Patents by Inventor Shigeru Sakurai
Shigeru Sakurai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230212241Abstract: (Objective) An objective of the present invention is to provide therapeutic agents that, in association with stimulation of PDGFR?-positive cells such as bone marrow mesenchymal stem cells, promote their mobilization into blood and accumulation in a damaged tissue, and induce tissue regeneration in a living body. (Means for solution) Multiple peptides were synthesized, and the migration-promoting activity of each peptide was evaluated. As a result, the present inventors successfully identified multiple peptides that have migration-promoting activity on a PDGFR?-positive bone marrow mesenchymal stem cell line (MSC-1). Further, the present inventors confirmed that the identified peptides also have migration-promoting activity on skin fibroblasts, which are PDGFR?-positive cells.Type: ApplicationFiled: December 21, 2022Publication date: July 6, 2023Inventors: KATSUTO TAMAI, TAKEHIKO YAMAZAKI, TSUTOMU KANEZAKI, SHIGERU SAKURAI, YUKIKO NOGUCHI, MAYUMI ENDO, NATSUMI HAMABUCHI, KANA NAITO
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Publication number: 20200369736Abstract: (Objective) An objective of the present invention is to provide therapeutic agents that, in association with stimulation of PDGFR?-positive cells such as bone marrow mesenchymal stem cells, promote their mobilization into blood and accumulation in a damaged tissue, and induce tissue regeneration in a living body. (Means for solution) Multiple peptides were synthesized, and the migration-promoting activity of each peptide was evaluated. As a result, the present inventors successfully identified multiple peptides that have migration-promoting activity on a PDGFR?-positive bone marrow mesenchymal stem cell line (MSC-1). Further, the present inventors confirmed that the identified peptides also have migration-promoting activity on skin fibroblasts, which are PDGFR?-positive cells.Type: ApplicationFiled: December 13, 2019Publication date: November 26, 2020Inventors: KATSUTO TAMAI, TAKEHIKO YAMAZAKI, TSUTOMU KANEZAKI, SHIGERU SAKURAI, YUKIKO NOGUCHI, MAYUMI ENDO, NATSUMI HAMABUCHI, KANA NAITO
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Patent number: 10550165Abstract: (Objective) An objective of the present invention is to provide therapeutic agents that, in association with stimulation of PDGFR?-positive cells such as bone marrow mesenchymal stem cells, promote their mobilization into blood and accumulation in a damaged tissue, and induce tissue regeneration in a living body. (Means for solution) Multiple peptides were synthesized, and the migration-promoting activity of each peptide was evaluated. As a result, the present inventors successfully identified multiple peptides that have migration-promoting activity on a PDGFR?-positive bone marrow mesenchymal stem cell line (MSC-1). Further, the present inventors confirmed that the identified peptides also have migration-promoting activity on skin fibroblasts, which are PDGFR?-positive cells.Type: GrantFiled: August 30, 2017Date of Patent: February 4, 2020Assignees: STEMRIM INC., OSAKA UNIVERSITYInventors: Katsuto Tamai, Takehiko Yamazaki, Tsutomu Kanezaki, Shigeru Sakurai, Yukiko Noguchi, Mayumi Endo, Natsumi Hamabuchi, Kana Naito
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Patent number: 10364276Abstract: (Objective) An objective of the present invention is to provide therapeutic agents that, in association with stimulation of PDGFR?-positive cells such as bone marrow mesenchymal stem cells, promote their mobilization into blood and accumulation in a damaged tissue, and induce tissue regeneration in a living body. (Means for solution) Multiple peptides were synthesized, and the migration-promoting activity of each peptide was evaluated. As a result, the present inventors successfully identified multiple peptides that have migration-promoting activity on a PDGFR?-positive bone marrow mesenchymal stem cell line (MSC-1). Further, the present inventors confirmed that the identified peptides also have migration-promoting activity on skin fibroblasts, which are PDGFR?-positive cells.Type: GrantFiled: April 3, 2012Date of Patent: July 30, 2019Assignees: STEMRIM INC., OSAKA UNIVERSITYInventors: Katsuto Tamai, Takehiko Yamazaki, Tsutomu Kanezaki, Shigeru Sakurai, Yukiko Noguchi, Mayumi Endo, Natsumi Hamabuchi, Kana Naito
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Patent number: 10160792Abstract: (Objective) An objective of the present invention is to provide therapeutic agents that, in association with stimulation of PDGFR?-positive cells such as bone marrow mesenchymal stem cells, promote their mobilization into blood and accumulation in a damaged tissue, and induce tissue regeneration in a living body. (Means for solution) Multiple peptides were synthesized, and the migration-promoting activity of each peptide was evaluated. As a result, the present inventors successfully identified multiple peptides that have migration-promoting activity on a PDGFR?-positive bone marrow mesenchymal stem cell line (MSC-1). Further, the present inventors confirmed that the identified peptides also have migration-promoting activity on skin fibroblasts, which are PDGFR?-positive cells.Type: GrantFiled: April 3, 2012Date of Patent: December 25, 2018Assignees: STEMRIM INC., OSAKA UNIVERSITYInventors: Katsuto Tamai, Takehiko Yamazaki, Tsutomu Kanezaki, Shigeru Sakurai, Yukiko Noguchi, Mayumi Endo, Natsumi Hamabuchi, Kana Naito
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Publication number: 20180072785Abstract: (Objective) An objective of the present invention is to provide therapeutic agents that, in association with stimulation of PDGFR?-positive cells such as bone marrow mesenchymal stem cells, promote their mobilization into blood and accumulation in a damaged tissue, and induce tissue regeneration in a living body. (Means for solution) Multiple peptides were synthesized, and the migration-promoting activity of each peptide was evaluated. As a result, the present inventors successfully identified multiple peptides that have migration-promoting activity on a PDGFR?-positive bone marrow mesenchymal stem cell line (MSC-1). Further, the present inventors confirmed that the identified peptides also have migration-promoting activity on skin fibroblasts, which are PDGFR?-positive cells.Type: ApplicationFiled: August 30, 2017Publication date: March 15, 2018Inventors: KATSUTO TAMAI, TAKEHIKO YAMAZAKI, TSUTOMU KANEZAKI, SHIGERU SAKURAI, YUKIKO NOGUCHI, MAYUMI ENDO, NATSUMI HAMABUCHI, KANA NAITO
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Publication number: 20140206619Abstract: (Objective) An objective of the present invention is to provide therapeutic agents that, in association with stimulation of PDGFR?-positive cells such as bone marrow mesenchymal stem cells, promote their mobilization into blood and accumulation in a damaged tissue, and induce tissue regeneration in a living body. (Means for solution) Multiple peptides were synthesized, and the migration-promoting activity of each peptide was evaluated. As a result, the present inventors successfully identified multiple peptides that have migration-promoting activity on a PDGFR?-positive bone marrow mesenchymal stem cell line (MSC-1). Further, the present inventors confirmed that the identified peptides also have migration-promoting activity on skin fibroblasts, which are PDGFR?-positive cells.Type: ApplicationFiled: April 3, 2012Publication date: July 24, 2014Applicants: OSAKA UNIVERSITY, GENOMIX CO., LTD.Inventors: Katsuto Tamai, Takehiko Yamazaki, Tsutomu Kanezaki, Shigeru Sakurai, Yukiko Noguchi, Mayumi Endo, Natsumi Hamabuchi, Kana Naito
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Patent number: 8420403Abstract: A method for evaluating the caking property of sodium hydrogencarbonate crystal particles, characterized in that sodium hydrogencarbonate crystal particles are hermetically sealed in a packaging material having a water vapor transmission rate of at least 3 g/(m2·24 h) (at 40° C. with a relative humidity difference of 90%) as stipulated in JIS K7129 and left at rest at a temperature of from 17 to 35° C. at a carbon dioxide gas concentration of from 0.03 to 0.05 vol % at a relative humidity of from 40 to 95% for from 2 weeks to 3 months, and the proportion of agglomerated sodium hydrogencarbonate crystal particles is determined to evaluate the caking tendency. A novel test method for evaluating the caking property of sodium hydrogencarbonate crystal particles, capable of providing results of the caking property test with high reproducibility, quantitatively with high versatility, can be provided.Type: GrantFiled: January 3, 2007Date of Patent: April 16, 2013Assignee: Asahi Glass Company, LimitedInventors: Shintaro Kikuchi, Fumiaki Nakashima, Hisakazu Arima, Shigeru Sakurai, Takako Hirano
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Patent number: 8236268Abstract: A process for producing sodium hydrogencarbonate crystal particles having a low caking property, which entails subjecting sodium hydrogencarbonate crystal particles having an average particle size of from 50 to 500 ?m based on the mass to heat treatment at a temperature of from 70 to 95° C. by a heating gas having a carbon dioxide gas concentration of at most the concentration calculated by the formula: Carbon dioxide gas concentration=0.071×e(0.1×T)×R(?0.0005×T?0.9574), where T (° C.) is the temperature of sodium hydrogencarbonate crystals, and R (%) is the relative humidity around the crystals at the temperature of the crystals, provided that the upper limit of the carbon dioxide gas concentration is 100 vol % to form anhydrous sodium carbonate on the surface of the sodium hydrogencarbonate crystal particles with a content of anhydrous sodium carbonate of from 0.03 to 0.4 mass % in the sodium hydrogencarbonate crystals.Type: GrantFiled: December 27, 2006Date of Patent: August 7, 2012Assignee: Asahi Glass Company, LimitedInventors: Hachirou Hirano, Takako Hirano, legal representative, Shintaro Kikuchi, Fumiaki Nakashima, Hisakazu Arima, Shigeru Sakurai
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Patent number: 8202370Abstract: To provide a method for removing an acidic deposit containing a sulfur compound, whereby the terminal point of the cleaning state can be ascertained simply and efficiently without necessity to visually directly observe the cleaning state or to observe the behavior of the pH value of the cleaning fluid. A method for removing an acidic deposit containing a sulfur compound, which comprises contacting the acidic deposit with a prescribed amount of an aqueous cleaning fluid, characterized in that the concentration of sulfate ion (SO42?) in the aqueous cleaning fluid is measured, and the contact with the aqueous cleaning fluid is terminated after the increase per hour of the measured value becomes 15 not more than 10%.Type: GrantFiled: October 25, 2007Date of Patent: June 19, 2012Assignee: Asahi Glass Company, LimitedInventors: Shigeru Sakurai, Masaharu Emoto
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Patent number: 8089226Abstract: A torque control device controlling torque of first and second mechanical units connected coaxially to each other through connecting members includes a controller generating first and second references from a command from a host system, first and second motors respectively driving the first and second mechanical units, first and second motor control units respectively controlling the first and second motors on the basis of the first and second references. The first and second references synchronously accelerate the first and second motors to first rotational speed, then increase rotational speed of the second motor according to a speed profile to produce torsional torque in the connecting members, decelerate the second motor to the first rotational speed after the torsional torque reaches a predetermined value, and synchronously decelerate and stop the first and second motors after a predetermined time period elapses.Type: GrantFiled: October 26, 2009Date of Patent: January 3, 2012Assignee: Kabushiki Kaisha Yaskawa DenkiInventors: Ryuta Matsutani, Kenji Yoshida, Shigeru Sakurai
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Patent number: 7976808Abstract: To provide an agent for removing a halogen series gas and a method for removing a halogen series gas which is excellent in a removing ability of removing the present halogen series gas in a low concentration area, which prevents an adsorbent from generating heat, and which is capable of reducing formation of a solid waste. A method for removing a halogen series gas, which comprises bringing a gas to be treated which contains at least one member selected from the halogen series gas group consisting of F2, Cl2, Br2, I2, and compounds which generate a hydrogen halide or hypohalogeneous acid upon hydrolysis, into contact with a granule comprising, based on the total mass of the granule, from 45 to 99.85 mass % of an alkali metal salt, from 0.1 to 40 mass % of a carbonaceous material, and from more than 0 mass % to 15 mass % of an alkaline earth metal salt, in the presence of water.Type: GrantFiled: November 19, 2008Date of Patent: July 12, 2011Assignee: Asahi Glass Company, LimitedInventors: Shigeru Sakurai, Hisakazu Arima
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Publication number: 20100039053Abstract: A torque control device controlling torque of first and second mechanical units connected coaxially to each other through connecting members includes a controller generating first and second references from a command from a host system, first and second motors respectively driving the first and second mechanical units, first and second motor control units respectively controlling the first and second motors on the basis of the first and second references. The first and second references synchronously accelerate the first and second motors to first rotational speed, then increase rotational speed of the second motor according to a speed profile to produce torsional torque in the connecting members, decelerate the second motor to the first rotational speed after the torsional torque reaches a predetermined value, and synchronously decelerate and stop the first and second motors after a predetermined time period elapses.Type: ApplicationFiled: October 26, 2009Publication date: February 18, 2010Applicant: KABUSHIKI KAISHA YASKAWA DENKIInventors: Ryuta MATSUTANI, Kenji Yoshida, Shigeru Sakurai
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Publication number: 20090130012Abstract: To provide an agent for removing a halogen series gas and a method for removing a halogen series gas which is excellent in a removing ability of removing the present halogen series gas in a low concentration area, which prevents an adsorbent from generating heat, and which is capable of reducing formation of a solid waste. A method for removing a halogen series gas, which comprises bringing a gas to be treated which contains at least one member selected from the halogen series gas group consisting of F2, Cl2, Br2, I2, and compounds which generate a hydrogen halide or hypohalogeneous acid upon hydrolysis, into contact with a granule comprising, based on the total mass of the granule, from 45 to 99.85 mass % of an alkali metal salt, from 0.1 to 40 mass % of a carbonaceous material, and from more than 0 mass % to 15 mass % of an alkaline earth metal salt, in the presence of water.Type: ApplicationFiled: November 19, 2008Publication date: May 21, 2009Applicant: ASAHI GLASS COMPANY, LIMITEDInventors: Shigeru Sakurai, Hisakazu Arima
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Sodium hydrogencarbonate crystal particles having low caking property and process for producing them
Patent number: 7485369Abstract: Sodium hydrogencarbonate crystal particles, which comprise sodium hydrogencarbonate crystal particles having an average particle size of from 50 to 500 ?m based on the mass, and anhydrous sodium carbonate, and sodium carbonate monohydrate and/or Wegscheider's salt, present on the surface of the sodium hydrogencarbonate crystal particles in such amounts that the total content of anhydrous sodium carbonate, sodium carbonate monohydrate, Wegscheider's salt and sodium sesquicarbonate in the sodium hydrogencarbonate crystal particles is from 0.04 to 1 mass % as calculated as anhydrous sodium carbonate, anhydrous sodium carbonate accounts for at least 40 mass % of the total content, and sodium carbonate monohydrate and/or Wegscheider's salt accounts for from 5 to 60 mass % of the total content. Sodium hydrogencarbonate crystal particles having a low caking property, which are useful in the field of food products, pharmaceuticals, bath additives, etc.Type: GrantFiled: January 3, 2007Date of Patent: February 3, 2009Assignee: Asahi Glass Company, LimitedInventors: Takako Hirano, legal representative, Shintaro Kikuchi, Fumiaki Nakashima, Hisakazu Arima, Shigeru Sakurai, Hachirou Hirano -
Patent number: 7485697Abstract: The object of this invention is to elucidate the factors involved in the regulation of AGE (advanced glycation endproducts, which are produced in a living body accompanied with diabetes and aging) and RAGE (the receptor for AGE), in order to facilitate investigation on the biological activities, physiological phenomenon and diseases related to AGE and RAGE. Plural molecular species are known to exist for RAGE, and among such molecular species, soluble RAGE exhibits the activity to modulate interaction between AGE and transmembrane-type RAGE. Using this soluble RAGE or a nucleic acid encoding it, the soluble RAGE can be measured, in addition, investigation on various physiological phenomenon, biological activities, and diseases related to interaction between AGE and RAGE can be performed to facilitate development a medicine having further efficacy.Type: GrantFiled: March 19, 2002Date of Patent: February 3, 2009Assignee: Japan as Represented by President of Kanazawa UniversityInventors: Hiroshi Yamamoto, Hideto Yonekura, Yasuhiko Yamamoto, Shigeru Sakurai, Takuo Watanabe
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Publication number: 20090016949Abstract: Sodium hydrogencarbonate crystal particles excellent in anti-caking property and anti-thermal decomposition property, and its production process, are provided. Sodium hydrogencarbonate crystal particles whose color 1 second after dropping of a phenolphthalein solution having a predetermined composition, is R=245 to 255, G=243 to 255 and B=245 to 255 in RGB 256 tone notation. The sodium hydrogencarbonate crystal particles are produced by subjecting sodium hydrogencarbonate crystal particles to a bicarbonation treatment in a humidified carbon dioxide gas atmosphere.Type: ApplicationFiled: September 12, 2008Publication date: January 15, 2009Applicant: ASAHI GLASS COMPANY, LIMITEDInventors: Hachirou Hirano, Takako Hirano, Hisakazu Arima, Shintaro Kikuchi, Fumiaki Nakashima, Shigeru Sakurai
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Publication number: 20080053483Abstract: To provide a method for removing an acidic deposit containing a sulfur compound, whereby the terminal point of the cleaning state can be ascertained simply and efficiently without necessity to visually directly observe the cleaning state or to observe the behavior of the pH value of the cleaning fluid. A method for removing an acidic deposit containing a sulfur compound, which comprises contacting the acidic deposit with a prescribed amount of an aqueous cleaning fluid, characterized in that the concentration of sulfate ion (SO42?) in the aqueous cleaning fluid is measured, and the contact with the aqueous cleaning fluid is terminated after the increase per hour of the measured value becomes not more than 10%.Type: ApplicationFiled: October 25, 2007Publication date: March 6, 2008Applicant: ASAHI GLASS COMPANY LIMITEDInventors: Shigeru Sakurai, Masaharu Emoto
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Publication number: 20070253879Abstract: To provide a method for removing a halogen series gas, which has high capability of treating a halogen series gas, can prevent ignition of an adsorbing agent, is free from formation of carbon dioxide and can reduce generation of wastes, and a removing agent to be used for the method. The method for removing a halogen series gas comprises bringing a gas comprising at least one halogen series gas selected from the group consisting of F2, Cl2, Br2, I2 and a compound which undergoes hydrolysis to form a hydrogen halide or hypohalogenous acid into contact with a granulated product comprising from 80 to 99.9 mass % of an alkali metal base and from 0.1 to 20 mass % of a thiosulfate based on the total mass of the granulated product, in the presence of water, to remove the halogen series gas.Type: ApplicationFiled: June 13, 2007Publication date: November 1, 2007Applicant: Asahi Glass Company, LimitedInventors: Shigeru SAKURAI, Hachirou Hirano, Takako Hirano, Hisakazu Arima
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Publication number: 20070178037Abstract: A process for producing sodium hydrogencarbonate crystals, which comprise subjecting sodium hydrogencarbonate crystal powder having an average particle size of from 50 to 500 ?m based on the mass to heat treatment at a temperature of from 70 to 95° C. by a heating gas having a carbon dioxide gas concentration of at most the concentration calculated by the following formula (1): Carbon dioxide gas concentration=0.07l×e(0.1×T)×R(?0.0005×T?0.9574)??(1) (wherein T is the temperature (%) of sodium hydrogencarbonate crystals, and R is the relative humidity (%), provided that the upper limit of the carbon dioxide gas concentration is 100 vol %) with reference to the graph of FIG. 1 wherein the horizontal axis (X-axis) represents the relative humidity and the vertical axis (Y-axis) represents the carbon dioxide gas concentration, to form anhydrous sodium carbonate on the surface of the sodium hydrogencarbonate crystal particles with a content of anhydrous sodium carbonate of from 0.03 to 0.Type: ApplicationFiled: December 27, 2006Publication date: August 2, 2007Applicant: ASAHI GLASS CO., LTD.Inventors: Hachirou Hirano, Takako Hirano, Shintaro Kikuchi, Fumiaki Nakashima, Hisakazu Arima, Shigeru Sakurai