expression mechanisms associated with changes in genome dynamics.

Abstract: If a commodity desired to purchase is selected in a purchaser terminal, a list of users (information providers) having a purchase history of the commodity at a shopping site is displayed. The purchaser terminal exchanges messages in real time with an information terminal of an information provider selected from the list, and obtains information concerning the commodity (information provision). In the case where the purchaser purchases the commodity, its commodity ID and a user ID of the information provider are associated with each other and stored in a shopping site operation apparatus. After the purchase of the commodity, a comment and/or evaluation concerning the information provision are input. On the basis of the comment and/or evaluation, privilege is granted to the information provider. The comment and/or evaluation are reflected in information of the information providers.

Abstract: There is provided a gene encoding a protein that has an activity of regulating the pH of vacuoles, for example a gene derived from morning glory encoding a protein that has the amino acid sequence as set forth in SEQ ID NO: 2. By introducing this gene into a plant, the flower color can be regulated via the control of the pH of vacuoles.

Abstract: A process for producing an antibody composition using a cell, which comprises using a cell resistant to a lectin which recognizes a sugar chain in which 1-position of fucose is bound to 6-position of N-acetylglucosamine in the reducing end through &agr;-bond in a complex N-glycoside-linked sugar chain, and a cell used for the process.