Patents by Inventor Shigeyoshi Fujiwara
Shigeyoshi Fujiwara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11364557Abstract: In this drill, a wall face of a chip removal groove includes a first wall face having a concave curve shape and a second wall face having a straight line shape in a cross section orthogonal to an axis of the drill main body, an extension line of a straight line of the second wall face extends in a direction opposite to a drill rotation direction as the straight line of the second wall face goes to an outer periphery side of the drill main body with respect to a radius line connecting an outer peripheral end of the second wall face and the axis with each other, the cutting edge includes a first cutting edge having a concave curve shape and a second cutting edge having a straight line shape which intersects with the first cutting edge at an obtuse angle.Type: GrantFiled: December 13, 2018Date of Patent: June 21, 2022Assignee: MOLDINO Tool Engineering, Ltd.Inventors: Shigeyoshi Fujiwara, Yusuke Hara
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Publication number: 20200398350Abstract: In this drill, a wall face of a chip removal groove includes a first wall face having a concave curve shape and a second wall face having a straight line shape in a cross section orthogonal to an axis of the drill main body, an extension line of a straight line of the second wall face extends in a direction opposite to a drill rotation direction as the straight line of the second wall face goes to an outer periphery side of the drill main body with respect to a radius line connecting an outer peripheral end of the second wall face and the axis with each other, the cutting edge includes a first cutting edge having a concave curve shape and a second cutting edge having a straight line shape which intersects with the first cutting edge at an obtuse angle.Type: ApplicationFiled: December 13, 2018Publication date: December 24, 2020Applicants: MOLDINO Tool Engineering, Ltd., MOLDINO Tool Engineering, Ltd.Inventors: Shigeyoshi Fujiwara, Yusuke Hara
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Publication number: 20200367804Abstract: The purpose of the present invention is to develop a method or system for measuring the skin condition easily and accurately. The method for determining the skin condition based on the thermal sensitivity in the skin was perfected by discovering that the skin condition, especially the skin barrier function, can be determined based on the thermal sensitivity in the skin.Type: ApplicationFiled: January 28, 2019Publication date: November 26, 2020Applicant: Shiseido Company, Ltd.Inventors: Ki SAI, Shigeyoshi FUJIWARA, Hirofumi AOKI, Takeshi HARIYA
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Patent number: 10344266Abstract: The present invention provides a method of producing a cell mass capable of serving as a primitive organ-like structure comprised of a plurality of somatic cell types of somatic origin, comprising: preparing cultures containing the plurality of types of somatic cells; mixing the plurality of types of somatic cell cultures followed by adding a Wnt signal activator to the mixed cell culture; subjecting the culture containing the Wnt signal activator to non-plate contact culturing over a predetermined time period; and replacing the medium of the culture cultured by the non-plate contact culturing with medium not containing Wnt signal activator and further culturing for a predetermined time period; wherein, at least one type of the plurality of somatic cells is maintained in an undifferentiated state.Type: GrantFiled: July 1, 2015Date of Patent: July 9, 2019Assignee: SHISEIDO COMPANY, LTD.Inventors: Shigeyoshi Fujiwara, Jiro Kishimoto, Tsutomu Soma
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Patent number: 10279398Abstract: A drill of the present invention includes: a drill main body; a plurality of convex-arc cutting edges which are formed on a tip side of the drill main body from an outer periphery of the drill main body to a chisel edge provided near to a rotational axis; second faces which are each formed in an approximately band shape and are each formed along each of the convex-arc cutting edges on a back side of the convex-arc cutting edge in the rotational direction; third faces which are each formed to be continuous with a back side of each of the second faces in the rotational direction; and fourth faces which are each formed to be continuous with a back side of each of the third faces in the rotational direction.Type: GrantFiled: March 17, 2016Date of Patent: May 7, 2019Assignee: Mitsubishi Hitachi Tool Engineering, Ltd.Inventors: Shigeyoshi Fujiwara, Teruaki Niwa
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Patent number: 10172332Abstract: Provided is a method for regenerating hair follicles by transplanting a composition containing CD36-expressing dermal sheath cells (DSc) to a human. The composition may be prepared by sorting CD36-expressing dermal sheath cells from a hair follicle tissue by use of a cell-sorting technique along with an antibody to CD36. The composition may also contain dermal papilla cells (DPc).Type: GrantFiled: March 22, 2016Date of Patent: January 8, 2019Assignee: SHISEIDO COMPANY, LTD.Inventors: Yuzo Yoshida, Tsutomu Soma, Shigeyoshi Fujiwara
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Publication number: 20180043441Abstract: A drill of the present invention includes: a drill main body; a plurality of convex-arc cutting edges which are formed on a tip side of the drill main body from an outer periphery of the drill main body to a chisel edge provided near to a rotational axis; second faces which are each formed in an approximately band shape and are each formed along each of the convex-arc cutting edges on a back side of the convex-arc cutting edge in the rotational direction; third faces which are each formed to be continuous with a back side of each of the second faces in the rotational direction; and fourth faces which are each formed to be continuous with a back side of each of the third faces in the rotational direction.Type: ApplicationFiled: March 17, 2016Publication date: February 15, 2018Applicant: Mitsubishi Hitachi Tool Engineering, Ltd.Inventors: Shigeyoshi FUJIWARA, Teruaki NIWA
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Publication number: 20160193140Abstract: Provided is a method for regenerating hair follicles by transplanting a composition containing CD36-expressing dermal sheath cells (DSc) to a human. The composition may be prepared by sorting CD36-expressing dermal sheath cells from a hair follicle tissue by use of a cell-sorting technique along with an antibody to CD36. The composition may also contain dermal papilla cells (DPc).Type: ApplicationFiled: March 22, 2016Publication date: July 7, 2016Applicant: Shiseido Company, Ltd.Inventors: Yuzo YOSHIDA, Tsutomu SOMA, Shigeyoshi FUJIWARA
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Publication number: 20160160185Abstract: The present invention provides a method of producing a cell mass capable of serving as a primitive organ-like structure comprised of a plurality of somatic cell types of somatic origin, comprising: preparing cultures containing the plurality of types of somatic cells; mixing the plurality of types of somatic cell cultures followed by adding a Wnt signal activator to the mixed cell culture; subjecting the culture containing the Wnt signal activator to non-plate contact culturing over a predetermined time period; and replacing the medium of the culture cultured by the non-plate contact culturing with medium not containing Wnt signal activator and further culturing for a predetermined time period; wherein, at least one type of the plurality of somatic cells is maintained in an undifferentiated state.Type: ApplicationFiled: July 1, 2015Publication date: June 9, 2016Applicant: Shiseido Company, Ltd.Inventors: Shigeyoshi Fujiwara, Jiro Kishimoto, Tsutomu Soma
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Patent number: 9347031Abstract: A container for forming a cell aggregate is provided in which a group represented by a general formula of: (in the formula, each of R1, R2, and R3 is independently a an alkyl group with a carbon number of 1 or more and 6 or less and m is an integer of 2 or more and 6 or less.) and at least one of an amino group, a carboxyl group, and a hydroxyl group are present near a surface thereof.Type: GrantFiled: June 15, 2010Date of Patent: May 24, 2016Assignee: SHISEIDO COMPANY, LTD.Inventors: Shigeyoshi Fujiwara, Keigo Takei, Aya Hirayama, Yukimitsu Suda
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Publication number: 20140106432Abstract: The present invention provides a method of producing a cell mass capable of serving as a primitive organ-like structure comprised of a plurality of somatic cell types of somatic origin, comprising: preparing cultures containing the plurality of types of somatic cells; mixing the plurality of types of somatic cell cultures followed by adding a Wnt signal activator to the mixed cell culture; subjecting the culture containing the Wnt signal activator to non-plate contact culturing over a predetermined time period; and replacing the medium of the culture cultured by the non-plate contact culturing with medium not containing Wnt signal activator and further culturing for a predetermined time period; wherein, at least one type of the plurality of somatic cells is maintained in an undifferentiated state.Type: ApplicationFiled: September 18, 2013Publication date: April 17, 2014Applicant: Shiseido Company, Ltd.Inventors: Shigeyoshi Fujiwara, Jiro Kishimoto, Tsutomu Soma
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Patent number: 8563309Abstract: The present invention provides a method of producing a cell mass capable of serving as a primitive organ-like structure comprised of a plurality of somatic cell types of somatic origin, comprising: preparing cultures containing the plurality of types of somatic cells; mixing the plurality of types of somatic cell cultures followed by adding a Wnt signal activator to the mixed cell culture; subjecting the culture containing the Wnt signal activator to non-plate contact culturing over a predetermined time period; and replacing the medium of the culture cultured by the non-plate contact culturing with medium not containing Wnt signal activator and further culturing for a predetermined time period; wherein, at least one type of the plurality of somatic cells is maintained in an undifferentiated state.Type: GrantFiled: June 27, 2007Date of Patent: October 22, 2013Assignee: Shiseido Company, Ltd.Inventors: Shigeyoshi Fujiwara, Jiro Kishimoto, Tsutomu Soma
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Publication number: 20130266954Abstract: A method for forming a cell aggregate in the present invention is a method for forming a cell aggregate by using a culturing vessel and culturing an adhesive cell, wherein the culturing vessel is such that an amino group, a carboxyl group, and/or a hydroxyl group, and a group represented by a general formula of (in the formula, each of R1, R2, and R3 is independently an alkyl group with a carbon number greater than or equal to 1 and less than or equal to 6 and m is an integer greater than or equal to 2 and less than or equal to 6.) are present near a surface thereof and the adhesive cell is a mesenchymal stem cell, a hepatic cell, or a cancer cell.Type: ApplicationFiled: December 7, 2011Publication date: October 10, 2013Applicant: SHISEIDO COMPANY, LTD.Inventors: Shigeyoshi Fujiwara, Keigo Takei, Yukimitsu Suda
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Publication number: 20130212724Abstract: Provided is a composition for regenerating hair follicles comprising CD36-expressing dermal sheath cells (DSc).Type: ApplicationFiled: September 29, 2010Publication date: August 15, 2013Applicant: SHISEIDO COMPANY, LTD.Inventors: Yuzo Yoshida, Tsutomu Soma, Shigeyoshi Fujiwara
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Patent number: 8257972Abstract: Disclosed is a cell transformed by a vector containing human Wnt3a gene, wherein the cell is selected from a group consisting of hair follicle-derived cells and prostate cancer-derived cells.Type: GrantFiled: January 21, 2009Date of Patent: September 4, 2012Assignee: Shiseido Company, Ltd.Inventors: Yumiko Ishimatsu, Shunsuke Iriyama, Shigeyoshi Fujiwara, Tsutomu Soma, Jiro Kishimoto
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Publication number: 20120156696Abstract: A container for forming a cell aggregate is provided in which a group represented by a general formula of: (in the formula, each of R1, R2, and R3 is independently a an alkyl group with a carbon number of 1 or more and 6 or less and m is an integer of 2 or more and 6 or less.) and at least one of an amino group, a carboxyl group, and a hydroxyl group are present near a surface thereof.Type: ApplicationFiled: June 15, 2010Publication date: June 21, 2012Applicant: SHISEIDO COMPANY, LTD.Inventors: Shigeyoshi Fujiwara, Keigo Takei, Aya Hirayama, Yukimitsu Suda
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Publication number: 20100311163Abstract: Disclosed is a cell transformed by a vector containing human Wnt3a gene, wherein the cell is selected from a group consisting of hair follicle-derived cells and prostate cancer-derived cells.Type: ApplicationFiled: January 21, 2009Publication date: December 9, 2010Inventors: Yumiko Ishimatsu, Shunsuke Iriyama, Shigeyoshi Fujiwara, Tsutomu Soma, Jiro Kishimoto
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Patent number: 7785636Abstract: A first subject of the present invention is an insoluble powder characterized in that a zeta-potential is a negative value. It is preferable that barium sulfate is a main ingredient in the insoluble powder. It is preferable that an average primary particle diameter is 3 to 100 ?m, and an aspect ratio is 3 to 250 in the insoluble powder. It is preferable that the insoluble powder is a metal-doped barium sulfate powder obtained by reacting a barium ion and a sulfate ion in the presence of a metal ion. It is preferable that the metal ion is one or more selected from the group consisting of a lithium ion, a sodium ion and a zinc ion in the insoluble powder. A second subject of the present invention is a skin barrier function recovering powder, or a skin roughening preventing and improving powder, which comprises the aforementioned powder. A third subject of the present invention is a skin external composition characterized in that a content of the aforementioned powder is 1 to 40% by weight.Type: GrantFiled: March 28, 2003Date of Patent: August 31, 2010Assignee: Shiseido Co., Ltd.Inventors: Shigeyoshi Fujiwara, Mitsuhiro Denda, Katsuki Ogawa, Tsuyoshi Miyamoto, Sadaki Takata
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Publication number: 20050209201Abstract: The present invention provides a method and composition which ameliorate inflammation, and suppress its onset, by allowing ATP receptor antagonists to act on ATP receptors of cells to block them and thereby inhibit the release of inflammatory cytokines, particularly interleukin-6 (IL-6) and/or interleukin-8 (IL-8), by the cells.Type: ApplicationFiled: March 11, 2005Publication date: September 22, 2005Applicant: Shiseido Co., Ltd.Inventors: Kaori Inoue, Mitsuhiro Denda, Shigeyoshi Fujiwara
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Publication number: 20050175645Abstract: A first subject of the present invention is an insoluble powder characterized in that a zeta-potential is a negative value. It is preferable that barium sulfate is a main ingredient in the insoluble powder. It is preferable that an average primary particle diameter is 3 to 100 ?m, and an aspect ratio is 3 to 250 in the insoluble powder. It is preferable that the insoluble powder is a metal-doped barium sulfate powder obtained by reacting a barium ion and a sulfate ion in the presence of a metal ion. It is preferable that the metal ion is one or more selected from the group consisting of a lithium ion, a sodium ion and a zinc ion in the insoluble powder. A second subject of the present invention is a skin barrier function recovering powder, or a skin roughening preventing and improving powder, which comprises the aforementioned powder. A third subject of the present invention is a skin external composition characterized in that a content of the aforementioned powder is 1 to 40% by weight.Type: ApplicationFiled: March 28, 2003Publication date: August 11, 2005Inventors: Shigeyoshi Fujiwara, Mitsuhiro Denda, Katsuki Ogawa, Tsuyoshi Miyamoto, Sadaki Takata