Patents by Inventor Shigeru Yamabe
Shigeru Yamabe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4668514Abstract: This invention provides a penicillin derivative of the formula ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and represent hydrogen, C.sub.1-6 alkyl, C.sub.1-6 hydroxyalkyl, C.sub.3-9 acyloxyalkyl, C.sub.8-13 benzyloxyalkyl, C.sub.2-7 alkoxyalkyl, C.sub.2-7 alkoxycarbonyl, C.sub.3-8 alkenyloxycarbonyl, C.sub.3-8 alkynyloxycarbonyl, phenyl, amino, cyano, formyl, trifluoromethyl, C.sub.2-6 acyl, carbamoyl, C.sub.2-7 alkylcarbamoyl, benzyloxycarbonylamino, C.sub.2-7 alkoxycarbonylamino; and R.sub.3 is hydrogen, a group for forming a pharmaceutically acceptable salt, or a penicillin carboxyl protecting group, with the proviso that both of R.sub.1 and R.sub.2 are not hydrogen or C.sub.2-7 alkoxycarbonyl at the same time and that when one of R.sub.1 and R.sub.2 is hydrogen, the other is not C.sub.2-7 alkoxycarbonyl, or a pharmaceutically acceptable acid addition salt, process for preparing the derivative, and a pharmaceutical composition containing the derivative.Type: GrantFiled: October 5, 1984Date of Patent: May 26, 1987Assignee: Taiho Pharmaceutical Company LimitedInventors: Ronald G. Micetich, Shigeru Yamabe, Motoaki Tanaka, Tomio Yamazaki, Naobumi Ishida, Makoto Kajitani
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Patent number: 4562073Abstract: A penicillin derivative represented by the following formula ##STR1## wherein R.sub.1 is hydrogen or trialkylsilyl; R.sub.2 is hydrogen, trialkylsilyl or COOR.sub.2 ' wherein R.sub.2 ' is hydrogen, C.sub.1-18 alkyl, C.sub.2-7 alkoxymethyl, C.sub.3-8 alkylcarbonyloxymethyl, C.sub.4-9 alkylcarbonyloxyethyl, (C.sub.5-7 cycloalkyl)carbonyloxymethyl, C.sub.9-14 benzylcarbonyloxyalkyl, C.sub.3-8 alkoxycarbonylmethyl, C.sub.4-9 alkoxycarbonylethyl, phthalidyl, crotonolacton-4-yl, .gamma.-butyrolacton-4-yl, halogenated C.sub.1-6 alkyl substituted with 1 to 3 halogen atoms, C.sub.1-6 alkoxy- or nitro-substituted or unsubstituted benzyl, benzhydryl, tetrahydropyranyl, dimethylaminoethyl, dimethylchlorosilyl, trichlorosilyl, (5-substituted C.sub.1-6 alkyl or phenyl or unsubstituted-2-oxo-1,3-dioxoden-4-yl)methyl, C.sub.8-13 benzoyloxyalkyl or group for forming a pharmaceutically acceptable salt; and R.sub.3 has the same meaning as above R.sub.2 '.Type: GrantFiled: August 1, 1983Date of Patent: December 31, 1985Assignee: Taiho Pharmaceutical Company LimitedInventors: Ronald G. Micetich, Shigeru Yamabe, Motoaki Tanaka, Makoto Kajitani, Tomio Yamazaki, Naobumi Ishida
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Patent number: 4529592Abstract: A penicillin derivative represented by the following formula ##STR1## wherein R.sub.1 and R.sub.2 are each the same or different and represent hydrogen, C.sub.1-18 alkyl, mononitro-substituted benzyl or group for forming a pharmaceutically acceptable salt and R.sub.3 is selected from the group consisting of hydrogen, C.sub.1-6 alkyl, C.sub.2-7 alkoxymethyl, C.sub.3-8 alkylcarbonyloxymethyl, C.sub.4-9 alkylcarbonyloxyethyl, (C.sub.5-7 cycloalkyl)carbonyloxymethyl, C.sub.9-14 benzylcarbonyloxyalkyl, C.sub.3-8 alkoxycarbonylmethyl, C.sub.4-9 alkoxycarbonylethyl, phthalidyl, crotonolacton-4-yl, .gamma.-butyrolacton-4-yl, halogenated C.sub.1-6 alkyl substituted with 1 to 3 halogen atoms, C.sub.1-6 alkoxy- or nitro-substituted or unsubstituted benzyl, benzhydryl, tetrahydropyranyl, dimethylaminoethyl, dimethylchlorosilyl, trichlorosilyl, (5-substituted C.sub.1-6 alkyl or phenyl or unsubstituted-2-oxo-1,3-dioxoden-4-yl)methyl, C.sub.8-13 benzoyloxyalkyl and group for forming a pharmaceutically acceptable salt.Type: GrantFiled: June 6, 1983Date of Patent: July 16, 1985Assignee: Taiho Pharmaceutical Company, LimitedInventors: Ronald G. Micetich, Shigeru Yamabe, Tomio Yamazaki, Naobumi Ishida, Takeshi Ishizawa
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Patent number: 4507239Abstract: A penicillin derivative represented by the following formula, a pharmaceutically acceptable salt thereof and an ester thereof: ##STR1## wherein n is 0, 1 or 2 and process for preparing the same.Type: GrantFiled: June 22, 1983Date of Patent: March 26, 1985Assignee: Taiho Pharmaceutical Company, LimitedInventors: Ronald J. Micetich, Shigeru Yamabe, Shuichi Ueda, Naobumi Ishida, Takeshi Ishizawa
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Patent number: 4496484Abstract: This invention provides a penicillin derivative of the formula and a salt thereof ##STR1## wherein X represents chlorine atom or bromine atom and R represents hydrogen atom or penicillin carboxy-protecting radical, and a process for preparing the derivative of the formula (I) and a salt thereof by reacting a compound of the formula ##STR2## wherein R is as defined above with a chlorinating reagent or brominating reagent and, when required, forming a salt thereof.Type: GrantFiled: April 22, 1983Date of Patent: January 29, 1985Assignee: Taiho Pharmaceutical Company, LimitedInventors: Ronald G. Micetich, Shigeru Yamabe, Shoji Hirata, Naobumi Ishida
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Patent number: 4448769Abstract: A 1,1-dioxopenicillanic acid ester represented by formula (I) ##STR1## wherein R represents a methyl or phenyl group. The ester of formula (I) may be prepared by reacting 1,1-dioxopenicillanic acid or its salt with a compound represented by formula (III) ##STR2## wherein R is as defined above, and X represents a halogen atom, or by oxidizing a compound of formula (V) ##STR3## wherein R is as defined above. The ester of the formula (I) is useful as a .beta.-lactamase inhibitor and may be used in association with a .beta.-lactam antibiotic.Type: GrantFiled: July 8, 1982Date of Patent: May 15, 1984Assignee: Kanebo Ltd.Inventors: Shoji Ikeda, Fumio Sakamoto, Goro Tsukamoto, Shigeru Yamabe
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Patent number: 4377702Abstract: Acetic acid derivatives having the formula, ##STR1## wherein X represents an oxygen or two hydrogen atoms, Y represents CH or N, A represents an oxygen or sulfur atom, and R represents hydroxy, amino or a lower alkoxy group having 1 to 5 carbon atoms possess excellent antiinfammatory activities.Type: GrantFiled: September 15, 1980Date of Patent: March 22, 1983Assignee: Nippon Chemiphar Co., Ltd.Inventors: Yasuo Fujimoto, Shigeru Yamabe
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Patent number: 4282245Abstract: A compound of the formula (I), ##STR1## wherein R.sub.1 represents a halogen atom, or a hydroxy, nitro, amino, trihalogenomethyl or lower alkoxy group having 1 to 5 carbon atoms, and R.sub.2 represents a hydroxy or amino group is an antiinflammatory agent.Type: GrantFiled: May 23, 1979Date of Patent: August 4, 1981Assignee: Nippon Chemiphar Co., Ltd.Inventors: Yasuo Fujimoto, Shigeru Yamabe
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Patent number: 4263437Abstract: Acetic acid derivatives having the formula, ##STR1## wherein X represents an oxygen or two hydrogen atoms, Y represents CH or N, A represents an oxygen or sulfur atom, and R represents hydroxy, amino or a lower alkoxy group having 1 to 5 carbon atoms possess excellent antiinflammatory activities.Type: GrantFiled: February 27, 1979Date of Patent: April 21, 1981Assignee: Nippon Chemiphar Co., Ltd.Inventors: Yasuo Fujimoto, Shigeru Yamabe
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Patent number: 4247706Abstract: A compound of the formula, ##STR1## wherein R represents a hydroxy or amino group is an antiinflammatory and analgesic agent.Type: GrantFiled: October 12, 1979Date of Patent: January 27, 1981Assignee: Nippon Chemiphar Co., Ltd.Inventors: Yasuo Fujimoto, Shigeru Yamabe
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Patent number: 4228284Abstract: 9-(.beta.-hydroxyethyl) piperazinyl-carbonyl-2-trifluoromethyl-10, 11-dihydrodibenzo[b,f]thiepin is prepared and disclosed as having antiinflamatory action.Type: GrantFiled: February 7, 1979Date of Patent: October 14, 1980Assignee: Nippon Chemiphar Company, LimitedInventors: Shigeru Yamabe, Yasuo Fujimoto, Shoji Ryu, Yoshio Suzuki, Yoshihiro Tanaka, Toru Yamanaka, Kiyosato Nyu
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Patent number: 4205170Abstract: Propionic acid derivatives having the formula ##STR1## wherein X represents an oxygen or two hydrogen atoms, Y represents CH or N, A represents an oxygen or sulfur atom, and R represents hydroxy, amino, or a lower alkoxy group having 1 to 5 carbon atoms are antiinflammatory agents.Type: GrantFiled: November 28, 1977Date of Patent: May 27, 1980Assignee: Nippon Chemiphar Company, LimitedInventors: Yasuo Fujimoto, Shigeru Yamabe
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Patent number: 4166127Abstract: Novel benzo [b,f] thiepin derivatives possessing strong anti-flammatory action and presenting few adverse reactions, of the formula (I) ##STR1## wherein R represents a fluorine atom, or a trifluoromethyl or 1-5C lower alkoxy group, and R.sub.3 and R.sub.4 each represent a 1-4C lower alkyl group or R.sub.3 and R.sub.4 together with the adjacent nitrogen atom to which they are attached form a heterocyclic group. Pharmaceutical compositions comprising an anti-inflammatory effective amount of the compound according to formula (I) in the presence of an inert carrier.Type: GrantFiled: January 16, 1978Date of Patent: August 28, 1979Assignee: Nippon Chemiphar Co., Ltd.Inventors: Shigeru Yamabe, Yasuo Fujimoto, Shoji Ryu, Yoshio Suzuki, Yoshihiro Tanaka, Toru Yamanaka, Kiyosato Nyu
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Patent number: 4101667Abstract: Dihydrodibenzo[b,f]thiepin compounds of formula (I) and process for making them. These compounds have antiinflammatory action. ##STR1## wherein R represents a hydrogen, fluorine atom, a trifluoromethyl, 1-5C lower alkoxy, hydroxy, hydroxyethoxy, aminoethoxy group or the group of the formula --OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OH, Y represents a hydroxy group or the group of the formula ##STR2## (R.sub.3 and R.sub.4 represent a 1-4C lower alkyl group or R.sub.3 and R.sub.4 may jointly form a heterocyclic group together with an adjacent nitrogen atom.Type: GrantFiled: May 25, 1976Date of Patent: July 18, 1978Assignee: Nippon Chemiphar Co., Ltd.Inventors: Shigeru Yamabe, Yasuo Fujimoto, Shoji Ryu, Yoshio Suzuki, Yoshihiro Tanaka, Toru Yamanaka, Kiyosato Nyu
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Patent number: 3971828Abstract: Compounds useful for prophylaxis and therapy in treating a metabolic disorder, such as nosotoxicosis due to a heavy metal radiation disorder, diabetes or hepatitis. ##EQU1## and intermediates therefor are disclosed.Type: GrantFiled: December 23, 1974Date of Patent: July 27, 1976Assignee: Santen Pharmaceutical Co. Ltd.Inventors: Itaru Mita, Shigeo Okumura, Shigeru Yamabe, Yoshihiko Funae, Junzo Matumoto