Patents by Inventor Shigeyoshi Horiike
Shigeyoshi Horiike has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9535034Abstract: A suppressor is structured by an ion exchange section being structured by an eluate path forming member forming an eluate path and a regenerant path forming member forming a regenerant path being stacked across an ion exchange film, and a heat-conductive heat block covering the outside of the ion exchange section. A separation column, the suppressor, and an electrical conductivity meter are accommodated in a common constant temperature bath. The inside of the constant temperature bath is feedback-controlled by a temperature control section so as to be maintained at constant temperature.Type: GrantFiled: October 15, 2012Date of Patent: January 3, 2017Assignee: SHIMADZU CORPORATIONInventors: Katsumasa Sakamoto, Yukio Oikawa, Shigeyoshi Horiike
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Patent number: 9513257Abstract: An aging treatment is performed by using cleaning gas obtained by mixing inert gas, as an impurity, to plasma gas. Plasma generation by dielectric-barrier discharge is performed until a predetermined period of time has elapsed by applying high AC voltage to an electrode while supplying the cleaning gas to a dielectric tube from a gas inlet.Type: GrantFiled: March 15, 2012Date of Patent: December 6, 2016Assignee: SHIMADZU CORPORATIONInventors: Shigeyoshi Horiike, Kei Shinada, Takahiro Nishimoto
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Patent number: 9366656Abstract: An analysis device comprising a discharge ionization current detector, a plasma gas supply section, a sample gas supply section, a flow rate setting condition holding section and a gas flow rate setting means controller. The flow rate setting condition holding section holds, as a flow rate setting condition, a relationship between a sample gas supply flow rate from the sample gas supply section and a supply flow rate of plasma gas to be set with respect to the sample gas supply flow rate and the gas flow rate controller is configured to set a plasma gas supply flow rate from the plasma gas supply section to a flow rate according to the sample gas supply flow rate, based on the flow rate setting condition held in the flow rate setting condition holding section.Type: GrantFiled: February 20, 2013Date of Patent: June 14, 2016Assignee: SHIMADZU CORPORATIONInventors: Kei Shinada, Shigeyoshi Horiike, Takahiro Nishimoto
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Publication number: 20150377844Abstract: A discharge ionization current detector of the present invention is used for a detector for a gas chromatograph and suitable for analyzing high-boiling components. A discharge ionization current detector 10 is mainly constituted by a plasma generating section 20 and an ion collecting section 30. Regarding the ion collecting section 30, an ion collecting electrode 31 and a bias electrode 32 are arranged, and furthermore, an insulating member made of sapphire or aluminum oxide having a purity equal to or greater than 99.5% is arranged between the ion collecting electrode 31 and the bias electrode 32.Type: ApplicationFiled: February 15, 2013Publication date: December 31, 2015Applicant: SHIMADZU CORPORATIONInventors: Shigeyoshi HORIIKE, Kei SHINADA
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Publication number: 20150369777Abstract: An adjusting method for a discharge ionization current detector of the present invention is provided for a discharge ionization current detector for a gas chromatograph, which improves the precision and reproducibility of measurements results of the detector. The discharge ionization current detector adjusts at least one of purity of introduced helium gas, a flow rate of the introduced helium gas, an amplitude of voltage of the low-frequency dielectric barrier discharge, and a frequency of the voltage of the low-frequency dielectric barrier discharge so that intensity of light having a wavelength of 640 nm reaches the maximum in a range of wavelengths of 250 to 700 nm with respect to light emitted by the helium plasma.Type: ApplicationFiled: February 15, 2013Publication date: December 24, 2015Applicant: SHIMADZU CORPORATIONInventors: Kei SHINADA, Shigeyoshi HORIIKE
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Publication number: 20150253286Abstract: To widen the dynamic range of a dielectric barrier ionization detector (BID), an insertion length of a sample injection tube 16 into a second gas passage 11 is set so that a sample-gas ejection port 16a is located on the downstream side of a dilution gas from the upper edge of a collector electrode 14 at which a DC electric field concentrates. By this setting, although the detection sensitivity is lower than in the case where the sample-gas ejection port 16a is placed to maximize the detection sensitivity, the decrease in the detection sensitivity to high-concentration samples is reduced since absorption of light by the sample gas is alleviated. Consequently, the sample-concentration range with a linearly-changing sensitivity becomes wider than that of conventional BIDs. Although the detection sensitivity becomes lower than that of conventional BIDs, a detection sensitivity adequately higher than that of FIDs can be ensured.Type: ApplicationFiled: February 2, 2015Publication date: September 10, 2015Applicant: SHIMADZU CORPORATIONInventors: Kei Shinada, Shigeyoshi Horiike
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Patent number: 8970221Abstract: A discharge ionization current detector capable of supplying plasma gas in large quantity to stabilize plasma simultaneously with lowering the sample dilution ratio to improve detection sensitivity is provided. A gas supply pipe 7 for supplying a plasma gas, which also functions as a dilution gas, is connected to a point near the connecting section of a first gas passage 3 having electrodes 4-6 for plasma generation and a second gas passage having electrodes 16 and 17 for ion detection. A first gas discharge pipe 8 is connected to the other end of the first gas passage 3, and a second gas discharge pipe 13 is connected to the other end of the second gas passage 11. Flow controllers 9 and 14 are provided in the gas discharge pipes 8 and 13, respectively. The flow rate of the gas passing through a plasma generation area and that of the gas passing through an ion current detection area can be independently regulated.Type: GrantFiled: January 20, 2011Date of Patent: March 3, 2015Assignee: Shimadzu CorporationInventors: Kei Shinada, Shigeyoshi Horiike, Takahiro Nishimoto
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Publication number: 20150054521Abstract: An aging treatment is performed by using cleaning gas obtained by mixing inert gas, as an impurity, to plasma gas. Plasma generation by dielectric-barrier discharge is performed until a predetermined period of time has elapsed by applying high AC voltage to an electrode while supplying the cleaning gas to a dielectric tube from a gas inlet.Type: ApplicationFiled: March 15, 2012Publication date: February 26, 2015Applicant: SHIMADZU CORPORATIONInventors: Shigeyoshi Horiike, Kei Shinada, Takahiro Nishimoto
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Publication number: 20150042354Abstract: An analysis device comprising a discharge ionization current detector, a plasma gas supply section, a sample gas supply section, a flow rate setting condition holding section and a gas flow rate setting means controller. The flow rate setting condition holding section holds, as a flow rate setting condition, a relationship between a sample gas supply flow rate from the sample gas supply section and a supply flow rate of plasma gas to be set with respect to the sample gas supply flow rate and the gas flow rate controller is configured to set a plasma gas supply flow rate from the plasma gas supply section to a flow rate according to the sample gas supply flow rate, based on the flow rate setting condition held in the flow rate setting condition holding section.Type: ApplicationFiled: February 20, 2013Publication date: February 12, 2015Inventors: Kei Shinada, Shigeyoshi Horiike, Takahiro Nishimoto
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Publication number: 20140320146Abstract: A suppressor is structured by an ion exchange section being structured by an eluate path forming member forming an eluate path and a regenerant path forming member forming a regenerant path being stacked across an ion exchange film, and a heat-conductive heat block covering the outside of the ion exchange section. A separation column, the suppressor, and an electrical conductivity meter are accommodated in a common constant temperature bath. The inside of the constant temperature bath is feedback-controlled by a temperature control section so as to be maintained at constant temperature.Type: ApplicationFiled: October 15, 2012Publication date: October 30, 2014Inventors: Katsumasa Sakamoto, Yukio Oikawa, Shigeyoshi Horiike
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Patent number: 8829913Abstract: A technique for reducing an electromagnetic noise entering an electrode or a drift of a signal due to a fluctuation in the ambient temperature is provided to improve the S/N ratio of a signal originating from a component of interest. A dummy electrode having the same structure as an ion-collecting electrode is provided within a lower gas passage at a position where dilution gas with no sample gas mixed therein flows. A differential amplifier is provided to perform differential detection between output A of a current amplifier connected to the ion-collecting electrode and output B of a current amplifier connected to the dummy electrode. The differential signal is free from a common mode noise or drift and hence accurately reflects the amount of the component of interest.Type: GrantFiled: June 23, 2011Date of Patent: September 9, 2014Assignees: Shimadzu Corporation, Osaka UniversityInventors: Kei Shinada, Shigeyoshi Horiike, Takahiro Nishimoto, Katsuhisa Kitano
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Patent number: 8797041Abstract: A discharge ionization current detector using a low-frequency dielectric barrier discharge with an improved S/N ratio is provided. A current detector 20 is disposed between an excitation high-voltage power source 8 and a discharge electrode 5 to detect a discharge current flowing in pulses due to plasma generation. The detection signal of the current detector 20 and an output signal from a current amplifier 18 for amplifying an ion current are inputted into an output extraction unit 21. The output extraction unit 21 detects a precipitous-rise portion of the discharge current detection signal and generates a trigger signal, and then extracts an ion current signal for a predetermined time period from the trigger signal. This can remove an influence of a noise appearing in a signal during a time period where no plasma emission is generated, thereby improving the S/N ratio of the detection signal.Type: GrantFiled: April 21, 2011Date of Patent: August 5, 2014Assignees: Shimadzu Corporation, Osaka UniversityInventors: Kei Shinada, Shigeyoshi Horiike, Takahiro Nishimoto, Katsuhisa Kitano
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Patent number: 8773138Abstract: A discharge ionization current detector using a low-frequency barrier discharge is provided to improve the linearity of detection sensitivity with respect to a sample introduction amount. From a lower end of a lower gas passage connected to a lower end of an upper gas passage, a dilution gas is supplied upward against a downward flow of a plasma gas. A gas discharge passage for discharging a plasma gas, the dilution gas and a sample gas is arranged between an ion-collecting electrode and a bias voltage application electrode. The sample gas introduced through a capillary tube is mixed with the plasma gas and the dilution gas due to a disturbed flow generated by collision of the plasma gas and the dilution gas. The sample component is efficiently ionized by light from the plasma without undergoing light-shielding effect of concentrated sample components.Type: GrantFiled: June 23, 2011Date of Patent: July 8, 2014Assignee: Shimadzu CorporationInventors: Kei Shinada, Shigeyoshi Horiike, Takahiro Nishimoto
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Publication number: 20140145724Abstract: A low-OH-content quartz glass with an OH content equal to or lower than 5 ppm is used as a cylindrical tube (2) covering the surface of metallic plasma generation electrodes (4, 5 and 6) for generating a low-frequency barrier discharge. It has been found that, in the low-frequency barrier discharge, hydrogen and oxygen originating from the OH contained in a dielectric material are released into plasma gas for a long period of time, constituting a primary cause of an increase in the baseline current. The use of a low-OH-content quartz glass dramatically lowers the baseline current and thereby improves the S/N ratio and the detection limit.Type: ApplicationFiled: May 31, 2012Publication date: May 29, 2014Inventors: Kei Shinada, Shigeyoshi Horiike, Takahiro Nishimoto
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Patent number: 8551760Abstract: [Problems] To immobilize a chain-type biopolymer in an elongated state at a predetermined position on a substrate. [Means for Solving Problems] A substrate (1) for immobilizing a biopolymer, which has a mask layer (2) provided with multiple through-holes at predetermined positions on a flat active face, is brought into contact with a solution containing a chain-type biopolymer (7). After thus immobilizing the nucleic acid molecule (7) on the active face within a through-hole (3) via physical adsorption or chemical binding, the mask layer (2) is dissolved in a solvent and thus removed while leaving the nucleic acid molecule (7a) alone having been immobilized on the active face within the through-hole (3). Subsequently, the nucleic acid molecule (7a) having been immobilized on the active face is elongated.Type: GrantFiled: September 5, 2005Date of Patent: October 8, 2013Assignee: Shimadzu CorporationInventors: Shigeyoshi Horiike, Yukio Oikawa, Takahiro Nishimoto
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Patent number: 8425842Abstract: A suppressor which comprises: an ion-exchange membrane; an eluate channel which is in contact with one side of the ion-exchange membrane, serves as a channel through which an eluate discharged from a separation column flows, and has inside no obstacle to the flow; a regenerant channel which is in contact with the other side of the ion-exchange membrane, serves as a channel through which a regenerant for regenerating ionic functional groups of the ion-exchange membrane flows, has been disposed so that the regenerant channel has no region facing the eluate channel and extends in parallel to the eluate channel in such a nearby position that the ionic functional groups can move through the ion-exchange membrane, and has inside no obstacle to the flow; and an ion-exchange membrane support member which is in contact at least with that region on one side of the ion-exchange membrane which is opposed to the regenerant channel and with that region on the other side of the ion-exchange membrane which is opposed to theType: GrantFiled: January 7, 2008Date of Patent: April 23, 2013Assignee: Shimadzu CorporationInventor: Shigeyoshi Horiike
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Patent number: 8217094Abstract: A monolith separation medium comprising a skeletal phase and continuous pores forming a three-dimensional network structure, which has a functional group enabling the introduction of a new functional group on the surface of the skeletal phase. The skeletal phase has an average diameter of a submicron to micrometer size and is in a co-continuous structure of the non-particle-aggregation type. It is composed of an addition polymer of 1,3-bis(N,N?-diglycidylaminomethyl)cyclohexane as an epoxy compound with a bifunctional or higher amine compound, is rich in organic matters and is free from any aromatic-origin carbon atom. Thus, it is an organic polymer monolith separation medium of the non-particle-aggregation type.Type: GrantFiled: October 17, 2007Date of Patent: July 10, 2012Assignee: Shimadzu CorporationInventors: Ken Hosoya, Mari Sakamoto, Shigeyoshi Horiike
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Patent number: 8153992Abstract: Provided is an ionization emitter which can reduce a dead volume without deteriorating separating capacity. An ionization emitter (2) is provided with a tip (1) composed of a columnar or conical porous self-standing structure, and a channel for supplying a solution sample into the tip (1) from the base end side of the tip (1). The channel is formed by filling a pipe line with a packing, and the tip (1) is exposed from the pipe line of the channel. The packing and the porous self-standing structure constituting the tip (1) have an integrated structure composed of a same porous body formed at the same time.Type: GrantFiled: January 7, 2008Date of Patent: April 10, 2012Assignee: Shimadzu CorporationInventors: Shigeyoshi Horiike, Hiroaki Nakanishi
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Publication number: 20110316551Abstract: A technique for reducing an electromagnetic noise entering an electrode or a drift of a signal due to a fluctuation in the ambient temperature is provided to improve the S/N ratio of a signal originating from a component of interest. A dummy electrode 11 having the same structure as an ion-collecting electrode 10 is provided within a lower gas passage 14 at a position where dilution gas with no sample gas mixed therein flows. A differential amplifier 14 is provided to perform differential detection between output A of a current amplifier 21 connected to the ion-collecting electrode 10 and output B of a current amplifier 22 connected to the dummy electrode 11. The differential signal is free from a common mode noise or drift and hence accurately reflects the amount of the component of interest.Type: ApplicationFiled: June 23, 2011Publication date: December 29, 2011Applicants: OSAKA UNIVERSITY, SHIMADZU CORPORATIONInventors: Kei SHINADA, Shigeyoshi HORIIKE, Takahiro NISHIMOTO, Katsuhisa KITANO
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Publication number: 20110316552Abstract: A discharge ionization current detector using a low-frequency barrier discharge is provided to improve the linearity of detection sensitivity with respect to a sample introduction amount. From a lower end of a lower gas passage 10 connected to a lower end of an upper gas passage 4, a dilution gas is supplied upward against a downward flow of a plasma gas. A gas discharge passage 15 for discharging a plasma gas, the dilution gas and a sample gas is arranged between an ion-collecting electrode 11 and a bias voltage application electrode 12. The sample gas introduced through a capillary tube 16 is mixed with the plasma gas and the dilution gas due to a disturbed flow generated by collision of the plasma gas and the dilution gas. The sample component is efficiently ionized by light from the plasma without undergoing light-shielding effect of concentrated sample components.Type: ApplicationFiled: June 23, 2011Publication date: December 29, 2011Applicant: SHIMADZU CORPORATIONInventors: Kei SHINADA, Shigeyoshi HORIIKE, Takahiro NISHIMOTO