Patents by Inventor Shigeru Tsuboi

Shigeru Tsuboi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20030216295
    Abstract: The present invention provides antagonists to cell adhesion useful in controlling the negative effects of inflammation, and the metastasis of cancer cells. These antagonists are ligands to E-selectin containing the sialyl Lex structure, including sialyl Lex glycoproteins, sialyl Lex glycolipids, and sialyl Lex oligsaccharides, and other related sialyl Lex-containing molecules capable of inhibiting E-selectin mediated cell adhesion to endothelial cells. The present invention also provides antibodies against sialyl Lex determinants capable of interrupting E-selectin mediated cell adhesion, which are also considered antagonists according to the present invention. The present invention also provides methods of using the antagonists of the present invention to reduce inflammation, and methods to inhibit the process of metastasis by carcinogenic cells.
    Type: Application
    Filed: December 20, 2002
    Publication date: November 20, 2003
    Applicant: La Jolla Cancer Research Foundation
    Inventors: Minoru Fukuda, Ritsuko Sawada, Shigeru Tsuboi
  • Patent number: 6537553
    Abstract: The present invention provides antagonists to cell adhesion useful in controlling the negative effects of inflammation, and the metastasis of cancer cells. These antagonists are ligands to E-selectin containing the sialyl Lex structure, including sialyl Lex glycoproteins, sialyl Lex glycolipids, and sialyl Lex oligsaccharides, and other related sialyl Lex-containing molecules capable of inhibiting E-selectin mediated cell adhesion to endothelial cells. The present invention also provides antibodies against sialyl Lex determinants capable of interrupting E-selectin mediated cell adhesion, which are also considered antagonists according to the present invention. The present invention also provides methods of using the antagonists of the present invention to reduce inflammation, and methods to inhibit the process of metastasis by carcinogenic cells.
    Type: Grant
    Filed: January 6, 1995
    Date of Patent: March 25, 2003
    Assignee: La Jolla Cancer Research Foundation
    Inventors: Minoru Fukuda, Ritsuko Sawada, Shigeru Tsuboi
  • Patent number: 6371746
    Abstract: An electric sintering mold includes a clamping portion for clamping a powder material, the material clamped by the clamping portion being subjected to a pressure from a pressurizer and a pulsating electric current externally supplied, so that joule heat is generated within the material for sintering the material. The mold is formed of material containing metal boride having electroconductivity. An electric sintering apparatus using such mold and an electric sintering method utilizing such apparatus and mold are also disclosed.
    Type: Grant
    Filed: February 11, 2000
    Date of Patent: April 16, 2002
    Assignee: Kubota Corporation
    Inventors: Yasuaki Shiomi, Nobuhito Kuroishi, Shigeru Tsuboi, Atsushi Sugai, Masahiro Murata, Jun Yoshino
  • Patent number: 4793402
    Abstract: A heat storage composition excellent in heat storing effect contains calcium chloride hexahydrate as the main component and an appropriate amount of a nucleating agent combination for inhibiting supercooling which is composed of barium sulfide, barium chloride dihydrate and strontium chloride hexahydrate or of barium chloride dihydrate and strontium chloride hexahydrate and optionally contains an appropriate amount of a thickening agent combination composed of an ultrafine silica powder and glycerin. Latent heat storage capsules contain the above heat storage composition and are improved particularly in their structure such that improved heat storage and release effects can be produced. A temperature control apparatus can make most of the heat storage capsules in the temperature control of a hothouse or the like.
    Type: Grant
    Filed: September 16, 1987
    Date of Patent: December 27, 1988
    Assignee: Kubota Tekko Kabushiki Kaisha
    Inventors: Naomichi Yano, Tadatsugu Ueno, Shigeru Tsuboi
  • Patent number: 4715978
    Abstract: A heat storage composition excellent in heat storing effect contains calcium chloride hexahydrate as the main component and an appropriate amount of a nucleating agent combination for inhibiting supercooling which is composed of barium sulfide, barium chloride dihydrate and strontium chloride hexahydrate or of barium chloride dihydrate and strontium chloride hexahydrate and optionally contains an appropriate amount of a thickening agent combination composed of an ultrafine silica powder and glycerin. Latent heat storage capsules contain the above heat storage composition and are improved particularly in their structure such that improved heat storage and release effects can be produced. A temperature control apparatus can make most of the heat storage capsules in the temperature control of a hothouse or the like.
    Type: Grant
    Filed: April 10, 1986
    Date of Patent: December 29, 1987
    Assignee: Kubota Tekko Kabushiki Kaisha
    Inventors: Naomichi Yano, Tadatsugu Ueno, Shigeru Tsuboi